• 1766 Citations
  • 19 h-Index
19982019
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Research Output 1998 2019

  • 1766 Citations
  • 19 h-Index
  • 34 Article
  • 2 Review article
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Article
2019
1 Citation (Scopus)

Transcriptional Circuit Fragility Influences HIV Proviral Fate

Morton, E. L., Forst, C. V., Zheng, Y., DePaula-Silva, A. B., Ramirez, N. G. P., Planelles, V. & D'orso, I., Apr 2 2019, In : Cell Reports. 27, 1, p. 154-171.e9

Research output: Contribution to journalArticle

Open Access
HIV
Networks (circuits)
Transcriptional Activation
Viruses
Chemical activation
2018
3 Citations (Scopus)

The HIV-1 tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

Faust, T. B., Li, Y., Bacon, C. W., Jang, G. M., Weiss, A., Jayaraman, B., Newton, B. W., Krogan, N. J., D’orso, I. & Frankel, A. D., May 30 2018, In : eLife. 7, e31879.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Human Immunodeficiency Virus tat Gene Products
Small Nuclear Ribonucleoproteins
tat Gene Products
Ligases
2017
5 Citations (Scopus)
Deoxyribonucleases
Workflow
Sequencing
Work Flow
Genomics
1 Citation (Scopus)

Tandem affinity purification of protein complexes from eukaryotic cells

Ma, Z., Fung, V. & D'orso, I., Jan 26 2017, In : Journal of Visualized Experiments. 2017, 119, e55236.

Research output: Contribution to journalArticle

Eukaryotic Cells
Purification
Proteins
Post Translational Protein Processing
Acetylation
2016
8 Citations (Scopus)

7SKiing on chromatin: Move globally, act locally

D'Orso, I., Jun 2 2016, In : RNA Biology. 13, 6, p. 545-553 9 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Genetic Promoter Regions
Chromatin
Phosphotransferases
Small Nuclear Ribonucleoproteins
4 Citations (Scopus)

Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II

McNamara, R. P., Guzman, C., Reeder, J. E. & D'Orso, I., Mar 1 2016, In : Genomics Data. 7, p. 250-255 6 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Small Nuclear Ribonucleoproteins
RNA Polymerase II
Genes
Genome
50 Citations (Scopus)

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II

McNamara, R. P., Reeder, J. E., McMillan, E. A., Bacon, C. W., McCann, J. L. & D'Orso, I., Jan 7 2016, In : Molecular Cell. 61, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

Small Nuclear Ribonucleoproteins
Positive Transcriptional Elongation Factor B
RNA Polymerase II
Genetic Promoter Regions
Genes
2015
2 Citations (Scopus)

Association of UBP1 to ribonucleoprotein complexes is regulated by interaction with the trypanosome ortholog of the human multifunctional P32 protein

Cassola, A., Romaniuk, M. A., Primrose, D., Cervini, G., D'Orso, I. & Frasch, A. C., Sep 1 2015, In : Molecular Microbiology. 97, 6, p. 1079-1096 18 p.

Research output: Contribution to journalArticle

Trypanosoma
Ribonucleoproteins
Trypanosomiasis
Proteins
Messenger RNA
15 Citations (Scopus)

HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

Reeder, J. E., Kwak, Y. T., McNamara, R. P., Forst, C. V. & D’Orso, I., Oct 21 2015, In : eLife. 4, OCTOBER2015, 08955.

Research output: Contribution to journalArticle

RNA Polymerase II
Epigenomics
Transcription
Genes
HIV
19 Citations (Scopus)

PPM1G binds 7SK RNA and Hexim1 to block P-TEFb assembly into the 7SK snRNP and sustain transcription elongation

Gudipaty, S. A., McNamara, R. P., Morton, E. L. & D'Orso, I., 2015, In : Molecular and Cellular Biology. 35, 22, p. 3810-3828 19 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Small Nuclear Ribonucleoproteins
RNA
Phosphotransferases
Biological Phenomena
2013
Posters
Transcription
Ports and harbors
Medical Schools
Atmosphere
43 Citations (Scopus)

Transcription factors mediate the enzymatic disassembly of promoter-bound 7sk snrnp to locally recruit p-tefb for transcription elongation

McNamara, R., McCann, J., Gudipaty, S. A. & D'Orso, I., Dec 12 2013, In : Cell Reports. 5, 5, p. 1256-1268 13 p.

Research output: Contribution to journalArticle

Small Nuclear Ribonucleoproteins
Peptide Elongation Factors
Transcription
Elongation
Transcription Factors
2012
381 Citations (Scopus)

Global landscape of HIV-human protein complexes

Jäger, S., Cimermancic, P., Gulbahce, N., Johnson, J. R., McGovern, K. E., Clarke, S. C., Shales, M., Mercenne, G., Pache, L., Li, K., Hernandez, H., Jang, G. M., Roth, S. L., Akiva, E., Marlett, J., Stephens, M., D'Orso, I., Fernandes, J., Fahey, M., Mahon, C. & 17 others, Oĝdonoghue, A. J., Todorovic, A., Morris, J. H., Maltby, D. A., Alber, T., Cagney, G., Bushman, F. D., Young, J. A., Chanda, S. K., Sundquist, W. I., Kortemme, T., Hernandez, R. D., Craik, C. S., Burlingame, A., Sali, A., Frankel, A. D. & Krogan, N. J., Jan 19 2012, In : Nature. 481, 7381, p. 365-370 6 p.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus Proteins
HIV
Viral Proteins
Proteins
Prokaryotic Initiation Factor-3
15 Citations (Scopus)

Transcription control by long non-coding RNAs

Faust, T., Frankel, A. D. & D'Orso, I., Mar 2012, In : Transcription. 3, 2, p. 78-86 9 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Untranslated RNA
Transcription
Gene expression
Genes
32 Citations (Scopus)

Transition step during assembly of HIV tat: P-TEFb transcription complexes and transfer to TAR RNA

D'orso, I., Jang, G. M., Pastuszak, A. W., Faust, T. B., Quezada, E., Booth, D. S. & Frankel, A. D., Dec 2012, In : Molecular and Cellular Biology. 32, 23, p. 4780-4793 14 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Small Nuclear Ribonucleoproteins
HIV
RNA
Phosphotransferases
2011
41 Citations (Scopus)

Purification and characterization of HIV-human protein complexes

Jäger, S., Gulbahce, N., Cimermancic, P., Kane, J., He, N., Chou, S., D'Orso, I., Fernandes, J., Jang, G., Frankel, A. D., Alber, T., Zhou, Q. & Krogan, N. J., Jan 2011, In : Methods. 53, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus Proteins
Purification
Proteins
Viral Proteins
Pathogens
2010
13 Citations (Scopus)

HIV-1 Tat: Its dependence on host factors is crystal clear

D'Orso, I. & Frankel, A. D., Oct 2010, In : Viruses. 2, 10, p. 2226-2234 9 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
HIV-1
Cyclin T
tat Gene Products
Viral Proteins
77 Citations (Scopus)

RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation

D'Orso, I. & Frankel, A. D., Jul 2010, In : Nature Structural and Molecular Biology. 17, 7, p. 815-821 7 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Small Nuclear Ribonucleoproteins
RNA
HIV-1
Untranslated RNA
2009
334 Citations (Scopus)

Host cell factors in HIV replication: Meta-analysis of genome-wide studies

Bushman, F. D., Malani, N., Fernandes, J., D'Orso, I., Cagney, G., Diamond, T. L., Zhou, H., Hazuda, D. J., Espeseth, A. S., König, R., Bandyopadhyay, S., Ideker, T., Goff, S. P., Krogan, N. J., Frankel, A. D., Young, J. A. T. & Chanda, S. K., May 2009, In : PLoS Pathogens. 5, 5, e1000437.

Research output: Contribution to journalArticle

Meta-Analysis
HIV
Genome
Genes
Small Interfering RNA
52 Citations (Scopus)
Cyclin T
Viral RNA
Acetylation
Proteins
tat Gene Products
2008
80 Citations (Scopus)

A Solution to Limited Genomic Capacity: Using Adaptable Binding Surfaces to Assemble the Functional HIV Rev Oligomer on RNA

Daugherty, M. D., D'Orso, I. & Frankel, A. D., Sep 26 2008, In : Molecular Cell. 31, 6, p. 824-834 11 p.

Research output: Contribution to journalArticle

HIV
RNA
Ribonucleoproteins
Viral Genome
Protein Subunits
11 Citations (Scopus)

Targeting Tat inhibitors in the assembly of human immunodeficiency virus type 1 transcription complexes

D'Orso, I., Grunwell, J. R., Nakamura, R. L., Das, C. & Frankel, A. D., Oct 2008, In : Journal of Virology. 82, 19, p. 9492-9504 13 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
RNA Polymerase II
DNA-directed RNA polymerase
Positive Transcriptional Elongation Factor B
2007
33 Citations (Scopus)

mRNA maturation by two-step trans-splicing/polyadenylation processing in trypanosomes

Jäger, A. V., De Gaudenzi, J. G., Cassola, A., D'Orso, I. & Frasch, A. C., Feb 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 7, p. 2035-2042 8 p.

Research output: Contribution to journalArticle

Trans-Splicing
Polyadenylation
Trypanosomiasis
Messenger RNA
Polypyrimidine Tract-Binding Protein
33 Citations (Scopus)

Small trypanosome RNA-binding proteins TbUBP1 and TbUBP2 influence expression of F-box protein mRNAs in bloodstream trypanosomes

Hartmann, C., Benz, C., Brems, S., Ellis, L., Luu, V. D., Stewart, M., D'Orso, I., Busold, C., Fellenberg, K., Frasch, A. C. C., Carrington, M., Hoheisel, J. & Clayton, C. E., Nov 2007, In : Eukaryotic Cell. 6, 11, p. 1964-1978 15 p.

Research output: Contribution to journalArticle

F-Box Proteins
F-box proteins
RNA-binding proteins
RNA-Binding Proteins
Trypanosomiasis
2005
15 Citations (Scopus)

Insights into a CRM1-mediated RNA-nuclear export pathway in Trypanosoma cruzi

Cuevas, I. C., Frasch, A. C. C. & D'Orso, I., Jan 2005, In : Molecular and Biochemical Parasitology. 139, 1, p. 15-24 10 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Trypanosoma cruzi
RNA
Nuclear Export Signals
Proteins
28 Citations (Scopus)

NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: Contribution of a β hairpin to RNA binding

Volpon, L., D'Orso, I., Young, C. R., Frasch, A. C. & Gehring, K., Mar 15 2005, In : Biochemistry. 44, 10, p. 3708-3717 10 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
RNA
Proteins
2003
48 Citations (Scopus)

RNA-binding proteins and mRNA turnover in trypanosomes

D'Orso, I., De Gaudenzi, J. G. & Frasch, A. C. C., Apr 1 2003, In : Trends in Parasitology. 19, 4, p. 151-155 5 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Trypanosomiasis
AU Rich Elements
Messenger RNA
Kinetoplastida
36 Citations (Scopus)

RNA recognition motif-type RNA-binding proteins in Trypanosoma cruzi form a family involved in the interaction with specific transcripts in vivo

De Gaudenzi, J. G., D'Orso, I. & Frasch, A. C. C., May 23 2003, In : Journal of Biological Chemistry. 278, 21, p. 18884-18894 11 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Trypanosoma cruzi
RNA
Trypanosomiasis
Kinetoplastida
15 Citations (Scopus)

Solution structure of the C-terminal domain from poly(A)-binding protein in trypanosoma cruzi: A vegetal PABC domain

Siddiqui, N., Kozlov, G., D'Orso, I., Trempe, J. F. & Gehring, K., Sep 1 2003, In : Protein Science. 12, 9, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

Poly(A)-Binding Proteins
Trypanosoma cruzi
Proteins
Peptides
Poly A
2002
61 Citations (Scopus)
Poly(A)-Binding Proteins
AU Rich Elements
Ribonucleoproteins
Trypanosomiasis
RNA-Binding Proteins
2001
44 Citations (Scopus)
AU Rich Elements
RNA-Binding Proteins
Trypanosoma cruzi
RNA Stability
Messenger RNA
67 Citations (Scopus)

TcUBP-1, a Developmentally Regulated U-rich RNA-binding Protein Involved in Selective mRNA Destabilization in Trypanosomes

D'Orso, I. & Frasch, A. C. C., Sep 14 2001, In : Journal of Biological Chemistry. 276, 37, p. 34801-34809 9 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Trypanosomiasis
Messenger RNA
Parasites
RNA Stability
2000
112 Citations (Scopus)

AU-rich elements in the 3'-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency

Di Noia, J. M., D'Orso, I., Sánchez, D. O. & Frasch, A. C. C., Apr 7 2000, In : Journal of Biological Chemistry. 275, 14, p. 10218-10227 10 p.

Research output: Contribution to journalArticle

AU Rich Elements
Trypanosoma cruzi
RNA Stability
3' Untranslated Regions
Mucins
1998
65 Citations (Scopus)

The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions

Di Noia, J. M., D'Orso, I., Åslund, L., Sánchez, D. O. & Frasch, A. C. C., May 1 1998, In : Journal of Biological Chemistry. 273, 18, p. 10843-10850 8 p.

Research output: Contribution to journalArticle

Trypanosoma cruzi
Mucins
Genes
Parasites
Clone Cells