ZBTB1 is a determinant of lymphoid development

Owen M. Siggs, Xiaohong Li, Yu Xia, And Bruce Beutler

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In this study, we describe a chemically induced mouse mutation that caused a complete and cell-intrinsic T cell deficiency. Development of other lymphoid lineages was also partially impaired and was severely compromised under competitive conditions. Positional cloning, retroviral transduction, and a somatic reversion event revealed that the causative mutation lay within Zbtb1 (zinc finger and BTB domain containing 1), a gene conserved throughout vertebrate evolution. Our data establish ZBTB1 as a critical determinant of T cell development and lymphopoiesis in general, most likely by acting as a transcriptional regulator.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalJournal of Experimental Medicine
Volume209
Issue number1
DOIs
StatePublished - Jan 2012

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Lymphopoiesis
T-Lymphocytes
Mutation
Zinc Fingers
Vertebrates
Organism Cloning
Genes
BTB-POZ Domain

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

ZBTB1 is a determinant of lymphoid development. / Siggs, Owen M.; Li, Xiaohong; Xia, Yu; Beutler, And Bruce.

In: Journal of Experimental Medicine, Vol. 209, No. 1, 01.2012, p. 19-27.

Research output: Contribution to journalArticle

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