ZMYND8 is a primary HIF coactivator that mediates breast cancer progression

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Abstract

Epigenetic regulator plays a pivotal role in breast cancer progression. We recently demonstrated that the epigenetic reader zinc finger MYND-type containing 8 (ZMYND8) mediates breast cancer progression and metastasis by activating hypoxia-inducible factor (HIF). This discovery provides new insights into the molecular mechanism underlying HIF activation and breast cancer progression.

Original languageEnglish (US)
Article numbere1479619
JournalMolecular and Cellular Oncology
Volume5
Issue number4
DOIs
StatePublished - Jul 4 2018

Keywords

  • breast cancer
  • epigenetic reader
  • gene regulation
  • Hypoxia-inducible factor

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine

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