WNKs

Protein kinases with a unique kinase domain

Chou Long Huang, Seung Kuy Cha, Hao Ran Wang, Jian Xie, Melanie H. Cobb

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyperkalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.

Original languageEnglish (US)
Pages (from-to)565-573
Number of pages9
JournalExperimental and Molecular Medicine
Volume39
Issue number5
StatePublished - Oct 31 2007

Fingerprint

Ion Transport
Protein Kinases
Lysine
Phosphotransferases
Ions
Hyperkalemia
Protein-Serine-Threonine Kinases
Cell signaling
Embryonic Development
Cell Survival
Cell Proliferation
Cell proliferation
Hypertension
Mutation

Keywords

  • Genome, human
  • Hyperkalemia
  • Hypertension
  • Neoplasms
  • Protein kinases
  • Pseudohypoaldosteronisms
  • WNK1 protein, human

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

WNKs : Protein kinases with a unique kinase domain. / Huang, Chou Long; Cha, Seung Kuy; Wang, Hao Ran; Xie, Jian; Cobb, Melanie H.

In: Experimental and Molecular Medicine, Vol. 39, No. 5, 31.10.2007, p. 565-573.

Research output: Contribution to journalArticle

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