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2014

Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice

Heiden, S., Vignon-Zellweger, N., Masuda, S., Yagi, K., Nakayama, K., Yanagisawa, M. & Emoto, N., Feb 11 2014, In : PloS one. 9, 2, e88730.

Research output: Contribution to journalArticle

15 Scopus citations
2013

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

Shibata, N., Carlin, A. F., Spann, N. J., Saijo, K., Morello, C. S., McDonald, J. G., Romanoski, C. E., Maurya, M. R., Kaikkonen, M. U., Lam, M. T., Crotti, A., Reichart, D., Fox, J. N., Quehenberger, O., Raetz, C. R. H., Cameron Sullards, M., Murphy, R. C., Merrill, A. H., Alex Brown, H., Dennis, E. A. & 6 others, Fahy, E., Subramaniam, S., Cavener, D. R., Spector, D. H., Russell, D. W. & Glassa, C. K., Dec 13 2013, In : Journal of Biological Chemistry. 288, 50, p. 35812-35823 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Absence of cardiotrophin 1 is associated with decreased age-dependent arterial stiffness and increased longevity in mice

López-Andrés, N., Calvier, L., Labat, C., Fay, R., Díez, J., Benetos, A., Zannad, F., Lacolley, P. & Rossignol, P., Jan 2013, In : Hypertension. 61, 1, p. 120-129 10 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages

Maurya, M. R., Gupta, S., Li, X., Fahy, E., Dinasarapu, A. R., Sud, M., Brown, H. A., Glass, C. K., Murphy, R. C., Russell, D. W., Dennis, E. A. & Subramaniam, S., Sep 2013, In : Journal of lipid research. 54, 9, p. 2525-2542 18 p.

Research output: Contribution to journalArticle

24 Scopus citations
52 Scopus citations

An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis

Jeon, T. I., Esquejo, R. M., Roqueta-Rivera, M., Phelan, P. E., Moon, Y. A., Govindarajan, S. S., Esau, C. C. & Osborne, T. F., Jul 2 2013, In : Cell Metabolism. 18, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice

Choi, H. Y., Liu, Y., Tennert, C., Sugiura, Y., Karakatsani, A., Kröger, S., Johnson, E. B., Hammer, R. E., Lin, W. & Herz, J., Aug 20 2013, In : eLife. 2013, 2, e00220.

Research output: Contribution to journalArticle

32 Scopus citations

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

Buchovecky, C. M., Turley, S. D., Brown, H. M., Kyle, S. M., McDonald, J. G., Liu, B., Pieper, A. A., Huang, W., Katz, D. M., Russell, D. W., Shendure, J. & Justice, M. J., Sep 1 2013, In : Nature genetics. 45, 9, p. 1013-1020 8 p.

Research output: Contribution to journalArticle

106 Scopus citations
33 Scopus citations

Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: Role of autophagy

Ceylan-Isik, A. F., Dong, M., Zhang, Y., Dong, F., Turdi, S., Nair, S., Yanagisawa, M. & Ren, J., Jan 1 2013, In : Basic Research in Cardiology. 108, 2, 335.

Research output: Contribution to journalArticle

44 Scopus citations

Characterization of a far upstream located promoter expressing the acetyl-CoA carboxylase-alpha in the brain of cattle

Shi, X., Metges, C. C. & Seyfert, H. M., Feb 25 2013, In : Gene. 515, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Christian Raetz: scientist and friend extraordinaire.

Dowhan, W., Nikaido, H., Stubbe, J., Kozarich, J. W., Wickner, W. T., Russell, D. W., Garrett, T. A., Brozek, K. & Modrich, P., 2013, In : Unknown Journal. 82, p. 1-24 24 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: Implications for orexinergic signaling in arousal and narcolepsy

Kohlmeier, K. A., Tyler, C. J., Kalogiannis, M., Ishibashi, M., Kristensen, M. P., Gumenchuk, I., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., 2013, In : Frontiers in Neuroscience. 7 DEC, 246.

Research output: Contribution to journalArticle

36 Scopus citations

Dysregulation of Protease and Protease Inhibitors in a Mouse Model of Human Pelvic Organ Prolapse

Budatha, M., Silva, S., Montoya, T. I., Suzuki, A., Shah-Simpson, S., Wieslander, C. K., Yanagisawa, M., Word, R. A. & Yanagisawa, H., Feb 20 2013, In : PloS one. 8, 2, e56376.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis

Hyter, S., Coleman, D. J., Ganguli-Indra, G., Merrill, G. F., Ma, S., Yanagisawa, M. & Indra, A. K., Mar 1 2013, In : Pigment Cell and Melanoma Research. 26, 2, p. 247-258 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice

Chang, I., Bramall, A. N., Baynash, A. G., Rattner, A., Rakheja, D., Post, M., Joza, S., McKerlie, C., Stewart, D. J., McInnes, R. R. & Yanagisawa, M., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2643-2653 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Endothelin-2-Mediated Protection of Mutant Photoreceptors in Inherited Photoreceptor Degeneration

Bramall, A. N., Szego, M. J., Pacione, L. R., Chang, I., Diez, E., D'Orleans-Juste, P., Stewart, D. J., Hauswirth, W. W., Yanagisawa, M. & McInnes, R. R., Feb 28 2013, In : PloS one. 8, 2, e58023.

Research output: Contribution to journalArticle

18 Scopus citations

Epigenetic silencing of antiviral genes renders clones of Huh-7 cells permissive for hepatitis C virus replication

Chen, Q., Denard, B., Huang, H. & Ye, J., Jan 1 2013, In : Journal of virology. 87, 1, p. 659-665 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency

Setchell, K. D. R., Heubi, J. E., Shah, S., Lavine, J. E., Suskind, D., Al-Edreesi, M., Potter, C., Russell, D. W., O'Connell, N. C., Wolfe, B., Jha, P., Zhang, W., Bove, K. E., Knisely, A. S., Hofmann, A. F., Rosenthal, P. & Bull, L. N., May 2013, In : Gastroenterology. 144, 5, p. 945-955.e6

Research output: Contribution to journalArticle

47 Scopus citations

Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase

Fernandes, N. V., Yeganehjoo, H., Katuru, R., DeBose-Boyd, R. A., Morris, L. L., Michon, R., Yu, Z. L. & Mo, H., Nov 1 2013, In : Experimental Biology and Medicine. 238, 11, p. 1265-1274 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human apolipoprotein e isoforms differentially affect bone mass and turnover in vivo

Dieckmann, M., Timo Beil, F., Mueller, B., Bartelt, A., Marshall, R. P., Koehne, T., Amling, M., Ruether, W., Cooper, J. A., Humphries, S. E., Herz, J. & Niemeier, A., Feb 1 2013, In : Journal of Bone and Mineral Research. 28, 2, p. 236-245 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

Faulkner, R. A., Nguyen, A. D., Jo, Y. & DeBose-Boyd, R. A., Apr 1 2013, In : Journal of lipid research. 54, 4, p. 1011-1022 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes

Nakajima, C., Kulik, A., Frotscher, M., Herz, J., Schäfer, M., Bock, H. H. & May, P., Jul 26 2013, In : Journal of Biological Chemistry. 288, 30, p. 21909-21923 15 p.

Research output: Contribution to journalArticle

36 Scopus citations

Massive palmitoylation-dependent endocytosis during reoxygenation of anoxic cardiac muscle

Lin, M. J., Fine, M., Lu, J. Y., Hofmann, S. L., Frazier, G. & Hilgemann, D. W., Nov 26 2013, In : eLife. 2013, 2, e01295.

Research output: Contribution to journalArticle

42 Scopus citations

Metabolic response to high-carbohydrate and low-carbohydrate meals in a nonhuman primate model

Fabbrini, E., Higgins, P. B., Magkos, F., Bastarrachea, R. A., Saroja Voruganti, V., Comuzzie, A. G., Shade, R. E., Gastaldelli, A., Horton, J. D., Omodei, D., Patterson, B. W. & Klein, S., Feb 15 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 4, p. E444-E451

Research output: Contribution to journalArticle

12 Scopus citations

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

Wang, Y., Quagliarini, F., Gusaroèa, È., Gromada, J., Èalenzuela, D. M., Cohen, J. C. & Hobbs, H. H., Oct 1 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 40, p. 16109-16114 6 p.

Research output: Contribution to journalArticle

197 Scopus citations

Modulation of circadian glucocorticoid oscillation via adrenal Opioid-CXCR7 Signaling alters emotional behavior

Ikeda, Y., Kumagai, H., Skach, A., Sato, M. & Yanagisawa, M., Dec 5 2013, In : Cell. 155, 6, p. 1323-1336 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Neurotensin Co-Expressed in Orexin-Producing Neurons in the Lateral Hypothalamus Plays an Important Role in Regulation of Sleep/Wakefulness States

Furutani, N., Hondo, M., Kageyama, H., Tsujino, N., Mieda, M., Yanagisawa, M., Shioda, S. & Sakurai, T., Apr 19 2013, In : PloS one. 8, 4, e62391.

Research output: Contribution to journalArticle

49 Scopus citations

Olfactory receptor responding to gut microbiotaderived signals plays a role in renin secretion and blood pressure regulation

Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L. X., Rey, F., Wang, T., Firestein, S. J., Yanagisawa, M., Gordon, J. I., Eichmann, A., Peti-Peterdi, J. & Caplan, M. J., Mar 12 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 11, p. 4410-4415 6 p.

Research output: Contribution to journalArticle

411 Scopus citations

Opening up new fronts in the fight against cholesterol

DeBose-Boyd, R. A. & Horton, J. D., Apr 9 2013, In : eLife. 2013, 2, e00663.

Research output: Contribution to journalArticle

2 Scopus citations

Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation

Soya, S., Shoji, H., Hasegawa, E., Hondo, M., Miyakawa, T., Yanagisawa, M., Mieda, M. & Sakurai, T., Sep 9 2013, In : Journal of Neuroscience. 33, 36, p. 14549-14557 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Point mutation in luminal Loop 7 of scap protein blocks interaction with Loop 1 and abolishes movement to Golgi

Zhang, Y., Motamed, M., Seemann, J., Brown, M. S. & Goldstein, J. L., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14059-14067 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells

Chen, X., Chang, J., Deng, Q., Xu, J., Nguyen, T. A., Martens, L. H., Cenik, B., Taylor, G., Hudson, K. F., Chung, J., Yu, K., Yu, P., Herz, J., Farese, R. V., Kukar, T. & Tansey, M. G., May 22 2013, In : Journal of Neuroscience. 33, 21, p. 9202-9213 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Reelin induces EphB activation

Bouché, E., Romero-Ortega, M. I., Henkemeyer, M., Catchpole, T., Leemhuis, J., Frotscher, M., May, P., Herz, J. & Bock, H. H., Apr 1 2013, In : Cell Research. 23, 4, p. 473-490 18 p.

Research output: Contribution to journalArticle

41 Scopus citations

Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission

Bal, M., Leitz, J., Reese, A. L., Ramirez, D. M. O., Durakoglugil, M. S., Herz, J., Monteggia, L. M. & Kavalali, E. T., Nov 20 2013, In : Neuron. 80, 4, p. 934-946 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice

Brunne, B., Franco, S., Bouché, E., Herz, J., Howell, B. W., Pahle, J., Müller, U., May, P., Frotscher, M. & Bock, H. H., Aug 1 2013, In : GLIA. 61, 8, p. 1347-1363 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)

Nguyen, A. D., Nguyen, T. A., Cenik, B., Yu, G., Herz, J., Walther, T. C., Davidson, W. S. & Farese, R. V., Mar 22 2013, In : Journal of Biological Chemistry. 288, 12, p. 8627-8635 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice

Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M. & Kim, C. H., Aug 2013, In : Gastroenterology. 145, 2, p. 396-406.e10

Research output: Contribution to journalArticle

303 Scopus citations

Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells

Elsabrouty, R., Jo, Y., Dinh, T. T. & DeBose-Boyd, R. A., Nov 1 2013, In : Molecular biology of the cell. 24, 21, p. 3300-3308 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Structure of a presenilin family intramembrane aspartate protease

Li, X., Dang, S., Yan, C., Gong, X., Wang, J. & Shi, Y., Jan 3 2013, In : Nature. 493, 7430, p. 56-61 6 p.

Research output: Contribution to journalArticle

143 Scopus citations

Sufficient production of geranylgeraniol is required to maintain Endotoxin tolerance in macrophages

Ye, J., Kim, J., Lee, J. N., Ye, J., Hao, R. & Debose-Boyd, R., Dec 2013, In : Journal of lipid research. 54, 12, p. 3430-3437 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons

Ding, B., Wang, W., Selvakumar, T., Xi, H. S., Zhu, H., Chow, C. W., Horton, J. D., Gronostajski, R. M. & Kilpatrick, D. L., Feb 13 2013, In : Journal of Neuroscience. 33, 7, p. 2860-2872 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the Brain

Carlo, A. S., Gustafsen, C., Mastrobuoni, G., Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M., Nykjaer, A., Herz, J., Heeren, J., Kempa, S., Petersen, C. M. & Willnow, T. E., Jan 2 2013, In : Journal of Neuroscience. 33, 1, p. 358-370 13 p.

Research output: Contribution to journalArticle

52 Scopus citations

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

Deng, Y., Wang, Z., Tao, C., Gao, N., Holland, W. L., Ferdous, A., Repa, J., Liang, G., Ye, J., Lehrman, M. A., Hill, J. A., Horton, J. D. & Scherer, P. E., Jan 2 2013, In : Journal of Clinical Investigation. 123, 1, p. 455-468 14 p.

Research output: Contribution to journalArticle

81 Scopus citations

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids

Kim, H., Zhang, H., Meng, D., Russell, G., Lee, J. N. & Ye, J., Aug 1 2013, In : Journal of lipid research. 54, 8, p. 2144-2152 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
58 Scopus citations

Utilizing-score to identify oncogenic pathways of cholangiocarcinoma

Hsiao, T. H., Chen, H. I. H., Lu, J. Y., Lin, P. Y., Keller, C., Comerford, S. A., Tomlinson, G. E. & Chen, Y., Feb 1 2013, In : Translational Cancer Research. 2, 1, p. 6-17 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012
2 Scopus citations

Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis

Tawaramoto, K., Kotani, K., Hashiramoto, M., Kanda, Y., Nagare, T., Sakaue, H., Ogawa, W., Emoto, N., Yanagisawa, M., Noda, T., Kasuga, M. & Kaku, K., Jan 2012, In : Molecular Endocrinology. 26, 1, p. 95-109 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma

McDonald, J. G., Smith, D. D., Stiles, A. R. & Russell, D. W., Jul 1 2012, In : Journal of lipid research. 53, 7, p. 1399-1409 11 p.

Research output: Contribution to journalArticle

113 Scopus citations