Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane

John S. Oghalai, Hong Bo Zhao, J. Walter Kutz, William E. Brownell

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

The mechanism responsible for electromotility of outer hair cells in the ear is unknown but is thought to reside within the plasma membrane. Lipid lateral diffusion in the outer hair cell plasma membrane is a sigmoidal function of transmembrane potential and bathing media osmolality. Cell depolarization or hyposmotic challenge shorten the cell and reduce membrane fluidity by half. Changing the membrane tension with amphipathic drugs results in similar reductions. These dynamic changes in membrane fluidity represent the modulation of membrane tension by lipid-protein interactions. The voltage dependence may be associated with the force-generating motors that contribute to the exquisite sensitivity of mammalian hearing.

Original languageEnglish (US)
Pages (from-to)658-661
Number of pages4
JournalScience
Volume287
Issue number5453
DOIs
StatePublished - Jan 28 2000

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Outer Auditory Hair Cells
Cell Membrane
Lipids
Membrane Fluidity
Membrane Lipids
Membrane Potentials
Osmolar Concentration
Hearing
Ear
Membranes
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • General

Cite this

Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane. / Oghalai, John S.; Zhao, Hong Bo; Kutz, J. Walter; Brownell, William E.

In: Science, Vol. 287, No. 5453, 28.01.2000, p. 658-661.

Research output: Contribution to journalArticle

Oghalai, John S. ; Zhao, Hong Bo ; Kutz, J. Walter ; Brownell, William E. / Voltage- and tension-dependent lipid mobility in the outer hair cell plasma membrane. In: Science. 2000 ; Vol. 287, No. 5453. pp. 658-661.
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