Visual Pathway Measures are Associated with Neuropsychological Function in Multiple Sclerosis

James Nguyen, Alissa Rothman, Kathryn Fitzgerald, Anna Whetstone, Stephanie Syc-Mazurek, Jannelle Aquino, Laura J. Balcer, Elliot Frohman, Teresa C. Frohman, Ciprian Crainiceanu, Meghan Beier, Scott D. Newsome, Peter A. Calabresi, Shiv Saidha

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To determine the relationships between visual function and ganglion cell and inner plexiform layer thickness and neuropsychological measures in multiple sclerosis (MS). Methods: Ninety-five relapsing–remitting MS (RRMS) and 36 progressive MS patients underwent 100%-contrast visual acuity (VA), 2.5%- and 1.25%-contrast letter acuity (LA) testing, Cirrus-HD-optical coherence tomography, and neuropsychological assessments. Mixed-effects regression models were used to assess relationships. Results: Across the cohort, 1.25%-contrast LA was associated with Symbol Digit Modalities Test (SDMT; β = 2.17, p = 0.005) and Brief Visuospatial Memory Test-Revised (BVMT-R) total recall (TR) and delayed recall (DR) scores (β = 0.31, p < 0.001; β = 0.15, p = 0.039, respectively). 2.5%-contrast LA was associated with BVMT-R TR scores (β = 0.27, p = 0.006). In the RRMS cohort, 1.25%-contrast LA was generally more significantly associated with cognitive measures: SDMT (β = 2.97, p = 0.001) and BVMT-R TR (β = 0.32, p < 0.001) and DR (β = 0.22, p = 0.012). Conclusion: This study suggests that visual pathway measures, particularly visual function measures, reflect aspects of cognitive function in MS, further supporting their roles as complementary outcomes in MS neuroprotection trials.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCurrent Eye Research
DOIs
StateAccepted/In press - May 2 2018

Fingerprint

Visual Pathways
Multiple Sclerosis
Optical Coherence Tomography
Ganglia
Cognition
Visual Acuity

Keywords

  • multiple sclerosis
  • neuropsychological assessment
  • optical coherence tomography
  • visual function
  • Visual pathway

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Nguyen, J., Rothman, A., Fitzgerald, K., Whetstone, A., Syc-Mazurek, S., Aquino, J., ... Saidha, S. (Accepted/In press). Visual Pathway Measures are Associated with Neuropsychological Function in Multiple Sclerosis. Current Eye Research, 1-8. https://doi.org/10.1080/02713683.2018.1459730

Visual Pathway Measures are Associated with Neuropsychological Function in Multiple Sclerosis. / Nguyen, James; Rothman, Alissa; Fitzgerald, Kathryn; Whetstone, Anna; Syc-Mazurek, Stephanie; Aquino, Jannelle; Balcer, Laura J.; Frohman, Elliot; Frohman, Teresa C.; Crainiceanu, Ciprian; Beier, Meghan; Newsome, Scott D.; Calabresi, Peter A.; Saidha, Shiv.

In: Current Eye Research, 02.05.2018, p. 1-8.

Research output: Contribution to journalArticle

Nguyen, J, Rothman, A, Fitzgerald, K, Whetstone, A, Syc-Mazurek, S, Aquino, J, Balcer, LJ, Frohman, E, Frohman, TC, Crainiceanu, C, Beier, M, Newsome, SD, Calabresi, PA & Saidha, S 2018, 'Visual Pathway Measures are Associated with Neuropsychological Function in Multiple Sclerosis', Current Eye Research, pp. 1-8. https://doi.org/10.1080/02713683.2018.1459730
Nguyen, James ; Rothman, Alissa ; Fitzgerald, Kathryn ; Whetstone, Anna ; Syc-Mazurek, Stephanie ; Aquino, Jannelle ; Balcer, Laura J. ; Frohman, Elliot ; Frohman, Teresa C. ; Crainiceanu, Ciprian ; Beier, Meghan ; Newsome, Scott D. ; Calabresi, Peter A. ; Saidha, Shiv. / Visual Pathway Measures are Associated with Neuropsychological Function in Multiple Sclerosis. In: Current Eye Research. 2018 ; pp. 1-8.
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abstract = "Purpose: To determine the relationships between visual function and ganglion cell and inner plexiform layer thickness and neuropsychological measures in multiple sclerosis (MS). Methods: Ninety-five relapsing–remitting MS (RRMS) and 36 progressive MS patients underwent 100{\%}-contrast visual acuity (VA), 2.5{\%}- and 1.25{\%}-contrast letter acuity (LA) testing, Cirrus-HD-optical coherence tomography, and neuropsychological assessments. Mixed-effects regression models were used to assess relationships. Results: Across the cohort, 1.25{\%}-contrast LA was associated with Symbol Digit Modalities Test (SDMT; β = 2.17, p = 0.005) and Brief Visuospatial Memory Test-Revised (BVMT-R) total recall (TR) and delayed recall (DR) scores (β = 0.31, p < 0.001; β = 0.15, p = 0.039, respectively). 2.5{\%}-contrast LA was associated with BVMT-R TR scores (β = 0.27, p = 0.006). In the RRMS cohort, 1.25{\%}-contrast LA was generally more significantly associated with cognitive measures: SDMT (β = 2.97, p = 0.001) and BVMT-R TR (β = 0.32, p < 0.001) and DR (β = 0.22, p = 0.012). Conclusion: This study suggests that visual pathway measures, particularly visual function measures, reflect aspects of cognitive function in MS, further supporting their roles as complementary outcomes in MS neuroprotection trials.",
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AU - Fitzgerald, Kathryn

AU - Whetstone, Anna

AU - Syc-Mazurek, Stephanie

AU - Aquino, Jannelle

AU - Balcer, Laura J.

AU - Frohman, Elliot

AU - Frohman, Teresa C.

AU - Crainiceanu, Ciprian

AU - Beier, Meghan

AU - Newsome, Scott D.

AU - Calabresi, Peter A.

AU - Saidha, Shiv

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N2 - Purpose: To determine the relationships between visual function and ganglion cell and inner plexiform layer thickness and neuropsychological measures in multiple sclerosis (MS). Methods: Ninety-five relapsing–remitting MS (RRMS) and 36 progressive MS patients underwent 100%-contrast visual acuity (VA), 2.5%- and 1.25%-contrast letter acuity (LA) testing, Cirrus-HD-optical coherence tomography, and neuropsychological assessments. Mixed-effects regression models were used to assess relationships. Results: Across the cohort, 1.25%-contrast LA was associated with Symbol Digit Modalities Test (SDMT; β = 2.17, p = 0.005) and Brief Visuospatial Memory Test-Revised (BVMT-R) total recall (TR) and delayed recall (DR) scores (β = 0.31, p < 0.001; β = 0.15, p = 0.039, respectively). 2.5%-contrast LA was associated with BVMT-R TR scores (β = 0.27, p = 0.006). In the RRMS cohort, 1.25%-contrast LA was generally more significantly associated with cognitive measures: SDMT (β = 2.97, p = 0.001) and BVMT-R TR (β = 0.32, p < 0.001) and DR (β = 0.22, p = 0.012). Conclusion: This study suggests that visual pathway measures, particularly visual function measures, reflect aspects of cognitive function in MS, further supporting their roles as complementary outcomes in MS neuroprotection trials.

AB - Purpose: To determine the relationships between visual function and ganglion cell and inner plexiform layer thickness and neuropsychological measures in multiple sclerosis (MS). Methods: Ninety-five relapsing–remitting MS (RRMS) and 36 progressive MS patients underwent 100%-contrast visual acuity (VA), 2.5%- and 1.25%-contrast letter acuity (LA) testing, Cirrus-HD-optical coherence tomography, and neuropsychological assessments. Mixed-effects regression models were used to assess relationships. Results: Across the cohort, 1.25%-contrast LA was associated with Symbol Digit Modalities Test (SDMT; β = 2.17, p = 0.005) and Brief Visuospatial Memory Test-Revised (BVMT-R) total recall (TR) and delayed recall (DR) scores (β = 0.31, p < 0.001; β = 0.15, p = 0.039, respectively). 2.5%-contrast LA was associated with BVMT-R TR scores (β = 0.27, p = 0.006). In the RRMS cohort, 1.25%-contrast LA was generally more significantly associated with cognitive measures: SDMT (β = 2.97, p = 0.001) and BVMT-R TR (β = 0.32, p < 0.001) and DR (β = 0.22, p = 0.012). Conclusion: This study suggests that visual pathway measures, particularly visual function measures, reflect aspects of cognitive function in MS, further supporting their roles as complementary outcomes in MS neuroprotection trials.

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KW - optical coherence tomography

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