Zinc as an Imaging Biomarker of Prostate Cancer

Su Tang Lo, André F. Martins, Veronica Clavijo Jordan, A. Dean Sherry

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Zinc has long been the focus of many biological investigations because of its essential role in biology including a catalytic role in many enzymes, a structural role in the many zinc finger proteins, and a physiological role in many secretory cell processes. Divalent zinc is known to be highly abundant in healthy prostate tissues and lower in prostate cancer (PCa). Given the need for newer diagnostic methods for detection of prostate cancer, zinc-responsive probes of various types have been considered as imaging tools for detecting tissue levels of zinc. Among them, recent zinc-responsive MRI probes show great promise for non-invasive detection of zinc ion secretion from the prostate and other tissues in vivo. In this review, we summarize the need for new diagnostic tools and demonstrate how responsive zinc probes and MRI could satisfy this unmet need.

Original languageEnglish (US)
Pages (from-to)854-886
Number of pages33
JournalIsrael Journal of Chemistry
Volume57
Issue number9
DOIs
StatePublished - Sep 2017

Keywords

  • Magnetic Resonance Imaging
  • Prostate Cancer
  • Zinc

ASJC Scopus subject areas

  • Chemistry(all)

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