Immunology - Pasare Lab

Research Output

2018

BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation

Deason, K., Troutman, T. D., Jain, A., Challa, D. K., Mandraju, R., Brewer, T., Ward, E. S. & Pasare, C., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2413-2428 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

MyD88 signaling in T cells is critical for effector CD4 T cell differentiation following a transitional T follicular helper cell stage

Mandraju, R., Jain, A., Gao, Y., Ouyang, Z., Norgard, M. V. & Pasare, C., May 1 2018, In : Infection and immunity. 86, 5, e00791-17.

Research output: Contribution to journalArticle

1 Scopus citations

Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity

Szczepanik, M., Majewska-Szczepanik, M., Wong, F. S., Kowalczyk, P., Pasare, C. & Wen, L., Oct 1 2018, In : Contact Dermatitis. 79, 4, p. 197-207 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

Jain, A., Song, R., Wakeland, E. K. & Pasare, C., Dec 1 2018, In : Nature communications. 9, 1, 3185.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Inhibition of IRAK1 ubiquitination determines glucocorticoid sensitivity for tlr9-induced inflammation in macrophages

Kong, F., Liu, Z., Jain, V. G., Shima, K., Suzuki, T., Muglia, L. J., Starczynowski, D. T., Pasare, C. & Bhattacharyya, S., Nov 15 2017, In : Journal of Immunology. 199, 10, p. 3654-3667 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Innate control of adaptive immunity: Beyond the three-signal paradigm

Jain, A. & Pasare, C., May 15 2017, In : Journal of Immunology. 198, 10, p. 3791-3800 10 p.

Research output: Contribution to journalReview article

33 Scopus citations
2016

ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination

Akbar, M. A., Mandraju, R., Tracy, C., Hu, W., Pasare, C. & Krämer, H., 2016, In : Immunity. 45, 2, p. 267-279 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

Sun, J., Li, N., Oh, K. S., Dutta, B., Vayttaden, S. J., Lin, B., Ebert, T. S., De Nardo, D., Davis, J., Bagirzadeh, R., Lounsbury, N. W., Pasare, C., Latz, E., Hornung, V. & Fraser, I. D. C., Jan 5 2016, In : Science Signaling. 9, 409, ra3.

Research output: Contribution to journalArticle

28 Scopus citations

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B. E., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I., Carr-Johnson, F., Mitrovic, M., Wiley, G. B., Kelly, J. A., Lauwerys, B. R., Olsen, N. J., Cotsapas, C., Garcia, C. K., Wise, C. A., Harley, J. B. & 9 others, Nath, S. K., James, J. A., Jacob, C. O., Tsao, B. P., Pasare, C., Karp, D. R., Li, Q. Z., Gaffney, P. M. & Wakeland, E. K., Feb 15 2016, In : eLife. 5, FEBRUARY2016, e12089.

Research output: Contribution to journalArticle

49 Scopus citations
2015

Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation

Hu, W., Jain, A., Gao, Y., Dozmorov, I. M., Mandraju, R., Wakeland, E. K. & Pasare, C., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 13994-13999 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense

Hu, S., Peng, L., Kwak, Y. T., Tekippe, E. M., Pasare, C., Malter, J. S., Hooper, L. V. & Zaki, M. H., Apr 3 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

51 Scopus citations
2014

Differential ability of surface and endosomal TLRs to Induce CD8 T Cell Responses in Vivo

Mandraju, R., Murray, S., Forman, J. & Pasare, C., May 1 2014, In : Journal of Immunology. 192, 9, p. 4303-4315 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors

Furlan, S. N., Mandraju, R., Brewer, T., Roybal, K., Troutman, T. D., Hu, W., Palm, N. W., Unni, A. & Pasare, C., Jan 1 2014, In : mAbs. 6, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Erratum: IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 2, (775-780) DOI: 10.1073/pnas.1320294111)

Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A. & Pasare, C., Feb 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 8, 1 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

IRAK-1 bypasses priming and directly links TLRs torapid NLRP3 inflammasome activation

Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A. & Pasare, C., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 775-780 6 p.

Research output: Contribution to journalArticle

101 Scopus citations
2013

Location, location, location: Tissue-specific regulation of immune responses

Hu, W. & Pasare, C., Sep 1 2013, In : Journal of Leukocyte Biology. 94, 3, p. 409-421 13 p.

Research output: Contribution to journalReview article

31 Scopus citations
2012

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

Troutman, T. D., Hu, W., Fulenchek, S., Yamazaki, T., Kurosaki, T., Bazand, J. F. & Pasare, C., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 273-278 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Toll-like receptors, signalingadapters and regulation of the pro-inflammatory response by PI3K

Troutman, T. D., Bazan, J. F. & Pasare, C., Oct 1 2012, In : Cell Cycle. 11, 19, p. 3559-3567 9 p.

Research output: Contribution to journalReview article

78 Scopus citations
2011

Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment

Hu, W., Troutman, T. D., Edukulla, R. & Pasare, C., Dec 23 2011, In : Immunity. 35, 6, p. 1010-1022 13 p.

Research output: Contribution to journalArticle

68 Scopus citations
2006

Immunology: Toll-like receptors and antibody responses (reply)

Pasare, C. & Medzhitov, R., May 18 2006, In : Nature. 441, 7091, p. E4

Research output: Contribution to journalComment/debate

16 Scopus citations
2005

Control of B-cell responses by Toll-like receptors

Pasare, C. & Medzhitov, R., Nov 17 2005, In : Nature. 438, 7066, p. 364-368 5 p.

Research output: Contribution to journalArticle

562 Scopus citations

Erratum: Toll-dependent control mechanisms of CD4 T cell activation (Immunity (2004) 21 (733-741) DOI: 10.1016/j.immuni.2005.03.001)

Pasare, C. & Medzhitov, R., Mar 2005, In : Immunity. 22, 3, p. 397-398 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Toll-like receptors: Linking innate and adaptive immunity

Pasare, C. & Medzhitov, R., Jan 1 2005, In : Advances in experimental medicine and biology. 560, p. 11-18 8 p.

Research output: Contribution to journalArticle

390 Scopus citations
2004

Toll-dependent control mechanisms of CD4 T cell activation

Pasare, C. & Medzhitov, R., Nov 1 2004, In : Immunity. 21, 5, p. 733-741 9 p.

Research output: Contribution to journalArticle

303 Scopus citations

Toll-like receptors: Linking innate and adaptive immunity

Pasare, C. & Medzhitov, R., Jan 1 2004, In : Microbes and Infection. 6, 15, p. 1382-1387 6 p.

Research output: Contribution to journalShort survey

331 Scopus citations

Toll-like receptors and acquired immunity

Pasare, C. & Medzhitov, R., Feb 2004, In : Seminars in Immunology. 16, 1, p. 23-26 4 p.

Research output: Contribution to journalArticle

162 Scopus citations
2003

Toll-like receptors: Balancing host resistance with immune tolerance

Pasare, C. & Medzhitov, R., Dec 2003, In : Current Opinion in Immunology. 15, 6, p. 677-682 6 p.

Research output: Contribution to journalReview article

109 Scopus citations

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

Pasare, C. & Medzhitov, R., Feb 14 2003, In : Science. 299, 5609, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

1728 Scopus citations
2001

T cells in mice expressing a transgenic human TCRβ chain get positively selected but cannot be activated in the periphery by signaling through TCR

Pasare, C., Mukherjee, P., Verhoef, A., Bansal, P., Mendiratta, S. K., George, A., Lamb, J. R., Rath, S. & Bal, V., Jan 1 2001, In : International Immunology. 13, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1999

Expression of an immunoglobulin heavy chain transgene in macrophage as well as lymphocyte lineages in vivo

Pasare, C., Noggle, S., Entringer, M., Heinzelmann, A., Bansal, P., George, A., Bal, V., Rath, S. & Durdik, J. M., Jan 1 1999, In : European Journal of Immunology. 29, 4, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
1998

Presence of activated antigen-binding B cells during immunization enhances relative levels of IFN-γ in T cell responses

Pasare, C., Morafo, V., Entringer, M., Bansal, P., George, A., Bal, V., Rath, S. & Durdik, J. M., Jan 15 1998, In : Journal of Immunology. 160, 2, p. 778-787 10 p.

Research output: Contribution to journalArticle

9 Scopus citations