Immunology - Farrar Lab

Research Output 1990 2019

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Article
2018
3 Citations (Scopus)

Adrenergic signaling at the interface of allergic asthma and viral infections

Agaç, D., Gill, M. A. & Farrar, J. D., Apr 11 2018, In : Frontiers in Immunology. 9, APR, 736.

Research output: Contribution to journalArticle

Virus Diseases
Adrenergic Agents
Asthma
Rhinovirus
Norepinephrine
10 Citations (Scopus)

The β2-adrenergic receptor controls inflammation by driving rapid IL-10 secretion

Ağaç, D., Estrada, L. D., Maples, R., Hooper, L. V. & Farrar, J. D., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Interleukin-10
Adrenergic Receptors
Norepinephrine
Inflammation
Lipopolysaccharides
2016
18 Citations (Scopus)

Cutting Edge: Critical role of glycolysis in human plasmacytoid dendritic cell antiviral responses

Bajwa, G., DeBerardinis, R. J., Shao, B., Hall, B., Farrar, J. D. & Gill, M. A., Mar 1 2016, In : Journal of Immunology. 196, 5, p. 2004-2009 6 p.

Research output: Contribution to journalArticle

Glycolysis
Dendritic Cells
Antiviral Agents
Orthomyxoviridae
Viruses
3 Citations (Scopus)

STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells

Gonzales-van Horn, S. R., Estrada, L. D., van Oers, N. S. C. & Farrar, J. D., Jun 1 2016, In : European Journal of Immunology. 46, 6, p. 1504-1510 7 p.

Research output: Contribution to journalArticle

Th2 Cells
Interleukin-5
Interferons
Genes
Cytokines
20 Citations (Scopus)

Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8+ T-cell effector function

Estrada, L. D., Ağaç, D. & Farrar, J. D., Aug 1 2016, In : European Journal of Immunology. 46, 8, p. 1948-1958 11 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Adrenergic Receptors
Norepinephrine
T-Lymphocytes
Interleukin-18
2015
17 Citations (Scopus)

Housing temperature-induced stress is suppressing murine Graft-versus-host disease through β2-adrenergic receptor signaling

Leigh, N. D., Kokolus, K. M., O'Neill, R. E., Du, W., Eng, J. W. L., Qiu, J., Chen, G. L., McCarthy, P. L., Farrar, J. D., Cao, X. & Repasky, E. A., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 5045-5054 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Adrenergic Receptors
Temperature
Norepinephrine
Bone Marrow
18 Citations (Scopus)

Interferon at the crossroads of allergy and viral infections

Gonzales-van Horn, S. R. & David Farrar, J., Aug 1 2015, In : Journal of Leukocyte Biology. 98, 2, p. 185-194 10 p.

Research output: Contribution to journalArticle

Virus Diseases
Interferons
Hypersensitivity
Asthma
GATA3 Transcription Factor
2014
15 Citations (Scopus)

IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells

Huber, J. P., Gonzales-Van Horn, S. R., Roybal, K. T., Gill, M. A. & Farrar, J. D., Jun 15 2014, In : Journal of Immunology. 192, 12, p. 5687-5694 8 p.

Research output: Contribution to journalArticle

Th2 Cells
Exons
Interleukin-4
GATA3 Transcription Factor
Histone Code
8 Citations (Scopus)

Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions

Chowdhury, F. Z., Estrada, L. D., Murray, S., Forman, J. & Farrar, J. D., Mar 18 2014, In : PLoS One. 9, 3, e92187.

Research output: Contribution to journalArticle

cytotoxic T-lymphocytes
T-cells
Cytotoxic T-Lymphocytes
Pharmacology
interleukin-12
2013
12 Citations (Scopus)
Phagocytosis
Immunoglobulin E
Monocytes
Interleukin-10
Serum
75 Citations (Scopus)

SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

Becker, A. M., Dao, K. H., Han, B. K., Kornu, R., Lakhanpal, S., Mobley, A. B., Li, Q. Z., Lian, Y., Wu, T., Reimold, A. M., Olsen, N. J., Karp, D. R., Chowdhury, F. Z., Farrar, J. D., Satterthwaite, A. B., Mohan, C., Lipsky, P. E., Wakeland, E. K. & Davis, L. S., Jun 24 2013, In : PLoS One. 8, 6, e67003.

Research output: Contribution to journalArticle

lupus erythematosus
T-cells
Myeloid Cells
interferons
Transcriptome
2011
27 Citations (Scopus)

IL-12 selectively programs effector pathways that are stably expressed in human CD8 + effector memory T cells in vivo

Chowdhury, F. Z., Ramos, H. J., Davis, L. S., Forman, J. & Farrar, J. D., Oct 6 2011, In : Blood. 118, 14, p. 3890-3900 11 p.

Research output: Contribution to journalArticle

T-cells
Interleukin-12
T-Lymphocytes
Data storage equipment
Genes
118 Citations (Scopus)

Regulation of effector and memory T-cell functions by type I interferon

Huber, J. P. & David Farrar, J., Apr 2011, In : Immunology. 132, 4, p. 466-474 9 p.

Research output: Contribution to journalArticle

Interferon Type I
Interferons
T-Lymphocytes
Cytokines
Antigens
2010
82 Citations (Scopus)

Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3

Huber, J. P., Ramos, H. J., Gill, M. A. & Farrar, J. D., Jul 15 2010, In : Journal of Immunology. 185, 2, p. 813-817 5 p.

Research output: Contribution to journalArticle

Th2 Cells
GATA3 Transcription Factor
Asthma
Cytokines
Helminths
2009
46 Citations (Scopus)

Reciprocal responsiveness to interleukin-12 and interferon-α specifies human CD8+ effector versus central memory T-cell fates

Ramos, H. J., Davis, A. M., Cole, A. G., Schatzle, J. D., Forman, J. & Farrar, J. D., 2009, In : Blood. 113, 22, p. 5516-5525 10 p.

Research output: Contribution to journalArticle

T-cells
Interleukin-12
Interferons
T-Lymphocytes
Data storage equipment
2008
13 Citations (Scopus)

Blockade of virus infection by human CD4 + T cells via a cytokine relay network

Davis, A. M., Hagan, K. A., Matthews, L. A., Bajwa, G., Gill, M. A., Gale, M. & Farrar, J. D., 2008, In : Journal of Immunology. 180, 10, p. 6923-6932 10 p.

Research output: Contribution to journalArticle

Virus Diseases
Th1 Cells
Antiviral Agents
Cytokines
T-Lymphocytes
20 Citations (Scopus)

Cutting edge: A T-bet-independent role for IFN-α/β in regulating IL-2 secretion in human CD4+ central memory T cells

Davis, A. M., Ramos, H. J., Davis, L. S. & David Farrar, J., Dec 15 2008, In : Journal of Immunology. 181, 12, p. 8204-8208 5 p.

Research output: Contribution to journalArticle

Interleukin-2
T-Lymphocytes
Interleukin-12
Th1 Cells
Cytokines
17 Citations (Scopus)

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions

Young, J. A., Becker, A. M., Medeiros, J. J., Shapiro, V. S., Wang, A., Farrar, J. D., Quill, T. A., van Huijsduijnen, R. H. & van Oers, N. S. C., Aug 2008, In : Molecular Immunology. 45, 14, p. 3756-3766 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
T-Lymphocytes
Enzymes
Phosphorylation
Listeria monocytogenes
2007
32 Citations (Scopus)

IFN-α is not sufficient to drive Th1 development due to lack of stable T-bet expression

Ramos, H. J., Davis, A. M., George, T. C. & Farrar, J. D., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3792-3803 12 p.

Research output: Contribution to journalArticle

Interleukin-12
T-Lymphocytes
Human Development
Aptitude
Phosphorylation
21 Citations (Scopus)

Pre-assembly of STAT4 with the human IFN-alpha/beta receptor-2 subunit is mediated by the STAT4 N-domain.

Tyler, D. R., Persky, M. E., Matthews, L. A., Chan, S. & Farrar, J. D., Mar 2007, In : Molecular Immunology. 44, 8, p. 1864-1872 9 p.

Research output: Contribution to journalArticle

Interleukin-12
Cytokines
STAT4 Transcription Factor
Phosphorylation
T-Lymphocytes
2006
28 Citations (Scopus)

Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-α

Berenson, L. S., Gavrieli, M., Farrar, J. D., Murphy, T. L. & Murphy, K. M., Oct 15 2006, In : Journal of Immunology. 177, 8, p. 5195-5203 9 p.

Research output: Contribution to journalArticle

Interleukin-12
T-Lymphocytes
Th1 Cells
Phosphorylation
Interleukin-18
2005
21 Citations (Scopus)

IL-12, but not IFN-α, promotes STAT4 activation and Th1 development in murine CD4+ T cells expressing a chimeric murine/human Stat2 gene

Persky, M. E., Murphy, K. M. & Farrar, J. D., Jan 1 2005, In : Journal of Immunology. 174, 1, p. 294-301 8 p.

Research output: Contribution to journalArticle

Interleukin-12
T-Lymphocytes
Genes
Mutation
Th1 Cells
2004
22 Citations (Scopus)

Frontline: Absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-α

Berenson, L. S., Farrar, J. D., Murphy, T. L. & Murphy, K. M., Sep 2004, In : European Journal of Immunology. 34, 9, p. 2365-2374 10 p.

Research output: Contribution to journalArticle

Interleukin-12
Tyrosine
Phosphorylation
T-Lymphocytes
Interleukin-18
2002
128 Citations (Scopus)

T helper subset development: Roles of instruction, selection, and transcription

David Farrar, J., Asnagli, H. & Murphy, K. M., 2002, In : Journal of Clinical Investigation. 109, 4, p. 431-435 5 p.

Research output: Contribution to journalArticle

GATA3 Transcription Factor
Genetic Transcription
Biological Models
Th2 Cells
Th1 Cells
2001
85 Citations (Scopus)

An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3

David Farrar, J., Ouyang, W., Löhning, M., Assenmacher, M., Radbruch, A., Kanagawa, O. & Murphy, K. M., Mar 5 2001, In : Journal of Experimental Medicine. 193, 5, p. 643-649 7 p.

Research output: Contribution to journalArticle

Th2 Cells
Cytokines
Phenotype
Interleukin-4
Transcription Factor 3
2000
84 Citations (Scopus)

Recruitment of Stat4 to the human interferon-α/β receptor requires activated Stat2

Farrar, J. D., Smith, J. D., Murphy, T. L. & Murphy, K. M., Jan 28 2000, In : Journal of Biological Chemistry. 275, 4, p. 2693-2697 5 p.

Research output: Contribution to journalArticle

Interferon Receptors
T-cells
Chemical activation
Th1 Cells
Interferons
40 Citations (Scopus)

Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation

Murphy, T. L., Geissal, E. D., Farrar, J. D. & Murphy, K. M., 2000, In : Molecular and Cellular Biology. 20, 19, p. 7121-7131 11 p.

Research output: Contribution to journalArticle

Transducers
Phosphorylation
Tyrosine
Interferons
STAT Transcription Factors
138 Citations (Scopus)

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

Farrar, J. D., Smith, J. D., Murphy, T. L., Leung, S., Stark, G. R. & Murphy, K. M., Jul 2000, In : Nature Immunology. 1, 1, p. 65-69 5 p.

Research output: Contribution to journalArticle

Interferon Type I
Minisatellite Repeats
Adaptive Immunity
Innate Immunity
T-Lymphocytes
507 Citations (Scopus)

Signaling and transcription in T helper development

Murphy, K. M., Ouyang, W., Farrar, J. D., Yang, J., Ranganath, S., Asnagli, H., Afkarian, M. & Murphy, T. L., 2000, In : Annual Review of Immunology. 18, p. 451-494 44 p.

Research output: Contribution to journalArticle

Cytokines
T-Lymphocytes
Interleukin-18
T-Lymphocyte Subsets
Interleukin-12
90 Citations (Scopus)

Type I interferons and T helper development

Farrar, J. D. & Murphy, K. M., 2000, In : Immunology Today. 21, 10, p. 484-489 6 p.

Research output: Contribution to journalArticle

Interferon Type I
T-Lymphocytes
Aptitude
Human Development
1999
101 Citations (Scopus)

Cancer dormancy. VII. A regulatory role for CD8+ T cells and IFN-γ in establishing and maintaining the tumor-dormant state

Farrar, J. D., Katz, K. H., Windsor, J., Thrush, G., Scheuermann, R. H., Uhr, J. W. & Street, N. E., Mar 1 1999, In : Journal of Immunology. 162, 5, p. 2842-2849 8 p.

Research output: Contribution to journalArticle

SCID Mice
T-Lymphocytes
Neoplasms
B-Cell Lymphoma
Humoral Immunity
3 Citations (Scopus)

Molecular mechanisms in T helper phenotype development

Farrar, J. D., Ranganath, S. H. & Murphy, K. M., 1999, In : Springer Seminars in Immunopathology. 21, 3, p. 211-230 20 p.

Research output: Contribution to journalArticle

Immunophenotyping
Th2 Cells
Th1 Cells
Cell Communication
Cell Differentiation
1996

Regulation of tumor dormancy by cd4+ and cd8+ t cell subpopulations

David Farrar, J., Katz, K. S., Windsor, J. L., Jonathan, W. & Street, U. N. E., 1996, In : FASEB Journal. 10, 6

Research output: Contribution to journalArticle

T-cells
dormancy
Tumors
T-Lymphocytes
T-lymphocytes
1995
8 Citations (Scopus)
Cytokines
Messenger RNA
DNA
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-10
1993
48 Citations (Scopus)

Defective mannosylation of glycosylphosphatidylinositol in Lec35 Chinese hamster ovary cells

Camp, L. A., Chauhan, P., Farrar, J. D. & Lehrman, M. A., Mar 25 1993, In : Journal of Biological Chemistry. 268, 9, p. 6721-6728 8 p.

Research output: Contribution to journalArticle

Dolichol
Glycosylphosphatidylinositols
Cricetulus
Mannose
Ovary
1992
42 Citations (Scopus)
Decidua
Laminin
Extracellular Matrix
Messenger RNA
Transforming Growth Factors
1990
50 Citations (Scopus)

Selective activation of the N-glycosylation apparatus in uteri by estrogen

Carson, D. D., David Farrar, J., Laidlaw, J. & Wright, D. A., 1990, In : Journal of Biological Chemistry. 265, 5, p. 2947-2955 9 p.

Research output: Contribution to journalArticle

Glycosylation
Uterus
Glycoproteins
Estrogens
Chemical activation