ZBTB1 is a determinant of lymphoid development

Owen M. Siggs, Xiaohong Li, Yu Xia, And Bruce Beutler

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalJournal of Experimental Medicine
Volume209
Issue number1
DOIs
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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