Contact allergy has been regarded as a form of delayed-type hypersensitivity mediated primarily by T cells in response to chemical allergens that get in contact with skin. Recent advances in immunology have emphasized the roles of antigen-presenting cells, TH1 and TH2 subsets, and microenvironmental conditions on the generation of immune responses. Such knowledge, while providing an improved matrix for understanding contact allergy, has also raised new questions concerning the pathomechanisms involved in this disorder. These issues are discussed in the present report from both clinical and scientific perspectives.
|Original language||English (US)|
|Number of pages||5|
|Journal||American Journal of Contact Dermatitis|
|State||Published - Dec 1 1994|
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