Cell Biology - Division A

Research Output 1980 2019

2019

A nostalgic look back 40 years after the discovery of receptor-mediated endocytosis

Schmid, S. L., Jan 1 2019, In : Molecular Biology of the Cell. 30, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Endocytosis
2 Citations (Scopus)

Cell type and receptor identity regulate cholera toxin subunit B (CTB) internalization

Sethi, A., Wands, A. M., Mettlen, M., Krishnamurthy, S., Wu, H. & Kohler, J. J., Apr 6 2019, In : Interface Focus. 9, 2, 20180076.

Research output: Contribution to journalArticle

Cholera Toxin
Cells
Glycoconjugates
Ports and harbors
G(M1) Ganglioside

Mutant p53 amplifies a dynamin-1/APPL1 endosome feedback loop that regulates recycling and migration

Lakoduk, A. M., Roudot, P., Mettlen, M., Grossman, H. M., Schmid, S. L. & Chen, P. H., Jun 3 2019, In : The Journal of cell biology. 218, 6, p. 1928-1942 15 p.

Research output: Contribution to journalArticle

Open Access
Dynamin I
Endosomes
Recycling
Integrins
Focal Adhesions

The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months

Richardson, L. A., Schmid, S. L., Bhandoola, A., Harly, C., Hedenström, A., Laub, M. T., Mace, G. M., Sengupta, P., Stock, A. M., Read, A. F., Malik, H. S., Estelle, M., Lowell, S. & Kimmelman, J., Feb 1 2019, In : PLoS biology. 17, 2, p. e3000180

Research output: Contribution to journalArticle

Open Access
Biological Sciences
2018
4 Citations (Scopus)

A noncanonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells

Srinivasan, S., Burckhardt, C. J., Bhave, M., Chen, Z., Chen, P. H., Wang, X., Danuser, G. & Schmid, S. L., Apr 18 2018, In : PLoS Biology. 16, 4, e2005377.

Research output: Contribution to journalArticle

Dynamin I
clathrin
Clathrin
endocytosis
Endocytosis
12 Citations (Scopus)

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

Zhang, Z., Zi, Z., Lee, E. E., Zhao, J., Contreras, D. C., South, A. P., Abel, E. D., Chong, B. F., Vandergriff, T., Hosler, G. A., Scherer, P. E., Mettlen, M., Rathmell, J. C., DeBerardinis, R. J. & Wang, R. C., Apr 16 2018, (Accepted/In press) In : Nature Medicine. p. 1-11 11 p.

Research output: Contribution to journalArticle

Keratinocytes
Psoriasis
Skin
Homeostasis
Glucose
28 Citations (Scopus)

Regulation of Clathrin-Mediated Endocytosis

Mettlen, M., Chen, P. H., Srinivasan, S., Danuser, G. & Schmid, S. L., Jun 20 2018, In : Annual Review of Biochemistry. 87, p. 871-896 26 p.

Research output: Contribution to journalReview article

Clathrin
Endocytosis
Vesicular Transport Adaptor Proteins
Clathrin-Coated Vesicles
Dynamins
2 Citations (Scopus)
Clathrin
Endocytosis
Neoplasms
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
8 Citations (Scopus)

The dynamin superfamily

Ramachandran, R. & Schmid, S. L., Apr 23 2018, In : Current Biology. 28, 8, p. R411-R416

Research output: Contribution to journalShort survey

Dynamins
GTP Phosphohydrolases
guanosinetriphosphatase
rab GTP-Binding Proteins
ras Proteins
2017
2 Citations (Scopus)

A highly-sensitive high throughput assay for dynamin's basal GTPase activity

Mohanakrishnan, A., Tran, T. V. M., Kumar, M., Chen, H., Posner, B. A. & Schmid, S. L., 2017, In : PLoS One. 12, 9, p. e0185639

Research output: Contribution to journalArticle

Dynamins
GTP Phosphohydrolases
guanosinetriphosphatase
Assays
Throughput
20 Citations (Scopus)

Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature

Daste, F., Walrant, A., Holst, M. R., Gadsby, J. R., Mason, J., Lee, J. E., Brook, D., Mettlen, M., Larsson, E., Lee, S. F., Lundmark, R. & Gallop, J. L., Nov 1 2017, In : Journal of Cell Biology. 216, 11, p. 3745-3765 21 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Polymerization
Actins
Membranes
Oculocerebrorenal Syndrome
20 Citations (Scopus)

Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis

Chen, P. H., Bendris, N., Hsiao, Y. J., Reis, C. R., Mettlen, M., Chen, H. Y., Yu, S. L. & Schmid, S. L., Feb 6 2017, In : Developmental Cell. 40, 3, p. 278-288.e5

Research output: Contribution to journalArticle

Dynamin I
Clathrin
Crosstalk
Endocytosis
Epidermal Growth Factor Receptor
5 Citations (Scopus)

Decoupling global biases and local interactions between cell biological variables

Zaritsky, A., Obolski, U., Gan, Z., Reis, C. R., Kadlecova, Z., Du, Y., Schmid, S. L. & Danuser, G., Mar 13 2017, In : eLife. 6, e22323.

Research output: Contribution to journalArticle

Cell Communication
Cytology
Proxy
Computational methods
Cell Biology
16 Citations (Scopus)

Endocytosis, Metastasis and Beyond: Multiple Facets of SNX9

Bendris, N. & Schmid, S. L., Mar 1 2017, In : Trends in Cell Biology. 27, 3, p. 189-200 12 p.

Research output: Contribution to journalReview article

Clathrin
Endocytosis
Sorting Nexins
Neoplasm Metastasis
Cell Division
9 Citations (Scopus)

Five years post-DORA: Promoting best practices for research assessment

Schmid, S. L., Nov 1 2017, In : Molecular Biology of the Cell. 28, 22, p. 2941-2944 4 p.

Research output: Contribution to journalReview article

Practice Guidelines
Research
Journal Impact Factor
San Francisco
Proxy

Not just Salk

Greider, C., Hopkins, N., Steitz, J., Amon, A., Asai, D., Barres, B., Bass, B., Bassler, B., Birgeneau, R., Bjorkman, P., Botchan, M., Brugge, J., Cech, T., Colwell, R., Craig, N., Delange, T., Eisen, M., Gottesman, S., Green, R., Handelsman, J. & 17 others, Kimble, J., King, M. C., Lehmann, R., Marder, E., Mullins, D., O’Shea, E., Schmid, S., Seydoux, G., Spradling, A., Storz, G., Szostak, J., Telesnitsky, A., Tilghman, S., Tjian, R., Vale, R., Wolberger, C. & Zakian, V., Sep 15 2017, In : Science. 357, 6356, p. 1105-1106 2 p.

Research output: Contribution to journalLetter

31 Citations (Scopus)

Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell

Schmid, S. L., Sep 1 2017, In : Journal of Cell Biology. 216, 9, p. 2623-2632 10 p.

Research output: Contribution to journalArticle

Dynamin I
Endocytosis
Clathrin
Neoplasms
GTP Phosphohydrolases
30 Citations (Scopus)

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

Kadlecova, Z., Spielman, S. J., Loerke, D., Mohanakrishnan, A., Reed, D. K. & Schmid, S. L., 2017, In : Journal of Cell Biology. 216, 1, p. 167-179 13 p.

Research output: Contribution to journalArticle

Clathrin
Endocytosis
Proteins
Adaptor Protein Complex 2
Phosphatidylinositols
16 Citations (Scopus)

TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation

Reis, C. R., Chen, P. H., Bendris, N. & Schmid, S. L., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 504-509 6 p.

Research output: Contribution to journalArticle

Dynamin I
TNF-Related Apoptosis-Inducing Ligand Receptors
Death Domain Receptors
Endocytosis
Apoptosis
2016
5 Citations (Scopus)

Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection

Perelman, S. S., Abrams, M. E., Eitson, J. L., Chen, D., Jimenez, A., Mettlen, M., Schoggins, J. W. & Alto, N. M., Dec 21 2016, In : PLoS Pathogens. 12, 12, e1006102.

Research output: Contribution to journalArticle

Listeriosis
Listeria monocytogenes
Interferons
Genes
Interferon Type I
17 Citations (Scopus)

Diagonally Scanned Light-Sheet Microscopy for Fast Volumetric Imaging of Adherent Cells

Dean, K. M., Roudot, P., Reis, C. R., Welf, E. S., Mettlen, M. & Fiolka, R., Mar 29 2016, In : Biophysical Journal. 110, 6, p. 1456-1465 10 p.

Research output: Contribution to journalArticle

Microscopy
Light
Clathrin
Glass
Transport Vesicles
36 Citations (Scopus)

Endocytic pathways and endosomal trafficking: a primer

Elkin, S. R., Lakoduk, A. M. & Schmid, S. L., Feb 9 2016, (Accepted/In press) In : Wiener Medizinische Wochenschrift. p. 1-9 9 p.

Research output: Contribution to journalArticle

Endosomes
Multivesicular Bodies
trans-Golgi Network
Phosphatidylinositols
Lysosomes
15 Citations (Scopus)

Identification and function of conformational dynamics in the multidomain GTPase dynamin

Srinivasan, S., Dharmarajan, V., Reed, D. K., Griffin, P. R. & Schmid, S. L., Feb 15 2016, In : EMBO Journal. 35, 4, p. 443-457 15 p.

Research output: Contribution to journalArticle

Dynamins
GTP Phosphohydrolases
Membranes
Conformations
Congenital Structural Myopathies
14 Citations (Scopus)

Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis

Elkin, S. R., Oswald, N. W., Reed, D. K., Mettlen, M., MacMillan, J. B. & Schmid, S. L., Oct 1 2016, In : Traffic. 17, 10, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

Clathrin
Endocytosis
Biological Products
Cell Line
Biochemistry
133 Citations (Scopus)

Membrane fission by dynamin: what we know and what we need to know

Antonny, B., Burd, C., De Camilli, P., Chen, E., Daumke, O., Faelber, K., Ford, M., Frolov, V. A., Frost, A., Hinshaw, J. E., Kirchhausen, T., Kozlov, M. M., Lenz, M., Low, H. H., McMahon, H., Merrifield, C., Pollard, T. D., Robinson, P. J., Roux, A. & Schmid, S. L., Nov 2 2016, In : EMBO Journal. 35, 21, p. 2270-2284 15 p.

Research output: Contribution to journalReview article

Dynamins
Membranes
Guanosine Triphosphate
GTP Phosphohydrolases
Muscle Contraction
13 Citations (Scopus)

SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases

Bendris, N., Williams, K. C., Reis, C. R., Welf, E. S., Chen, P. H., Lemmers, B., Hahne, M., Leong, H. S. & Schmid, S. L., May 1 2016, In : Molecular Biology of the Cell. 27, 9, p. 1409-1419 11 p.

Research output: Contribution to journalArticle

Sorting Nexins
Neoplasm Metastasis
Neoplasms
Breast Neoplasms
Focal Adhesion Protein-Tyrosine Kinases
8 Citations (Scopus)

Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells

Bendris, N., Stearns, C. J. S., Reis, C. R., Rodriguez-Canales, J., Liu, H., Witkiewicz, A. W. & Schmid, S. L., Jul 15 2016, In : Journal of Cell Science. 129, 14, p. 2804-2816 13 p.

Research output: Contribution to journalArticle

Sorting Nexins
Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Matrix Metalloproteinase 14
2015
46 Citations (Scopus)

A hemi-fission intermediate links two mechanistically distinct stages of membrane fission

Mattila, J. P., Shnyrova, A. V., Sundborger, A. C., Hortelano, E. R., Fuhrmans, M., Neumann, S., Müller, M., Hinshaw, J. E., Schmid, S. L. & Frolov, V. A., Aug 6 2015, In : Nature. 524, 7563, p. 109-113 5 p.

Research output: Contribution to journalArticle

Dynamins
Guanosine Triphosphate
Membranes
Dynamin I
GTP Phosphohydrolases
15 Citations (Scopus)

A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells

Elkin, S. R., Bendris, N., Reis, C. R., Zhou, Y., Xie, Y., Huffman, K. E., Minna, J. D. & Schmid, S. L., Nov 1 2015, In : Cancer Research. 75, 21, p. 4640-4650 11 p.

Research output: Contribution to journalArticle

Endocytosis
Clathrin
Neoplasms
Phenotype
Epithelial Cells
43 Citations (Scopus)

Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis

Reis, C. R., Chen, P. H., Srinivasan, S., Aguet, F., Mettlen, M. & Schmid, S. L., Aug 13 2015, In : EMBO Journal. 34, 16, p. 2132-2146 15 p.

Research output: Contribution to journalArticle

Dynamin I
Clathrin
Crosstalk
Endocytosis
Chemical activation
30 Citations (Scopus)

Fucosylation and protein glycosylation create functional receptors for cholera toxin

Wands, A. M., Fujita, A., McCombs, J. E., Cervin, J., Dedic, B., Rodriguez, A. C., Nischan, N., Bond, M. R., Mettlen, M., Trudgian, D. C., Lemoff, A., Quiding-Järbrink, M., Gustavsson, B., Steentoft, C., Clausen, H., Mirzaei, H., Teneberg, S., Yrlid, U. & Kohler, J. J., Oct 29 2015, In : eLife. 4, OCTOBER2015, e09545.

Research output: Contribution to journalArticle

Glycosylation
Glycoproteins
Gangliosides
Cholera Toxin
Proteins
5 Citations (Scopus)

Migrasomes: A new organelle of migrating cells

Da Rocha-Azevedo, B. & Schmid, S. L., Jan 5 2015, In : Cell Research. 25, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Organelles
Exosomes
Cell Movement
Research
2014
30 Citations (Scopus)

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

Lee, E. E., Ma, J., Sacharidou, A., Mi, W., Salato, V. K., Nguyen, N., Jiang, Y., Pascual, J. M., North, P. E., Shaul, P. W., Mettlen, M. & Wang, R. C., Nov 24 2014, (Accepted/In press) In : Molecular Cell.

Research output: Contribution to journalArticle

Protein Kinase C
Phosphorylation
Glucose
Acetates
Glucose Transporter Type 1
18 Citations (Scopus)

Endocytosis: Past, Present, And future

Schmid, S. L., Sorkin, A. & Zerial, M., Dec 1 2014, In : Cold Spring Harbor perspectives in biology. 6, 12, a022509.

Research output: Contribution to journalArticle

From junior to senior: Advice from the benefit of 20/20 hindsight

Schmid, S. L., Nov 1 2014, In : Molecular Biology of the Cell. 25, 21, p. 3259-3262 4 p.

Research output: Contribution to journalArticle

Cell Biology
Students
Research
Mentoring
13 Citations (Scopus)

Imaging and modeling the dynamics of clathrin-mediated endocytosis

Mettlen, M. & Danuser, G., Dec 1 2014, In : Cold Spring Harbor perspectives in biology. 6, 12, a017038.

Research output: Contribution to journalArticle

Clathrin
Endocytosis
Imaging techniques
Data Mining
Image analysis
3 Citations (Scopus)

Intrapolypeptide interactions between the GTPase effector domain (GED) and the GTPase domain form the bundle signaling element in dynamin dimers.

Srinivasan, S., Mattila, J. P. & Schmid, S. L., 2014, In : Biochemistry. 53, 36, p. 5724-5726 3 p.

Research output: Contribution to journalArticle

Dynamins
GTP Phosphohydrolases
Dimers
Docks
Escherichia coli
2013
142 Citations (Scopus)

Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint

Aguet, F., Antonescu, C., Mettlen, M., Schmid, S. & Danuser, G., Aug 12 2013, In : Developmental Cell. 26, 3, p. 279-291 13 p.

Research output: Contribution to journalArticle

Dynamins
Clathrin
Accessories
Noise
Proteins
20 Citations (Scopus)

Analyzing membrane remodeling and fission using supported bilayers with excess membrane reservoir

Neumann, S., Pucadyil, T. J. & Schmid, S. L., Jan 2013, In : Nature Protocols. 8, 1, p. 213-222 10 p.

Research output: Contribution to journalArticle

Membranes
Microscopy
Assays
Microscopic examination
Sedimentation
133 Citations (Scopus)

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

Sharma, S., Quintana, A., Findlay, G. M., Mettlen, M., Baust, B., Jain, M., Nilsson, R., Rao, A. & Hogan, P. G., 2013, In : Nature. 499, 7457, p. 238-242 5 p.

Research output: Contribution to journalArticle

Septins
Small Interfering RNA
Cell Membrane
Endoplasmic Reticulum
Membrane Microdomains
13 Citations (Scopus)

Cell biology: Lipid switches and traffic control

Schmid, S. L. & Mettlen, M., 2013, In : Nature. 499, 7457, p. 161-162 2 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Endocytosis
Cell Biology
Lipids
36 Citations (Scopus)

Dual role of BAR domain-containing proteins in regulating vesicle release catalyzed by the GTPase, dynamin-2

Neumann, S. & Schmid, S. L., Aug 30 2013, In : Journal of Biological Chemistry. 288, 35, p. 25119-25128 10 p.

Research output: Contribution to journalArticle

Dynamin II
GTP Phosphohydrolases
Proteins
Membranes
Clathrin
11 Citations (Scopus)

Dynamin-Catalyzed Membrane Fission Requires Coordinated GTP Hydrolysis

Liu, Y. W., Mattila, J. P. & Schmid, S. L., Jan 31 2013, In : PLoS One. 8, 1, e55691.

Research output: Contribution to journalArticle

Dynamins
GTP Phosphohydrolases
guanosinetriphosphatase
Guanosine Triphosphate
Hydrolysis
77 Citations (Scopus)

Geometric catalysis of membrane fission driven by flexible dynamin rings

Shnyrova, A. V., Bashkirov, P. V., Akimov, S. A., Pucadyil, T. J., Zimmerberg, J., Schmid, S. L. & Frolov, V. A., Mar 22 2013, In : Science. 339, 6126, p. 1433-1436 4 p.

Research output: Contribution to journalArticle

Dynamins
Catalysis
Membranes
Nanotubes
Guanosine
6 Citations (Scopus)

Integrated Electron Microscopy: Super-Duper Resolution

Krijnse Locker, J. & Schmid, S. L., Aug 2013, In : PLoS Biology. 11, 8, e1001639.

Research output: Contribution to journalArticle

Electron microscopy
Caveolae
electron microscopy
Electron Microscopy
Membranes
2012

An MBoC favorite: Myosin-1a is critical for normal brush border structure and composition.

Schmid, S. L., Jul 2012, In : Molecular Biology of the Cell. 23, 13, p. 2401 1 p.

Research output: Contribution to journalArticle

Myosin Heavy Chains
Enterocytes
Myosins
Microvilli
40 Citations (Scopus)

Context-Dependent Proangiogenic Function of Bone Morphogenetic Protein Signaling Is Mediated by Disabled Homolog 2

Kim, J. D., Kang, H., Larrivée, B., Lee, M. Y., Mettlen, M., Schmid, S. L., Roman, B. L., Qyang, Y., Eichmann, A. & Jin, S. W., Aug 14 2012, In : Developmental Cell. 23, 2, p. 441-448 8 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Endothelial Cells
Endothelial cells
Vesicular Transport Adaptor Proteins
Bone Morphogenetic Protein Receptors

Structural Analysis of Dynamin Reveals a Mechanism of Membrane Fission

Hinshaw, J., Chappie, J. S., Mears, J. A., Fang, S., Leonard, M., Schmid, S. L., Milligan, R. A., Dyda, F. & Hinshaw, J. E., 2012, In : Microscopy and Microanalysis. 18, p. 58-59 2 p.

Research output: Contribution to journalArticle

structural analysis
Structural analysis
fission
membranes
Membranes
81 Citations (Scopus)

Structural tuning of the fluorescent protein iLOV for improved photostability

Christie, J. M., Hitomi, K., Arvai, A. S., Hartfield, K. A., Mettlen, M., Pratt, A. J., Tainer, J. A. & Getzoff, E. D., Jun 22 2012, In : Journal of Biological Chemistry. 287, 26, p. 22295-22304 10 p.

Research output: Contribution to journalArticle

Flavin Mononucleotide
Tuning
Oxygen
Light
Proteins
13 Citations (Scopus)
Molecular Sequence Data
Dynamins
Amino Acid Sequence Homology
Clathrin
Organ Specificity