• 7884 Citations
  • 15 h-Index
19962019
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Research Output 1996 2019

  • 7884 Citations
  • 15 h-Index
  • 20 Article
  • 1 Chapter
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Article
2019

Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification

Povedano, J. M., Liou, J., Wei, D., Srivatsav, A., Kim, J., Xie, Y., Nijhawan, D. & McFadden, D. G., Sep 19 2019, In : Cell Chemical Biology. 26, 9, p. 1315-1321.e3

Research output: Contribution to journalArticle

DNA Mismatch Repair
Genetic Engineering
Cultured Cells
Cells
Repair
2018
1 Citation (Scopus)

Discovery of Cytochrome P450 4F11-Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Winterton, S. E., Capota, E., Wang, X., Chen, H., Mallipeddi, P. L., Williams, N. S., Posner, B. A., Nijhawan, D. & Ready, J. M., Jan 12 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Cytochrome P-450 Enzyme System
Unsaturated Fatty Acids
Structure-Activity Relationship
Urea
2017
70 Citations (Scopus)

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15

Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T. C., Xie, Y., Williams, N. S. & Nijhawan, D., Mar 16 2017, (Accepted/In press) In : Science. p. 1-21 21 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Sulfonamides
Proteolysis
RNA Precursors
N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichlorobenzamide
2016
20 Citations (Scopus)

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Theodoropoulos, P. C., Gonzales, S. S., Winterton, S. E., Rodriguez-Navas, C., McKnight, J. S., Morlock, L. K., Hanson, J. M., Cross, B., Owen, A. E., Duan, Y., Moreno, J. R., Lemoff, A., Mirzaei, H., Posner, B. A., Williams, N. S., Ready, J. M. & Nijhawan, D., Apr 1 2016, In : Nature Chemical Biology. 12, 4, p. 218-225 8 p.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Benzothiazoles
Neoplasms
Cell Line
Cytochrome P-450 Enzyme System
15 Citations (Scopus)

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

Zhang, L., Theodoropoulos, P. C., Eskiocak, U., Wang, W., Moon, Y. A., Posner, B., Williams, N. S., Wright, W. E., Kim, S. B., Nijhawan, D., De Brabander, J. K. & Shay, J. W., Oct 19 2016, In : Science Translational Medicine. 8, 361, 361ra140.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Colorectal Neoplasms
Adenomatous Polyposis Coli Protein
Epithelial Cells
APC Genes
11 Citations (Scopus)

The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α

Han, T., Goralski, M., Capota, E., Padrick, S. B., Kim, J., Xie, Y. & Nijhawan, D., May 16 2016, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Nucleic Acid Synthesis Inhibitors
Mutation
Clustered Regularly Interspaced Short Palindromic Repeats
Fluorescence Polarization
Retinoids
2014
97 Citations (Scopus)

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage

Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M. & McKnight, S. L., Sep 11 2014, In : Cell. 158, 6, p. 1324-1334 11 p.

Research output: Contribution to journalArticle

Salvaging
Nicotinamide Phosphoribosyltransferase
NAD
Enzymes
Doxorubicin
2013
4 Citations (Scopus)

Erratum: β-catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis (Cell (2012) 151 (1457-1473))

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., Shao, D. D., Schumacher, S. E., Weir, B. A., Vazquez, F., Cowley, G. S., Root, D. E., Mesirov, J. P., Beroukhim, R., Kuo, C. J., Goessling, W. & 1 others, Hahn, W. C., Mar 28 2013, In : Cell. 153, 1, p. 267-270 4 p.

Research output: Contribution to journalArticle

2012
114 Citations (Scopus)

Cancer vulnerabilities unveiled by genomic loss

Nijhawan, D., Zack, T. I., Ren, Y., Strickland, M. R., Lamothe, R., Schumacher, S. E., Tsherniak, A., Besche, H. C., Rosenbluh, J., Shehata, S., Cowley, G. S., Weir, B. A., Goldberg, A. L., Mesirov, J. P., Root, D. E., Bhatia, S. N., Beroukhim, R. & Hahn, W. C., Aug 17 2012, In : Cell. 150, 4, p. 842-854 13 p.

Research output: Contribution to journalArticle

Genes
Genomic Instability
Proteasome Endopeptidase Complex
Neoplasms
Spliceosomes
353 Citations (Scopus)

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., Shao, D. D., Schumacher, S. E., Weir, B. A., Vazquez, F., Cowley, G. S., Root, D. E., Mesirov, J. P., Beroukhim, R., Kuo, C. J., Goessling, W. & 1 others, Hahn, W. C., Dec 21 2012, In : Cell. 151, 7, p. 1457-1473 17 p.

Research output: Contribution to journalArticle

Catenins
Carcinogenesis
Neoplasms
Genes
Cells
2011
26 Citations (Scopus)

Rmrp is a non-coding rna essential for early murine development

Rosenbluh, J., Nijhawan, D., Chen, Z., Wong, K. K., Masutomi, K. & Hahn, W. C., 2011, In : PLoS One. 6, 10, e26270.

Research output: Contribution to journalArticle

Untranslated RNA
Cartilage
mice
Alleles
alleles
2009

Regulating TERT: Location, location, location

Rosenbluh, J., Nijhawan, D. & Hahn, W. C., Oct 15 2009, In : Cell Cycle. 8, 20, p. 3257 1 p.

Research output: Contribution to journalArticle

2004
97 Citations (Scopus)

Mitochondrial activation of apoptosis.

Li, P., Nijhawan, D. & Wang, X., Jan 23 2004, In : Cell. 116, 2 Suppl

Research output: Contribution to journalArticle

21st Century History
20th Century History
Autobiography
Oncogene Proteins
Molecular Biology
2003
469 Citations (Scopus)

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

Nijhawan, D., Fang, M., Traer, E., Zhong, Q., Gao, W., Du, F. & Wang, X., Jun 15 2003, In : Genes and Development. 17, 12, p. 1475-1486 12 p.

Research output: Contribution to journalArticle

Caspases
Cytochromes c
Mitochondria
Apoptosis
Proteasome Endopeptidase Complex
2000
240 Citations (Scopus)

Apoptosis in neural development and disease

Nijhawan, D., Honarpour, N. & Wang, X., 2000, In : Annual Review of Neuroscience. 23, p. 73-87 15 p.

Research output: Contribution to journalArticle

Apoptosis
Neurodegenerative Diseases
Cell Death
Neurons
Proteins
1998
152 Citations (Scopus)

Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

Hentati, A., Ouahchi, K., Pericak-Vance, M. A., Nijhawan, D., Ahmad, A., Yang, Y., Rimmler, J., Hung, W. Y., Schlotter, B., Ahmed, A., Ben Hamida, M., Hentati, F. & Siddique, T., 1998, In : Neurogenetics. 2, 1, p. 55-60 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Chromosomes
Genetic Loci
Genetic Heterogeneity
Genetic Markers
1997
356 Citations (Scopus)

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

Rawson, R. B., Zelenski, N. G., Nijhawan, D., Ye, J., Sakai, J., Hasan, M. T., Chang, T. Y., Brown, M. S. & Goldstein, J. L., Dec 1997, In : Molecular Cell. 1, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Proteins
Metalloproteases
Organism Cloning
Genes
Zinc
5739 Citations (Scopus)

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S. & Wang, X., Nov 14 1997, In : Cell. 91, 4, p. 479-489 11 p.

Research output: Contribution to journalArticle

Caspase 9
Cytochromes c
Peptide Hydrolases
Caspase 3
Chemical activation
29 Citations (Scopus)

Familial amyotrophic lateral sclerosis

Siddique, T., Nijhawan, D. & Hentati, A., 1997, In : Journal of Neural Transmission, Supplement. 49, p. 219-233 15 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 21
Mutation
Poisons
Motor Neurons
Transgenic Mice
1996
91 Citations (Scopus)

Molecular genetic basis of familial ALS

Siddique, T., Nijhawan, D. & Hentati, A., Oct 1996, In : Neurology. 47, 4 SUPPL.

Research output: Contribution to journalArticle

Molecular Biology
Mutation
Chromosomes, Human, Pair 21
Motor Neuron Disease
Poisons