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2010
31 Scopus citations

Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia

Rios, J., Stein, E., Shendure, J., Hobbs, H. H. & Cohen, J. C., Nov 1 2010, In : Human molecular genetics. 19, 22, p. 4313-4318 6 p., ddq352.

Research output: Contribution to journalArticle

119 Scopus citations

Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes

Wang, M. L., Motamed, M., Infante, R. E., Abi-Mosleh, L., Kwon, H. J., Brown, M. S. & Goldstein, J. L., Aug 4 2010, In : Cell Metabolism. 12, 2, p. 166-173 8 p.

Research output: Contribution to journalArticle

137 Scopus citations

Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

Lee, J. N., Kim, H., Yao, H., Chen, Y., Weng, K. & Ye, J., Dec 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21424-21429 6 p.

Research output: Contribution to journalArticle

61 Scopus citations

Indices of cholesterol metabolism and relative responsiveness to ezetimibe and simvastatin

Lakoski, S. G., Xu, F., Vega, G. L., Grundy, S. M., Chandalia, M., Lam, C., Lowe, R. S., Stepanavage, M. E., Musliner, T. A., Cohen, J. C. & Hobbs, H. H., Feb 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 2, p. 800-809 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
71 Scopus citations
5 Scopus citations

Isoenzyme-specific thermostability of human cytosolic creatine kinase

Gao, Y. S., Zhao, T. J., Chen, Z., Li, C., Wang, Y., Yan, Y. B. & Zhou, H. M., Jul 1 2010, In : International Journal of Biological Macromolecules. 47, 1, p. 27-32 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Joseph Goldstein and Michael Brown: demoting egos, promoting success. Interview by Ruth Williams.

Goldstein, J. & Brown, M., Apr 2 2010, In : Circulation research. 106, 6, p. 1006-1010 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lipidomics reveals a remarkable diversity of lipids in human plasma1

Quehenberger, O., Armando, A. M., Brown, A. H., Milne, S. B., Myers, D. S., Merrill, A. H., Bandyopadhyay, S., Jones, K. N., Kelly, S., Shaner, R. L., Sullards, C. M., Wang, E., Murphy, R. C., Barkley, R. M., Leiker, T. J., Raetz, C. R. H., Guan, Z., Laird, G. M., Six, D. A., Russell, D. W. & 4 others, McDonald, J. G., Subramaniam, S., Fahy, E. & Dennis, E. A., Nov 2010, In : Journal of lipid research. 51, 11, p. 3299-3305 7 p.

Research output: Contribution to journalArticle

676 Scopus citations

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato, H., Sato, M., Sinton, C. M., Gautron, L., Williams, S. C., Skach, A., Elmquist, J. K., Skoultchi, A. I. & Yanagisawa, M., Oct 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 42, p. 18155-18160 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Low blood pressure in endothelial cell-specific endothelin 1 knockout mice

Kisanuki, Y. Y., Emoto, N., Ohuchi, T., Widyantoro, B., Yagi, K., Nakayama, K., Kedzierski, R. M., Hammer, R. E., Yanagisawa, H., Williams, S. C., Richardson, J. A., Suzuki, T. & Yanagisawa, M., Jul 1 2010, In : Hypertension. 56, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

LRP4 Mutations Alter Wnt/β-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome

Li, Y., Pawlik, B., Elcioglu, N., Aglan, M., Kayserili, H., Yigit, G., Percin, F., Goodman, F., Nürnberg, G., Cenani, A., Urquhart, J., Chung, B. D., Ismail, S., Amr, K., Aslanger, A. D., Becker, C., Netzer, C., Scambler, P., Eyaid, W., Hamamy, H. & 6 others, Clayton-Smith, J., Hennekam, R., Nürnberg, P., Herz, J., Temtamy, S. A. & Wollnik, B., May 14 2010, In : American Journal of Human Genetics. 86, 5, p. 696-706 11 p.

Research output: Contribution to journalArticle

100 Scopus citations

Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation - a mouse model for cenani-lenz syndrome

Karner, C. M., Dietrich, M. F., Johnson, E. B., Kappesser, N., Tennert, C., Percin, F., Wollnik, B., Carroll, T. J. & Herz, J., 2010, In : PloS one. 5, 4, e10418.

Research output: Contribution to journalArticle

37 Scopus citations

LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size

Okazaki, H., Goldstein, J. L., Brown, M. S. & Liang, G., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6801-6810 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Mechanism of substrate recognition and transport by an amino acid antiporter

Gao, X., Zhou, L., Jiao, X., Lu, F., Yan, C., Zeng, X., Wang, J. & Shi, Y., Feb 11 2010, In : Nature. 463, 7282, p. 828-832 5 p.

Research output: Contribution to journalArticle

136 Scopus citations

Monoaminergic neuronal changes in orexin deficient mice

Mori, T., Ito, S., Kuwaki, T., Yanagisawa, M., Sakurai, T. & Sawaguchi, T., Mar 2010, In : Neuropharmacology. 58, 4-5, p. 826-832 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Monoclonal antibodies to human transglutaminase 4

Cho, S. Y., Jeon, J. H., Kim, C. W., Shin, D. M., Jang, G. Y., Jeong, E. M., Lee, S. E., Song, K. Y. & Kim, I. G., Jun 1 2010, In : Hybridoma. 29, 3, p. 263-267 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons

Kalogiannis, M., Grupke, S. L., Potter, P. E., Edwards, J. G., Chemelli, R. M., Kisanuki, Y. Y., Yanagisawa, M. & Leonard, C. S., Jul 2010, In : European Journal of Neuroscience. 32, 1, p. 130-142 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus

Brunne, B., Zhao, S., Derouiche, A., Herz, J., Petra, M., Frotscher, M. & Bock, H. H., Oct 1 2010, In : GLIA. 58, 13, p. 1553-1569 17 p.

Research output: Contribution to journalArticle

56 Scopus citations

Phase separations in binary and ternary cholesterol-phospholipid mixtures

Radhakrishnan, A., May 5 2010, In : Biophysical journal. 98, 9, p. L41-L43

Research output: Contribution to journalArticle

7 Scopus citations

Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling

Jedrychowski, M. P., Gartner, C. A., Gygi, S. P., Zhou, L., Herz, J., Kandror, K. V. & Pilch, P. F., Jan 1 2010, In : Journal of Biological Chemistry. 285, 1, p. 104-114 11 p.

Research output: Contribution to journalArticle

85 Scopus citations

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

Leemhuis, J., Bouché, E., Frotscher, M., Henle, F., Hein, L., Herz, J., Meyer, D. K., Pichler, M., Roth, G., Schwan, C. & Bock, H. H., Nov 3 2010, In : Journal of Neuroscience. 30, 44, p. 14759-14772 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

Sterol-induced dislocation of 3-Hydroxy-3-methylglutaryl coenzyme a reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets

Hartman, I. Z., Liu, P., Zehmer, J. K., Luby-Phelps, K., Jo, Y., Anderson, R. G. W. & DeBose-Boyd, R. A., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19288-19298 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Structure of a fucose transporter in an outward-open conformation

Dang, S., Sun, L., Huang, Y., Lu, F., Liu, Y., Gong, H., Wang, J. & Yan, N., Oct 7 2010, In : Nature. 467, 7316, p. 734-738 5 p.

Research output: Contribution to journalArticle

189 Scopus citations

Subcellular organelle lipidomics in TLR-4-activated macrophages

Andreyev, A. Y., Fahy, E., Guan, Z., Kelly, S., Li, X., McDonald, J. G., Milne, S., Myers, D., Park, H., Ryan, A., Thompson, B. M., Wang, E., Zhao, Y., Brown, H. A., Merrill, A. H., Raetz, C. R. H., Russell, D. W., Subramaniam, S. & Dennis, E. A., Sep 1 2010, In : Journal of lipid research. 51, 9, p. 2785-2797 13 p.

Research output: Contribution to journalArticle

127 Scopus citations

Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women

Kars, M., Yang, L., Gregor, M. F., Mohammed, B. S., Pietka, T. A., Finck, B. N., Patterson, B. W., Horton, J. D., Mittendorfer, B., Hotamisligil, G. S. & Klein, S., Aug 1 2010, In : Diabetes. 59, 8, p. 1899-1905 7 p.

Research output: Contribution to journalArticle

245 Scopus citations

TDP-43 is a developmentally regulated protein essential for early embryonic development

Sephton, C. F., Good, S. K., Atkin, S., Dewey, C. M., Mayer, P., Herz, J. & Yu, G., Feb 26 2010, In : Journal of Biological Chemistry. 285, 9, p. 6826-6834 9 p.

Research output: Contribution to journalArticle

218 Scopus citations

Transgenic wheat progenies resistant to powdery mildew generated by Agrobacterium transformation of barley Mlo anti-sense gene

Zhao, T. J., Liu, H., Zhao, S. Y., Chen, H. M. & Xia, G. M., Jul 1 2010, In : Plant Physiology Communications. 46, 7, p. 731-736 6 p.

Research output: Contribution to journalArticle

Transglutaminase 2 inhibits apoptosis induced by calciumoverload through down-regulation of Bax

Cho, S. Y., Lee, J. H., Bae, H. D., Jeong, E. M., Jang, G. Y., Kim, C. W., Shin, D. M., Jeon, J. H. & Kim, I. G., 2010, In : Experimental and Molecular Medicine. 42, 9, p. 639-650 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-κB activity in hypoxic tumor cells

Jang, G. Y., Jeon, J. H., Cho, S. Y., Shin, D. M., Kim, C. W., Jeong, E. M., Bae, H. C., Kim, T. W., Lee, S. H., Choi, Y., Lee, D. S., Park, S. C. & Kim, I. G., Jan 1 2010, In : Oncogene. 29, 3, p. 356-367 12 p.

Research output: Contribution to journalArticle

86 Scopus citations
2009

[New advancement of genetically manipulated mouse models in dyslipidemia and atherosclerosis].

Ding, Y. Y. & Liu, G. Q., Apr 1 2009, In : Sheng li ke xue jin zhan [Progress in physiology]. 40, 2, p. 151-153 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
186 Scopus citations

A case-control study on the relationship between HDL2b and non-alcoholic fatty liver disease in Chinese type 2 diabetic patients

Ma, Y. H., Zhao, L., Xian, X. D., Yang, D., Huang, W., Wang, Y. H., Mueller, O., Chang, E., Konigshofer, Y., Van-Cleve, M., Liu, G. & Yang, J. K., Sep 1 2009, In : Clinical Chemistry and Laboratory Medicine. 47, 9, p. 1067-1072 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice

Guan, H. P., Goldstein, J. L., Brown, M. S. & Liang, G., Sep 4 2009, In : Journal of Biological Chemistry. 284, 36, p. 24644-24652 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells

McNutt, M. C., Kwon, H. J., Chen, C., Chen, J. R., Horton, J. D. & Lagace, T. A., Apr 17 2009, In : Journal of Biological Chemistry. 284, 16, p. 10561-10570 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor

Owen, D. M., Huang, H., Ye, J. & Gale, M., Nov 10 2009, In : Virology. 394, 1, p. 99-108 10 p.

Research output: Contribution to journalArticle

167 Scopus citations

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

Irukayama-Tomobe, Y., Tanaka, H., Yokomizo, T., Hashidate-Yoshida, T., Yanagisawa, M. & Sakurai, T., Mar 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 10, p. 3930-3934 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage

Li, X., Wang, B., Feng, L., Kang, H., Qi, Y., Wang, J. & Shi, Y., Sep 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 35, p. 14837-14842 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

Okamura, M., Kudo, H., Wakabayashi, K. I., Tanaka, T., Nonaka, A., Uchida, A., Tsutsumi, S., Sakakibara, I., Naito, M., Osborne, T. F., Hamakubo, T., Ito, S., Aburatani, H., Yanagisawa, M., Kodama, T. & Sakai, J., Apr 7 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 14, p. 5819-5824 6 p.

Research output: Contribution to journalArticle

130 Scopus citations
108 Scopus citations

Degradation of transglutaminase 2 by calcium-mediated ubiquitination responding to high oxidative stress

Jeong, E. M., Kim, C. W., Cho, S. Y., Jang, G. Y., Shin, D. M., Jeon, J. H. & Kim, I. G., Feb 18 2009, In : FEBS Letters. 583, 4, p. 648-654 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

Moon, Y. A., Hammer, R. E. & Horton, J. D., Apr 1 2009, In : Journal of lipid research. 50, 3, p. 412-423 12 p.

Research output: Contribution to journalArticle

109 Scopus citations

Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling

Masiulis, I., Quill, T. A., Burk, R. F. & Herz, J., Jan 1 2009, In : Biological Chemistry. 390, 1, p. 67-73 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Dual effect of a single nucleotide polymorphism in the first intron of the porcine Secreted phosphoprotein 1 gene: Allele-specific binding of C/EBP beta and activation of aberrant splicing

Muráni, E., Ponsuksili, S., Seyfert, H. M., Shi, X. & Wimmers, K., Oct 21 2009, In : BMC Molecular Biology. 10, 1 p., 100.

Research output: Contribution to journalArticle

19 Scopus citations

Endothelial ETB limits vascular remodelling and development of pulmonary hypertension during hypoxia

Kelland, N. F., Bagnall, A. J., Morecroft, I., Gulliver-Sloan, F. H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M. R., Kotelevtsev, Y. V. & Webb, D. J., Jan 1 2009, In : Journal of Vascular Research. 47, 1, p. 16-22 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Endothelin-1 impairs alveolar epithelial function via endothelial ET B receptor

Comellas, A. P., Briva, A., Dada, L. A., Butti, M. L., Trejo, H. E., Yshii, C., Azzam, Z. S., Litvan, J., Chen, J., Lecuona, E., Pesce, L. M., Yanagisawa, M. & Sznajder, J. I., Jan 15 2009, In : American journal of respiratory and critical care medicine. 179, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice

Xian, X., Ding, Y., Zhang, L., Wang, Y., McNutt, M. A., Ross, C., Hayden, M. R., Deng, X. & Liu, G., Aug 7 2009, In : Biochemical and Biophysical Research Communications. 385, 4, p. 563-569 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity

Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y., Williams, S. C., Sakurai, T. & Yanagisawa, M., Jan 7 2009, In : Cell Metabolism. 9, 1, p. 64-76 13 p.

Research output: Contribution to journalArticle

185 Scopus citations

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2

Sakakibara, I., Fujino, T., Ishii, M., Tanaka, T., Shimosawa, T., Miura, S., Zhang, W., Tokutake, Y., Yamamoto, J., Awano, M., Iwasaki, S., Motoike, T., Okamura, M., Inagaki, T., Kita, K., Ezaki, O., Naito, M., Kuwaki, T., Chohnan, S., Yamamoto, T. T. & 4 others, Hammer, R. E., Kodama, T., Yanagisawa, M. & Sakai, J., Feb 4 2009, In : Cell Metabolism. 9, 2, p. 191-202 12 p.

Research output: Contribution to journalArticle

55 Scopus citations