TY - JOUR
T1 - Weight loss reduces dyspnea on exertion in obese women
AU - Bernhardt, Vipa
AU - Babb, Tony G.
N1 - Funding Information:
The authors wish to thank Raksa Moran, Todd Bassett, Dr. Santiago Lorenzo, Jessica Pineda, Joseph Genovese, Sarah Haller-Martineau, and Dr. Matthew Spencer for their assistance in various stages of this project, and the staff members of the Texas Health Finley Ewing Cardiovascular & Fitness Center Dallas (Gerry, Susan, Kim, Erika, Mark, Denise, Will, and others) for their expertise in implementing the diet and exercise program. The authors thank Dr. Trey Miller for statistical guidance and Dr. Paul Weatherall for MRI assistance with this project.Funding for this project was received from National Institutes of Health ( HL096782 ), King Charitable Foundation Trust , Cain Foundation , and Texas Health Presbyterian Hospital Dallas .
PY - 2014/12/1
Y1 - 2014/12/1
N2 - During submaximal exercise, some otherwise healthy obese women experience breathlessness, or dyspnea on exertion (+DOE), while others have mild or no DOE (-DOE). We investigated whether weight loss could reduce DOE. Twenty nine obese women were grouped based on their Ratings of Perceived Breathlessness (RPB) during constant load 60W cycling: +DOE (n=14, RPB≥4, 34±8 years, and 36±3kg/m2) and -DOE (n=15, RPB≤2, 32±8 years, and 36±4kg/m2) and then completed a 12-week weight loss program. Both groups lost a moderate amount of weight (+DOE: 6.6±2.4kg, -DOE: 8.4±3.5kg, and p<0.001). RPB decreased significantly in the +DOE group (from 4.7±1.1 to 3.1±1.6) and remained low in the -DOE (from 1.5±0.7 to 1.6±1.1) (interaction p<0.002). Most physiological variables measured (i.e. body composition, fat distribution, pulmonary function, oxygen cost of breathing, and cardiorespiratory measures) improved with weight loss; however, the decrease in RPB was not correlated with any of these variables (p>0.05). In conclusion, moderate weight loss was effective in reducing breathlessness on exertion in obese women who experienced DOE at baseline.
AB - During submaximal exercise, some otherwise healthy obese women experience breathlessness, or dyspnea on exertion (+DOE), while others have mild or no DOE (-DOE). We investigated whether weight loss could reduce DOE. Twenty nine obese women were grouped based on their Ratings of Perceived Breathlessness (RPB) during constant load 60W cycling: +DOE (n=14, RPB≥4, 34±8 years, and 36±3kg/m2) and -DOE (n=15, RPB≤2, 32±8 years, and 36±4kg/m2) and then completed a 12-week weight loss program. Both groups lost a moderate amount of weight (+DOE: 6.6±2.4kg, -DOE: 8.4±3.5kg, and p<0.001). RPB decreased significantly in the +DOE group (from 4.7±1.1 to 3.1±1.6) and remained low in the -DOE (from 1.5±0.7 to 1.6±1.1) (interaction p<0.002). Most physiological variables measured (i.e. body composition, fat distribution, pulmonary function, oxygen cost of breathing, and cardiorespiratory measures) improved with weight loss; however, the decrease in RPB was not correlated with any of these variables (p>0.05). In conclusion, moderate weight loss was effective in reducing breathlessness on exertion in obese women who experienced DOE at baseline.
KW - Body composition
KW - Exercise
KW - Pulmonary function
KW - Shortness of breath
KW - Work of breathing
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U2 - 10.1016/j.resp.2014.09.004
DO - 10.1016/j.resp.2014.09.004
M3 - Article
C2 - 25220695
AN - SCOPUS:84910628831
VL - 204
SP - 86
EP - 92
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
ER -