• 2576 Citations
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20042019
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Research Output 2004 2019

2019
2 Citations (Scopus)

Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations (Nature, (2016), 540, 7632, (270-275), 10.1038/nature20592)

Kang, E., Wu, J., Gutierrez, N. M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S. & 10 others, Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D. P., Temiakov, D., Belmonte, J. C. I., Amato, P. & Mitalipov, S., Mar 14 2019, In : Nature. 567, 7747, p. E5-E9

Research output: Contribution to journalComment/debate

Open Access
Mitochondrial DNA
Haplotypes
Oocytes
Ovum
History
3 Citations (Scopus)

Dissecting primate early post-implantation development using long-term in vitro embryo culture

Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., Wei, J., Liu, L., Feng, S., Kang, Y., Si, W., Wang, H., Zhang, E., Zhao, L., Li, Z., Luo, X., Cui, G. & 4 others, Peng, G., Belmonte, J. C. I., Ji, W. & Tan, T., Nov 15 2019, In : Science. 366, 6467, eaaw5754.

Research output: Contribution to journalArticle

Primates
Embryonic Structures
Single-Cell Analysis
RNA Sequence Analysis
Germ Layers

Embryonic chimeras with human pluripotent stem cells

De Los Angeles, A., Sakurai, M. & Wu, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 125-151 27 p. (Methods in Molecular Biology; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pluripotent Stem Cells
Primates
Blastocyst
Tankyrases
Cercopithecus aethiops
4 Citations (Scopus)

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., Liao, H. K., Qiao, J., Deng, H., Nuñez-Delicado, E., Rodriguez Esteban, C., Wu, J. & Izpisua Belmonte, J. C., Oct 17 2019, In : Cell. 179, 3, p. 687-702.e18

Research output: Contribution to journalArticle

Blastocyst
Stem cells
Cell culture
Embryonic Structures
Cell Culture Techniques

Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system

Xu, J., Yu, L., Guo, J., Xiang, J., Zheng, Z., Gao, D., Shi, B., Hao, H., Jiao, D., Zhong, L., Wang, Y., Wu, J., Wei, H. & Han, J., Jun 27 2019, In : Stem Cell Research and Therapy. 10, 1, 193.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Stem cells
Cell culture
Pericytes

Highly efficient derivation of pluripotent stem cells from mouse preimplantation and postimplantation embryos in serum-free conditions

De Los Angeles, A., Okamura, D. & Wu, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 29-36 8 p. (Methods in Molecular Biology; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pluripotent Stem Cells
Blastocyst
Serum
Germ Layers
Axin Protein
4 Citations (Scopus)

In vitro breeding: Application of embryonic stem cells to animal production

Goszczynski, D. E., Cheng, H., Demyda-Peyrás, S., Medrano, J. F., Wu, J. & Ross, P. J., Jan 1 2019, In : Biology of reproduction. 100, 4, p. 885-895 11 p.

Research output: Contribution to journalReview article

Open Access
Embryonic Stem Cells
Breeding
Livestock
Germ Cells
Blastocyst Inner Cell Mass

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Hishida, T., Vazquez-Ferrer, E., Hishida-Nozaki, Y., Sancho-Martinez, I., Takahashi, Y., Hatanaka, F., Wu, J., Ocampo, A., Reddy, P., Wu, M. Z., Gerken, L., Shaw, R. J., Rodriguez Esteban, C., Benner, C., Nakagawa, H., Guillen Garcia, P., Nuñez Delicado, E., Castells, A., Campistol, J. M., Liu, G. H. & 1 others, Izpisua Belmonte, J. C., Jul 1 2019, In : Protein and Cell. 10, 7, p. 485-495 11 p.

Research output: Contribution to journalArticle

Open Access
Tumors
Hyperplasia
Mutation
Neoplasms
Epithelial Cells

Pig chimeric model with human pluripotent stem cells

Zhong, C., Wu, J. & Izpisua Belmonte, J. C., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 101-124 24 p. (Methods in Molecular Biology; vol. 2005).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pluripotent Stem Cells
Swine
Embryonic Structures
Tissue Donors
Regenerative Medicine
1 Citation (Scopus)

Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

Suzuki, K., Yamamoto, M., Hernandez-Benitez, R., Li, Z., Wei, C., Soligalla, R. D., Aizawa, E., Hatanaka, F., Kurita, M., Reddy, P., Ocampo, A., Hishida, T., Sakurai, M., Nemeth, A. N., Nuñez Delicado, E., Campistol, J. M., Magistretti, P., Guillen, P., Rodriguez Esteban, C., Gong, J. & 7 others, Yuan, Y., Gu, Y., Liu, G. H., López-Otín, C., Wu, J., Zhang, K. & Izpisua Belmonte, J. C., Oct 1 2019, In : Cell Research. 29, 10, p. 804-819 16 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Gene Targeting
Introns
Gene Knock-In Techniques
Premature Aging
4 Citations (Scopus)

Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

Zhang, Y., Li, T., Preissl, S., Amaral, M. L., Grinstein, J. D., Farah, E. N., Destici, E., Qiu, Y., Hu, R., Lee, A. Y., Chee, S., Ma, K., Ye, Z., Zhu, Q., Huang, H., Fang, R., Yu, L., Izpisua Belmonte, J. C., Wu, J., Evans, S. M. & 2 others, Chi, N. C. & Ren, B., Sep 1 2019, In : Nature genetics. 51, 9, p. 1380-1388 9 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Pluripotent Stem Cells
Retroelements
Chromatin
Hominidae
3 Citations (Scopus)

Up-regulation of FOXD1 by yap alleviates senescence and osteoarthritis

Fu, L., Hu, Y., Song, M., Liu, Z., Zhang, W., Yu, F. X., Wu, J., Wang, S., Belmonte, J. C. I., Chan, P., Qu, J., Tang, F. & Liu, G. H., Apr 2019, In : PLoS biology. 17, 4, e3000201.

Research output: Contribution to journalArticle

Open Access
Yap
osteoarthritis
Forkhead Transcription Factors
Osteoarthritis
Up-Regulation
2018
19 Citations (Scopus)

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

Wang, S., Hu, B., Ding, Z., Dang, Y., Wu, J., Li, D., Liu, X., Xiao, B., Zhang, W., Ren, R., Lei, J., Hu, H., Chen, C., Chan, P., Li, D., Qu, J., Tang, F. & Liu, G. H., Dec 1 2018, In : Cell Discovery. 4, 1, 2.

Research output: Contribution to journalArticle

Open Access
Cell Aging
Stem cells
Mesenchymal Stromal Cells
Organelles
Homeostasis
32 Citations (Scopus)

Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts

Bogliotti, Y. S., Wu, J., Vilarino, M., Okamura, D., Soto, D. A., Zhong, C., Sakurai, M., Sampaio, R. V., Suzuki, K., Izpisua Belmonte, J. C. & Ross, P. J., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2090-2095 6 p.

Research output: Contribution to journalArticle

Open Access
Pluripotent Stem Cells
Blastocyst
Embryonic Stem Cells
Wnt Signaling Pathway
Blastocyst Inner Cell Mass
3 Citations (Scopus)

First stem cell transplantation to regenerate human lung

Wang, S., Wu, J. & Liu, G. H., Mar 1 2018, In : Protein and Cell. 9, 3, p. 244-245 2 p.

Research output: Contribution to journalArticle

Open Access
Regenerative Medicine
Stem Cell Transplantation
Cell Culture Techniques
Lung
22 Citations (Scopus)

In vivo reprogramming of wound-resident cells generates skin epithelial tissue

Kurita, M., Araoka, T., Hishida, T., O’keefe, D. D., Takahashi, Y., Sakamoto, A., Sakurai, M., Suzuki, K., Wu, J., Yamamoto, M., Hernandez-Benitez, R., Ocampo, A., Reddy, P., Shokhirev, M. N., Magistretti, P., Delicado, E. N., Eto, H., Harii, K. & Belmonte, J. C. I., Jan 1 2018, In : Nature. 561, 7722, p. 243-270 28 p.

Research output: Contribution to journalLetter

Skin Ulcer
Epithelium
Skin
Wounds and Injuries
Cell Lineage
11 Citations (Scopus)

Ma et al. reply

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Hayama, T., Darby, H., Van Dyken, C., Li, Y., Koski, A., Liang, D., Suzuki, K., Gu, Y., Gong, J., Xu, X., Ahmed, R., Lee, Y., Kang, E., Ji, D., Park, A. R., Kim, D. & 12 others, Kim, S. T., Heitner, S. B., Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Amato, P., Kaul, S., Belmonte, J. C. I., Kim, J. S. & Mitalipov, S., Aug 9 2018, In : Nature. 560, 7717, p. E10-E23

Research output: Contribution to journalArticle

2017
340 Citations (Scopus)

Correction of a pathogenic gene mutation in human embryos

Ma, H., Marti-Gutierrez, N., Park, S. W., Wu, J., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., Darby, H., Van Dyken, C., Li, Y., Kang, E., Park, A. R., Kim, D., Kim, S. T., Gong, J., Gu, Y., Xu, X. & 11 others, Battaglia, D., Krieg, S. A., Lee, D. M., Wu, D. H., Wolf, D. P., Heitner, S. B., Belmonte, J. C. I., Amato, P., Kim, J. S., Kaul, S. & Mitalipov, S., Aug 24 2017, In : Nature. 548, 7668, p. 413-419 7 p.

Research output: Contribution to journalArticle

Embryonic Structures
Mutation
Genes
Clustered Regularly Interspaced Short Palindromic Repeats
Preimplantation Diagnosis
14 Citations (Scopus)

CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs

Wu, J., Vilarino, M., Suzuki, K., Okamura, D., Bogliotti, Y. S., Park, I., Rowe, J., McNabb, B., Ross, P. J. & Belmonte, J. C. I., Dec 1 2017, In : Scientific reports. 7, 1, 10487.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Swine
Gene Targeting
Zygote
Human Development
90 Citations (Scopus)

Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency

Yang, Y., Liu, B., Xu, J., Wang, J., Wu, J., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., Zhu, J., Xiong, L., Zhu, D., Li, X., Yang, W., Yamauchi, T., Sugawara, A., Li, Z., Sun, F., Li, X. & 15 others, Li, C., He, A., Du, Y., Wang, T., Zhao, C., Li, H., Chi, X., Zhang, H., Liu, Y., Li, C., Duo, S., Yin, M., Shen, H., Belmonte, J. C. I. & Deng, H., Apr 6 2017, In : Cell. 169, 2, p. 243-257.e25

Research output: Contribution to journalArticle

Open Access
Pluripotent Stem Cells
Stem cells
Stem Cells
Translational Medical Research
Tetraploidy
5 Citations (Scopus)

Developmental competence of porcine genome-edited zygotes

Gil, M. A., Martinez, C. A., Nohalez, A., Parrilla, I., Roca, J., Wu, J., Ross, P. J., Cuello, C., Izpisua, J. C. & Martinez, E. A., Sep 2017, In : Molecular Reproduction and Development. 84, 9, p. 814-821 8 p.

Research output: Contribution to journalReview article

Zygote
Mental Competency
Swine
Genome
Clustered Regularly Interspaced Short Palindromic Repeats
22 Citations (Scopus)

Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding

Yang, J., Li, J., Suzuki, K., Liu, X., Wu, J., Zhang, W., Ren, R., Zhang, W., Chan, P., Izpisua Belmonte, J. C., Qu, J., Tang, F. & Liu, G. H., Sep 1 2017, In : Cell Research. 27, 9, p. 1178-1181 4 p.

Research output: Contribution to journalLetter

Genetic Enhancement
Adult Stem Cells
Nucleotides
16 Citations (Scopus)

Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells

Takahashi, Y., Wu, J., Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H. K., Wu, M. Z., Hernández-Benítez, R., Hishida, T., Shokhirev, M. N., Rodriguez Esteban, C., Sancho-Martinez, I. & Izpisua Belmonte, J. C., May 5 2017, In : Science. 356, 6337, p. 503-508 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
CpG Islands
Methylation
DNA
Angelman Syndrome
155 Citations (Scopus)

Interspecies Chimerism with Mammalian Pluripotent Stem Cells

Wu, J., Platero-Luengo, A., Sakurai, M., Sugawara, A., Gil, M. A., Yamauchi, T., Suzuki, K., Bogliotti, Y. S., Cuello, C., Morales Valencia, M., Okumura, D., Luo, J., Vilariño, M., Parrilla, I., Soto, D. A., Martinez, C. A., Hishida, T., Sánchez-Bautista, S., Martinez-Martinez, M. L., Wang, H. & 17 others, Nohalez, A., Aizawa, E., Martinez-Redondo, P., Ocampo, A., Reddy, P., Roca, J., Maga, E. A., Esteban, C. R., Berggren, W. T., Nuñez Delicado, E., Lajara, J., Guillen, I., Guillen, P., Campistol, J. M., Martinez, E. A., Ross, P. J. & Izpisua Belmonte, J. C., Jan 26 2017, In : Cell. 168, 3, p. 473-486.e15

Research output: Contribution to journalArticle

Open Access
Pluripotent Stem Cells
Chimerism
Stem cells
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
23 Citations (Scopus)

Visualization of aging-associated chromatin alterations with an engineered TALE system

Ren, R., Deng, L., Xue, Y., Suzuki, K., Zhang, W., Yu, Y., Wu, J., Sun, L., Gong, X., Luan, H., Yang, F., Ju, Z., Ren, X., Wang, S., Tang, H., Geng, L., Zhang, W., Li, J., Qiao, J., Xu, T. & 2 others, Qu, J. & Liu, G. H., Apr 1 2017, In : Cell Research. 27, 4, p. 483-504 22 p.

Research output: Contribution to journalArticle

Thioredoxins
Chromatin
Premature Aging
Biological Phenomena
Centromere
2016
61 Citations (Scopus)

3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors

Li, Z., Araoka, T., Wu, J., Liao, H. K., Li, M., Lazo, M., Zhou, B., Sui, Y., Wu, M. Z., Tamura, I., Xia, Y., Beyret, E., Matsusaka, T., Pastan, I., Rodriguez Esteban, C., Guillen, I., Guillen, P., Campistol, J. M. & Izpisua Belmonte, J. C., Oct 6 2016, In : Cell Stem Cell. 19, 4, p. 516-529 14 p.

Research output: Contribution to journalArticle

Open Access
Nephrons
Stem Cells
Kidney
Organoids
Induced Pluripotent Stem Cells
14 Citations (Scopus)

An overview of mammalian pluripotency

Wu, J., Yamauchi, T. & Belmonte, J. C. I., May 15 2016, In : Development (Cambridge). 143, 10, p. 1644-1648 5 p.

Research output: Contribution to journalArticle

Open Access
Pluripotent Stem Cells
Stem Cell Research
Germ Layers
Posters
Translational Medical Research
43 Citations (Scopus)

Cellular Metabolism and Induced Pluripotency

Wu, J., Ocampo, A. & Belmonte, J. C. I., Sep 8 2016, In : Cell. 166, 6, p. 1371-1385 15 p.

Research output: Contribution to journalReview article

Open Access
Stem cells
Metabolism
Induced Pluripotent Stem Cells
Plasticity
Metabolic Networks and Pathways
12 Citations (Scopus)

Generation of human organs in pigs via interspecies blastocyst complementation

Wu, J., Platero Luengo, A., Gil, M. A., Suzuki, K., Cuello, C., Morales Valencia, M., Parrilla, I., Martinez, C. A., Nohalez, A., Roca, J., Martinez, E. A. & Izpisua Belmonte, J. C., Oct 1 2016, In : Reproduction in Domestic Animals. 51, p. 18-24 7 p.

Research output: Contribution to journalArticle

Blastocyst
blastocyst
Induced Pluripotent Stem Cells
Swine
stem cells
10 Citations (Scopus)

Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts

Wu, J. & Belmonte, J. C. I., Jun 1 2016, In : Transgenic Research. 25, 3, p. 375-384 10 p.

Research output: Contribution to journalReview article

Stem Cell Research
Pluripotent Stem Cells
Tissue and Organ Procurement
Zygote
Organ Transplantation
322 Citations (Scopus)

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E. J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., Kurita, M., Hishida, T., Li, M., Aizawa, E., Guo, S., Chen, S., Goebl, A., Soligalla, R. D., Qu, J., Jiang, T. & 15 others, Fu, X., Jafari, M., Esteban, C. R., Berggren, W. T., Lajara, J., Nuñez-Delicado, E., Guillen, P., Campistol, J. M., Matsuzaki, F., Liu, G. H., Magistretti, P., Zhang, K., Callaway, E. M., Zhang, K. & Belmonte, J. C. I., Dec 1 2016, In : Nature. 540, 7631, p. 144-149 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Retinal Degeneration
Inborn Genetic Diseases
Retinitis Pigmentosa
Transgenes
24 Citations (Scopus)

Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells

Suzuki, A., Hirasaki, M., Hishida, T., Wu, J., Okamura, D., Ueda, A., Nishimoto, M., Nakachi, Y., Mizuno, Y., Okazaki, Y., Matsui, Y., Belmonte, J. C. I. & Okuda, A., Mar 30 2016, In : Nature communications. 7, 11056.

Research output: Contribution to journalArticle

Open Access
stem cells
Meiosis
Stem cells
entry
mice
78 Citations (Scopus)

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

Kang, E., Wu, J., Gutierrez, N. M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., Hayama, T., Van Dyken, C., Wang, X., Luo, S., Ahmed, R., Li, Y., Ji, D., Kayali, R., Cinnioglu, C., Olson, S. & 10 others, Jensen, J., Battaglia, D., Lee, D., Wu, D., Huang, T., Wolf, D. P., Temiakov, D., Belmonte, J. C. I., Amato, P. & Mitalipov, S., Dec 8 2016, In : Nature. 540, 7632, p. 270-275 6 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Oocytes
Mutation
Mothers
Tissue Donors
18 Citations (Scopus)

Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs

Fu, L., Xu, X., Ren, R., Wu, J., Zhang, W., Yang, J., Ren, X., Wang, S., Zhao, Y., Sun, L., Yu, Y., Wang, Z., Yang, Z., Yuan, Y., Qiao, J., Belmonte, J. C. I., Qu, J. & Liu, G. H., Mar 1 2016, In : Protein and Cell. 7, 3, p. 210-221 12 p.

Research output: Contribution to journalArticle

Open Access
Xeroderma Pigmentosum
Induced Pluripotent Stem Cells
Pathology
Stem cells
DNA
89 Citations (Scopus)

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., Li, Y., Yang, J., Hao, Y., Yuan, T., Yuan, G., Wang, H., Ju, Z., Mao, Z., Li, J., Qu, J. & 2 others, Tang, F. & Liu, G. H., Feb 1 2016, In : Cell Research. 26, 2, p. 190-205 16 p.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Oxidative Stress
Heme Oxygenase-1
Homeostasis
Chromosomal Instability
36 Citations (Scopus)

Stem Cells: A Renaissance in Human Biology Research

Wu, J. & Izpisua Belmonte, J. C., Jun 16 2016, In : Cell. 165, 7, p. 1572-1585 14 p.

Research output: Contribution to journalReview article

Open Access
Stem cells
Stem Cells
Research
Innovation
Inventions
50 Citations (Scopus)

Stem cells and interspecies chimaeras

Wu, J., Greely, H. T., Jaenisch, R., Nakauchi, H., Rossant, J. & Belmonte, J. C. I., Dec 1 2016, In : Nature. 540, 7631, p. 51-59 9 p.

Research output: Contribution to journalReview article

Stem Cells
Imagination
Research
5 Citations (Scopus)

The Molecular Harbingers of Early Mammalian Embryo Patterning

Wu, J. & Belmonte, J. C. I., Mar 24 2016, In : Cell. 165, 1, p. 13-15 3 p.

Research output: Contribution to journalShort survey

Open Access
Mammalian Embryo
2015
119 Citations (Scopus)

An alternative pluripotent state confers interspecies chimaeric competency

Wu, J., Okamura, D., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., Krause, M. N., Nery, J. R., Du, T., Zhang, Z., Hishida, T., Takahashi, Y., Aizawa, E., Kim, N. Y., Lajara, J., Guillen, P. & 7 others, Campistol, J. M., Esteban, C. R., Ross, P. J., Saghatelian, A., Ren, B., Ecker, J. R. & Belmonte, J. C. I., May 21 2015, In : Nature. 521, 7552, p. 316-321 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Aptitude
Stem Cells
Embryonic Structures
Germ Layers
109 Citations (Scopus)

Brains, Genes, and Primates

Izpisua Belmonte, J. C., Callaway, E. M., Churchland, P., Caddick, S. J., Feng, G., Homanics, G. E., Lee, K. F., Leopold, D. A., Miller, C. T., Mitchell, J. F., Mitalipov, S., Moutri, A. R., Movshon, J. A., Okano, H., Reynolds, J. H., Ringach, D., Sejnowski, T. J., Silva, A. C., Strick, P. L., Wu, J. & 1 others, Zhang, F., May 6 2015, In : Neuron. 86, 3, p. 617-631 15 p.

Research output: Contribution to journalReview article

Open Access
Primates
Brain
Genes
Opsins
Neurobiology

Corrigendum to Brains, Genes, and Primates [Neuron 86, 617-631; May 6, 2015]

Belmonte, J. C. I., Callaway, E. M., Caddick, S. J., Churchland, P., Feng, G., Homanics, G. E., Lee, K. F., Leopold, D. A., Miller, C. T., Mitchell, J. F., Mitalipov, S., Moutri, A. R., Movshon, J. A., Okano, H., Reynolds, J. H., Ringach, D. L., Sejnowski, T. J., Silva, A. C., Strick, P. L., Wu, J. & 1 others, Zhang, F., Aug 5 2015, In : Neuron. 87, 3, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Primates
Neurons
Brain
Genes
corrigendum
52 Citations (Scopus)

Creating Patient-Specific Neural Cells for the in Vitro Study of Brain Disorders

Brennand, K. J., Marchetto, M. C., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J. C., Kaykas, A., Lancaster, M. A., Livesey, F. J., McConnell, M. J., McKay, R. D., Morrow, E. M., Muotri, A. R., Panchision, D. M., Rubin, L. L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S. & 5 others, Vaccarino, F. M., Wu, J., Vanderhaeghen, P., Gage, F. H. & Jaenisch, R., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 933-945 13 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Brain Diseases
Brain
Drug Discovery
In Vitro Techniques
4 Citations (Scopus)

CRISPR/Cas9 and TALE: beyond cut and paste

Deng, L., Ren, R., Wu, J., Suzuki, K., Izpisua Belmote, J. C. & Liu, G. H., Jan 1 2015, In : Protein and Cell. 6, 3, p. 157-159 3 p.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Gene therapy
Regulator Genes
Ointments
Gene expression
79 Citations (Scopus)

Dynamic Pluripotent Stem Cell States and Their Applications

Wu, J. & Izpisua Belmonte, J. C., Nov 5 2015, In : Cell Stem Cell. 17, 5, p. 509-525 17 p.

Research output: Contribution to journalReview article

Open Access
Pluripotent Stem Cells
Animal Structures
Aptitude
Regenerative Medicine
Zygote
15 Citations (Scopus)

Metabolic exit from naive pluripotency

Wu, J. & Belmonte, J. C. I., Nov 27 2015, In : Nature Cell Biology. 17, 12, p. 1519-1521 3 p.

Research output: Contribution to journalArticle

Histone Code
Metabolome
Human Development
Embryonic Development
Drive
85 Citations (Scopus)

Metabolic rescue in pluripotent cells from patients with mtDNA disease

Ma, H., Folmes, C. D. L., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., Kang, E., Lee, Y., Hayama, T., Li, Y., Van Dyken, C., Gutierrez, N. M., Tippner-Hedges, R., Koski, A., Mitalipov, N., Amato, P. & 6 others, Wolf, D. P., Huang, T., Terzic, A., Laurent, L. C., Belmonte, J. C. I. & Mitalipov, S., Aug 13 2015, In : Nature. 524, 7564, p. 234-238 5 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Pluripotent Stem Cells
Leigh Disease
Induced Pluripotent Stem Cells
Mitochondrial Encephalomyopathies
55 Citations (Scopus)

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Duan, S., Yuan, G., Liu, X., Ren, R., Li, J., Zhang, W., Wu, J., Xu, X., Fu, L., Li, Y., Yang, J., Zhang, W., Bai, R., Yi, F., Suzuki, K., Gao, H., Esteban, C. R., Zhang, C., Belmonte, J. C. I., Chen, Z. & 5 others, Wang, X., Jiang, T., Qu, J., Tang, F. & Liu, G. H., Dec 3 2015, In : Nature communications. 6, 10068.

Research output: Contribution to journalArticle

Open Access
phenotype
Neural Stem Cells
stem cells
Glioblastoma
Stem cells
6 Citations (Scopus)

Regenerative medicine: Targeted genome editing in vivo

Wang, L., Wu, J., Fang, W., Liu, G. H. & Belmonte, J. C. I., Mar 5 2015, In : Cell Research. 25, 3, p. 271-272 2 p.

Research output: Contribution to journalArticle

Open Access
CRISPR-Cas Systems
Regenerative Medicine
Inborn Genetic Diseases
Medical Genetics
Genetic Therapy
124 Citations (Scopus)

Selective elimination of mitochondrial mutations in the germline by genome editing

Reddy, P., Ocampo, A., Suzuki, K., Luo, J., Bacman, S. R., Williams, S. L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., Lam, D., Xiong, X., Montserrat, N., Esteban, C. R., Liu, G. H., Sancho-Martinez, I., Manau, D., Civico, S., Cardellach, F., Del Mar O'Callaghan, M. & 5 others, Campistol, J., Zhao, H., Campistol, J. M., Moraes, C. T. & Izpisua Belmonte, J. C., Apr 23 2015, In : Cell. 161, 3, p. 459-469 11 p.

Research output: Contribution to journalArticle

Open Access
Germ-Line Mutation
Mitochondrial DNA
Genes
Mitochondrial Diseases
Mitochondria
2014
10 Citations (Scopus)

Stem cells: A designer's guide to pluripotency

Wu, J. & Belmonte, J. C. I., Dec 11 2014, In : Nature. 516, 7530, p. 172-173 2 p.

Research output: Contribution to journalShort survey

Genetic Epigenesis
Induced Pluripotent Stem Cells
bioinformatics
biotechnology
Biotechnology