Research Output

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Review article
2019

Artificial intelligence in lung cancer pathology image analysis

Wang, S., Yang, D. M., Rong, R., Zhan, X., Fujimoto, J., Liu, H., Minna, J., Wistuba, I. I., Xie, Y. & Xiao, G., Nov 2019, In : Cancers. 11, 11, 1673.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations
2017

Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies

Tang, H., Wang, S., Xiao, G., Schiller, J., Papadimitrakopoulou, V., Minna, J., Wistuba, I. I. & Xie, Y., Apr 1 2017, In : Annals of Oncology. 28, 4, p. 733-740 8 p., mdw683.

Research output: Contribution to journalReview article

20 Scopus citations

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types

Windhorst, S., Song, K. & Gazdar, A. F., Aug 1 2017, In : Biochemical Pharmacology. 137, p. 1-9 9 p.

Research output: Contribution to journalReview article

4 Scopus citations

Small-cell lung cancer: What we know, what we need to know and the path forward

Gazdar, A. F., Bunn, P. A. & Minna, J. D., Dec 1 2017, In : Nature Reviews Cancer. 17, 12, p. 725-737 13 p.

Research output: Contribution to journalReview article

129 Scopus citations
2016

Small cell lung cancer: Can recent advances in biology and molecular biology be translated into improved outcomes?

Bunn, P. A., Minna, J. D., Augustyn, A., Gazdar, A. F., Ouadah, Y., Krasnow, M. A., Berns, A., Brambilla, E., Rekhtman, N., Massion, P. P., Niederst, M., Peifer, M., Yokota, J., Govindan, R., Poirier, J. T., Byers, L. A., Wynes, M. W., McFadden, D. G., MacPherson, D., Hann, C. L. & 34 others, Farago, A. F., Dive, C., Teicher, B. A., Peacock, C. D., Johnson, J. E., Cobb, M. H., Wendel, H. G., Spigel, D., Sage, J., Yang, P., Pietanza, M. C., Krug, L. M., Heymach, J., Ujhazy, P., Zhou, C., Goto, K., Dowlati, A., Christensen, C. L., Park, K., Einhorn, L. H., Edelman, M. J., Giaccone, G., Gerber, D. E., Salgia, R., Owonikoko, T., Malik, S., Karachaliou, N., Gandara, D. R., Slotman, B. J., Blackhall, F., Goss, G., Thomas, R., Rudin, C. M. & Hirsch, F. R., Jan 1 2016, In : Journal of Thoracic Oncology. 11, 4, p. 453-474 22 p.

Research output: Contribution to journalReview article

76 Scopus citations
2014

Analysis of TP53 mutation status in human cancer cell lines: A reassessment

Leroy, B., Girard, L., Hollestelle, A., Minna, J. D., Gazdar, A. F. & Soussi, T., Jun 2014, In : Human mutation. 35, 6, p. 756-765 10 p.

Research output: Contribution to journalReview article

62 Scopus citations
2013

Diagnosis of lung adenocarcinoma in resected specimens: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European respiratory society classification

Travis, W. D., Brambilla, E., Noguchi, M., Nicholson, A. G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D. B., Franklin, W., Gazdar, A., Hasleton, P. S., Henderson, D. W., Kerr, K. M., Nakatani, Y., Petersen, I., Roggli, V., Thunnissen, E. & Tsao, M., May 1 2013, In : Archives of Pathology and Laboratory Medicine. 137, 5, p. 685-705 21 p.

Research output: Contribution to journalReview article

87 Scopus citations

Diagnosis of lung cancer in small biopsies and cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European respiratory society classification

Travis, W. D., Brambilla, E., Noguchi, M., Nicholson, A. G., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D. B., Franklin, W., Gazdar, A., Hasleton, P. S., Henderson, D. W., Kerr, K. M., Petersen, I., Roggli, V., Thunnissen, E. & Tsao, M., May 1 2013, In : Archives of Pathology and Laboratory Medicine. 137, 5, p. 668-684 17 p.

Research output: Contribution to journalReview article

213 Scopus citations

DNA methylation data analysis and its application to cancer research

Ma, X., Wang, Y. W., Zhang, M. Q. & Gazdar, A. F., Jun 1 2013, In : Epigenomics. 5, 3, p. 301-316 16 p.

Research output: Contribution to journalReview article

55 Scopus citations

Molecular biology of lung cancer

Cooper, W. A., Lam, D. C. L., O'Toole, S. A. & Minna, J. D., 2013, In : Journal of Thoracic Disease. 5, SUPPL.5, p. S479-S490

Research output: Contribution to journalReview article

172 Scopus citations

The pivotal role of pathology in the management of lung cancer

Davidson, M. R., Gazdar, A. F. & Clarke, B. E., 2013, In : Journal of Thoracic Disease. 5, SUPPL.5, p. S463-S478

Research output: Contribution to journalReview article

81 Scopus citations
2012

Malignant mesothelioma: Facts, Myths, and Hypotheses

Carbone, M., Ly, B. H., Dodson, R. F., Pagano, I., Morris, P. T., Dogan, U. A., Gazdar, A. F., Pass, H. I. & Yang, H., Jan 1 2012, In : Journal of cellular physiology. 227, 1, p. 44-58 15 p.

Research output: Contribution to journalReview article

208 Scopus citations

Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study

Thunnissen, E., Beasley, M. B., Borczuk, A. C., Brambilla, E., Chirieac, L. R., Dacic, S., Flieder, D., Gazdar, A., Geisinger, K., Hasleton, P., Ishikawa, Y., Kerr, K. M., Lantejoul, S., Matsuno, Y., Minami, Y., Moreira, A. L., Motoi, N., Nicholson, A. G., Noguchi, M., Nonaka, D. & 12 others, Pelosi, G., Petersen, I., Rekhtman, N., Roggli, V., Travis, W. D., Tsao, M. S., Wistuba, I., Xu, H., Yatabe, Y., Zakowski, M., Witte, B. & Kuik, D. J., Dec 1 2012, In : Modern Pathology. 25, 12, p. 1574-1583 10 p.

Research output: Contribution to journalReview article

123 Scopus citations
2011

How do we safely get people to stop smoking?

Lam, D. C. L. & Minna, J. D., Nov 1 2011, In : Cancer Prevention Research. 4, 11, p. 1724-1727 4 p.

Research output: Contribution to journalReview article

1 Scopus citations

Molecular Biology of Lung Cancer: Clinical Implications

Larsen, J. E. & Minna, J. D., Dec 1 2011, In : Clinics in Chest Medicine. 32, 4, p. 703-740 38 p.

Research output: Contribution to journalReview article

122 Scopus citations

Targeted therapies for lung cancer: Clinical experience and novel agents

Larsen, J. E., Cascone, T., Gerber, D. E., Heymach, J. V. & Minna, J. D., Nov 1 2011, In : Cancer Journal. 17, 6, p. 512-527 16 p.

Research output: Contribution to journalReview article

77 Scopus citations
2010

ALK Inhibition for Non-Small Cell Lung Cancer: From Discovery to Therapy in Record Time

Gerber, D. E. & Minna, J. D., Dec 14 2010, In : Cancer Cell. 18, 6, p. 548-551 4 p.

Research output: Contribution to journalReview article

175 Scopus citations

DNA methylation based biomarkers in non-invasive cancer screening

Shivapurkar, N. & Gazdar, A. F., Mar 1 2010, In : Current molecular medicine. 10, 2, p. 123-132 10 p.

Research output: Contribution to journalReview article

86 Scopus citations

Epidermal growth factor receptor inhibition in lung cancer: The evolving role of individualized therapy

Gazdar, A. F., Mar 1 2010, In : Cancer and Metastasis Reviews. 29, 1, p. 37-48 12 p.

Research output: Contribution to journalReview article

72 Scopus citations

Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy

Sullivan, J. P., Minna, J. D. & Shay, J. W., Mar 1 2010, In : Cancer and Metastasis Reviews. 29, 1, p. 61-72 12 p.

Research output: Contribution to journalReview article

127 Scopus citations

Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer

Chari, R., Thu, K. L., Wilson, I. M., Lockwood, W. W., Lonergan, K. M., Coe, B. P., Malloff, C. A., Gazdar, A. F., Lam, S., Garnis, C., MacAulay, C. E., Alvarez, C. E. & Lam, W. L., Mar 1 2010, In : Cancer and Metastasis Reviews. 29, 1, p. 73-93 21 p.

Research output: Contribution to journalReview article

37 Scopus citations

Lung cancer cell lines: Useless artifacts or invaluable tools for medical science?

Gazdar, A. F., Gao, B. & Minna, J. D., Jun 1 2010, In : Lung Cancer. 68, 3, p. 309-318 10 p.

Research output: Contribution to journalReview article

65 Scopus citations

Lung cancer cell lines as tools for biomedical discovery and research

Gazdar, A. F., Girard, L., Lockwood, W. W., Lam, W. L. & Minna, J. D., Sep 8 2010, In : Journal of the National Cancer Institute. 102, 17, p. 1310-1321 12 p.

Research output: Contribution to journalReview article

114 Scopus citations

Natural history of bronchial preinvasive lesions

Ishizumi, T., McWilliams, A., MacAulay, C., Gazdar, A. & Lam, S., Mar 1 2010, In : Cancer and Metastasis Reviews. 29, 1, p. 5-14 10 p.

Research output: Contribution to journalReview article

58 Scopus citations

Radiogenomics predicting tumor responses to radiotherapy in lung cancer

Das, A. K., Bell, M. H., Nirodi, C. S., Story, M. D. & Minna, J. D., Jul 1 2010, In : Seminars in Radiation Oncology. 20, 3, p. 149-155 7 p.

Research output: Contribution to journalReview article

23 Scopus citations

Tobacco and cancer: An American Association for Cancer Research policy statement

Viswanath, K., Herbst, R. S., Land, S. R., Leischow, S. J., Shields, P. G., Brandon, T. H., Fiore, M. C., Gritz, E. R., Hecht, S. S., Lerman, C., Minna, J. D. & Sidransky, D., May 1 2010, In : Cancer research. 70, 9, p. 3419-3430 12 p.

Research output: Contribution to journalReview article

46 Scopus citations
2009

Activating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors

Gazdar, A. F., Aug 2009, In : Oncogene. 28, p. S24-S31

Research output: Contribution to journalReview article

550 Scopus citations

Pathogenesis of lung cancer signalling pathways: Roadmap for therapies

Brambilla, E. & Gazdar, A., Jun 1 2009, In : European Respiratory Journal. 33, 6, p. 1485-1497 13 p.

Research output: Contribution to journalReview article

91 Scopus citations
2008

Deregulated EGFR signaling during lung cancer progression: Mutations, amplicons, and autocrine loops

Gazdar, A. F. & Minna, J. D., Aug 1 2008, In : Cancer Prevention Research. 1, 3, p. 156-160 5 p.

Research output: Contribution to journalReview article

62 Scopus citations

Small-cell lung cancer: Translational research enroute to therapeutic advances

Dowell, J. & Minna, J. D., Nov 30 2008, In : ONCOLOGY. 22, 13, p. 1493+1495

Research output: Contribution to journalReview article

2 Scopus citations
2007

DNA methylation in health, disease, and cancer

Shames, D. S., Minna, J. D. & Gazdar, A. F., Feb 1 2007, In : Current molecular medicine. 7, 1, p. 85-102 18 p.

Research output: Contribution to journalReview article

147 Scopus citations

Genes regulating the sensitivity of solid tumor cell lines to cytotoxic agents: A literature review

Sekine, I., Minna, J. D., Nishio, K., Saijo, N. & Tamura, T., May 1 2007, In : Japanese Journal of Clinical Oncology. 37, 5, p. 329-336 8 p.

Research output: Contribution to journalReview article

13 Scopus citations

Lung cancer in never smokers - A different disease

Sun, S., Schiller, J. H. & Gazdar, A. F., Oct 1 2007, In : Nature Reviews Cancer. 7, 10, p. 778-790 13 p.

Research output: Contribution to journalReview article

887 Scopus citations

New molecularly targeted therapies for lung cancer

Sun, S., Schiller, J. H., Spinola, M. & Minna, J. D., Oct 1 2007, In : Journal of Clinical Investigation. 117, 10, p. 2740-2750 11 p.

Research output: Contribution to journalReview article

166 Scopus citations
2006

A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer

Sekine, I., Minna, J. D., Nishio, K., Tamura, T. & Saijo, N., Jan 1 2006, In : Journal of Thoracic Oncology. 1, 1, p. 31-37 7 p.

Research output: Contribution to journalReview article

18 Scopus citations

EGFR mutations and molecularly targeted therapy: A new era in the treatment of lung cancer

Dowell, J. E. & Minna, J. D., Apr 1 2006, In : Nature Clinical Practice Oncology. 3, 4, p. 170-171 2 p.

Research output: Contribution to journalReview article

13 Scopus citations

Lung cancer preneoplasia

Wistuba, I. I. & Gazdar, A. F., Jan 1 2006, In : Annual Review of Pathology. 1, p. 331-348 18 p.

Research output: Contribution to journalReview article

143 Scopus citations
2005

3p21.3 tumor suppressor cluster: Prospects for translational applications

Ji, L., Minna, J. D. & Roth, J. A., Jan 1 2005, In : Future Oncology. 1, 1, p. 79-92 14 p.

Research output: Contribution to journalReview article

72 Scopus citations

The epidemiology of EGFR mutations

Shigematsu, H. & Gazdar, A., May 1 2005, In : Signal. 6, 1, p. 4-8 5 p.

Research output: Contribution to journalReview article

5 Scopus citations
2004

A bull's eye for targeted lung cancer therapy

Minna, J. D., Gazdar, A. F., Sprang, S. R. & Herz, J., Jun 4 2004, In : Science. 304, 5676, p. 1458-1461 4 p.

Research output: Contribution to journalReview article

63 Scopus citations

Gallbladder cancer: Lessons from a rare tumour

Wistuba, I. I. & Gazdar, A. F., Sep 1 2004, In : Nature Reviews Cancer. 4, 9, p. 695-706 12 p.

Research output: Contribution to journalReview article

264 Scopus citations
11 Scopus citations
2003

A big step in the study of small cell lung cancer

Minna, J. D., Kurie, J. M. & Jacks, T., Sep 1 2003, In : Cancer Cell. 4, 3, p. 163-166 4 p.

Research output: Contribution to journalReview article

42 Scopus citations

Apoptosis and lung cancer: A review

Shivapurkar, N., Reddy, J., Chaudhary, P. M. & Gazdar, A. F., Apr 1 2003, In : Journal of Cellular Biochemistry. 88, 5, p. 885-898 14 p.

Research output: Contribution to journalReview article

162 Scopus citations

Characteristic genetic alterations in lung cancer.

Wistuba, I. I. & Gazdar, A. F., 2003, In : Methods in molecular medicine. 74, p. 3-28 26 p.

Research output: Contribution to journalReview article

13 Scopus citations

Environmental tobacco smoke, carcinogenesis, and angiogenesis: A double whammy?

Gazdar, A. F., Sep 1 2003, In : Cancer Cell. 4, 3, p. 159-160 2 p.

Research output: Contribution to journalReview article

4 Scopus citations

Key issues in lung cancer chemoprevention trials of new agents.

Lam, S., MacAulay, C., LeRiche, J. C. & Gazdar, A. F., 2003, In : Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer. 163, p. 182-195; discussion 264-266

Research output: Contribution to journalReview article

5 Scopus citations

Lung cancer · 9: Molecular biology of lung cancer: Clinical implications

Fong, K. M., Sekido, Y., Gazdar, A. F. & Minna, J. D., Oct 1 2003, In : Thorax. 58, 10, p. 892-900 9 p.

Research output: Contribution to journalReview article

107 Scopus citations

Molecular Genetics of Lung Cancer

Sekido, Y., Fong, K. M. & Minna, J. D., Nov 19 2003, In : Annual review of medicine. 54, p. 73-87 15 p.

Research output: Contribution to journalReview article

255 Scopus citations

The TP53 gene, tobacco exposure, and lung cancer

Toyooka, S., Tsuda, T. & Gazdar, A. F., Mar 18 2003, In : Human mutation. 21, 3, p. 229-239 11 p.

Research output: Contribution to journalReview article

214 Scopus citations