Yersinia outer proteins: Yops

Jennifer E. Trosky, Amy D B Liverman, Kim Orth

Research output: Contribution to journalShort survey

81 Scopus citations

Abstract

The pathogenic bacteria Yersinia spp. contain a virulence plasmid that encodes a type III secretion system and effectors. During infection, four of the effectors target the actin cytoskeleton, crippling the phagocytic machinery in the infected cell. The remaining two effectors dampen the innate immune response by targeting important signalling pathways. Although the biochemical activity for each of these effectors is known, the mechanisms involved in their ordered secretion and delivery remain elusive.

Original languageEnglish (US)
Pages (from-to)557-565
Number of pages9
JournalCellular Microbiology
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2008

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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