Immunology - Pasare Lab

Research Output 1998 2018

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2018
8 Citations (Scopus)

BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation

Deason, K., Troutman, T. D., Jain, A., Challa, D. K., Mandraju, R., Brewer, T., Ward, E. S. & Pasare, C., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2413-2428 16 p.

Research output: Contribution to journalArticle

Th17 Cells
1-Phosphatidylinositol 4-Kinase
Interleukins
Sirolimus
Phosphatidylinositol 3-Kinases
1 Citation (Scopus)
Differentiation Antigens
Helper-Inducer T-Lymphocytes
Cell Differentiation
T-Lymphocytes
Cues
1 Citation (Scopus)

Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity

Szczepanik, M., Majewska-Szczepanik, M., Wong, F. S., Kowalczyk, P., Pasare, C. & Wen, L., Oct 1 2018, In : Contact Dermatitis. 79, 4, p. 197-207 11 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Contact Dermatitis
Innate Immunity
Dendritic Cells
Skin
5 Citations (Scopus)

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

Jain, A., Song, R., Wakeland, E. K. & Pasare, C., Dec 1 2018, In : Nature Communications. 9, 1, 3185.

Research output: Contribution to journalArticle

effectors
T-cells
Licensure
licensing
Cytokines
2017
5 Citations (Scopus)

Inhibition of IRAK1 ubiquitination determines glucocorticoid sensitivity for tlr9-induced inflammation in macrophages

Kong, F., Liu, Z., Jain, V. G., Shima, K., Suzuki, T., Muglia, L. J., Starczynowski, D. T., Pasare, C. & Bhattacharyya, S., Nov 15 2017, In : Journal of Immunology. 199, 10, p. 3654-3667 14 p.

Research output: Contribution to journalArticle

Ubiquitination
Glucocorticoids
Phosphotransferases
Macrophages
Inflammation
2016
11 Citations (Scopus)

ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination

Akbar, M. A., Mandraju, R., Tracy, C., Hu, W., Pasare, C. & Krämer, H., 2016, In : Immunity. 45, 2, p. 267-279 13 p.

Research output: Contribution to journalArticle

Endosomes
Pattern Recognition Receptors
Toll-Like Receptors
Proteins
Phagosomes
26 Citations (Scopus)

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

Sun, J., Li, N., Oh, K. S., Dutta, B., Vayttaden, S. J., Lin, B., Ebert, T. S., De Nardo, D., Davis, J., Bagirzadeh, R., Lounsbury, N. W., Pasare, C., Latz, E., Hornung, V. & Fraser, I. D. C., Jan 5 2016, In : Science Signaling. 9, 409, ra3.

Research output: Contribution to journalArticle

Toll-Like Receptors
RNA Interference
Screening
RNA
Macrophages
42 Citations (Scopus)

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B. E., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I., Carr-Johnson, F., Mitrovic, M., Wiley, G. B., Kelly, J. A., Lauwerys, B. R., Olsen, N. J., Cotsapas, C., Garcia, C. K., Wise, C. A., Harley, J. B. & 9 others, Nath, S. K., James, J. A., Jacob, C. O., Tsao, B. P., Pasare, C., Karp, D. R., Li, Q. Z., Gaffney, P. M. & Wakeland, E. K., Feb 15 2016, In : eLife. 5, FEBRUARY2016, e12089.

Research output: Contribution to journalArticle

Polymorphism
Autoimmunity
Systemic Lupus Erythematosus
Molecules
D region
2015
26 Citations (Scopus)

Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation

Hu, W., Jain, A., Gao, Y., Dozmorov, I. M., Mandraju, R., Wakeland, E. K. & Pasare, C., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 13994-13999 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Interferon Regulatory Factor-3
Myeloid Differentiation Factor 88
Toll-Like Receptor 3
Interleukin-1 Receptors
47 Citations (Scopus)
Inflammasomes
Interleukin-18
Homeostasis
Escherichia coli
DNA
2014
21 Citations (Scopus)

Differential ability of surface and endosomal TLRs to Induce CD8 T Cell Responses in Vivo

Mandraju, R., Murray, S., Forman, J. & Pasare, C., May 1 2014, In : Journal of Immunology. 192, 9, p. 4303-4315 13 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Dendritic Cells
Bacterial Infections
Virus Diseases
Allergy and Immunology
2 Citations (Scopus)

Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors

Furlan, S. N., Mandraju, R., Brewer, T., Roybal, K., Troutman, T. D., Hu, W., Palm, N. W., Unni, A. & Pasare, C., Jan 2014, In : mAbs. 6, 1, p. 108-118 11 p.

Research output: Contribution to journalArticle

Fc Receptors
Immunity
Immunoglobulin G
Dendritic Cells
Neoplasms
91 Citations (Scopus)

IRAK-1 bypasses priming and directly links TLRs torapid NLRP3 inflammasome activation

Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A. & Pasare, C., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 775-780 6 p.

Research output: Contribution to journalArticle

Inflammasomes
Toll-Like Receptors
Caspase 1
Interleukin-10
Toll-Like Receptor 1
4 Citations (Scopus)
2013
27 Citations (Scopus)

Location, location, location: Tissue-specific regulation of immune responses

Hu, W. & Pasare, C., Sep 1 2013, In : Journal of Leukocyte Biology. 94, 3, p. 409-421 13 p.

Research output: Contribution to journalArticle

Adaptive Immunity
Thromboplastin
Stromal Cells
Immune System
T Lymphocyte Differentiation Antigens
2012
75 Citations (Scopus)

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

Troutman, T. D., Hu, W., Fulenchek, S., Yamazaki, T., Kurosaki, T., Bazand, J. F. & Pasare, C., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 273-278 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Protein-Serine-Threonine Kinases
Phosphatidylinositol 3-Kinases
B-Lymphocytes
Interleukin-1 Receptors
61 Citations (Scopus)

Toll-like receptors, signalingadapters and regulation of the pro-inflammatory response by PI3K

Troutman, T. D., Bazan, J. F. & Pasare, C., Oct 1 2012, In : Cell Cycle. 11, 19, p. 3559-3567 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Phosphatidylinositol 3-Kinases
Pattern Recognition Receptors
Molecular Structure
Cell Survival
2011
67 Citations (Scopus)

Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment

Hu, W., Troutman, T. D., Edukulla, R. & Pasare, C., Dec 23 2011, In : Immunity. 35, 6, p. 1010-1022 13 p.

Research output: Contribution to journalArticle

Th17 Cells
Cell Lineage
Cytokines
Interleukin-6
Dendritic Cells
2006
16 Citations (Scopus)

Immunology: Toll-like receptors and antibody responses (reply)

Pasare, C. & Medzhitov, R., May 18 2006, In : Nature. 441, 7091

Research output: Contribution to journalArticle

2005
555 Citations (Scopus)

Control of B-cell responses by Toll-like receptors

Pasare, C. & Medzhitov, R., Nov 17 2005, In : Nature. 438, 7066, p. 364-368 5 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
B-Lymphocytes
Helper-Inducer T-Lymphocytes
Antibody Formation
Viral Tumor Antigens
2 Citations (Scopus)

Erratum: Toll-dependent control mechanisms of CD4 T cell activation (Immunity (2004) 21 (733-741) DOI: 10.1016/j.immuni.2005.03.001)

Pasare, C. & Medzhitov, R., Mar 2005, In : Immunity. 22, 3, p. 397-398 2 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
386 Citations (Scopus)

Toll-like receptors: Linking innate and adaptive immunity

Pasare, C. & Medzhitov, R., 2005, In : Advances in Experimental Medicine and Biology. 560, p. 11-18 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Adaptive Immunity
Innate Immunity
Pathogens
Chemical activation
2004
300 Citations (Scopus)

Toll-dependent control mechanisms of CD4 T cell activation

Pasare, C. & Medzhitov, R., Nov 2004, In : Immunity. 21, 5, p. 733-741 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
T-Lymphocytes
Adaptive Immunity
Regulatory T-Lymphocytes
Dendritic Cells
322 Citations (Scopus)

Toll-like receptors: Linking innate and adaptive immunity

Pasare, C. & Medzhitov, R., 2004, In : Microbes and Infection. 6, 15, p. 1382-1387 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Adaptive Immunity
Innate Immunity
Pattern Recognition Receptors
DNA Viruses
160 Citations (Scopus)

Toll-like receptors and acquired immunity

Pasare, C. & Medzhitov, R., Feb 2004, In : Seminars in Immunology. 16, 1, p. 23-26 4 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Adaptive Immunity
Pattern Recognition Receptors
Gram-Positive Bacteria
Gram-Negative Bacteria
2003
108 Citations (Scopus)

Toll-like receptors: Balancing host resistance with immune tolerance

Pasare, C. & Medzhitov, R., Dec 2003, In : Current Opinion in Immunology. 15, 6, p. 677-682 6 p.

Research output: Contribution to journalArticle

Immune Tolerance
Toll-Like Receptors
Rheumatoid Factor
Adaptive Immunity
Antigen-Presenting Cells
1717 Citations (Scopus)

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

Pasare, C. & Medzhitov, R., Feb 14 2003, In : Science. 299, 5609, p. 1033-1036 4 p.

Research output: Contribution to journalArticle

Adaptive Immunity
Dendritic Cells
T-Lymphocytes
Toll-Like Receptors
Histocompatibility Antigens Class II
2001
2 Citations (Scopus)

T cells in mice expressing a transgenic human TCRβ chain get positively selected but cannot be activated in the periphery by signaling through TCR

Pasare, C., Mukherjee, P., Verhoef, A., Bansal, P., Mendiratta, S. K., George, A., Lamb, J. R., Rath, S. & Bal, V., 2001, In : International Immunology. 13, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Transgenes
Interleukin-2
T-Cell Antigen Receptor-CD3 Complex
Calcium Signaling
1999
2 Citations (Scopus)

Expression of an immunoglobulin heavy chain transgene in macrophage as well as lymphocyte lineages in vivo

Pasare, C., Noggle, S., Entringer, M., Heinzelmann, A., Bansal, P., George, A., Bal, V., Rath, S. & Durdik, J. M., 1999, In : European Journal of Immunology. 29, 4, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Heavy Chains
Transgenes
Macrophages
Lymphocytes
Proteins
1998
9 Citations (Scopus)

Presence of activated antigen-binding B cells during immunization enhances relative levels of IFN-γ in T cell responses

Pasare, C., Morafo, V., Entringer, M., Bansal, P., George, A., Bal, V., Rath, S. & Durdik, J. M., Jan 15 1998, In : Journal of Immunology. 160, 2, p. 778-787 10 p.

Research output: Contribution to journalArticle

Immunization
B-Lymphocytes
T-Lymphocytes
Antigens
Transgenic Mice