• 8148 Citations
  • 16 h-Index
19962020

Research output per year

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Research Output

  • 8148 Citations
  • 16 h-Index
  • 19 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Chapter
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Article
2020

A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins

Theodoropoulos, P. C., Wang, W., Budhipramono, A., Thompson, B. M., Madhusudhan, N., Mitsche, M. A., McDonald, J. G., De Brabander, J. K. & Nijhawan, D., Apr 1 2020, In : Journal of the American Chemical Society. 142, 13, p. 6128-6138 11 p.

Research output: Contribution to journalArticle

Biomarkers for RBM39 degradation in acute myeloid leukemia

Hsiehchen, D., Goralski, M., Kim, J., Xie, Y. & Nijhawan, D., Jul 1 2020, In : Leukemia. 34, 7, p. 1924-1928 5 p.

Research output: Contribution to journalArticle

Target discovery of selective non-small-cell lung cancer toxins reveals inhibitors of mitochondrial complex i

Madhusudhan, N., Hu, B., Mishra, P., Calva-Moreno, J. F., Patel, K., Boriack, R., Ready, J. M. & Nijhawan, D., Jan 17 2020, In : ACS chemical biology. 15, 1, p. 158-170 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15

Ting, T. C., Goralski, M., Klein, K., Wang, B., Kim, J., Xie, Y. & Nijhawan, D., Nov 5 2019, In : Cell Reports. 29, 6, p. 1499-1510.e6

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification

Povedano, J. M., Liou, J., Wei, D., Srivatsav, A., Kim, J., Xie, Y., Nijhawan, D. & McFadden, D. G., Sep 19 2019, In : Cell Chemical Biology. 26, 9, p. 1315-1321.e3

Research output: Contribution to journalArticle

2 Scopus citations

Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820

Du, X., Volkov, O. A., Czerwinski, R. M., Tan, H. L., Huerta, C., Morton, E. R., Rizzi, J. P., Wehn, P. M., Xu, R., Nijhawan, D. & Wallace, E. M., Nov 5 2019, In : Structure. 27, 11, p. 1625-1633.e3

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Winterton, S. E., Capota, E., Wang, X., Chen, H., Mallipeddi, P. L., Williams, N. S., Posner, B. A., Nijhawan, D. & Ready, J. M., Jun 28 2018, In : Journal of Medicinal Chemistry. 61, 12, p. 5199-5221 23 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15

Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T. C., Xie, Y., Williams, N. S. & Nijhawan, D., Mar 16 2017, (Accepted/In press) In : Science. p. 1-21 21 p.

Research output: Contribution to journalArticle

116 Scopus citations
2016

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Theodoropoulos, P. C., Gonzales, S. S., Winterton, S. E., Rodriguez-Navas, C., McKnight, J. S., Morlock, L. K., Hanson, J. M., Cross, B., Owen, A. E., Duan, Y., Moreno, J. R., Lemoff, A., Mirzaei, H., Posner, B. A., Williams, N. S., Ready, J. M. & Nijhawan, D., Apr 1 2016, In : Nature Chemical Biology. 12, 4, p. 218-225 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

Zhang, L., Theodoropoulos, P. C., Eskiocak, U., Wang, W., Moon, Y. A., Posner, B., Williams, N. S., Wright, W. E., Kim, S. B., Nijhawan, D., De Brabander, J. K. & Shay, J. W., Oct 19 2016, In : Science translational medicine. 8, 361, 361ra140.

Research output: Contribution to journalArticle

18 Scopus citations

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

Han, T., Goralski, M., Capota, E., Padrick, S. B., Kim, J., Xie, Y. & Nijhawan, D., May 16 2016, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

20 Scopus citations
2014

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.

Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M. & McKnight, S. L., Sep 11 2014, In : Cell. 158, 6, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

111 Scopus citations
2012

Cancer vulnerabilities unveiled by genomic loss

Nijhawan, D., Zack, T. I., Ren, Y., Strickland, M. R., Lamothe, R., Schumacher, S. E., Tsherniak, A., Besche, H. C., Rosenbluh, J., Shehata, S., Cowley, G. S., Weir, B. A., Goldberg, A. L., Mesirov, J. P., Root, D. E., Bhatia, S. N., Beroukhim, R. & Hahn, W. C., Aug 17 2012, In : Cell. 150, 4, p. 842-854 13 p.

Research output: Contribution to journalArticle

126 Scopus citations

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., Shao, D. D., Schumacher, S. E., Weir, B. A., Vazquez, F., Cowley, G. S., Root, D. E., Mesirov, J. P., Beroukhim, R., Kuo, C. J., Goessling, W. & 1 others, Hahn, W. C., Dec 21 2012, In : Cell. 151, 7, p. 1457-1473 17 p.

Research output: Contribution to journalArticle

392 Scopus citations
2011

Rmrp is a non-coding rna essential for early murine development

Rosenbluh, J., Nijhawan, D., Chen, Z., Wong, K. K., Masutomi, K. & Hahn, W. C., Oct 25 2011, In : PloS one. 6, 10, e26270.

Research output: Contribution to journalArticle

28 Scopus citations
2003

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

Nijhawan, D., Fang, M., Traer, E., Zhong, Q., Gao, W., Du, F. & Wang, X., Jun 15 2003, In : Genes and Development. 17, 12, p. 1475-1486 12 p.

Research output: Contribution to journalArticle

478 Scopus citations
1998

Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

Hentati, A., Ouahchi, K., Pericak-Vance, M. A., Nijhawan, D., Ahmad, A., Yang, Y., Rimmler, J., Hung, W. Y., Schlotter, B., Ahmed, A., Ben Hamida, M., Hentati, F. & Siddique, T., 1998, In : Neurogenetics. 2, 1, p. 55-60 6 p.

Research output: Contribution to journalArticle

153 Scopus citations
1997

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. T., Chang, T. Y., Brown, M. S. & Goldstein, J. L., Dec 1997, In : Molecular cell. 1, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

Open Access
364 Scopus citations

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S. & Wang, X., Nov 14 1997, In : Cell. 91, 4, p. 479-489 11 p.

Research output: Contribution to journalArticle

Open Access
5833 Scopus citations