In this work, we investigated the visibility of microcalcifications in CCD-based cone beam CT (CBCT) breast imaging. A paraffin cylinder with a diameter of 135 mm and a thickness of 40 mm was used to simulate a 100% adipose breast. Calcium carbonate grains, ranging from 140-150 to 200-212 μmu; m in size, were used to simulate the microcalcifications. Groups of 25 same size microcalcifications were arranged into 5 × 5 clusters. Each cluster was embedded at the center of a smaller (15 mm diameter) cylindrical paraffin phantom, which were inserted into a hole at the center of the breast phantom. The breast phantom with the simulated microcalcifications was scanned on a bench top experimental CCDbased cone beam CT system at various exposure levels with two CCD cameras: Hamamatsu's C4742-56-12ER and Dalsa 99-66-0000-00. 300 projection images were acquired over 360 and reconstructed with Feldkamp's backprojection algorithm using a ramp filter. The images were reviewed by 6 readers independently. The ratios of visible microcalcifications were recorded and averaged over all readers. These ratios were plotted as the function of measured image signal-to-noise ratio (SNR) for various scans. It was found that 94% visibility was achieved for 200-212 μmu; m calcifications at an SNR of 48.2 while 50% visibility was achieved for 200-212, 180-200, 160-180, 150-160 and 140-150 μmu; m calcifications at an SNR of 25.0, 35.3, 38.2, 42.2 and 64.4, respectively.