Research Output 1979 2019

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2011
14 Citations (Scopus)
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Dihydrolipoamide Dehydrogenase
Thermodynamics
Asparagine
Nuclear magnetic resonance
86 Citations (Scopus)

Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein

Nash, A. I., McNulty, R., Shillito, M. E., Swartz, T. E., Bogomolni, R. A., Luecke, H. & Gardner, K. H., Jun 7 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 23, p. 9449-9454 6 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Oxygen
Light
Lighting
Proteins
575 Citations (Scopus)

Structure and function of an irreversible agonist-β2 adrenoceptor complex

Rosenbaum, D. M., Zhang, C., Lyons, J. A., Holl, R., Aragao, D., Arlow, D. H., Rasmussen, S. G. F., Choi, H. J., Devree, B. T., Sunahara, R. K., Chae, P. S., Gellman, S. H., Dror, R. O., Shaw, D. E., Weis, W. I., Caffrey, M., Gmeiner, P. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 236-242 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Adrenergic Receptors
Adrenergic Agonists
Heterotrimeric GTP-Binding Proteins
Antibodies
1055 Citations (Scopus)

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Rasmussen, S. G. F., Choi, H. J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., Jan 13 2011, In : Nature. 469, 7329, p. 175-181 7 p.

Research output: Contribution to journalArticle

Single-Domain Antibodies
G-Protein-Coupled Receptors
Adrenergic Receptors
GTP-Binding Proteins
Opsins
95 Citations (Scopus)

Structure of C3PO and mechanism of human RISC activation

Ye, X., Huang, N., Liu, Y., Paroo, Z., Huerta, C., Li, P., Chen, S., Liu, Q. & Zhang, H., Jun 2011, In : Nature Structural and Molecular Biology. 18, 6, p. 650-657 8 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
Small Interfering RNA
Endonucleases
RNA Interference
RNA
232 Citations (Scopus)

Synaptic vesicle exocytosis

Südhof, T. C. & Rizo-Rey, J., Dec 2011, In : Cold Spring Harbor perspectives in biology. 3, 12

Research output: Contribution to journalArticle

SNARE Proteins
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Synaptic Vesicles
Exocytosis
Fusion reactions
82 Citations (Scopus)

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold

Selyunin, A. S., Sutton, S. E., Weigele, B. A., Reddick, L. E., Orchard, R. C., Bresson, S. M., Tomchick, D. R. & Alto, N. M., Jan 6 2011, In : Nature. 469, 7328, p. 107-113 7 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
ADP-Ribosylation Factors
p21-Activated Kinases
Phosphotransferases
Enterohemorrhagic Escherichia coli
58 Citations (Scopus)

The crystal structure of a Munc13 C-terminal module exhibits a remarkable similarity to vesicle tethering factors

Li, W., Ma, C., Guan, R., Xu, Y., Tomchick, D. R. & Rizo-Rey, J., Oct 12 2011, In : Structure. 19, 10, p. 1443-1455 13 p.

Research output: Contribution to journalArticle

Syntaxin 1
SNARE Proteins
Neurotransmitter Agents
Membranes
12 Citations (Scopus)

The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements

Li, P., Martins, I. R. S. & Rosen, M. K., Sep 2011, In : Journal of Biomolecular NMR. 51, 1-2, p. 57-70 14 p.

Research output: Contribution to journalArticle

Benchmarking
Thermodynamics
Proteins
Chemical shift
Molecules
99 Citations (Scopus)

Tripping the light fantastic: Blue-light photoreceptors as examples of environmentally modulated protein-protein interactions

Zoltowski, B. D. & Gardner, K. H., Jan 11 2011, In : Biochemistry. 50, 1, p. 4-16 13 p.

Research output: Contribution to journalArticle

Light
Signal transduction
Proteins
Signal Transduction
Cryptochromes
31 Citations (Scopus)
Thermodynamics
Sedimentation
Thermodynamic properties
Software
Kinetics
23 Citations (Scopus)

Variations in protein-flavin hydrogen bonding in a light, oxygen, voltage domain produce non-Arrhenius kinetics of adduct decay

Zoltowski, B. D., Nash, A. I. & Gardner, K. H., Oct 18 2011, In : Biochemistry. 50, 41, p. 8771-8779 9 p.

Research output: Contribution to journalArticle

Hydrogen Bonding
Hydrogen bonds
Oxygen
Light
Kinetics
2010
36 Citations (Scopus)

Activated RhoA binds to the Pleckstrin Homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation

Chen, Z., Medina, F., Liu, M. Y., Thomas, C., Sprang, S. R. & Sternweis, P. C., Jul 2 2010, In : Journal of Biological Chemistry. 285, 27, p. 21070-21081 12 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Homeostasis
Nucleotides
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
35 Citations (Scopus)

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Westerberg, L. S., Meelu, P., Baptista, M., Eston, M. A., Adamovich, D. A., Cotta-de-Almeida, V., Seed, B., Rosen, M. K., Vandenberghe, P., Thrasher, A. J., Klein, C., Alt, F. W. & Snapper, S. B., Jun 7 2010, In : Journal of Experimental Medicine. 207, 6, p. 1145-1152 8 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein
Genomic Instability
Neutropenia
Polymerization
Actins
112 Citations (Scopus)

At the junction of SNARE and SM protein function.

Carr, C. M. & Rizo-Rey, J., Aug 2010, In : Current Opinion in Cell Biology. 22, 4, p. 488-495 8 p.

Research output: Contribution to journalArticle

Munc18 Proteins
SNARE Proteins
Membrane Fusion
74 Citations (Scopus)

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity

Xue, M., Craig, T. K., Xu, J., Chao, H. T., Rizo-Rey, J. & Rosenmund, C., May 2010, In : Nature Structural and Molecular Biology. 17, 5, p. 568-575 8 p.

Research output: Contribution to journalArticle

Synaptotagmin I
SNARE Proteins
Synaptic Vesicles
Exocytosis
Neurotransmitter Agents
80 Citations (Scopus)

Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression

Citri, A., Bhattacharyya, S., Ma, C., Morishita, W., Fang, S., Rizo-Rey, J. & Malenka, R. C., Dec 8 2010, In : Journal of Neuroscience. 30, 49, p. 16437-16452 16 p.

Research output: Contribution to journalArticle

AMPA Receptors
N-Methyl-D-Aspartate Receptors
Calcium
Neuronal Plasticity
Post-Synaptic Density
350 Citations (Scopus)

Cellular internalization of exosomes occurs through phagocytosis

Feng, D., Zhao, W. L., Ye, Y. Y., Bai, X. C., Liu, R. Q., Chang, L. F., Zhou, Q. & Sui, S. F., May 1 2010, In : Traffic. 11, 5, p. 675-687 13 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Exosomes
Clathrin
Polystyrenes
Latex
30 Citations (Scopus)

Characterization of the CpxRA regulon in Haemophilus ducreyi

Labandeira, M., Brautigam, C. A. & Hansen, E. J., Nov 2010, In : Infection and Immunity. 78, 11, p. 4779-4791 13 p.

Research output: Contribution to journalArticle

Haemophilus ducreyi
Regulon
Operon
Electrophoretic Mobility Shift Assay
Genetic Promoter Regions
33 Citations (Scopus)

Coactivator recruitment: A new role for PAS domains in transcriptional regulation by the bHLH-PAS family

Partch, C. L. & Gardner, K. H., Jun 2010, In : Journal of Cellular Physiology. 223, 3, p. 553-557 5 p.

Research output: Contribution to journalArticle

Transcription Factors
Oligomerization
Dimerization
Transcriptional Activation
Proteins
17 Citations (Scopus)

Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: Implication for structure-based drug design and improvement

Huang, N., Kolhatkar, R., Eyobo, Y., Sorci, L., Rodionova, I., Osterman, A. L., MacKerell, A. D. & Zhang, H., Jul 22 2010, In : Journal of Medicinal Chemistry. 53, 14, p. 5229-5239 11 p.

Research output: Contribution to journalArticle

Bacillus anthracis
Drug Design
Essential Genes
NAD
Oxidation-Reduction
9 Citations (Scopus)

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins

Leung, D. W., Borek, D., Farahbakhsh, M., Ramanan, P., Nix, J. C., Wang, T., Prins, K. C., Otwinowski, Z., Honzatko, R. B., Helgeson, L. A., Basler, C. F. & Amarasinghe, G. K., 2010, In : Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 66, 6, p. 689-692 4 p.

Research output: Contribution to journalArticle

interferon
X ray analysis
Mutant Proteins
Crystallization
Interferons
28 Citations (Scopus)

Crystal structure of the formin mDIA1 in autoinhibited conformation

Otomo, T., Tomchick, D. R., Otomo, C., Machius, M. & Rosen, M. K., 2010, In : PLoS One. 5, 9, p. 1-13 13 p., e12896.

Research output: Contribution to journalArticle

crystal structure
actin
Conformations
Actins
Crystal structure
31 Citations (Scopus)

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments

Padrick, S. B., Deka, R. K., Chuang, J. L., Wynn, R. M., Chuang, D. T., Norgard, M. V., Rosen, M. K. & Brautigam, C. A., Dec 2010, In : Analytical Biochemistry. 407, 1, p. 89-103 15 p.

Research output: Contribution to journalArticle

Sedimentation
Stoichiometry
Proteins
Experiments
Host-Pathogen Interactions
38 Citations (Scopus)

Diffraction data analysis in the presence of radiation damage

Borek, D., Cymborowski, M., MacHius, M., Minor, W. & Otwinowski, Z., 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 4, p. 426-436 11 p.

Research output: Contribution to journalArticle

X-Rays
Physical Phenomena
Radiation
Crystallography
Electrons
93 Citations (Scopus)

Dynameomics: A Comprehensive Database of Protein Dynamics

van der Kamp, M. W., Schaeffer, R. D., Jonsson, A. L., Scouras, A. D., Simms, A. M., Toofanny, R. D., Benson, N. C., Anderson, P. C., Merkley, E. D., Rysavy, S., Bromley, D., Beck, D. A. C. & Daggett, V., Mar 1 2010, In : Structure. 18, 4, p. 423-435 13 p.

Research output: Contribution to journalArticle

Protein Databases
Protein Folding
Databases
Proteins
Protein Unfolding
81 Citations (Scopus)

Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets

Flannagan, R. S., Harrison, R. E., Yip, C. M., Jaqaman, K. & Grinstein, S., Dec 13 2010, In : Journal of Cell Biology. 191, 6, p. 1205-1218 14 p.

Research output: Contribution to journalArticle

Actins
Macrophages
Phagocytes
Dendritic Cells
Complement C3b
16 Citations (Scopus)
Basic Amino Acids
Carboxy-Lyases
Substrate Specificity
Arginine
X-Rays
37 Citations (Scopus)

Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2

Mayer, P. R., Huang, N., Dewey, C. M., Dries, D. R., Zhang, H. & Yu, G., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 40387-40396 10 p.

Research output: Contribution to journalArticle

Nicotinamide-Nucleotide Adenylyltransferase
Neurons
Presynaptic Terminals
Membranes
HeLa Cells
626 Citations (Scopus)

Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor

Sheard, L. B., Tan, X., Mao, H., Withers, J., Ben-Nissan, G., Hinds, T. R., Kobayashi, Y., Hsu, F. F., Sharon, M., Browse, J., He, S. Y., Rizo-Rey, J., Howe, G. A. & Zheng, N., Nov 18 2010, In : Nature. 468, 7322, p. 400-407 8 p.

Research output: Contribution to journalArticle

Inositol Phosphates
F-Box Proteins
Hormones
Repressor Proteins
Aptitude
51 Citations (Scopus)

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain

Luong, P., Kinch, L. N., Brautigam, C. A., Grishin, N. V., Tomchick, D. R. & Orth, K. A., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20155-20163 9 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Adenosine Monophosphate
Kinetics
Vibrio
GTP Phosphohydrolases
87 Citations (Scopus)

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases

Jaqaman, K., King, E. M., Amaro, A. C., Winter, J. R., Dorn, J. F., Elliott, H. L., Mchedlishvili, N., McClelland, S. E., Porter, I. M., Posch, M., Toso, A., Danuser, G., McAinsh, A. D., Meraldi, P. & Swedlow, J. R., Mar 8 2010, In : Journal of Cell Biology. 188, 5, p. 665-679 15 p.

Research output: Contribution to journalArticle

Kinetochores
Centromere
Metaphase
Microtubules
Respiration
355 Citations (Scopus)

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

Bokoch, M. P., Zou, Y., Rasmussen, S. G. F., Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H. J., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L. & Kobilka, B. K., Jan 7 2010, In : Nature. 463, 7277, p. 108-112 5 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Ligands
GTP-Binding Proteins
Binding Sites
Drug Delivery Systems
81 Citations (Scopus)

Molecular basis for peptidoglycan recognition by a bactericidal lectin

Lehotzkya, R. E., Partchb, C. L., Mukherjeea, S., Casha, H. L., Goldman, W. E., Gardner, K. H. & Hooper, L. V., Apr 27 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 17, p. 7722-7727 6 p.

Research output: Contribution to journalArticle

Peptidoglycan
Lectins
Carbohydrates
Calcium
C-Type Lectins
115 Citations (Scopus)

Munc13 C 2 B domain is an activity-dependent Ca 2+ regulator of synaptic exocytosis

Shin, O. H., Lu, J., Rhee, J. S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., MacHius, M., Rizo-Rey, J., Rosenmund, C. & Südhof, T. C., Mar 2010, In : Nature Structural and Molecular Biology. 17, 3, p. 280-288 9 p.

Research output: Contribution to journalArticle

Exocytosis
Action Potentials
Synaptic Vesicles
Phospholipids
Mutation
158 Citations (Scopus)

Physical mechanisms of signal integration by WASP family proteins

Padrick, S. B. & Rosen, M. K., Jul 7 2010, In : Annual Review of Biochemistry. 79, p. 707-735 29 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein Family
Wiskott-Aldrich Syndrome Protein
Actin-Related Protein 2-3 Complex
Proteins
Allosteric Regulation
121 Citations (Scopus)

Rationally improving LOV domainĝ€"based photoswitches

Strickland, D., Yao, X., Gawlak, G., Rosen, M. K., Gardner, K. H. & Sosnick, T. R., Aug 2010, In : Nature Methods. 7, 8, p. 623-626 4 p.

Research output: Contribution to journalArticle

Phototropins
Optical engineering
Behavior Control
Photodetectors
Light
136 Citations (Scopus)

Recognition of nuclear targeting signals by Karyopherin-β proteins

Xu, D., Farmer, A. & Chook, Y. M., Dec 2010, In : Current Opinion in Structural Biology. 20, 6, p. 782-790 9 p.

Research output: Contribution to journalArticle

Karyopherins
Cell Nucleus Active Transport
Proteins
Nuclear Export Signals
Nuclear Localization Signals
47 Citations (Scopus)
stoichiometry
membrane proteins
Stoichiometry
detergents
Detergents
87 Citations (Scopus)

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M. E., Billadeau, D. D., Machius, M., Tomchick, D. R. & Rosen, M. K., Jan 22 2010, In : Cell. 140, 2, p. 246-256 11 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-vav
Phosphorylation
Chemical activation
Guanine Nucleotide Exchange Factors
rho GTP-Binding Proteins
79 Citations (Scopus)
Transcription Factors
Organ Size
DNA
Carcinogenesis
Binding Sites
18 Citations (Scopus)

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7

Xue, M., Craig, T. K., Shin, O. H., Li, L., Brautigam, C. A., Tomchick, D. R., Südhof, T. C., Rosenmund, C. & Rizo-Rey, J., 2010, In : PLoS One. 5, 9, p. 1-12 12 p., e12544.

Research output: Contribution to journalArticle

Synaptotagmin I
Synaptotagmins
calcium
chimerism
crystal structure
120 Citations (Scopus)

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

Leung, D. W., Prins, K. C., Borek, D. M., Farahbakhsh, M., Tufariello, J. M., Ramanan, P., Nix, J. C., Helgeson, L. A., Otwinowski, Z., Honzatko, R. B., Basler, C. F. & Amarasinghe, G. K., Feb 2010, In : Nature Structural and Molecular Biology. 17, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Viral Proteins
Interferons
Immune Evasion
Ebolavirus
212 Citations (Scopus)

Structure and control of the actin regulatory WAVE complex

Chen, Z., Borek, D., Padrick, S. B., Gomez, T. S., Metlagel, Z., Ismail, A. M., Umetani, J., Billadeau, D. D., Otwinowski, Z. & Rosen, M. K., Nov 25 2010, In : Nature. 468, 7323, p. 533-538 6 p.

Research output: Contribution to journalArticle

Actin-Related Protein 2-3 Complex
Actins
GTP Phosphohydrolases
Wiskott-Aldrich Syndrome Protein Family
Phosphotransferases
5 Citations (Scopus)

Synaptotagmin-SNARE coupling enlightened

Rizo-Rey, J., Mar 2010, In : Nature Structural and Molecular Biology. 17, 3, p. 260-262 3 p.

Research output: Contribution to journalArticle

Synaptotagmins
SNARE Proteins
Biological Models
Membrane Fusion
Calcium
20 Citations (Scopus)

The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution

Akella, R., Min, X., Wu, Q., Gardner, K. H. & Goldsmith, E. J., Dec 8 2010, In : Structure. 18, 12, p. 1571-1578 8 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Phosphotransferases
Peptides
Phosphoric Monoester Hydrolases
Catalytic Domain
4 Citations (Scopus)

The Three Rs of Transcription: Recruit, Retain, and Recycle

Motta-Mena, L. B., Partch, C. L. & Gardner, K. H., Dec 22 2010, In : Molecular Cell. 40, 6, p. 855-858 4 p.

Research output: Contribution to journalArticle

Recycling
Drosophila
Transcription Factors
Proteins
20 Citations (Scopus)

To automate or not to automate: This is the question

Cymborowski, M., Klimecka, M., Chruszcz, M., Zimmerman, M. D., Shumilin, I. A., Borek, D., Lazarski, K., Joachimiak, A., Otwinowski, Z., Anderson, W. & Minor, W., Sep 2010, In : Journal of Structural and Functional Genomics. 11, 3, p. 211-221 11 p.

Research output: Contribution to journalArticle

Productivity
Critical Pathways
Automation
Publications
Clone Cells
117 Citations (Scopus)

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

Jia, D., Gomez, T. S., Metlagel, Z., Umetani, J., Otwinowski, Z., Rosen, M. K. & Billadeau, D. D., Jun 8 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 23, p. 10442-10447 6 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein Family
Actins
Actin-Related Protein 2-3 Complex
Hereditary Spastic Paraplegia
Transport Vesicles
2009
59 Citations (Scopus)

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene

Beel, K., Cotter, M. M., Blatny, J., Bond, J., Lucas, G., Green, F., Vanduppen, V., Leung, D. W., Rooney, S., Smith, O. P., Rosen, M. K. & Vandenberghe, P., Jan 2009, In : British Journal of Haematology. 144, 1, p. 120-126 7 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein
Wiskott-Aldrich Syndrome
Neutropenia
Mutation
Guanosine Triphosphate