Yersinia outer proteins: Yops

Jennifer E. Trosky, Amy D B Liverman, Kim Orth

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The pathogenic bacteria Yersinia spp. contain a virulence plasmid that encodes a type III secretion system and effectors. During infection, four of the effectors target the actin cytoskeleton, crippling the phagocytic machinery in the infected cell. The remaining two effectors dampen the innate immune response by targeting important signalling pathways. Although the biochemical activity for each of these effectors is known, the mechanisms involved in their ordered secretion and delivery remain elusive.

Original languageEnglish (US)
Pages (from-to)557-565
Number of pages9
JournalCellular Microbiology
Volume10
Issue number3
DOIs
StatePublished - Mar 2008

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Yersinia
Actin Cytoskeleton
Innate Immunity
Machinery
Virulence
Actins
Bacteria
Plasmids
Infection
Proteins
Type III Secretion Systems

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Microbiology

Cite this

Yersinia outer proteins : Yops. / Trosky, Jennifer E.; Liverman, Amy D B; Orth, Kim.

In: Cellular Microbiology, Vol. 10, No. 3, 03.2008, p. 557-565.

Research output: Contribution to journalArticle

Trosky, Jennifer E. ; Liverman, Amy D B ; Orth, Kim. / Yersinia outer proteins : Yops. In: Cellular Microbiology. 2008 ; Vol. 10, No. 3. pp. 557-565.
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