Whole-body MR neurography: Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease

Avneesh Chhabra, John A. Carrino, Sahar J. Farahani, Gaurav K. Thawait, Charlotte J. Sumner, Vibhor Wadhwa, Vinay Chaudhary, Thomas E. Lloyd

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: To evaluate the feasibility of whole-body magnetic resonance neurography (WBMRN) in polyneuropathy for technical feasibility, distribution of nerve abnormalities, and differentiation. Materials and Methods: Twenty WBMRN examinations were performed on a 3T scanner over 2 years. Patient demographics including history of hereditary and acquired neuropathy were recorded. The images were evaluated by two independent readers with nerve imaging experience for quality. The nerve signal and size alterations were measured in the brachial plexus, lumbosacral plexus, and femoral and sciatic nerves; diffusion tensor imaging parameters (fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) were determined in plexuses, and tractography was performed. Nonparametric Wilcoxon rank sum test, receiver operating characteristic (ROC) analysis, and intraclass correlation coefficients (ICCs) were obtained. Results: Excellent image quality was obtained for the majority of lumbosacral (LS) plexus (18/20) and 50% of brachial plexus (10/20) regions. Qualitatively among cases, the nerve hyperintensity and/or thickening involved the brachial plexus (11/11), LS plexus (7/11), and both plexuses (7/11), with most nerve thickenings observed in Charcot-Marie-Tooth disease type 1. The nerve signal intensity alterations were significantly different for both brachial (P < 0.05) and LS (P < 0.05) plexuses in cases versus controls. The femoral and sciatic nerve size alterations were different (P < 0.05), while signal intensity differences were not significant (P = 0.1–0.97). Transverse dimensions of C8 (4 mm), L5 (6.2 mm) and S1 (5.1 mm) nerve roots, and sciatic nerves (10.2 mm) were the most accurate diagnostic performance measures in distinguishing cases from controls. Conclusion: WBMRN is feasible for use in the clinical practice for the identification and potential characterization of polyneuropathy. J. Magn. Reson. Imaging 2016;44:1513–1521.

Original languageEnglish (US)
Pages (from-to)1513-1521
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume44
Issue number6
DOIs
StatePublished - Dec 1 2016

Fingerprint

Lumbosacral Plexus
Charcot-Marie-Tooth Disease
Brachial Plexus
Polyneuropathies
Feasibility Studies
Sciatic Nerve
Femoral Nerve
Magnetic Resonance Spectroscopy
Prospective Studies
Nonparametric Statistics
Diffusion Tensor Imaging
Anisotropy
ROC Curve
Arm
Demography

Keywords

  • brachial plexus
  • Charcot-Marie-Tooth (CMT) disease
  • LS plexus
  • MR neurography
  • whole body magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Whole-body MR neurography : Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease. / Chhabra, Avneesh; Carrino, John A.; Farahani, Sahar J.; Thawait, Gaurav K.; Sumner, Charlotte J.; Wadhwa, Vibhor; Chaudhary, Vinay; Lloyd, Thomas E.

In: Journal of Magnetic Resonance Imaging, Vol. 44, No. 6, 01.12.2016, p. 1513-1521.

Research output: Contribution to journalArticle

Chhabra, A, Carrino, JA, Farahani, SJ, Thawait, GK, Sumner, CJ, Wadhwa, V, Chaudhary, V & Lloyd, TE 2016, 'Whole-body MR neurography: Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease', Journal of Magnetic Resonance Imaging, vol. 44, no. 6, pp. 1513-1521. https://doi.org/10.1002/jmri.25293
Chhabra, Avneesh ; Carrino, John A. ; Farahani, Sahar J. ; Thawait, Gaurav K. ; Sumner, Charlotte J. ; Wadhwa, Vibhor ; Chaudhary, Vinay ; Lloyd, Thomas E. / Whole-body MR neurography : Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease. In: Journal of Magnetic Resonance Imaging. 2016 ; Vol. 44, No. 6. pp. 1513-1521.
@article{42b15d8808ce4df7ac023d20804cc094,
title = "Whole-body MR neurography: Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease",
abstract = "Purpose: To evaluate the feasibility of whole-body magnetic resonance neurography (WBMRN) in polyneuropathy for technical feasibility, distribution of nerve abnormalities, and differentiation. Materials and Methods: Twenty WBMRN examinations were performed on a 3T scanner over 2 years. Patient demographics including history of hereditary and acquired neuropathy were recorded. The images were evaluated by two independent readers with nerve imaging experience for quality. The nerve signal and size alterations were measured in the brachial plexus, lumbosacral plexus, and femoral and sciatic nerves; diffusion tensor imaging parameters (fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) were determined in plexuses, and tractography was performed. Nonparametric Wilcoxon rank sum test, receiver operating characteristic (ROC) analysis, and intraclass correlation coefficients (ICCs) were obtained. Results: Excellent image quality was obtained for the majority of lumbosacral (LS) plexus (18/20) and 50{\%} of brachial plexus (10/20) regions. Qualitatively among cases, the nerve hyperintensity and/or thickening involved the brachial plexus (11/11), LS plexus (7/11), and both plexuses (7/11), with most nerve thickenings observed in Charcot-Marie-Tooth disease type 1. The nerve signal intensity alterations were significantly different for both brachial (P < 0.05) and LS (P < 0.05) plexuses in cases versus controls. The femoral and sciatic nerve size alterations were different (P < 0.05), while signal intensity differences were not significant (P = 0.1–0.97). Transverse dimensions of C8 (4 mm), L5 (6.2 mm) and S1 (5.1 mm) nerve roots, and sciatic nerves (10.2 mm) were the most accurate diagnostic performance measures in distinguishing cases from controls. Conclusion: WBMRN is feasible for use in the clinical practice for the identification and potential characterization of polyneuropathy. J. Magn. Reson. Imaging 2016;44:1513–1521.",
keywords = "brachial plexus, Charcot-Marie-Tooth (CMT) disease, LS plexus, MR neurography, whole body magnetic resonance imaging",
author = "Avneesh Chhabra and Carrino, {John A.} and Farahani, {Sahar J.} and Thawait, {Gaurav K.} and Sumner, {Charlotte J.} and Vibhor Wadhwa and Vinay Chaudhary and Lloyd, {Thomas E.}",
year = "2016",
month = "12",
day = "1",
doi = "10.1002/jmri.25293",
language = "English (US)",
volume = "44",
pages = "1513--1521",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Whole-body MR neurography

T2 - Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease

AU - Chhabra, Avneesh

AU - Carrino, John A.

AU - Farahani, Sahar J.

AU - Thawait, Gaurav K.

AU - Sumner, Charlotte J.

AU - Wadhwa, Vibhor

AU - Chaudhary, Vinay

AU - Lloyd, Thomas E.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Purpose: To evaluate the feasibility of whole-body magnetic resonance neurography (WBMRN) in polyneuropathy for technical feasibility, distribution of nerve abnormalities, and differentiation. Materials and Methods: Twenty WBMRN examinations were performed on a 3T scanner over 2 years. Patient demographics including history of hereditary and acquired neuropathy were recorded. The images were evaluated by two independent readers with nerve imaging experience for quality. The nerve signal and size alterations were measured in the brachial plexus, lumbosacral plexus, and femoral and sciatic nerves; diffusion tensor imaging parameters (fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) were determined in plexuses, and tractography was performed. Nonparametric Wilcoxon rank sum test, receiver operating characteristic (ROC) analysis, and intraclass correlation coefficients (ICCs) were obtained. Results: Excellent image quality was obtained for the majority of lumbosacral (LS) plexus (18/20) and 50% of brachial plexus (10/20) regions. Qualitatively among cases, the nerve hyperintensity and/or thickening involved the brachial plexus (11/11), LS plexus (7/11), and both plexuses (7/11), with most nerve thickenings observed in Charcot-Marie-Tooth disease type 1. The nerve signal intensity alterations were significantly different for both brachial (P < 0.05) and LS (P < 0.05) plexuses in cases versus controls. The femoral and sciatic nerve size alterations were different (P < 0.05), while signal intensity differences were not significant (P = 0.1–0.97). Transverse dimensions of C8 (4 mm), L5 (6.2 mm) and S1 (5.1 mm) nerve roots, and sciatic nerves (10.2 mm) were the most accurate diagnostic performance measures in distinguishing cases from controls. Conclusion: WBMRN is feasible for use in the clinical practice for the identification and potential characterization of polyneuropathy. J. Magn. Reson. Imaging 2016;44:1513–1521.

AB - Purpose: To evaluate the feasibility of whole-body magnetic resonance neurography (WBMRN) in polyneuropathy for technical feasibility, distribution of nerve abnormalities, and differentiation. Materials and Methods: Twenty WBMRN examinations were performed on a 3T scanner over 2 years. Patient demographics including history of hereditary and acquired neuropathy were recorded. The images were evaluated by two independent readers with nerve imaging experience for quality. The nerve signal and size alterations were measured in the brachial plexus, lumbosacral plexus, and femoral and sciatic nerves; diffusion tensor imaging parameters (fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) were determined in plexuses, and tractography was performed. Nonparametric Wilcoxon rank sum test, receiver operating characteristic (ROC) analysis, and intraclass correlation coefficients (ICCs) were obtained. Results: Excellent image quality was obtained for the majority of lumbosacral (LS) plexus (18/20) and 50% of brachial plexus (10/20) regions. Qualitatively among cases, the nerve hyperintensity and/or thickening involved the brachial plexus (11/11), LS plexus (7/11), and both plexuses (7/11), with most nerve thickenings observed in Charcot-Marie-Tooth disease type 1. The nerve signal intensity alterations were significantly different for both brachial (P < 0.05) and LS (P < 0.05) plexuses in cases versus controls. The femoral and sciatic nerve size alterations were different (P < 0.05), while signal intensity differences were not significant (P = 0.1–0.97). Transverse dimensions of C8 (4 mm), L5 (6.2 mm) and S1 (5.1 mm) nerve roots, and sciatic nerves (10.2 mm) were the most accurate diagnostic performance measures in distinguishing cases from controls. Conclusion: WBMRN is feasible for use in the clinical practice for the identification and potential characterization of polyneuropathy. J. Magn. Reson. Imaging 2016;44:1513–1521.

KW - brachial plexus

KW - Charcot-Marie-Tooth (CMT) disease

KW - LS plexus

KW - MR neurography

KW - whole body magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=84973131303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973131303&partnerID=8YFLogxK

U2 - 10.1002/jmri.25293

DO - 10.1002/jmri.25293

M3 - Article

C2 - 27126998

AN - SCOPUS:84973131303

VL - 44

SP - 1513

EP - 1521

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 6

ER -