WNK Kinases in Development and Disease

Aylin R. Rodan, Andreas Jenny

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

WNK (With-No-Lysine (K)) kinases are serine–threonine kinases characterized by an atypical placement of a catalytic lysine within the kinase domain. Mutations in human WNK1 or WNK4 cause an autosomal dominant syndrome of hypertension and hyperkalemia, reflecting the fact that WNK kinases are critical regulators of renal ion transport processes. Here, the role of WNKs in the regulation of ion transport processes in vertebrate and invertebrate renal function, cellular and organismal osmoregulation, and cell migration and cerebral edema will be reviewed, along with emerging literature demonstrating roles for WNKs in cardiovascular and neural development, Wnt signaling, and cancer. Conserved roles for these kinases across phyla are emphasized.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Developmental Biology
PublisherAcademic Press Inc.
Pages1-47
Number of pages47
Volume123
DOIs
StatePublished - 2017

Publication series

NameCurrent Topics in Developmental Biology
Volume123
ISSN (Print)00702153

Keywords

  • Blood pressure
  • C. elegans
  • Drosophila
  • Excretory canal
  • Kidney
  • Lhx8
  • Malpighian tubule
  • Mo25/Cab39
  • SPAK/OSR1
  • Wnt signaling
  • Zebrafish

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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  • Cite this

    Rodan, A. R., & Jenny, A. (2017). WNK Kinases in Development and Disease. In Current Topics in Developmental Biology (Vol. 123, pp. 1-47). (Current Topics in Developmental Biology; Vol. 123). Academic Press Inc.. https://doi.org/10.1016/bs.ctdb.2016.08.004