Who really benefits from nephron-sparing surgery?

Solomon L. Woldu, Aaron C. Weinberg, Ruslan Korets, Rashed Ghandour, Matthew R. Danzig, Arindam Roychoudhury, Sean D. Kalloo, Mitchell C. Benson, G. Joel Decastro, James M. McKiernan

Research output: Contribution to journalArticle

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Abstract

Objective To analyze the influence of preoperative renal function on postoperative renal outcomes after radical nephrectomy (RN) and nephron-sparing surgery (NSS) for malignancy in patients stratified according to preoperative chronic kidney disease (CKD) stage and surgical extent (NSS vs RN). Patients and Methods Retrospective review of patients undergoing renal surgery for localized renal masses stratified by surgical extent and preoperative CKD stage based on glomerular filtration rate (GFR) level: stage I (>90 mL/min/1.73 m2), stage II (60-89 mL/min/1.73 m2), and stage III (30-59 mL/min/1.73 m2). Survival analysis for significant renal impairment was based on freedom from the development of new-onset GFR <30 or <45 mL/min/1.73 m2. Results A total of 1306 patients were included in the analysis with preoperative CKD stage I (27.9%), II (52.1%), and III (20.1%); 41.3% and 58.7% underwent NSS and RN, respectively. NSS was associated with a lower annual rate of GFR decline in preoperative CKD stage-I (P =.028) and stage-II patients (P =.018), but not in CKD stage-III patients (P =.753). Overall, 5.0% and 15.0% developed new-onset GFR <30 mL/min/1.73 m2 and <45 mL/min/1.73 m2, respectively. There was no difference in the probability of developing significant renal impairment between NSS and RN in CKD stage-I or -III patients, whereas only in CKD stage-II patients was the surgical extent independently associated with development of significant renal impairment (RN: odds ratio, 9.0; P =.042 for GFR <30 mL/min/1.73 m2 and odds ratio, 2.3; P =.003 for GFR <45 mL/min/1.73 m2). Conclusion Compared with RN, NSS is associated with a lower rate of GFR decline for preoperative CKD stage-I and -II patients, but only CKD stage-II patients demonstrated a decreased risk of developing significant renal impairment.

Original languageEnglish (US)
Pages (from-to)860-868
Number of pages9
JournalUrology
Volume84
Issue number4
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

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Nephrons
Chronic Renal Insufficiency
Glomerular Filtration Rate
Nephrectomy
Kidney
Odds Ratio
Survival Analysis

ASJC Scopus subject areas

  • Urology

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Woldu, S. L., Weinberg, A. C., Korets, R., Ghandour, R., Danzig, M. R., Roychoudhury, A., ... McKiernan, J. M. (2014). Who really benefits from nephron-sparing surgery? Urology, 84(4), 860-868. https://doi.org/10.1016/j.urology.2014.05.061

Who really benefits from nephron-sparing surgery? / Woldu, Solomon L.; Weinberg, Aaron C.; Korets, Ruslan; Ghandour, Rashed; Danzig, Matthew R.; Roychoudhury, Arindam; Kalloo, Sean D.; Benson, Mitchell C.; Decastro, G. Joel; McKiernan, James M.

In: Urology, Vol. 84, No. 4, 01.10.2014, p. 860-868.

Research output: Contribution to journalArticle

Woldu, SL, Weinberg, AC, Korets, R, Ghandour, R, Danzig, MR, Roychoudhury, A, Kalloo, SD, Benson, MC, Decastro, GJ & McKiernan, JM 2014, 'Who really benefits from nephron-sparing surgery?', Urology, vol. 84, no. 4, pp. 860-868. https://doi.org/10.1016/j.urology.2014.05.061
Woldu SL, Weinberg AC, Korets R, Ghandour R, Danzig MR, Roychoudhury A et al. Who really benefits from nephron-sparing surgery? Urology. 2014 Oct 1;84(4):860-868. https://doi.org/10.1016/j.urology.2014.05.061
Woldu, Solomon L. ; Weinberg, Aaron C. ; Korets, Ruslan ; Ghandour, Rashed ; Danzig, Matthew R. ; Roychoudhury, Arindam ; Kalloo, Sean D. ; Benson, Mitchell C. ; Decastro, G. Joel ; McKiernan, James M. / Who really benefits from nephron-sparing surgery?. In: Urology. 2014 ; Vol. 84, No. 4. pp. 860-868.
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abstract = "Objective To analyze the influence of preoperative renal function on postoperative renal outcomes after radical nephrectomy (RN) and nephron-sparing surgery (NSS) for malignancy in patients stratified according to preoperative chronic kidney disease (CKD) stage and surgical extent (NSS vs RN). Patients and Methods Retrospective review of patients undergoing renal surgery for localized renal masses stratified by surgical extent and preoperative CKD stage based on glomerular filtration rate (GFR) level: stage I (>90 mL/min/1.73 m2), stage II (60-89 mL/min/1.73 m2), and stage III (30-59 mL/min/1.73 m2). Survival analysis for significant renal impairment was based on freedom from the development of new-onset GFR <30 or <45 mL/min/1.73 m2. Results A total of 1306 patients were included in the analysis with preoperative CKD stage I (27.9{\%}), II (52.1{\%}), and III (20.1{\%}); 41.3{\%} and 58.7{\%} underwent NSS and RN, respectively. NSS was associated with a lower annual rate of GFR decline in preoperative CKD stage-I (P =.028) and stage-II patients (P =.018), but not in CKD stage-III patients (P =.753). Overall, 5.0{\%} and 15.0{\%} developed new-onset GFR <30 mL/min/1.73 m2 and <45 mL/min/1.73 m2, respectively. There was no difference in the probability of developing significant renal impairment between NSS and RN in CKD stage-I or -III patients, whereas only in CKD stage-II patients was the surgical extent independently associated with development of significant renal impairment (RN: odds ratio, 9.0; P =.042 for GFR <30 mL/min/1.73 m2 and odds ratio, 2.3; P =.003 for GFR <45 mL/min/1.73 m2). Conclusion Compared with RN, NSS is associated with a lower rate of GFR decline for preoperative CKD stage-I and -II patients, but only CKD stage-II patients demonstrated a decreased risk of developing significant renal impairment.",
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AU - Woldu, Solomon L.

AU - Weinberg, Aaron C.

AU - Korets, Ruslan

AU - Ghandour, Rashed

AU - Danzig, Matthew R.

AU - Roychoudhury, Arindam

AU - Kalloo, Sean D.

AU - Benson, Mitchell C.

AU - Decastro, G. Joel

AU - McKiernan, James M.

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N2 - Objective To analyze the influence of preoperative renal function on postoperative renal outcomes after radical nephrectomy (RN) and nephron-sparing surgery (NSS) for malignancy in patients stratified according to preoperative chronic kidney disease (CKD) stage and surgical extent (NSS vs RN). Patients and Methods Retrospective review of patients undergoing renal surgery for localized renal masses stratified by surgical extent and preoperative CKD stage based on glomerular filtration rate (GFR) level: stage I (>90 mL/min/1.73 m2), stage II (60-89 mL/min/1.73 m2), and stage III (30-59 mL/min/1.73 m2). Survival analysis for significant renal impairment was based on freedom from the development of new-onset GFR <30 or <45 mL/min/1.73 m2. Results A total of 1306 patients were included in the analysis with preoperative CKD stage I (27.9%), II (52.1%), and III (20.1%); 41.3% and 58.7% underwent NSS and RN, respectively. NSS was associated with a lower annual rate of GFR decline in preoperative CKD stage-I (P =.028) and stage-II patients (P =.018), but not in CKD stage-III patients (P =.753). Overall, 5.0% and 15.0% developed new-onset GFR <30 mL/min/1.73 m2 and <45 mL/min/1.73 m2, respectively. There was no difference in the probability of developing significant renal impairment between NSS and RN in CKD stage-I or -III patients, whereas only in CKD stage-II patients was the surgical extent independently associated with development of significant renal impairment (RN: odds ratio, 9.0; P =.042 for GFR <30 mL/min/1.73 m2 and odds ratio, 2.3; P =.003 for GFR <45 mL/min/1.73 m2). Conclusion Compared with RN, NSS is associated with a lower rate of GFR decline for preoperative CKD stage-I and -II patients, but only CKD stage-II patients demonstrated a decreased risk of developing significant renal impairment.

AB - Objective To analyze the influence of preoperative renal function on postoperative renal outcomes after radical nephrectomy (RN) and nephron-sparing surgery (NSS) for malignancy in patients stratified according to preoperative chronic kidney disease (CKD) stage and surgical extent (NSS vs RN). Patients and Methods Retrospective review of patients undergoing renal surgery for localized renal masses stratified by surgical extent and preoperative CKD stage based on glomerular filtration rate (GFR) level: stage I (>90 mL/min/1.73 m2), stage II (60-89 mL/min/1.73 m2), and stage III (30-59 mL/min/1.73 m2). Survival analysis for significant renal impairment was based on freedom from the development of new-onset GFR <30 or <45 mL/min/1.73 m2. Results A total of 1306 patients were included in the analysis with preoperative CKD stage I (27.9%), II (52.1%), and III (20.1%); 41.3% and 58.7% underwent NSS and RN, respectively. NSS was associated with a lower annual rate of GFR decline in preoperative CKD stage-I (P =.028) and stage-II patients (P =.018), but not in CKD stage-III patients (P =.753). Overall, 5.0% and 15.0% developed new-onset GFR <30 mL/min/1.73 m2 and <45 mL/min/1.73 m2, respectively. There was no difference in the probability of developing significant renal impairment between NSS and RN in CKD stage-I or -III patients, whereas only in CKD stage-II patients was the surgical extent independently associated with development of significant renal impairment (RN: odds ratio, 9.0; P =.042 for GFR <30 mL/min/1.73 m2 and odds ratio, 2.3; P =.003 for GFR <45 mL/min/1.73 m2). Conclusion Compared with RN, NSS is associated with a lower rate of GFR decline for preoperative CKD stage-I and -II patients, but only CKD stage-II patients demonstrated a decreased risk of developing significant renal impairment.

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