• 11793 Citations
  • 58 h-Index
1991 …2019

Research output per year

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Research Output

  • 11793 Citations
  • 58 h-Index
  • 158 Article
  • 7 Review article
  • 2 Editorial
  • 1 Chapter
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Article
2019

Amyloid β perturbs elevated heme flux induced with neuronal development

Vidal, C., Daescu, K., Fitzgerald, K. E., Starokadomska, A., Bezprozvanny, I. & Zhang, L., Jan 1 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 27-37 11 p.

Research output: Contribution to journalArticle

An Optoelectronic Neurostimulation System with Adaptive Feedback

Matveev, M. V., Erofeev, A. I., Pyatishev, E. N., Akulshin, U. D., Bezprozvanny, I. & Vlasova, O. L., Jan 1 2019, In : Neuroscience and Behavioral Physiology.

Research output: Contribution to journalArticle

An Optogenetic Study of the Electrophysiological Properties of Hippocampal Neurons in PS1-M146V Transgenic Mice (a model of Alzheimer’s disease)

Erofeev, A. I., Zakharova, O. A., Terekhin, S. G., Plotnikova, P. V., Bezprozvanny, I. & Vlasova, O. L., Jan 1 2019, In : Neuroscience and Behavioral Physiology.

Research output: Contribution to journalArticle

Antagonist of neuronal store-operated calcium entry exerts beneficial effects in neurons expressing PSEN1ΔE9 mutant linked to familial Alzheimer disease

Chernyuk, D., Zernov, N., Kabirova, M., Bezprozvanny, I. & Popugaeva, E., Jul 1 2019, In : Neuroscience. 410, p. 118-127 10 p.

Research output: Contribution to journalArticle

Derivatives of piperazines as potential therapeutic agents for Alzheimer’s disease

Popugaeva, E., Chernyuk, D., Zhang, H., Postnikova, T. Y., Pats, K., Fedorova, E., Poroikov, V., Zaitsev, A. V. & Bezprozvanny, I., Apr 1 2019, In : Molecular Pharmacology. p. 337-348 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution

Chakraborty, T., Driscoll, M. K., Jeffery, E., Murphy, M. M., Roudot, P., Chang, B. J., Vora, S., Wong, W. M., Nielson, C. D., Zhang, H., Zhemkov, V., Hiremath, C., De La Cruz, E. D., Yi, Y., Bezprozvanny, I., Zhao, H., Tomer, R., Heintzmann, R., Meeks, J. P., Marciano, D. K. & 4 others, Morrison, S. J., Danuser, G., Dean, K. M. & Fiolka, R., Nov 1 2019, In : Nature methods. 16, 11, p. 1109-1113 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Light stimulation parameters determine neuron dynamic characteristics

Erofeev, A., Gerasimov, E., Lavrova, A., Bolshakova, A., Postnikov, E., Bezprozvanny, I. & Vlasova, O. L., Sep 1 2019, In : Applied Sciences (Switzerland). 9, 18, 3673.

Research output: Contribution to journalArticle

Open Access

Mechanism of action of the new ethanolamine derivative bis{2-[(2E)-4-hydroxy-4-oxobut-2-enoyloxy]-N,N-diethylethanaminium}butanedioate

Sysoev, Y. I., Popugaeva, E. A., Chernyuk, D. P., Titovich, I. A., Zagladkina, E. V., Bolotova, V. C., Bezprozvanny, I. & Okovityi, S. V., Jan 1 2019, In : Eksperimental'naya i Klinicheskaya Farmakologiya. 82, 4, p. 3-10 8 p.

Research output: Contribution to journalArticle

Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability

Ryskamp, D. A., Zhemkov, V. & Bezprozvanny, I., Sep 19 2019, In : Frontiers in Neuroscience. 13, 1012.

Research output: Contribution to journalArticle

Open Access

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor

Ryskamp, D., Wu, L., Wu, J., Kim, D., Rammes, G., Geva, M., Hayden, M. & Bezprozvanny, I., Apr 1 2019, In : Neurobiology of Disease. 124, p. 489-504 16 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018
9 Scopus citations

Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders

Egorova, P. A. & Bezprozvanny, I. B., Jan 1 2018, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

14 Scopus citations

In Vivo Analysis of the Climbing Fiber-Purkinje Cell Circuit in SCA2-58Q Transgenic Mouse Model

Egorova, P. A., Gavrilova, A. V. & Bezprozvanny, I. B., Jun 6 2018, (Accepted/In press) In : Cerebellum. p. 1-11 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pin1 mediates Aβ42-induced dendritic spine loss

Stallings, N. R., O'Neal, M. A., Hu, J., Kavalali, E. T., Bezprozvanny, I. & Malter, J. S., Mar 20 2018, In : Science Signaling. 11, 522, eaap8734.

Research output: Contribution to journalArticle

3 Scopus citations

Reactions of Cyclometalated Platinum(II) [Pt(NC)(PR3)Cl] Complexes with Imidazole and Imidazole-Containing Biomolecules: Fine-Tuning of Reactivity and Photophysical Properties via Ligand Design

Solomatina, A. I., Chelushkin, P. S., Abakumova, T. O., Zhemkov, V. A., Kim, M. W., Bezprozvanny, I., Gurzhiy, V. V., Melnikov, A. S., Anufrikov, Y. A., Koshevoy, I. O., Su, S. H., Chou, P. T. & Tunik, S. P., Jan 1 2018, (Accepted/In press) In : Inorganic Chemistry.

Research output: Contribution to journalArticle

1 Scopus citations

STIM proteins as regulators of neuronal store-operated calcium influx

Popugaeva, E. & Bezprozvanny, I., Feb 1 2018, In : Neurodegenerative disease management. 8, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation

Ivachtchenko, A. V., Okun, I., Aladinskiy, V., Ivanenkov, Y., Koryakova, A., Karapetyan, R., Mitkin, O., Salimov, R., Ivashchenko, A. & Bezprozvanny, I., 2017, In : Journal of Alzheimer's Disease. 58, 4, p. 1043-1063 21 p.

Research output: Contribution to journalArticle

3 Scopus citations

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

Pchitskaya, E., Popugaeva, E. & Bezprozvanny, I., 2017, (Accepted/In press) In : Cell Calcium.

Research output: Contribution to journalArticle

58 Scopus citations

Mutational re-modeling of di-aspartyl intramembrane proteases: Uncoupling physiologically-relevant activities from those associated with Alzheimer's disease

Grigorenko, A. P., Moliaka, Y. K., Plotnikova, O. V., Smirnov, A., Nikishina, V. A., Goltsov, A. Y., Gusev, F., Andreeva, T. V., Nelson, O., Bezprozvanny, I. & Rogaev, E. I., 2017, In : Oncotarget. 8, 47, p. 82006-82026 21 p.

Research output: Contribution to journalArticle

1 Scopus citations

Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease

Bol’shakova, A. V., Kraskovskaya, N. A., Gainullina, A. N., Kukanova, E. O., Vlasova, O. L. & Bezprozvanny, I. B., Dec 1 2017, In : Bulletin of Experimental Biology and Medicine. 164, 2, p. 252-258 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Optogenetic light pulses generator

Erofeev, A. I., Matveev, M. V., Zakharova, O. A., Terekhin, S. G., Kilimnik, V. A., Bezprozvanny, I. B. & Vlasova, O. L., Nov 23 2017, In : Journal of Physics: Conference Series. 917, 4, 042023.

Research output: Contribution to journalArticle

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

Pchitskaya, E., Kraskovskaya, N., Chernyuk, D., Popugaeva, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Dec 1 2017, In : Scientific Reports. 7, 1, 17625.

Research output: Contribution to journalArticle

9 Scopus citations

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

Ryskamp, D., Wu, J., Geva, M., Kusko, R., Grossman, I., Hayden, M. & Bezprozvanny, I., Jan 1 2017, In : Neurobiology of Disease. 97, p. 46-59 14 p.

Research output: Contribution to journalArticle

37 Scopus citations
2016

AF710B, a novel M1/σ1 agonist with therapeutic efficacy in animal models of Alzheimer's disease

Fisher, A., Bezprozvanny, I., Wu, L., Ryskamp, D. A., Bar-Ner, N., Natan, N., Brandeis, R., Elkon, H., Nahum, V., Gershonov, E., LaFerla, F. M. & Medeiros, R., Feb 1 2016, In : Neurodegenerative Diseases. 16, 1-2, p. 95-110 16 p.

Research output: Contribution to journalArticle

17 Scopus citations
9 Scopus citations

Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

Popugaeva, E., Pchitskaya, E. & Bezprozvanny, I., Sep 6 2016, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

58 Scopus citations

Enhanced store-operated calcium entry leads to striatal synaptic loss in a huntington’s disease mouse model

Wu, J., Ryskamp, D. A., Liang, X., Egorova, P., Zakharova, O., Hung, G. & Bezprozvanny, I., Jan 6 2016, In : Journal of Neuroscience. 36, 1, p. 125-141 17 p.

Research output: Contribution to journalArticle

55 Scopus citations

In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model

Egorova, P. A., Zakharova, O. A., Vlasova, O. L. & Bezprozvanny, I. B., Jun 1 2016, In : Journal of Neurophysiology. 115, 6, p. 2840-2851 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Store-operated calcium channel complex in postsynaptic spines: A new therapeutic target for alzheimer’s disease treatment

Zhang, H., Sun, S., Wu, L., Pchitskaya, E., Zakharova, O., Tacer, K. F. & Bezprozvanny, I., Nov 23 2016, In : Journal of Neuroscience. 36, 47, p. 11837-11850 14 p.

Research output: Contribution to journalArticle

39 Scopus citations

The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3

Zhemkov, V. A., Kulminskaya, A. A., Bezprozvanny, I. B. & Kim, M., Feb 1 2016, In : FEBS Open Bio. 6, 3, p. 168-178 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Use of optogenetic technology in cell culture models

Erofeev, A. I., Zakharova, O. A., Matveev, M. V., Terekhin, S. G., Bezprozvanny, I. B. & Vlasova, O. L., Sep 15 2016, In : Journal of Physics: Conference Series. 741, 1, 012067.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Calcium Signaling, Excitability, and Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease

Zhang, H., Liu, J., Sun, S., Pchitskaya, E., Popugaeva, E. & Bezprozvanny, I., 2015, In : Journal of Alzheimer's Disease. 45, 2, p. 561-580 20 p.

Research output: Contribution to journalArticle

36 Scopus citations

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

Egorova, P., Popugaeva, E. & Bezprozvanny, I., Apr 1 2015, In : Seminars in Cell and Developmental Biology. 40, p. 127-133 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Investigation of low amyloid level toxicity effects on the function of hippocampal neurons

Popugaeva, E., Pchitskaya, E., Zhang, H., Vlasova, O. & Bezprozvanny, I., Jan 1 2015, In : Open Life Sciences. 10, 1, p. 433-436 4 p.

Research output: Contribution to journalArticle

Neuronal store-operated calcium entry and mushroom spine loss in amyloid precursor protein knock-in mouse model of Alzheimer’s disease

Zhang, H., Wu, L., Pchitskaya, E., Zakharova, O., Saito, T., Saido, T. & Bezprozvanny, I., Sep 30 2015, In : Journal of Neuroscience. 35, 39, p. 13275-13286 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity

Popugaeva, E., Pchitskaya, E., Speshilova, A., Alexandrov, S., Zhang, H., Vlasova, O. & Bezprozvanny, I., Aug 15 2015, In : Molecular Neurodegeneration. 10, 1, 37.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Can the calcium hypothesis explain synaptic loss in alzheimer's disease?

Popugaeva, E. & Bezprozvanny, I., Jan 2014, In : Neurodegenerative Diseases. 13, 2-3, p. 139-141 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Huntington’s disease: Cellular and molecular basis of pathology

Korzhova, V. V., Artamonov, D. N., Vlasova, O. L. & Bezprozvanny, I. B., 2014, In : Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. 64, 4, p. 359-375 17 p.

Research output: Contribution to journalArticle

3 Scopus citations

Intracellular calcium channels: Inositol-1,4,5-trisphosphate receptors

Fedorenko, O. A., Popugaeva, E., Enomoto, M., Stathopulos, P. B., Ikura, M. & Bezprozvanny, I., Sep 15 2014, In : European Journal of Pharmacology. 739, C, p. 39-48 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Optogenetic approach to the studies of synaptic transmission

Artamonov, D. N., Korzhova, V. V., Vlasova, O. L. & Bezprozvannyi, I. B., 2014, In : Bulletin of Experimental Biology and Medicine. 157, 3, p. 404-407 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice

Sun, S., Zhang, H., Liu, J., Popugaeva, E., Xu, N. J., Feske, S., White, C. L. & Bezprozvanny, I., Apr 2 2014, In : Neuron. 82, 1, p. 79-93 15 p.

Research output: Contribution to journalArticle

129 Scopus citations

Simplified method to perform CLARITY imaging

Poguzhelskaya, E., Artamonov, D., Bolshakova, A., Vlasova, O. & Bezprozvanny, I., May 26 2014, In : Molecular Neurodegeneration. 9, 1, 19.

Research output: Contribution to journalArticle

29 Scopus citations

The effect of SK channel modulators on the simple spike firing frequency in discharge of cerebellar Purkinje cells in laboratory mice

Egorova, P. A., Karelina, T. V., Vlasova, O. L., Antonov, S. M. & Bezprozvanny, I. B., 2014, In : Journal of Evolutionary Biochemistry and Physiology. 50, 2, p. 114-120 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Liu, J., Supnet, C., Sun, S., Zhang, H., Good, L., Popugaeva, E. & Bezprozvanny, I., 2014, In : Channels. 8, 3, p. 230-242 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands

Luo, Y., Vali, S., Sun, S., Chen, X., Liang, X., Drozhzhina, T., Popugaeva, E. & Bezprozvanny, I., Jun 19 2013, In : ACS Chemical Neuroscience. 4, 6, p. 952-962 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Bilayer measurement of endoplasmic reticulum Ca2+ channels

Bezprozvanny, I., Nov 2013, In : Cold Spring Harbor Protocols. 2013, 11, p. 1012-1016 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of synaptic dysfunction in an in vitro corticostriatal model system of Huntington's disease

Artamonov, D. N., Korzhova, V. V., Wu, J., Rybalchenko, P. D., Im, K., Krasnoborova, V. A., Vlasova, O. L. & Bezprozvanny, I. B., Jul 2013, In : Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 7, 3, p. 192-202 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Characterization of synaptic dysfunction in an In Vitro corticostriatal model system of Huntington's disease

Artamonov, D. N., Korzhova, V. V., Wu, J., Rybalchenko, P. D., Im, C., Krasnoborova, V. A., Vlasova, O. L. & Bezprozvanny, I. B., 2013, In : Biologicheskie Membrany. 30, 4, p. 276-288 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Preparation of microsomes to study Ca2+ channels

Bezprozvanny, I., Nov 2013, In : Cold Spring Harbor Protocols. 2013, 11, p. 1037-1040 4 p.

Research output: Contribution to journalArticle

3 Scopus citations