• 105252 Citations
  • 174 h-Index
1970 …2019
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Research Output 1970 2019

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2010

The SREBP pathway. gene regulation through sterol sensing and gated protein trafficking

Radhakrishnan, A., Sun, L. P., Espenshade, P. J., Goldstein, J. L. & Brown, M. S., 2010, Handbook of Cell Signaling, 2/e. Elsevier Inc., Vol. 3. p. 2505-2510 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sterol Regulatory Element Binding Proteins
Sterols
Protein Transport
Gene expression
Cholesterol
2003

SREPBs: Gene Regulation through Controlled Protein Trafficking

Espenshade, P. J., Goldstein, J. L. & Brown, M. S., Nov 7 2003, Handbook of Cell Signaling. Elsevier Inc., Vol. 3-3. p. 353-358 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene expression
Proteins
1982
5 Citations (Scopus)

Receptor-mediated endocytosis and the structural organization of the cell membrane

Brown, M. S. & Goldstein, J. L., 1982, National Cancer Institute Monograph. Vol. No. 60. p. 3-6 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endocytosis
Cell Membrane
Biological Phenomena
Transport Vesicles
Extracellular Fluid
1980
24 Citations (Scopus)

LDL receptors in coated vesicles isolated from bovine adrenal cortex: Binding sites unmasked by detergent treatment

Mello, R. J., Brown, M. S., Goldstein, J. L. & Anderson, R. G. W., 1980, Cell. 3 ed. Vol. 20. p. 829-837 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Coated Vesicles
LDL Receptors
Adrenal Cortex
Detergents
Binding Sites
340 Citations (Scopus)

The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages

Brown, M. S., Basu, S. K., Falck, J. R., Ho, Y. K. & Goldstein, J. L., 1980, Journal of Supramolecular and Cellular Biochemistry. 1 ed. Vol. 13. p. 67-81 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lipoproteins
Macrophages
Binding Sites
oxidized low density lipoprotein
1979
83 Citations (Scopus)

Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cells

Krieger, M., Smith, L. C., Anderson, R. G. W., Goldstein, J. L., Kao, Y. J., Pownall, H. J., Gotto, A. M. & Brown, M. S., 1979, Journal of Supramolecular and Cellular Biochemistry. 4 ed. Vol. 10. p. 467-478 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fluorescent Dyes
LDL Lipoproteins
1978
60 Citations (Scopus)

Familial hypercholesterolemia: Pathogenesis of a receptor disease

Goldstein, J. L. & Brown, M. S., 1978, Johns Hopkins Medical Journal. 1 ed. Vol. 143. p. 8-16 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyperlipoproteinemia Type II
LDL Lipoproteins
Gene Dosage
Cell Surface Receptors
LDL Cholesterol
45 Citations (Scopus)

Inhibition of the binding of low-density lipoprotein to its cell surface receptor in human fibroblasts by positively charged proteins

Brown, M. S., Deuel, T. F., Basu, S. K. & Goldstein, J. L., 1978, Journal of Supramolecular and Cellular Biochemistry. 3 ed. Vol. 8. p. 223-234 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Surface Receptors
Fibroblasts
LDL Lipoproteins
Lysine
Protamines

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

Brown, M. S., Anderson, R. G. W. & Goldstein, J. L., 1978, Progress in Clinical and Biological Research. Vol. VOL.22. p. 25-34 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

LDL Lipoproteins
Smooth Muscle Myocytes
Hydrolysis
Fibroblasts
Lymphocytes
1977
8 Citations (Scopus)

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

Brown, M. S., Anderson, R. G. W. & Goldstein, J. L., 1977, Journal of Supramolecular and Cellular Biochemistry. 1 ed. Vol. 6. p. 85-94 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lymphocytes
Fibroblasts
LDL Lipoproteins
Metabolism
Smooth Muscle Myocytes
1974
6 Citations (Scopus)

Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man

Goldstein, J. L. & Brown, M. S., 1974, Transactions of the Association of American Physicians. Vol. 87. p. 120-131 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyperlipoproteinemia Type II
Heterozygote
Dominant Genes
Enzymes
Genes