White matter changes in healthy adolescents at familial risk for unipolar depression

A diffusion tensor imaging study

Hao Huang, Xin Fan, Douglas E. Williamson, Uma Rao

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Alterations in white matter integrity of several cortical and subcortical circuits have been reported in relation to unipolar major depressive disorder. It is not clear whether these white matter changes precede the onset of illness. In all, 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) and 18 adolescent volunteers with no personal history of a psychiatric illness including depression, but who were at high risk for developing unipolar depression by virtue of parental depression (high-risk youth), underwent diffusion tensor imaging studies. An automated tract-based spatial statistics method, a whole-brain voxel-by-voxel analysis, was used to analyze the scans. Population average diffusion parameter values were also calculated for each tract. Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate, and inferior fronto-occipital fasciculi than did controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness.

Original languageEnglish (US)
Pages (from-to)684-691
Number of pages8
JournalNeuropsychopharmacology
Volume36
Issue number3
DOIs
StatePublished - Feb 2011

Fingerprint

Diffusion Tensor Imaging
Depressive Disorder
Psychiatry
Volunteers
Depression
Corpus Callosum
Anisotropy
Major Depressive Disorder
White Matter
Brain
Population

Keywords

  • adolescent
  • corpus callosum
  • depression
  • high risk
  • magnetic resonance imaging
  • tract-based spatial statistical analysis

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

White matter changes in healthy adolescents at familial risk for unipolar depression : A diffusion tensor imaging study. / Huang, Hao; Fan, Xin; Williamson, Douglas E.; Rao, Uma.

In: Neuropsychopharmacology, Vol. 36, No. 3, 02.2011, p. 684-691.

Research output: Contribution to journalArticle

Huang, Hao ; Fan, Xin ; Williamson, Douglas E. ; Rao, Uma. / White matter changes in healthy adolescents at familial risk for unipolar depression : A diffusion tensor imaging study. In: Neuropsychopharmacology. 2011 ; Vol. 36, No. 3. pp. 684-691.
@article{4c3aae89d4774b83b1b28424fcdad36b,
title = "White matter changes in healthy adolescents at familial risk for unipolar depression: A diffusion tensor imaging study",
abstract = "Alterations in white matter integrity of several cortical and subcortical circuits have been reported in relation to unipolar major depressive disorder. It is not clear whether these white matter changes precede the onset of illness. In all, 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) and 18 adolescent volunteers with no personal history of a psychiatric illness including depression, but who were at high risk for developing unipolar depression by virtue of parental depression (high-risk youth), underwent diffusion tensor imaging studies. An automated tract-based spatial statistics method, a whole-brain voxel-by-voxel analysis, was used to analyze the scans. Population average diffusion parameter values were also calculated for each tract. Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate, and inferior fronto-occipital fasciculi than did controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness.",
keywords = "adolescent, corpus callosum, depression, high risk, magnetic resonance imaging, tract-based spatial statistical analysis",
author = "Hao Huang and Xin Fan and Williamson, {Douglas E.} and Uma Rao",
year = "2011",
month = "2",
doi = "10.1038/npp.2010.199",
language = "English (US)",
volume = "36",
pages = "684--691",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - White matter changes in healthy adolescents at familial risk for unipolar depression

T2 - A diffusion tensor imaging study

AU - Huang, Hao

AU - Fan, Xin

AU - Williamson, Douglas E.

AU - Rao, Uma

PY - 2011/2

Y1 - 2011/2

N2 - Alterations in white matter integrity of several cortical and subcortical circuits have been reported in relation to unipolar major depressive disorder. It is not clear whether these white matter changes precede the onset of illness. In all, 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) and 18 adolescent volunteers with no personal history of a psychiatric illness including depression, but who were at high risk for developing unipolar depression by virtue of parental depression (high-risk youth), underwent diffusion tensor imaging studies. An automated tract-based spatial statistics method, a whole-brain voxel-by-voxel analysis, was used to analyze the scans. Population average diffusion parameter values were also calculated for each tract. Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate, and inferior fronto-occipital fasciculi than did controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness.

AB - Alterations in white matter integrity of several cortical and subcortical circuits have been reported in relation to unipolar major depressive disorder. It is not clear whether these white matter changes precede the onset of illness. In all, 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) and 18 adolescent volunteers with no personal history of a psychiatric illness including depression, but who were at high risk for developing unipolar depression by virtue of parental depression (high-risk youth), underwent diffusion tensor imaging studies. An automated tract-based spatial statistics method, a whole-brain voxel-by-voxel analysis, was used to analyze the scans. Population average diffusion parameter values were also calculated for each tract. Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate, and inferior fronto-occipital fasciculi than did controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness.

KW - adolescent

KW - corpus callosum

KW - depression

KW - high risk

KW - magnetic resonance imaging

KW - tract-based spatial statistical analysis

UR - http://www.scopus.com/inward/record.url?scp=78651407337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651407337&partnerID=8YFLogxK

U2 - 10.1038/npp.2010.199

DO - 10.1038/npp.2010.199

M3 - Article

VL - 36

SP - 684

EP - 691

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 3

ER -