Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cells

T. Ungchusri, E. Y. Chiang, G. Brown, M. Chen, P. Tabaczewski, L. Timares, I. Stroynowski

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We reexamined expression patterns of one of the best characterized mouse class Ib MHC molecules, Qa-2. Transcripts encoding glycosylphosphatidylinositol-linked and soluble forms of Qa-2 are expressed in all organs except brain. The membrane-bound Qa-2 proteins are detectable, to varying degrees, in many cell types of immunological interest: on professional antigen-presenting cells capable of inducing anti-Qa-2 allogeneic responses, on thymic epithelial cells essential for T-cell positive selection, on mature as well as immature thymocytes, in immunologically privileged sites (testis/spermatazoa), and on cells implicated in mucosal immunity (lymphoid-derived and epithelial gut cells and hepatocytes). Although Qa-2 has a nearly ubiquitous tissue distribution similar to H2-Kb and Db molecules, the relative levels of Qa-2 and class Ia displayed on cell surfaces vary in a cell-specific fashion. Analyses of primary cell lines derived from normal mouse tissues also support the conclusion that Qa-2 is present in all cells that can express class Ia antigens. In contrast, tumor lines from Qa-2-positive mice are frequently Qa-2 deficient, suggesting that the Qa-2-negative phenotype of malignant cells is selected in vivo.

Original languageEnglish (US)
Pages (from-to)455-467
Number of pages13
JournalImmunogenetics
Volume53
Issue number6
DOIs
StatePublished - 2001

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Epithelial Cells
Mucosal Immunity
Glycosylphosphatidylinositols
Histocompatibility Antigens Class II
Antigen-Presenting Cells
Tissue Distribution
Thymocytes
Q surface antigens
Testis
Hepatocytes
T-Lymphocytes
Phenotype
Cell Line
Membranes
Brain
Neoplasms
Proteins
MHC Ib Qa-2 antigen

Keywords

  • Antigen presentation
  • Immunity
  • Qa-2
  • Tumor

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cells. / Ungchusri, T.; Chiang, E. Y.; Brown, G.; Chen, M.; Tabaczewski, P.; Timares, L.; Stroynowski, I.

In: Immunogenetics, Vol. 53, No. 6, 2001, p. 455-467.

Research output: Contribution to journalArticle

Ungchusri, T. ; Chiang, E. Y. ; Brown, G. ; Chen, M. ; Tabaczewski, P. ; Timares, L. ; Stroynowski, I. / Widespread expression of the nonclassical class I Qa-2 antigens in hemopoietic and nonhemopoietic cells. In: Immunogenetics. 2001 ; Vol. 53, No. 6. pp. 455-467.
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