White matter correlates of sensory processing in autism spectrum disorders

Jennifer R. Pryweller, Kimberly B. Schauder, Adam W. Anderson, Jessica L. Heacock, Jennifer H. Foss-Feig, Cassandra R. Newsom, Whitney A. Loring, Carissa J. Cascio

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) has been characterized by atypical socio-communicative behavior, sensorimotor impairment and abnormal neurodevelopmental trajectories. DTI has been used to determine the presence and nature of abnormality in white matter integrity that may contribute to the behavioral phenomena that characterize ASD. Although atypical patterns of sensory responding in ASD are well documented in the behavioral literature, much less is known about the neural networks associated with aberrant sensory processing. To address the roles of basic sensory, sensory association and early attentional processes in sensory responsiveness in ASD, our investigation focused on five white matter fiber tracts known to be involved in these various stages of sensory processing: superior corona radiata, centrum semiovale, inferior longitudinal fasciculus, posterior limb of the internal capsule, and splenium. We acquired high angular resolution diffusion images from 32 children with ASD and 26 typically developing children between the ages of 5 and 8. We also administered sensory assessments to examine brain-behavior relationships between white matter integrity and sensory variables. Our findings suggest a modulatory role of the inferior longitudinal fasciculus and splenium in atypical sensorimotor and early attention processes in ASD. Increased tactile defensiveness was found to be related to reduced fractional anisotropy in the inferior longitudinal fasciculus, which may reflect an aberrant connection between limbic structures in the temporal lobe and the inferior parietal cortex. Our findings also corroborate the modulatory role of the splenium in attentional orienting, but suggest the possibility of a more diffuse or separable network for social orienting in ASD. Future investigation should consider the use of whole brain analyses for a more robust assessment of white matter microstructure.

Original languageEnglish (US)
Pages (from-to)379-387
Number of pages9
JournalNeuroImage: Clinical
Volume6
DOIs
StatePublished - Jan 1 2014

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Internal Capsule
Parietal Lobe
Anisotropy
Brain
Touch
Temporal Lobe
Autism Spectrum Disorder
White Matter
Social Support
Extremities

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Pryweller, J. R., Schauder, K. B., Anderson, A. W., Heacock, J. L., Foss-Feig, J. H., Newsom, C. R., ... Cascio, C. J. (2014). White matter correlates of sensory processing in autism spectrum disorders. NeuroImage: Clinical, 6, 379-387. https://doi.org/10.1016/j.nicl.2014.09.018

White matter correlates of sensory processing in autism spectrum disorders. / Pryweller, Jennifer R.; Schauder, Kimberly B.; Anderson, Adam W.; Heacock, Jessica L.; Foss-Feig, Jennifer H.; Newsom, Cassandra R.; Loring, Whitney A.; Cascio, Carissa J.

In: NeuroImage: Clinical, Vol. 6, 01.01.2014, p. 379-387.

Research output: Contribution to journalArticle

Pryweller, JR, Schauder, KB, Anderson, AW, Heacock, JL, Foss-Feig, JH, Newsom, CR, Loring, WA & Cascio, CJ 2014, 'White matter correlates of sensory processing in autism spectrum disorders', NeuroImage: Clinical, vol. 6, pp. 379-387. https://doi.org/10.1016/j.nicl.2014.09.018
Pryweller JR, Schauder KB, Anderson AW, Heacock JL, Foss-Feig JH, Newsom CR et al. White matter correlates of sensory processing in autism spectrum disorders. NeuroImage: Clinical. 2014 Jan 1;6:379-387. https://doi.org/10.1016/j.nicl.2014.09.018
Pryweller, Jennifer R. ; Schauder, Kimberly B. ; Anderson, Adam W. ; Heacock, Jessica L. ; Foss-Feig, Jennifer H. ; Newsom, Cassandra R. ; Loring, Whitney A. ; Cascio, Carissa J. / White matter correlates of sensory processing in autism spectrum disorders. In: NeuroImage: Clinical. 2014 ; Vol. 6. pp. 379-387.
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