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2018

Using two-site binding models to analyze microscale thermophoresis data

Tso, S. C., Chen, Q., Vishnivetskiy, S. A., Gurevich, V. V., Iverson, T. M. & Brautigam, C. A., Jan 1 2018, In : Analytical Biochemistry. 540-541, p. 64-75 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Who's In and Who's Out—Compositional Control of Biomolecular Condensates

Ditlev, J. A., Case, L. B. & Rosen, M. K., Jan 1 2018, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

43 Scopus citations
2017

Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation

Huang, W. Y. C., Ditlev, J. A., Chiang, H. K., Rosen, M. K. & Groves, J. T., Dec 13 2017, In : Journal of the American Chemical Society. 139, 49, p. 18009-18015 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity

Arellano-Santoyo, H., Geyer, E. A., Stokasimov, E., Chen, G. Y., Su, X., Hancock, W., Rice, L. M. & Pellman, D., Jul 10 2017, In : Developmental Cell. 42, 1, p. 37-51.e8

Research output: Contribution to journalArticle

23 Scopus citations

Autoinhibition of munc18-1 modulates synaptobrevin binding and helps to enable munc13-dependent regulation of membrane fusion

Sitarska, E., Xu, J., Park, S., Liu, X., Quade, B., Stepien, K., Sugita, K., Brautigam, C. A., Sugita, S. & Rizo-Rey, J., May 6 2017, In : eLife. 6, e24278.

Research output: Contribution to journalArticle

19 Scopus citations

Biomolecular condensates: organizers of cellular biochemistry

Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K., Feb 22 2017, (Accepted/In press) In : Nature Reviews Molecular Cell Biology.

Research output: Contribution to journalArticle

715 Scopus citations

Complete genome of achalarus lyciades, the first representative of the eudaminae subfamily of skippers

Shen, J., Cong, Q., Borek, D., Otwinowski, Z. & Grishin, N. V., Aug 1 2017, In : Current Genomics. 18, 4, p. 366-374 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution

Boland, A., Martin, T. G., Zhang, Z., Yang, J., Bai, X. C., Chang, L., Scheres, S. H. W. & Barford, D., Apr 1 2017, In : Nature Structural and Molecular Biology. 24, 4, p. 414-418 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor

Hou, Z., Su, L., Pei, J., Grishin, N. V. & Zhang, H., 2017, (Accepted/In press) In : Structure.

Research output: Contribution to journalArticle

2 Scopus citations

Direct measurement of conformational strain energy in protofilaments curling outward from disassembling microtubule tips

Driver, J. W., Geyer, E. A., Bailey, M. E., Rice, L. M. & Asbury, C. L., Jun 19 2017, In : eLife. 6, e28433.

Research output: Contribution to journalArticle

14 Scopus citations

ECOD: New developments in the evolutionary classification of domains

Dustin Schaeffer, R., Liao, Y., Cheng, H. & Grishin, N. V., Jan 1 2017, In : Nucleic Acids Research. 45, D1, p. D296-D302

Research output: Contribution to journalArticle

21 Scopus citations
13 Scopus citations

Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum

Brautigam, C. A., Deka, R. K., Liu, W. Z., Tomchick, D. R. & Norgard, M. V., Apr 1 2017, In : Protein Science. 26, 4, p. 847-856 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming

Camacho, M., Basu, J., Trimbuch, T., Chang, S., Pulido-Lozano, C., Chang, S. S., Duluvova, I., Abo-Rady, M., Rizo-Rey, J. & Rosenmund, C., 2017, In : Nature communications. 8, 15293.

Research output: Contribution to journalArticle

24 Scopus citations

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

Harmon, T. S., Holehouse, A. S., Rosen, M. K. & Pappu, R. V., Nov 1 2017, In : eLife. 6, e30294.

Research output: Contribution to journalArticle

101 Scopus citations

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

Lin, Y., Currie, S. L. & Rosen, M. K., Nov 17 2017, In : Journal of Biological Chemistry. 292, 46, p. 19110-19120 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Ligand modulation of sidechain dynamics in a wild-type human GPCR

Clark, L. D., Dikiy, I., Chapman, K., Rödström, K. E. J., Aramini, J., LeVine, M. V., Khelashvili, G., Rasmussen, S. G. F., Gardner, K. H. & Rosenbaum, D. M., Oct 6 2017, In : eLife. 6, e28505.

Research output: Contribution to journalArticle

33 Scopus citations

Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

Brulotte, M. L., Jeong, B. C., Li, F., Li, B., Yu, E. B., Wu, Q., Brautigam, C. A., Yu, H. & Luo, X., Dec 1 2017, In : Nature communications. 8, 1, 1956.

Research output: Contribution to journalArticle

11 Scopus citations

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme

Li, Y., Zhou, M., Hu, Q., Bai, X. C., Huang, W., Scheres, S. H. W. & Shi, Y., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1542-1547 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

Xu, J., Camacho, M., Xu, Y., Esser, V., Liu, X., Trimbuch, T., Pan, Y. Z., Ma, C., Tomchick, D. R., Rosenmund, C. & Rizo-Rey, J., Feb 8 2017, In : eLife. 6, e22567.

Research output: Contribution to journalArticle

37 Scopus citations

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

Wong, W., Bai, X. C., Sleebs, B. E., Triglia, T., Brown, A., Thompson, J. K., Jackson, K. E., Hanssen, E., Marapana, D. S., Fernandez, I. S., Ralph, S. A., Cowman, A. F., Scheres, S. H. W. & Baum, J., Mar 13 2017, In : Nature Microbiology. 2, 17031.

Research output: Contribution to journalArticle

37 Scopus citations

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5

Obayashi, E., Luna, R. E., Nagata, T., Martin-Marcos, P., Hiraishi, H., Singh, C. R., Erzberger, J. P., Zhang, F., Arthanari, H., Morris, J., Pellarin, R., Moore, C., Harmon, I., Papadopoulos, E., Yoshida, H., Nasr, M. L., Unzai, S., Thompson, B., Aube, E., Hustak, S. & 8 others, Stengel, F., Dagraca, E., Ananbandam, A., Gao, P., Urano, T., Hinnebusch, A. G., Wagner, G. & Asano, K., Mar 14 2017, In : Cell Reports. 18, 11, p. 2651-2663 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

Fung, H. Y. J., Fu, S. C. & Chook, Y. M., Mar 10 2017, In : eLife. 6, e23961.

Research output: Contribution to journalArticle

23 Scopus citations

Piecewise-Stationary Motion Modeling and Iterative Smoothing to Track Heterogeneous Particle Motions in Dense Environments

Roudot, P., Ding, L., Jaqaman, K., Kervrann, C. & Danuser, G., Nov 2017, In : IEEE Transactions on Image Processing. 26, 11, p. 5395-5410 16 p., 7938386.

Research output: Contribution to journalArticle

12 Scopus citations

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

Chen, B., Chou, H. T., Brautigam, C. A., Xing, W., Yang, S., Henry, L., Doolittle, L. K., Walz, T. & Rosen, M. K., Sep 26 2017, In : eLife. 6, e29795.

Research output: Contribution to journalArticle

29 Scopus citations

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated snare complexes

Prinslow, E. A., Brautigam, C. A. & Rizo-Rey, J., Sep 7 2017, In : eLife. 6, e30286.

Research output: Contribution to journalArticle

5 Scopus citations

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

Bae, S. J., Ni, L., Osinski, A., Tomchick, D. R., Brautigam, C. A. & Luo, X., Oct 24 2017, In : eLife. 6, e30278.

Research output: Contribution to journalArticle

30 Scopus citations

Simultaneous lipid and content mixing assays for in vitro reconstitution studies of synaptic vesicle fusion

Liu, X., Seven, A. B., Xu, J., Esser, V., Su, L., Ma, C. & Rizo-Rey, J., Sep 1 2017, In : Nature Protocols. 12, 9, p. 2014-2028 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structural basis of arrestin-3 activation and signaling

Chen, Q., Perry, N. A., Vishnivetskiy, S. A., Berndt, S., Gilbert, N. C., Zhuo, Y., Singh, P. K., Tholen, J., Ohi, M. D., Gurevich, E. V., Brautigam, C. A., Klug, C. S., Gurevich, V. V. & Iverson, T. M., Dec 1 2017, In : Nature communications. 8, 1, 1427.

Research output: Contribution to journalArticle

30 Scopus citations

Structural differences between yeast and mammalian microtubules revealed by cryo-EM

Howes, S. C., Geyer, E. A., LaFrance, B., Zhang, R., Kellogg, E. H., Westermann, S., Rice, L. M. & Nogales, E., Sep 1 2017, In : Journal of Cell Biology. 216, 9, p. 2669-2677 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

Shang, G., Brautigam, C. A., Chen, R., Lu, D., Torres-Vázquez, J. & Zhang, X., May 24 2017, In : eLife. 6, e27322.

Research output: Contribution to journalArticle

13 Scopus citations

Structure of a spliceosome remodelled for exon ligation

Fica, S. M., Oubridge, C., Galej, W. P., Wilkinson, M. E., Bai, X. C., Newman, A. J. & Nagai, K., Feb 16 2017, In : Nature. 542, 7641, p. 377-380 4 p.

Research output: Contribution to journalArticle

83 Scopus citations

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

Chen, Q., She, J., Zeng, W., Guo, J., Xu, H., Bai, X. C. & Jiang, Y., Oct 19 2017, In : Nature. 550, 7676, 24035.

Research output: Contribution to journalArticle

57 Scopus citations

Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump

Fitzpatrick, A. W. P., Llabrés, S., Neuberger, A., Blaza, J. N., Bai, X. C., Okada, U., Murakami, S., Van Veen, H. W., Zachariae, U., Scheres, S. H. W., Luisi, B. F. & Du, D., May 15 2017, In : Nature microbiology. 2, 17070.

Research output: Contribution to journalArticle

46 Scopus citations

Structures of the calcium-activated, non-selective cation channel TRPM4

Guo, J., She, J., Zeng, W., Chen, Q., Bai, X. C. & Jiang, Y., Dec 14 2017, In : Nature. 552, 7684, p. 205-209 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Structures of the human mitochondrial ribosome in native states of assembly

Brown, A., Rathore, S., Kimanius, D., Aibara, S., Bai, X. C., Rorbach, J., Amunts, A. & Ramakrishnan, V., Oct 5 2017, In : Nature Structural and Molecular Biology. 24, 10, p. 866-869 4 p.

Research output: Contribution to journalArticle

37 Scopus citations

TAEL: A zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control

Reade, A., Motta-Mena, L. B., Gardner, K. H., Stainier, D. Y., Weiner, O. D. & Woo, S., Jan 15 2017, In : Development (Cambridge). 144, 2, p. 345-355 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The first complete genomes of Metalmarks and the classification of butterfly families

Cong, Q., Shen, J., Li, W., Borek, D., Otwinowski, Z. & Grishin, N. V., 2017, (Accepted/In press) In : Genomics.

Research output: Contribution to journalArticle

8 Scopus citations

UNC-18 and tomosyn antagonistically control synaptic vesicle priming downstream of UNC-13 in Caenorhabditis elegans

Park, S., Bin, N. R., Yu, B., Wong, R., Sitarska, E., Sugita, K., Ma, K., Xu, J., Tien, C. W., Algouneh, A., Turlova, E., Wang, S., Siriya, P., Shahid, W., Kalia, L., Feng, Z. P., Monnier, P. P., Sun, H. S., Zhen, M., Gao, S. & 2 others, Rizo-Rey, J. & Sugita, S., Sep 6 2017, In : Journal of Neuroscience. 37, 36, p. 8797-8815 19 p.

Research output: Contribution to journalArticle

9 Scopus citations

When coi barcodes deceive: Complete genomes reveal introgression in hairstreaks

Cong, Q., Shen, J., Borek, D., Robbins, R. K., Opler, P. A., Otwinowski, Z. & Grishin, N. V., Feb 8 2017, In : Proceedings of the Royal Society B: Biological Sciences. 284, 1848, 20161735.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi

Song, J., Wilhelm, C. L., Wangdi, T., Maira-Litran, T., Lee, S. J., Raetz, M., Sturge, C. R., Mirpuri, J., Pei, J., Grishin, N. V., McSorley, S. J., Gewirtz, A. T., Bäumler, A. J., Pier, G. B., Galán, J. E. & Yarovinsky, F., Feb 25 2016, In : Cell. 164, 5, p. 827-828 2 p.

Research output: Contribution to journalArticle

9 Scopus citations

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

Srinivasan, N., Gordon, O., Ahrens, S., Franz, A., Deddouche, S., Chakravarty, P., Phillips, D., Yunus, A. A., Rosen, M. K., Valente, R. S., Teixeira, L., Thompson, B., Dionne, M. S., Wood, W. & Reis e Sousa, C., Nov 22 2016, In : eLife. 5, NOVEMBER2016, e19662.

Research output: Contribution to journalArticle

23 Scopus citations

A new species of Oeneis from Alaska, United States, with notes on the Oeneis chryxus complex (Lepidoptera: Nymphalidae: Satyrinae)

Warren, A. D., Nakahara, S., Lukhtanov, V. A., Daly, K. M., Ferris, C. D., Grishin, N. V., Cesanek, M. & Pelham, J. P., 2016, In : Journal of Research on the Lepidoptera. 49, 1, p. 1-20 20 p.

Research output: Contribution to journalArticle

2 Scopus citations

Assessment of CASP11 contact-assisted predictions

Kinch, L. N., Li, W., Monastyrskyy, B., Kryshtafovych, A. & Grishin, N. V., 2016, (Accepted/In press) In : Proteins: Structure, Function and Bioinformatics.

Research output: Contribution to journalArticle

14 Scopus citations

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

Phillips, M. A., White, K. L., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D. M., Chiu, F. C. K., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 16 others, Martinez, M. S., Lafuente-Monasterio, M., Kaminsky, W., Silue, K., Zeeman, A. M., Kocken, C., Leroy, D., Blasco, B., Rossignol, E., Rueckle, T., Matthews, D., Burrows, J. N., Waterson, D., Palmer, M. J., Rathod, P. K. & Charman, S. A., Dec 9 2016, In : ACS infectious diseases. 2, 12, p. 945-957 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Basis of Mutual Domain Inhibition in a Bacterial Response Regulator

Corrêa, F. & Gardner, K. H., Aug 18 2016, In : Cell Chemical Biology. 23, 8, p. 945-955 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Bile salt receptor complex activates a pathogenic type III secretion system

Li, P., Rivera-Cancel, G., Kinch, L. N., Salomon, D., Tomchick, D. R., Grishin, N. V. & Orth, K., Jul 5 2016, In : eLife. 5, 2016JULY, e15718.

Research output: Contribution to journalArticle

19 Scopus citations

CASP 11 target classification

Kinch, L. N., Li, W., Schaeffer, R. D., Dunbrack, R. L., Monastyrskyy, B., Kryshtafovych, A. & Grishin, N. V., Sep 1 2016, In : Proteins. 84, p. 20-33 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Changes in single-molecule integrin dynamics linked to local cellular behavior

Jaqaman, K., Galbraith, J. A., Davidson, M. W. & Galbraith, C. G., May 15 2016, In : Molecular biology of the cell. 27, 10, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Complete genome of Pieris rapae, a resilient alien, a cabbage pest, and a source of anti-cancer proteins

Grishin, N. V., Shen, J., Cong, Q., Kinch, L. N., Borek, D. & Otwinowski, Z., 2016, In : F1000Research. 5, 2631.

Research output: Contribution to journalArticle

23 Scopus citations