• 13463 Citations
  • 59 h-Index
19962019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2007

Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers

Lam, D. C. L., Girard, L., Ramirez, R., Chau, W. S., Suen, W. S., Sheridan, S., Tin, V. P. C., Chung, L. P., Wong, M. P., Shay, J. W., Gazdar, A. F., Lam, W. K. & Minna, J. D., May 15 2007, In : Cancer research. 67, 10, p. 4638-4647 10 p.

Research output: Contribution to journalArticle

168 Scopus citations

Fragile histidine triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPase molecular switch

Jayachandran, G., Sazaki, J. I., Nishizaki, M., Xu, K., Girard, L., Minna, J. D., Roth, J. A. & Ji, L., Nov 1 2007, In : Cancer research. 67, 21, p. 10379-10388 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

High-throughput oncogene mutation profiling in human cancer

Thomas, R. K., Baker, A. C., DeBiasi, R. M., Winckler, W., LaFramboise, T., Lin, W. M., Wang, M., Feng, W., Zander, T., MacConnaill, L. E., Lee, J. C., Nicoletti, R., Hatton, C., Goyette, M., Girard, L., Majmudar, K., Ziaugra, L., Wong, K. K., Gabriel, S., Beroukhim, R. & 33 others, Peyton, M., Barretina, J., Dutt, A., Emery, C., Greulich, H., Shah, K., Sasaki, H., Gazdar, A., Minna, J., Armstrong, S. A., Mellinghoff, I. K., Hodi, F. S., Dranoff, G., Mischel, P. S., Cloughesy, T. F., Nelson, S. F., Liau, L. M., Mertz, K., Rubin, M. A., Moch, H., Loda, M., Catalona, W., Fletcher, J., Signoretti, S., Kaye, F., Anderson, K. C., Demetri, G. D., Dummer, R., Wagner, S., Herlyn, M., Sellers, W. R., Meyerson, M. & Garraway, L. A., Mar 1 2007, In : Nature genetics. 39, 3, p. 347-351 5 p.

Research output: Contribution to journalArticle

794 Scopus citations

Seizure 6-like (SEZ6L) gene and risk for lung cancer

Gorlov, I. P., Meyer, P., Liloglou, T., Myles, J., Boettger, M. B., Cassidy, A., Girard, L., Minna, J. D., Fischer, R., Duffy, S., Spitz, M. R., Haeussinger, K., Kammerer, S., Cantor, C., Dierkesmann, R., Field, J. K. & Amos, C. I., Sep 1 2007, In : Cancer research. 67, 17, p. 8406-8411 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

Whitehurst, A. W., Bodemann, B. O., Cardenas, J., Ferguson, D., Girard, L., Peyton, M., Minna, J. D., Michnoff, C., Hao, W., Roth, M. G., Xie, X. J. & White, M. A., Apr 12 2007, In : Nature. 446, 7137, p. 815-819 5 p.

Research output: Contribution to journalArticle

376 Scopus citations
2006

A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies

Shames, D. S., Girard, L., Gao, B., Sato, M., Lewis, C. M., Shivapurkar, N., Jiang, A., Perou, C. M., Kim, Y. H., Pollack, J. R., Fong, K. M., Lam, C. L., Wong, M., Shyr, Y., Nanda, R., Olopade, O. I., Gerald, W., Euhus, D. M., Shay, J. W., Gazdar, A. F. & 1 others, Minna, J. D., Dec 1 2006, In : PLoS Medicine. 3, 12, p. 2244-2263 20 p.

Research output: Contribution to journalArticle

192 Scopus citations

Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification

Kim, Y. H., Girard, L., Giacomini, C. P., Wang, P., Hernandez-Boussard, T., Tibshirani, R., Minna, J. D. & Pollack, J. R., Jan 5 2006, In : Oncogene. 25, 1, p. 130-138 9 p.

Research output: Contribution to journalArticle

133 Scopus citations

Differential disruption of cell cycle pathways in small cell and non-small cell lung cancer

Coe, B. P., Lockwood, W. W., Girard, L., Chari, R., MacAulay, C., Lam, S., Gazdar, A. F., Minna, J. D. & Lam, W. L., Jun 19 2006, In : British Journal of Cancer. 94, 12, p. 1927-1935 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features

Tam, I. Y. S., Chung, L. P., Suen, W. S., Wang, E., Wong, M. C. M., Ho, K. K., Lam, W. K., Chiu, S. W., Girard, L., Minna, J. D., Gazdar, A. F. & Wong, M. P., Mar 1 2006, In : Clinical Cancer Research. 12, 5, p. 1647-1653 7 p.

Research output: Contribution to journalArticle

332 Scopus citations

Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers

Lam, D. C. L., Girard, L., Suen, W. S., Chung, L. P., Tin, V. P. C., Lam, W. K., Minna, J. D. & Wong, M. P., Nov 1 2006, In : Journal of Thoracic Oncology. 1, 9, p. 932-942 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas

Heller, G., Fong, K. M., Girard, L., Seidl, S., End-Pfützenreuter, A., Lang, G., Gazdar, A. F., Minna, J. D., Zielinski, C. C. & Zöchbauer-Müller, S., Feb 9 2006, In : Oncogene. 25, 6, p. 959-968 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Gain of a region on 7p22.3, containing MADILI, is the most frequent event in small-cell lung cancer cell lines

Coe, B. P., Lee, E. H. L., Chi, B., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S., MacAulay, C. & Lam, W. L., Dec 1 2006, In : Genes Chromosomes and Cancer. 45, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH

Garnis, C., Lockwood, W. W., Vucic, E., Ge, Y., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S., MacAulay, C. & Lam, W. L., Mar 15 2006, In : International Journal of Cancer. 118, 6, p. 1556-1564 9 p.

Research output: Contribution to journalArticle

106 Scopus citations

Multiple oncogenic changes (K-RASV12, p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells

Sato, M., Vaughan, M. B., Girard, L., Peyton, M., Lee, W., Shames, D. S., Ramirez, R. D., Sunaga, N., Gazdar, A. F., Shay, J. W. & Minna, J. D., Feb 15 2006, In : Cancer Research. 66, 4, p. 2116-2128 13 p.

Research output: Contribution to journalArticle

196 Scopus citations

Non-small cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation

Das, A. K., Sato, M., Story, M. D., Peyton, M., Graves, R., Redpath, S., Girard, L., Gazdar, A. F., Shay, J. W., Minna, J. D. & Nirodi, C. S., Oct 1 2006, In : Cancer research. 66, 19, p. 9601-9608 8 p.

Research output: Contribution to journalArticle

165 Scopus citations

Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines

Witta, S. E., Gemmill, R. M., Hirsch, F. R., Coldren, C. D., Hedman, K., Ravdel, L., Helfrich, B., Dziadziuszko, R., Chan, D. C., Sugita, M., Chan, Z., Baron, A., Franklin, W., Drabkin, H. A., Girard, L., Gazdar, A. F., Minna, J. D. & Bunn, P. A., Jan 15 2006, In : Cancer Research. 66, 2, p. 944-950 7 p.

Research output: Contribution to journalArticle

395 Scopus citations

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

Zhou, B. B. S., Peyton, M., He, B., Liu, C., Girard, L., Caudler, E., Lo, Y., Baribaud, F., Mikami, I., Reguart, N., Yang, G., Li, Y., Yao, W., Vaddi, K., Gazdar, A. F., Friedman, S. M., Jablons, D. M., Newton, R. C., Fridman, J. S., Minna, J. D. & 1 others, Scherle, P. A., Jul 1 2006, In : Cancer Cell. 10, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

290 Scopus citations

The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells

Ueda, K., Kawashima, H., Ohtani, S., Deng, W. G., Ravoori, M., Bankson, J., Gao, B., Girard, L., Minna, J. D., Roth, J. A., Kundra, V. & Ji, L., Oct 1 2006, In : Cancer research. 66, 19, p. 9682-9690 9 p.

Research output: Contribution to journalArticle

56 Scopus citations
2005

Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer

Amann, J., Kalyankrishna, S., Massion, P. P., Ohm, J. E., Girard, L., Shigematsu, H., Peyton, M., Juroske, D., Huang, Y., Salmon, J. S., Kim, Y. H., Pollack, J. R., Yanagisawa, K., Gazdar, A., Minna, J. D., Kurie, J. M. & Carbone, D. P., Jan 1 2005, In : Cancer Research. 65, 1, p. 226-235 10 p.

Research output: Contribution to journalArticle

359 Scopus citations

Genomic and gene expression profiling of minute alterations of chromosome arm 1p in small-cell lung carcinoma cells

Henderson, L. J., Coe, B. P., Lee, E. H. L., Girard, L., Gazdar, A. F., Minna, J. D., Lam, S., MacAulay, C. & Lam, W. L., Apr 25 2005, In : British Journal of Cancer. 92, 8, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

Zhao, X., Weir, B. A., LaFramboise, T., Lin, M., Beroukhim, R., Garraway, L., Beheshti, J., Lee, J. C., Naoki, K., Richards, W. G., Sugarbaker, D., Chen, F., Rubin, M. A., Jänne, P. A., Girard, L., Minna, J., Christiani, D., Li, C., Sellers, W. R. & Meyerson, M., Jul 1 2005, In : Cancer Research. 65, 13, p. 5561-5570 10 p.

Research output: Contribution to journalArticle

275 Scopus citations

Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer

Holloway, S. E., Beck, A. W., Girard, L., Jaber, M. R., Barnett, C. C., Brekken, R. A. & Fleming, J. B., Mar 2005, In : Journal of the American College of Surgeons. 200, 3, p. 371-377 7 p.

Research output: Contribution to journalArticle

67 Scopus citations

Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays

Dobbin, K. K., Beer, D. G., Meyerson, M., Yeatman, T. J., Gerald, W. L., Jacobson, J. W., Conley, B., Buetow, K. H., Heiskanen, M., Simon, R. M., Minna, J. D., Girard, L., Misek, D. E., Taylor, J. M. G., Hanash, S., Naoki, K., Hayes, D. N., Ladd-Acosta, C., Enkemann, S. A., Viale, A. & 1 others, Giordano, T. J., Jan 15 2005, In : Clinical Cancer Research. 11, 2 I, p. 565-572 8 p.

Research output: Contribution to journalArticle

134 Scopus citations
2004

Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

Bentires-Alj, M., Paez, J. G., David, F. S., Keilhack, H., Halmos, B., Naoki, K., Maris, J. M., Richardson, A., Bardelli, A., Sagarbaker, D. J., Richards, W. G., Du, J., Girard, L., Minna, J. D., Loh, M. L., Fisher, D. E., Velculescu, V. E., Vogelstein, B., Meyerson, M., Sellers, W. R. & 1 others, Neel, B. G., Dec 15 2004, In : Cancer Research. 64, 24, p. 8816-8820 5 p.

Research output: Contribution to journalArticle

341 Scopus citations

An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays

Zhao, X., Li, C., Paez, J. G., Chin, K., Jänne, P. A., Chen, T. H., Girard, L., Minna, J., Christiani, D., Leo, C., Gray, J. W., Sellers, W. R. & Meyerson, M., May 1 2004, In : Cancer Research. 64, 9, p. 3060-3071 12 p.

Research output: Contribution to journalArticle

432 Scopus citations

High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines

Jänne, P. A., Li, C., Zhao, X., Girard, L., Chen, T. H., Minna, J., Christiani, D. C., Johnson, B. E. & Meyerson, M., Apr 8 2004, In : Oncogene. 23, 15, p. 2716-2726 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

Ramirez, R. D., Sheridan, S., Girard, L., Sato, M., Kim, Y., Pollack, J., Peyton, M., Zou, Y., Kurie, J. M., DiMaio, J. M., Milchgrub, S., Smith, A. L., Souza, R. F., Gilbey, L., Zhang, X., Gandia, K., Vaughan, M. B., Wright, W. E., Gazdar, A. F., Shay, J. W. & 1 others, Minna, J. D., Dec 15 2004, In : Cancer Research. 64, 24, p. 9027-9034 8 p.

Research output: Contribution to journalArticle

413 Scopus citations
2003

Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer

Sato, M., Girard, L., Sekine, I., Sunaga, N., Ramirez, R. D., Kamibayashi, C. & Minna, J. D., Oct 16 2003, In : Oncogene. 22, 46, p. 7243-7246 4 p.

Research output: Contribution to journalArticle

46 Scopus citations
2002

Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations

Jiang, X., Hanna, Z., Kaouass, M., Girard, L. & Jolicoeur, P., Sep 1 2002, In : Journal of virology. 76, 18, p. 9046-9059 14 p.

Research output: Contribution to journalArticle

56 Scopus citations

Methylation profiles of sporadic ovarian tumors and nonmalignant ovaries from high-risk women

Rathi, A., Virmani, A. K., Schorge, J. O., Elias, K. J., Maruyama, R., Minna, J. D., Mok, S. C., Girard, L., Fishman, D. A. & Gazdar, A. F., Nov 1 2002, In : Clinical Cancer Research. 8, 11, p. 3324-3331 8 p.

Research output: Contribution to journalArticle

109 Scopus citations
2001

DNA methylation profiles of lung tumors

Toyooka, S., Toyooka, K. O., Maruyama, R., Virmani, A. K., Girard, L., Miyajima, K., Harada, K., Ariyoshi, Y., Takahashi, T., Sugio, K., Brambilla, E., Gilcrease, M., Minna, J. D. & Gazdar, A. F., Nov 1 2001, In : Molecular Cancer Therapeutics. 1, 1, p. 61-67 7 p.

Research output: Contribution to journalArticle

221 Scopus citations
2000

Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering

Girard, L., Zochbauer-Muller, S., Virmani, A. K., Gazdar, A. F. & Minna, J. D., Sep 1 2000, In : Cancer Research. 60, 17, p. 4894-4906 13 p.

Research output: Contribution to journalArticle

302 Scopus citations

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints

Wistuba, I. I., Behrens, C., Virmani, A. K., Mele, G., Milchgrub, S., Girard, L., Fondon, J. W., Garner, H. R., McKay, B., Latif, F., Lerman, M. I., Lam, S., Gazdar, A. F. & Minna, J. D., Apr 1 2000, In : Cancer Research. 60, 7, p. 1949-1960 12 p.

Research output: Contribution to journalArticle

376 Scopus citations
499 Scopus citations

Two distinct Notch1 mutant alleles are involved in the induction of T- cell leukemia in c-myc transgenic mice

Hoemann, C. D., Beaulieu, N., Girard, L., Rebai, N. & Jolicoeur, P., Jun 1 2000, In : Molecular and cellular biology. 20, 11, p. 3831-3842 12 p.

Research output: Contribution to journalArticle

75 Scopus citations
1998
Open Access
13 Scopus citations
1996

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTV(D)/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis

Girard, L., Hanna, Z., Beaulieu, N., Hoemann, C. D., Simard, C., Kozak, C. A. & Jolicoeur, P., Jan 1 1996, In : Genes and Development. 10, 15, p. 1930-1944 15 p.

Research output: Contribution to journalArticle

Open Access
190 Scopus citations