TY - JOUR
T1 - ZBTB1 is a determinant of lymphoid development
AU - Siggs, Owen M.
AU - Li, Xiaohong
AU - Xia, Yu
AU - Beutler, And Bruce
PY - 2012/1
Y1 - 2012/1
N2 - In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.
AB - In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.
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U2 - 10.1084/jem.20112084
DO - 10.1084/jem.20112084
M3 - Article
C2 - 22201126
AN - SCOPUS:84863115210
SN - 0022-1007
VL - 209
SP - 19
EP - 27
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
ER -