Immunology - Van Oers Lab - Administration

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2019

FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans

Du, Q., Huynh, L. K., Coskun, F., Molina, E., King, M. A., Raj, P., Khan, S., Dozmorov, I., Seroogy, C. M., Wysocki, C. A., Padron, G. T., Yates, T. R., Louise Markert, M., Teresa de la Morena, M. & van Oers, N. S. C., Nov 1 2019, In : Journal of Clinical Investigation. 129, 11, p. 4724-4738 15 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary

Du, Q., Hoover, A. R., Dozmorov, I., Raj, P., Khan, S., Molina, E., Chang, T. C., de la Morena, M. T., Cleaver, O. B., Mendell, J. T. & van Oers, N. S. C., May 20 2019, In : Developmental cell. 49, 4, p. 618-631.e5

Research output: Contribution to journalArticle

6 Scopus citations
2017

Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations

Maryoung, L., Yue, Y., Young, A., Newton, C. A., Barba, C., Van Oers, N. S. C., Wang, R. C. & Garcia, C. K., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 982-986 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

MicroRNA-205 maintains T cell development following stress by regulating forkhead box N1 and selected chemokines

Hoover, A. R., Dozmorov, I., MacLeod, J., Du, Q., De La Teresa Morena, M., Forbess, J., Guleserian, K., Cleaver, O. B. & Van Oers, N. S. C., Oct 28 2016, In : Journal of Biological Chemistry. 291, 44, p. 23237-23247 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

RNA sequencing reveals the consequences of a novel insertion in dedicator of cytokinesis-8

Khan, S., Kuruvilla, M., Hagin, D., Wakeland, B., Liang, C., Vishwanathan, K., Gatti, R. A., Torgersen, T. R., Abraham, R. S., Wakeland, E. K., van Oers, N. S. C. & de la Morena, M. T., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 289-292.e6

Research output: Contribution to journalArticle

4 Scopus citations

STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells

Gonzales-van Horn, S. R., Estrada, L. D., van Oers, N. S. C. & Farrar, J. D., Jun 1 2016, In : European Journal of Immunology. 46, 6, p. 1504-1510 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

Iwashima, M., Irving, B. A., Van Oers, N. S. C., Chan, A. C. & Weiss, A., Nov 1 2014, In : Journal of Immunology. 193, 9, p. 4279-4282 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

The haemophilus ducreyi lspa1 protein inhibits phagocytosis by using a new mechanism involving Activation of C-terminal src kinase

Dodd, D. A., Worth, R. G., Rosen, M. K., Grinstein, S., van Oers, N. S. C. & Hansen, E. J., May 20 2014, In : mBio. 5, 3, e01178-14.

Research output: Contribution to journalArticle

7 Scopus citations

Transgenic expression of microRNA-181d augments the stress-sensitivity of CD4+CD8+ thymocytes

Belkaya, S. & Van Oers, N. S. C., Jan 9 2014, In : PloS one. 9, 1

Research output: Contribution to journalArticle

17 Scopus citations
2013

Signature MicroRNA expression patterns identified in humans with 22q11.2 deletion/DiGeorge syndrome

De la Morena, M. T., Eitson, J. L., Dozmorov, I. M., Belkaya, S., Hoover, A. R., Anguiano, E., Pascual, M. V. & van Oers, N. S. C., Apr 1 2013, In : Clinical Immunology. 147, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1

Belkaya, S., Murray, S. E., Eitson, J. L., De La Morena, M. T., Forman, J. A. & Van Oers, N. S. C., Oct 18 2013, In : Journal of Biological Chemistry. 288, 42, p. 30752-30762 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages

Eitson, J. L., Medeiros, J. J., Hoover, A. R., Srivastava, S., Roybal, K. T., Aínsa, J. A., Hansen, E. J., Gumbo, T. & Van Oersa, N. S. C., Oct 2012, In : Applied and environmental microbiology. 78, 19, p. 6829-6837 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

The antibiotic resistance arrow of time: Efflux pump induction is a general first step in the evolution of mycobacterial drug resistance

Schmalstieg, A. M., Srivastava, S., Belkaya, S., Deshpande, D., Meek, C., Leff, R., Van Oers, N. S. C. & Gumbo, T., Sep 1 2012, In : Antimicrobial agents and chemotherapy. 56, 9, p. 4806-4815 10 p.

Research output: Contribution to journalArticle

108 Scopus citations
2011

Basal and antigen-induced exposure of the proline-rich sequence in CD3ε

De La Cruz, J., Kruger, T., Parks, C. A., Silge, R. L., Van Oers, N. S. C., Luescher, I. F., Schrum, A. G. & Gil, D., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 2282-2290 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Dynamic modulation of thymic microRNAs in response to stress

Belkaya, S., Silge, R. L., Hoover, A. R., Medeiros, J. J., Eitson, J. L., Becker, A. M., de la Morena, M. T., Bassel-Duby, R. S. & van Oers, N. S. C., Nov 16 2011, In : PloS one. 6, 11, e27580.

Research output: Contribution to journalArticle

33 Scopus citations

The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse

DeFord-Watts, L. M., Dougall, D. S., Belkaya, S., Johnson, B. A., Eitson, J. L., Roybal, K. T., Barylko, B., Albanesi, J. P., Wülfing, C. & Van Oers, N. S. C., Jun 15 2011, In : Journal of Immunology. 186, 12, p. 6839-6847 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010
5 Scopus citations

Invariant NKT cell development requires a full complement of functional CD3 ζ immunoreceptor tyrosine-based activation motifs

Becker, A. M., Blevins, J. S., Tomson, F. L., Eitson, J. L., Medeiros, J. J., Yarovinsky, F., Norgard, M. V. & Van Oers, N. S. C., Jun 15 2010, In : Journal of Immunology. 184, 12, p. 6822-6832 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2009

Spatiotemporal patterning during T cell activation is highly diverse

Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., Van Oers, N. S. C. & Wülfing, C., Apr 7 2009, In : Science Signaling. 2, 65, p. ra15

Research output: Contribution to journalArticle

63 Scopus citations

The cytoplasmic tail of the T cell receptor CD3 ε subunit contains a phospholipid-binding motif that regulates T cell functions

DeFord-Watts, L. M., Tassin, T. C., Becker, A. M., Medeiros, J. J., Albanesi, J. P., Love, P. E., Wülfing, C. & Van Oers, N. S. C., Jul 15 2009, In : Journal of Immunology. 183, 2, p. 1055-1064 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
2008

Haemophilus ducreyi LspA proteins are tyrosine phosphorylated by macrophage-encoded protein tyrosine kinases

Deng, K., Mock, J. R., Greenberg, S., Van Oers, N. S. C. & Hansen, E. J., Oct 1 2008, In : Infection and immunity. 76, 10, p. 4692-4702 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity

Holst, J., Wang, H., Eder, K. D., Workman, C. J., Boyd, K. L., Baquet, Z., Singh, H., Forbes, K., Chruscinski, A., Smeyne, R., van Oers, N. S. C., Utz, P. J. & Vignali, D. A. A., Jun 1 2008, In : Nature Immunology. 9, 6, p. 658-666 9 p.

Research output: Contribution to journalArticle

101 Scopus citations

The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions

Young, J. A., Becker, A. M., Medeiros, J. J., Shapiro, V. S., Wang, A., Farrar, J. D., Quill, T. A., van Huijsduijnen, R. H. & van Oers, N. S. C., Aug 1 2008, In : Molecular Immunology. 45, 14, p. 3756-3766 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

The constitutive tyrosine phosphorylation of CD3ζ results from TCR-MHC interactions that are independent of thymic selection

Becker, A. M., DeFord-Watts, L. M., Wuelfing, C. & Van Oers, N. S. C., Apr 1 2007, In : Journal of Immunology. 178, 7, p. 4120-4128 9 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

The membrane-proximal portion of CD3 ε associates with the serine/threonine kinase GRK2

DeFord-Watts, L. M., Young, J. A., Pitcher, L. A. & Van Oers, N. S. C., Jun 1 2007, In : Journal of Biological Chemistry. 282, 22, p. 16126-16134 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2005

Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling

Mock, J. R., Vakevainen, M., Deng, K., Latimer, J. L., Young, J. A., Van Oers, N. S. C., Greenberg, S. & Hansen, E. J., Dec 1 2005, In : Infection and immunity. 73, 12, p. 7808-7816 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Selective expression of the 21-kilodalton tyrosine-phosphorylated form of TCR ζ promotes the emergence of T cells with autoreactive potential

Pitcher, L. A., Mathis, M. A., Subramanian, S., Young, J. A., Wakeland, E. K., Love, P. E. & Van Oers, N. S. C., May 15 2005, In : Journal of Immunology. 174, 10, p. 6071-6079 9 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
70 Scopus citations

The CD3 γε/δε signalling module provides normal T cell functions in the absence of the TCR ζ immunoreceptor tyrosine-based activation motifs

Pitcher, L. A., Mathis, M. A., Young, J. A., DeFord, L. M., Purtic, B., Wulfing, C. & van Oers, N. S. C., Dec 1 2005, In : European Journal of Immunology. 35, 12, p. 3643-3654 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2004

PTPH1 Is a Predominant Protein-tyrosine Phosphatase Capable of Interacting with and Dephosphorylating the T Cell Receptor ζ Subunit

Sozio, M. S., Mathis, M. A., Young, J. A., Wälchli, S., Pitcher, L. A., Wrage, P. C., Bartók, B., Campbell, A., Watts, J. D., Aebersold, R., Van Huijsduijnen, R. H. & Van Oers, N. S. C., Feb 27 2004, In : Journal of Biological Chemistry. 279, 9, p. 7760-7769 10 p.

Research output: Contribution to journalArticle

47 Scopus citations
2003

T cell antagonism is functionally uncoupled from the 21- and 23-kDa tyrosine-phosphorylated TCR ζ subunits

Pitcher, L. A., Ohashi, P. S. & Van Oers, N. S. C., Jul 15 2003, In : Journal of Immunology. 171, 2, p. 845-852 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2002

I-κB kinases α and β have distinct roles in regulating murine T cell function

Ren, H., Schmalstieg, A., Van Oers, N. S. C. & Gaynor, R. B., Apr 15 2002, In : Journal of Immunology. 168, 8, p. 3721-3731 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Positive selection by the pre-TCR yields mature CD8+ T cells

Ito, Y., Arai, S., Van Oers, N. S. C., Aifantis, I., Von Boehmer, H. & Miyazaki, T., Nov 1 2002, In : Journal of Immunology. 169, 9, p. 4913-4919 7 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2000

Tetracycline-controllable selection of CD4+ T cells: Half-life and survival signals in the absence of major histocompatibility complex class II molecules

Witherden, D., Van Oers, N., Waltzinger, C., Weiss, A., Benoist, C. & Mathis, D., Jan 17 2000, In : Journal of Experimental Medicine. 191, 2, p. 355-364 10 p.

Research output: Contribution to journalArticle

132 Scopus citations

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

Van Oers, N. S. C., Tohlen, B., Malissen, B., Moomaw, C. R., Afendis, S. & Slaughter, C. A., Oct 2000, In : Nature immunology. 1, 4, p. 322-328 7 p.

Research output: Contribution to journalArticle

74 Scopus citations
1999

Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression

Chu, D. H., Van Oers, N. S. C., Malissen, M., Harris, J., Elder, M. & Weiss, A., Sep 1 1999, In : Journal of Immunology. 163, 5, p. 2610-2620 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

T cell receptor-mediated signs and signals governing T cell development

Van Oers, N. S. C., Aug 1999, In : Seminars in Immunology. 11, 4, p. 227-237 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
1998

Differential requirements for ZAP-70 in TCR signaling and T cell development

Kadlecek, T. A., Van Oers, N. S. C., Lefrancois, L., Olson, S., Finlay, D., Chu, D. H., Connolly, K., Killeen, N. & Weiss, A., Nov 1 1998, In : Journal of Immunology. 161, 9, p. 4688-4694 7 p.

Research output: Contribution to journalArticle

92 Scopus citations

Regulation of TCR signal transduction in murine thymocytes by multiple TCR ζ-chain signaling motifs

Van Oers, N. S. C., Love, P. E., Shores, E. W. & Weiss, A., Jan 1 1998, In : Journal of Immunology. 160, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
1997

Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development

Page, S. T., Van Oers, N. S. C., Perlmutter, R. M., Weiss, A. & Pullen, A. M., Mar 3 1997, In : European Journal of Immunology. 27, 2, p. 554-562 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

Qian, D., Lev, S., Van Oers, N. S. C., Dikic, I., Schlessinger, J. & Weiss, A., Apr 7 1997, In : Journal of Experimental Medicine. 185, 7, p. 1253-1259 7 p.

Research output: Contribution to journalArticle

142 Scopus citations
1996

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

Van Oers, N. S. C., Killeen, N. & Weiss, A., Mar 1 1996, In : Journal of Experimental Medicine. 183, 3, p. 1053-1062 10 p.

Research output: Contribution to journalArticle

266 Scopus citations

αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

Van Oers, N. S. C., Lowin-Kropf, B., Finlay, D., Connolly, K. & Weiss, A., Nov 1996, In : Immunity. 5, 5, p. 429-436 8 p.

Research output: Contribution to journalArticle

238 Scopus citations
1995

Molecular and Genetic Insights into T‐Cell Antigen Receptor Signaling

Weiss, A., Kadlecek, T., Iwashima, M., Chan, A. & Van Oers, N., Sep 1995, In : Annals of the New York Academy of Sciences. 766, 1, p. 149-156 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Syk mutation in Jurkat E6-derived clones results in lack of p72(syk) expression

Fargnoli, J., Burkhardt, A. L., Laverty, M., Kut, S. A., Van Oers, N. S. C., Weiss, A. & Bolen, J. B., Jan 1 1995, In : Journal of Biological Chemistry. 270, 44, p. 26533-26537 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-ζ subunit

Van Oers, N. S. C., Von Boehmer, H. & Weiss, A., Nov 1 1995, In : Journal of Experimental Medicine. 182, 5, p. 1585-1590 6 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations

The syk/zap-70 protein tyrosine kinase connection to antigen receptor signalling processes

Van Oers, N. S. C. & Weiss, A., Jan 1 1995, In : Seminars in Immunology. 7, 4, p. 227-236 10 p.

Research output: Contribution to journalArticle

69 Scopus citations
1994

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling

Chan, A. C., Van Oers A, N. S. C., Tran, A., Turka, L., Law, C. L., Ryan, J. C., Clark, E. A. & Weiss, A., May 15 1994, In : Journal of Immunology. 152, 10, p. 4758-4766 9 p.

Research output: Contribution to journalArticle

224 Scopus citations

Production and characterization of monoclonal antibodies specific for the murine T cell receptor ζ chain

van Oers, N. S. C., Teh, S. J., Irving, B. A., Tiong, J., Weiss, A. & Teh, H. S., Apr 15 1994, In : Journal of Immunological Methods. 170, 2, p. 261-268 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

Iwashima, M., Irving, B. A., Van Oers, N. S. C., Chan, A. C. & Weiss, A., Jan 1 1994, In : Science. 263, 5150, p. 1136-1139 4 p.

Research output: Contribution to journalArticle

615 Scopus citations