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1976 …2020

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2008

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

Kuo, S. R., Willingham, M. C., Bour, S. H., Andreas, E. A., Park, S. K., Jackson, C., Duesbery, N. S., Leppla, S. H., Tang, W. J. & Frankel, A. E., Jun 1 2008, In : Microbial Pathogenesis. 44, 6, p. 467-472 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

Alfano, R. W., Leppla, S. H., Liu, S., Bugge, T. H., Herlyn, M., Smalley, K. S., Bromberg-White, J. L., Duesbery, N. S. & Frankel, A. E., Oct 13 2008, In : Molecular Cancer Therapeutics. 7, 5, p. 1218-1226 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

GMP production and characterization of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1) for phase I/II clinical trials

Woo, J. H., Liu, J. S., Kang, S. H., Singh, R., Park, S. K., Su, Y., Ortiz, J., Neville, D. M., Willingham, M. C. & Frankel, A. E., Mar 1 2008, In : Protein Expression and Purification. 58, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

Liu, S., Wang, H., Currie, B. M., Molinolo, A., Leung, H. J., Moayeri, M., Basile, J. R., Alfano, R. W., Gutkind, J. S., Frankel, A. E., Bugge, T. H. & Leppla, S. H., Jan 4 2008, In : Journal of Biological Chemistry. 283, 1, p. 529-540 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

Ding, Y., Boguslawski, E. A., Berghuis, B. D., Young, J. J., Zhang, Z., Hardy, K., Furge, K., Kort, E., Frankel, A. E., Hay, R. V., Resau, J. H. & Duesbery, N. S., Mar 1 2008, In : Molecular Cancer Therapeutics. 7, 3, p. 648-658 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia

Frankel, A., Liu, J. S., Rizzieri, D. & Hogge, D., Mar 1 2008, In : Leukemia and Lymphoma. 49, 3, p. 543-553 11 p.

Research output: Contribution to journalArticle

81 Scopus citations

Preclinical studies in rats and squirrel monkeys for safety evaluation of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1)

Woo, J. H., Bour, S. H., Dang, T., Lee, Y. J., Park, S. K., Andreas, E., Kang, S. H., Liu, J. S., Neville, D. M. & Frankel, A. E., Aug 1 2008, In : Cancer Immunology, Immunotherapy. 57, 8, p. 1225-1239 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Reducing anti-DT IgG concentrations to improve the efficacy of a diphtheria fusion protein

Hall, P. D., Beagle, K. L., Garrett-Mayer, E. & Frankel, A. E., Nov 1 2008, In : Anti-Cancer Drugs. 19, 10, p. 1007-1011 5 p.

Research output: Contribution to journalArticle

RLIP76 and Cancer

Awasthi, S., Singhal, S. S., Awasthi, Y. C., Martin, B., Woo, J. H., Cunningham, C. C. & Frankel, A. E., Jul 15 2008, In : Clinical Cancer Research. 14, 14, p. 4372-4384 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

SU‐GG‐J‐145: Physics Support for Intraprostatic Treatment of Patients with Locally Recurrent Prostate Cancer with the PSA‐Activated Protoxin PRX302

Boyer, A., Coffield, S., Culp, L., Frankel, A., Merchant, N. & Abi‐habib, R., 2008, In : Medical Physics. 35, 6, p. 2712 1 p.

Research output: Contribution to journalArticle

The systemic administration of lethal toxin achieves a growth delay of human melanoma and neuroblastoma xenografts: Assessment of receptor contribution

Rouleau, C., Menon, K., Boutin, P., Guyre, C., Yoshida, H., Kataoka, S., Perricone, M., Shankara, S., Frankel, A. E., Duesbery, N. S., Vande Woude, G., Biemann, H. P. & Teicher, B. A., Apr 1 2008, In : International journal of oncology. 32, 4, p. 739-748 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice

Su, Y., Vanderlaag, K., Ireland, C., Ortiz, J., Grage, H., Safe, S. & Frankel, A. E., Aug 31 2007, In : Breast Cancer Research. 9, 4, R56.

Research output: Contribution to journalArticle

15 Scopus citations

Anthrax lethal toxin inhibits growth of and vascular endothelial growth factor release from endothelial cells expressing the human herpes virus 8 viral G protein-coupled receptor

Depeille, P., Young, J. J., Boguslawski, E. A., Berghuis, B. D., Kort, E. J., Resau, J. H., Frankel, A. E. & Duesbery, N. S., Oct 1 2007, In : Clinical Cancer Research. 13, 19, p. 5926-5934 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Anthrax toxins induce shock in rats by depressed cardiac ventricular function

Watson, L. E., Kuo, S. R., Katki, K., Dang, T., Park, S. K., Dostal, D. E., Tang, W. J., Leppla, S. H. & Frankel, A. E., May 23 2007, In : PloS one. 2, 5, e466.

Research output: Contribution to journalArticle

49 Scopus citations

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction

Watson, L. E., Mock, J., Lal, H., Lu, G., Bourdeau, R. W., Tang, W. J., Leppla, S. H., Dostal, D. E. & Frankel, A. E., May 1 2007, In : Frontiers in Bioscience. 12, 12, p. 4670-4675 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Recombinant prostate-specific antigen proaerolysin shows selective protease sensitivity and cell cytotoxicity

Singh, R., Browning, J. L., Abi-Habib, R., Wong, K., Williams, S. A., Merchant, R., Denmeade, S. R., Buckley, T. J. & Frankel, A. E., Aug 1 2007, In : Anti-Cancer Drugs. 18, 7, p. 809-816 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

Su, Y., Ortiz, J., Liu, S., Bugge, T. H., Singh, R., Leppla, S. H. & Frankel, A. E., Apr 1 2007, In : Cancer research. 67, 7, p. 3329-3336 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2006

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

Abi-Habib, R. J., Singh, R., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Oct 1 2006, In : Molecular Cancer Therapeutics. 5, 10, p. 2556-2562 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
45 Scopus citations
4 Scopus citations

Phase II clinical studies of denileukin diftitox diphtheria toxin fusion protein in patients with previously treated chronic lymphocytic leukemia

Frankel, A. E., Surendranathan, A., Black, J. H., White, A., Ganjoo, K. & Cripe, L. D., May 15 2006, In : Cancer. 106, 10, p. 2158-2164 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice

Abi-Habib, R. J., Singh, R., Leppla, S. H., Greene, J. J., Ding, Y., Berghuis, B., Duesbery, N. S. & Frankel, A. E., Dec 15 2006, In : Clinical Cancer Research. 12, 24, p. 7437-7443 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors

Hogge, D. E., Yalcintepe, L., Wong, S. H., Gerhard, B. & Frankel, A. E., Feb 15 2006, In : Clinical Cancer Research. 12, 4, p. 1284-1291 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2005

BRAF status and mitogen-activated protein/extracellular signal regulated kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

Abi-Habib, R. J., Urieto, J. O., Liu, S., Leppla, S. H., Duesbery, N. S. & Frankel, A. E., Sep 1 2005, In : Molecular Cancer Therapeutics. 4, 9, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression

Testa, U., Riccioni, R., Biffoni, M., Diverio, D., Lo-Coco, F., Foà, R., Peschle, C. & Frankel, A. E., Oct 1 2005, In : Blood. 106, 7, p. 2527-2529 3 p.

Research output: Contribution to journalArticle

36 Scopus citations

Interstitial diphtheria toxin-epidermal growth factor fusion protein therapy produces regressions of subcutaneous human glioblastoma multiforme tumors in athymic nude mice

Liu, T. F., Hall, P. D., Cohen, K. A., Willingham, M. C., Cai, J., Thorburn, A. & Frankel, A. E., Jan 1 2005, In : Clinical Cancer Research. 11, 1, p. 329-334 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey

Cohen, K. A., Liu, T. F., Cline, J. M., Wagner, J. D., Hall, P. D. & Frankel, A. E., Jul 1 2005, In : Cancer Immunology, Immunotherapy. 54, 8, p. 799-806 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Toxin conjugate therapy of cancer

Wong, L., Suh, D. Y. & Frankel, A. E., Dec 2005, In : Seminars in oncology. 32, 6, p. 591-595 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
2004
22 Scopus citations

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

Abi-Habib, R. J., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Oct 1 2004, In : Blood. 104, 7, p. 2143-2148 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Diphtheria toxin fused to variant interleukin-3 provides enhanced binding to the interleukin-3 receptor and more potent leukemia cell cytotoxicity

Liu, T. F., Urieto, J. O., Moore, J. E., Miller, M. S., Lowe, A. C., Thorburn, A. & Frankel, A. E., Mar 1 2004, In : Experimental Hematology. 32, 3, p. 277-281 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells

Westcott, M. M., Abi-Habib, R. J., Cohen, K. A., Willingham, M. C., Liu, S., Bugge, T. H., Leppla, S. H. & Frankel, A. E., Dec 1 2004, In : Molecular Cancer Therapeutics. 3, 12, p. 1681-1689 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials

Urieto, J. O., Liu, T., Black, J. H., Cohen, K. A., Hall, P. D., Willingham, M. C., Pennell, L. K., Hogge, D. E., Kreitman, R. J. & Frankel, A. E., Jan 2004, In : Protein Expression and Purification. 33, 1, p. 123-133 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

The efficacy of diphtheria-growth factor fusion proteins is enhanced by co-administration of cytosine arabinoside in an immunodeficient mouse model of human acute myeloid leukemia

Hogge, D. E., Feuring-Buske, M., Gerhard, B. & Frankel, A. E., Nov 1 2004, In : Leukemia Research. 28, 11, p. 1221-1226 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys

Cohen, K. A., Liu, T. F., Cline, J. M., Wagner, J. D., Hall, P. D. & Frankel, A. E., Aug 1 2004, In : Leukemia and Lymphoma. 45, 8, p. 1647-1656 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

VEGF and myeloid leukemias

Frankel, A. E. & Gill, P. S., Jul 2004, In : Leukemia Research. 28, 7, p. 675-677 3 p.

Research output: Contribution to journalArticle

16 Scopus citations
2003

A diphtheria toxin-epidermal growth factor fusion protein is cytotoxic to human glioblastoma multiforme cells

Liu, T. F., Cohen, K. A., Ramage, J. G., Willingham, M. C., Thorburn, A. M. & Frankel, A. E., Apr 15 2003, In : Cancer research. 63, 8, p. 1834-1837 4 p.

Research output: Contribution to journalArticle

43 Scopus citations

A phase II study of DT fusion protein denileukin diftitox in patients with fludarabine-refractory chronic lymphocytic leukemia

Frankel, A. E., Fleming, D. R., Hall, P. D., Powell, B. L., Black, J. H., Leftwich, C. & Gartenhaus, R., Oct 1 2003, In : Clinical Cancer Research. 9, 10 I, p. 3555-3561 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein

Thorburn, J., Frankel, A. E. & Thorburn, A., Feb 1 2003, In : Clinical Cancer Research. 9, 2, p. 861-865 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Combination fusion protein therapy of refractory brain tumors: Demonstration of efficacy in cell culture

Liu, T. F., Cohen, K. A., Willingham, M. C., Tatter, S. B., Puri, R. K. & Frankel, A. E., Oct 1 2003, In : Journal of Neuro-Oncology. 65, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Diphtheria Toxin-Epidermal Growth Factor Fusion Protein and Pseudomonas Exotoxin-Interleukin 13 Fusion Protein Exert Synergistic Toxicity against Human Glioblastoma Multiforme Cells

Liu, T. F., Willingham, M. C., Tatter, S. B., Cohen, K. A., Corinne Lowe, A., Thorburn, A. & Frankel, A. E., Nov 1 2003, In : Bioconjugate Chemistry. 14, 6, p. 1107-1114 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Diphtheria-toxin-interleukin-3 fusion protein (DT388IL3) prolongs disease-free survival of leukemic immunocompromised mice

Black, J. H., McCubrey, J. A., Willingham, M. C., Ramage, J., Hogge, D. E. & Frankel, A. E., Jan 1 2003, In : Leukemia. 17, 1, p. 155-159 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Growth factor receptor expression varies among high-grade gliomas and normal brain: Epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy

Liu, T. F., Tatter, S. B., Willingham, M. C., Yang, M., Hu, J. J. & Frankel, A. E., Aug 1 2003, In : Molecular Cancer Therapeutics. 2, 8, p. 783-787 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Immunotoxin therapy of hematologic malignancies

Frankel, A. E., Neville, D. M., Bugge, T. A., Kreitman, R. J. & Leppla, S. H., Aug 2003, In : Seminars in oncology. 30, 4, p. 545-557 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells

Ramage, J. G., Vallera, D. A., Black, J. H., Aplan, P. D., Kees, U. R. & Frankel, A. E., Jan 1 2003, In : Leukemia Research. 27, 1, p. 79-84 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
2002

A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors

Feuring-Buske, M., Frankel, A. E., Alexander, R. L., Gerhard, B. & Hogge, D. E., Mar 15 2002, In : Cancer research. 62, 6, p. 1730-1736 7 p.

Research output: Contribution to journalArticle

100 Scopus citations

Effective targeted cytotoxicity of neuroblastoma cells

Thomas, P. B., Delatte, S. J., Sutphin, A., Frankel, A. E. & Tagge, E. P., Jan 1 2002, In : Journal of Pediatric Surgery. 37, 3, p. 539-544 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Efficacy and safety of gemtuzumab ozogamicin in patients with poor-prognosis acute myeloid leukemia

Roboz, G. J., Knovich, M. A., Bayer, R. L., Schuster, M. W., Seiter, K., Powell, B. L., Woodruff, R. D., Silver, R. T., Frankel, A. E. & Feldman, E. J., Oct 1 2002, In : Leukemia and Lymphoma. 43, 10, p. 1951-1955 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Malignant progenitors from patients with CD87+ acute myelogenous leukemia are sensitive to a diphtheria toxin-urokinase fusion protein

Frankel, A. E., Beran, M., Hogge, D. E., Powell, B. L., Thorburn, A., Chen, Y. Q. & Vallera, D. A., Nov 1 2002, In : Experimental Hematology. 30, 11, p. 1316-1323 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia

Frankel, A. E., Powell, B. L., Hall, P. D., Case, L. D. & Kreitman, R. J., May 2002, In : Clinical Cancer Research. 8, 5, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

111 Scopus citations