TY - JOUR
T1 - Virilizing Adrenal Adenoma in a 2-Year-Old Girl
T2 - Analysis of Tumor Steroids Using High-Performance Liquid Chromatography
AU - Richards, Gail E.
AU - Griffiths, Marilyn D.
AU - Hoelzer, Dennis J.
AU - Kessler, Michael J.
AU - Dan, Maria
AU - Marshall, Robert N.
AU - Pottkotter, Louis E.
PY - 1983/8
Y1 - 1983/8
N2 - A 2-year-old girl with virilization had an adrenal tumor that produced testosterone with little evidence of excessive urinary androgen excretion. Plasma testosterone concentration was 407 ng/dL and urinary 17-ketosteroid (17KS) levels were 3 and 2 mg/day. Excretion of 17KS decreased to 1.8 mg/day after suppression of dexamethasone therapy, but urinary 17-hydroxycorticosteroid excretion did not change from 1.0 to 0.7 mg/day after administration of dexamethasone. She had a blunted response to administration of metyrapone and insulin and a small diurnal variation in cortisol concentration suggesting suppression of corticotropin secretion, even though the plasma cortisol concentration was in the normal range and there were no clinical signs of cortisol excess. High-performance liquid chromatography was used to analyze the steroid content of tumor tissue. Those portions of the tumor that were rich in steroids contained predominantly testosterone.
AB - A 2-year-old girl with virilization had an adrenal tumor that produced testosterone with little evidence of excessive urinary androgen excretion. Plasma testosterone concentration was 407 ng/dL and urinary 17-ketosteroid (17KS) levels were 3 and 2 mg/day. Excretion of 17KS decreased to 1.8 mg/day after suppression of dexamethasone therapy, but urinary 17-hydroxycorticosteroid excretion did not change from 1.0 to 0.7 mg/day after administration of dexamethasone. She had a blunted response to administration of metyrapone and insulin and a small diurnal variation in cortisol concentration suggesting suppression of corticotropin secretion, even though the plasma cortisol concentration was in the normal range and there were no clinical signs of cortisol excess. High-performance liquid chromatography was used to analyze the steroid content of tumor tissue. Those portions of the tumor that were rich in steroids contained predominantly testosterone.
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U2 - 10.1001/archpedi.1983.02140340025006
DO - 10.1001/archpedi.1983.02140340025006
M3 - Article
C2 - 6307039
AN - SCOPUS:0020608933
SN - 0002-922X
VL - 137
SP - 741
EP - 744
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 8
ER -