Patrick J Leavey

  • 1020 Citations
  • 17 h-Index
1989 …2019
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Research Output 1989 2019

  • 1020 Citations
  • 17 h-Index
  • 48 Article
  • 2 Conference contribution
  • 1 Comment/debate
  • 1 Review article
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Article
2019

Novel PDGFRB rearrangement in multifocal infantile myofibromatosis is tumorigenic and sensitive to imatinib

Hassan, M., Butler, E., Wilson, R., Roy, A., Zheng, Y., Liem, P., Rakheja, D., Pavlick, D., Young, L. L., Rosenzweig, M., Erlich, R., Ali, S. M., Leavey, P. J., Parsons, D. W., Skapek, S. X. & Laetsch, T. W., Oct 1 2019, In : Cold Spring Harbor Molecular Case Studies. 5, 5

Research output: Contribution to journalArticle

Open Access
Platelet-Derived Growth Factor beta Receptor
Tumors
Fibroblasts
Neoplasms
Protein-Tyrosine Kinases
17 Citations (Scopus)

Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort

Smeland, S., Bielack, S. S., Whelan, J., Bernstein, M., Hogendoorn, P., Krailo, M. D., Gorlick, R., Janeway, K. A., Ingleby, F. C., Anninga, J., Antal, I., Arndt, C., Brown, K. L. B., Butterfass-Bahloul, T., Calaminus, G., Capra, M., Dhooge, C., Eriksson, M., Flanagan, A. M., Friedel, G. & 32 others, Gebhardt, M. C., Gelderblom, H., Goldsby, R., Grier, H. E., Grimer, R., Hawkins, D. S., Hecker-Nolting, S., Sundby Hall, K., Isakoff, M. S., Jovic, G., Kühne, T., Kager, L., von Kalle, T., Kabickova, E., Lang, S., Lau, C. C., Leavey, P. J., Lessnick, S. L., Mascarenhas, L., Mayer-Steinacker, R., Meyers, P. A., Nagarajan, R., Randall, R. L., Reichardt, P., Renard, M., Rechnitzer, C., Schwartz, C. L., Strauss, S., Teot, L., Timmermann, B., Sydes, M. R. & Marina, N., Mar 1 2019, In : European Journal of Cancer. 109, p. 36-50 15 p.

Research output: Contribution to journalArticle

Open Access
Osteosarcoma
Cohort Studies
Confidence Intervals
Survival
Neoplasm Metastasis

Viable and necrotic tumor assessment from whole slide images of osteosarcoma using machine-learning and deep-learning models

Arunachalam, H. B., Mishra, R., Daescu, O., Cederberg, K. B., Rakheja, D., Sengupta, A. L., Leonard, D., Hallac, R. R. & Leavey, P. J., Apr 1 2019, In : PloS one. 14, 4, e0210706.

Research output: Contribution to journalArticle

Open Access
osteosarcoma
artificial intelligence
Osteosarcoma
Learning systems
Tumors
2018
4 Citations (Scopus)

Convolutional neural network for histopathological analysis of osteosarcoma

Mishra, R., Daescu, O., Leavey, P., Rakheja, D. & Sengupta, A., Mar 1 2018, In : Journal of Computational Biology. 25, 3, p. 313-325 13 p.

Research output: Contribution to journalArticle

Osteosarcoma
Tumors
Tumor
Neural Networks
Neural networks
10 Citations (Scopus)

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group

Shulman, D. S., Klega, K., Imamovic-Tuco, A., Clapp, A., Nag, A., Thorner, A. R., Van Allen, E., Ha, G., Lessnick, S. L., Gorlick, R., Janeway, K. A., Leavey, P. J., Mascarenhas, L., London, W. B., Vo, K. T., Stegmaier, K., Hall, D., Krailo, M. D., Barkauskas, D. A., DuBois, S. G. & 1 others, Crompton, B. D., Aug 28 2018, In : British Journal of Cancer. 119, 5, p. 615-621 7 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Osteosarcoma
DNA
Neoplasms
Disease-Free Survival
2 Citations (Scopus)

Hope as a Predictor of Anxiety and Depressive Symptoms Following Pediatric Cancer Diagnosis

Germann, J. N., Leonard, D., Heath, C. L., Stewart, S. M. & Leavey, P. J., Mar 1 2018, In : Journal of Pediatric Psychology. 43, 2, p. 152-161 10 p.

Research output: Contribution to journalArticle

Hope
Anxiety
Depression
Pediatrics
Neoplasms

Prolonged response to sorafenib in a patient with refractory metastatic osteosarcoma and a somatic PDGFRA D846V mutation

Armstrong, A. E., Walterhouse, D. O., Leavey, P. J., Reichek, J. & Walz, A. L., Jan 1 2018, (Accepted/In press) In : Pediatric Blood and Cancer. e27493.

Research output: Contribution to journalArticle

Osteosarcoma
Mutation
Biomarkers
Recurrence
Terminology
3 Citations (Scopus)

The American Society of Pediatric Hematology/Oncology workforce assessment: Part 2—Implications for fellowship training

on behalf of the American Society of Pediatric Hematology/Oncology Workforce Advisory Taskforce, Feb 1 2018, In : Pediatric Blood and Cancer. 65, 2, e26765.

Research output: Contribution to journalArticle

Hematology
Pediatrics
Physicians
Education
2 Citations (Scopus)

The American Society of Pediatric Hematology/Oncology workforce assessment: Part 1—Current state of the workforce

on behalf of the American Society of Pediatric Hematology/Oncology Workforce Advisory Taskforce, Feb 1 2018, In : Pediatric Blood and Cancer. 65, 2, e26780.

Research output: Contribution to journalArticle

Hematology
Pediatrics
American Medical Association
Workplace
Physicians
2016
1 Citation (Scopus)

Biomarker development in osteosarcoma—Is there no longer any utility to tumor necrosis?

Leavey, P. J., Oct 1 2016, In : Pediatric Blood and Cancer. 63, 10, p. 1702-1703 2 p.

Research output: Contribution to journalArticle

Osteosarcoma
Necrosis
Biomarkers
Neoplasms
88 Citations (Scopus)

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial

Marina, N. M., Smeland, S., Bielack, S. S., Bernstein, M., Jovic, G., Krailo, M. D., Hook, J. M., Arndt, C., van den Berg, H., Brennan, B., Brichard, B., Brown, K. L. B., Butterfass-Bahloul, T., Calaminus, G., Daldrup-Link, H. E., Eriksson, M., Gebhardt, M. C., Gelderblom, H., Gerss, J., Goldsby, R. & 33 others, Goorin, A., Gorlick, R., Grier, H. E., Hale, J. P., Hall, K. S., Hardes, J., Hawkins, D. S., Helmke, K., Hogendoorn, P. C. W., Isakoff, M. S., Janeway, K. A., Jürgens, H., Kager, L., Kühne, T., Lau, C. C., Leavey, P. J., Lessnick, S. L., Mascarenhas, L., Meyers, P. A., Mottl, H., Nathrath, M., Papai, Z., Randall, R. L., Reichardt, P., Renard, M., Safwat, A. A., Schwartz, C. L., Stevens, M. C. G., Strauss, S. J., Teot, L., Werner, M., Sydes, M. R. & Whelan, J. S., Oct 1 2016, In : The Lancet Oncology. 17, 10, p. 1396-1408 13 p.

Research output: Contribution to journalArticle

Ifosfamide
Etoposide
Osteosarcoma
Randomized Controlled Trials
Drug Therapy
6 Citations (Scopus)

COMPUTER AIDED IMAGE SEGMENTATION AND CLASSIFICATION FOR VIABLE AND NON-VIABLE TUMOR IDENTIFICATION IN OSTEOSARCOMA

Arunachalam, H. B., Mishra, R., Armaselu, B., Daescu, O., Martinez, M., Leavey, P. J., Rakheja, D., Cederberg, K. B., Sengupta, A. L. & Ni'suilleabhain, M., 2016, In : Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 22, p. 195-206 12 p.

Research output: Contribution to journalArticle

Osteosarcoma
Neoplasms
Necrosis
Observer Variation
Bone Neoplasms
2015
8 Citations (Scopus)
Vinblastine
Methotrexate
Drug Therapy
Pediatrics
Skin
5 Citations (Scopus)

Humanism and professionalism education for pediatric hematology-oncology fellows: A model for pediatric subspecialty training

Kesselheim, J. C., Atlas, M., Adams, D., Aygun, B., Barfield, R., Eisenman, K., Fulbright, J., Garvey, K., Kersun, L., Nageswara Rao, A., Reilly, A., Sharma, M., Shereck, E., Wang, M., Watt, T. & Leavey, P., Feb 1 2015, In : Pediatric Blood and Cancer. 62, 2, p. 335-340 6 p.

Research output: Contribution to journalArticle

Humanism
Hematology
Curriculum
Pediatrics
Teaching
4 Citations (Scopus)

PAX genes in childhood oncogenesis: Developmental biology gone awry?

Mahajan, P., Leavey, P. J. & Galindo, R. L., May 21 2015, In : Oncogene. 34, 21, p. 2681-2689 9 p.

Research output: Contribution to journalArticle

Developmental Biology
Carcinogenesis
Genes
Neoplasms
Inborn Genetic Diseases
53 Citations (Scopus)

Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney

Roy, A., Kumar, V., Zorman, B., Fang, E., Haines, K. M., Doddapaneni, H., Hampton, O. A., White, S., Bavle, A. A., Patel, N. R., Eldin, K. W., John Hicks, M., Rakheja, D., Leavey, P. J., Skapek, S. X., Amatruda, J. F., Nuchtern, J. G., Chintagumpala, M. M., Wheeler, D. A., Plon, S. E. & 2 others, Sumazin, P. & Parsons, D. W., Nov 17 2015, In : Nature Communications. 6, 8891.

Research output: Contribution to journalArticle

Clear Cell Sarcoma
Co-Repressor Proteins
kidneys
cancer
Tumors
2014
3 Citations (Scopus)

Bone scintigraphy in osteosarcoma: A single institution experience

Powers, J. M., Cost, C., Cederberg, K., Leonard, D. & Leavey, P. J., Nov 8 2014, In : Journal of Pediatric Hematology/Oncology. 36, 8, p. e543-e545

Research output: Contribution to journalArticle

Osteosarcoma
Radionuclide Imaging
Bone and Bones
Recurrence
20 Citations (Scopus)

Do pediatric hematology/oncology (PHO) fellows receive communication training?

File, W., Bylund, C. L., Kesselheim, J., Leonard, D. & Leavey, P., Mar 2014, In : Pediatric Blood and Cancer. 61, 3, p. 502-506 5 p.

Research output: Contribution to journalArticle

Hematology
Communication
Pediatrics
Graduate Medical Education
Accreditation
14 Citations (Scopus)

Hoping is coping: A guiding theoretical framework for promoting coping and adjustment following pediatric cancer diagnosis

Germann, J. N., Leonard, D., Stuenzi, T. J., Pop, R. B., Stewart, S. M. & Leavey, P. J., Oct 27 2014, In : Journal of Pediatric Psychology. 40, 9, p. 846-855 10 p.

Research output: Contribution to journalArticle

Hope
Social Adjustment
Pediatrics
Anxiety
Quality of Life
1 Citation (Scopus)

Important principles in Ewing sarcoma treatment

Leavey, P. J., Dec 1 2014, In : Pediatric Blood and Cancer. 61, 12, p. 2149-2150 2 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Bone Neoplasms
Ewing's Sarcoma
Lung Neoplasms
2013
1 Citation (Scopus)

How many physicians do we need? A benchmark for pediatric hematology/oncology

Leavey, P. J., Apr 2013, In : Pediatric Blood and Cancer. 60, 4, p. 527-528 2 p.

Research output: Contribution to journalArticle

Benchmarking
Medical Oncology
Hematology
Pediatrics
Physicians
7 Citations (Scopus)

IL-8 predicts pediatric oncology patients with febrile neutropenia at low risk for bacteremia

Cost, C. R., Stegner, M. M., Leonard, D. & Leavey, P., Apr 2013, In : Journal of Pediatric Hematology/Oncology. 35, 3, p. 206-211 6 p.

Research output: Contribution to journalArticle

Febrile Neutropenia
Bacteremia
Interleukin-8
Pediatrics
Logistic Models
2012
2 Citations (Scopus)

Graduate medical education changes: Yes we can or enough already?

Leavey, P. J. & Jubran, R. F., Dec 15 2012, In : Pediatric Blood and Cancer. 59, 7, p. 1168-1172 5 p.

Research output: Contribution to journalArticle

Graduate Medical Education
Pediatrics
Accreditation
Hematology
Certification
5 Citations (Scopus)
Febrile Neutropenia
Chemokine CCL2
Interleukin-5
Bacteremia
Cytokines
2009
185 Citations (Scopus)

Dose-intensified compared with standard chemotherapy for nonmetastatic ewing sarcoma family of tumors: A children's oncology group study

Granowetter, L., Womer, R., Devidas, M., Krailo, M., Wang, C., Bernstein, M., Marina, N., Leavey, P., Gebhardt, M., Healey, J., Shamberger, R. C., Goorin, A., Miser, J., Meyer, J., Arndt, C. A. S., Sailer, S., Marcus, K., Perlman, E., Dickman, P. & Grier, H. E., May 20 2009, In : Journal of Clinical Oncology. 27, 15, p. 2536-2541 6 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Drug Therapy
Vincristine
Ifosfamide
Doxorubicin
2008
46 Citations (Scopus)

Ewing sarcoma: Prognostic criteria, outcomes and future treatment

Leavey, P. J. & Collier, A. B., Apr 2008, In : Expert Review of Anticancer Therapy. 8, 4, p. 617-624 8 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Orphan Drug Production
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 11
Therapeutics
94 Citations (Scopus)

Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: A report from the children's oncology group

Leavey, P. J., Mascarenhas, L., Marina, N., Chen, Z., Krailo, M., Miser, J., Brown, K., Tarbell, N., Bernstein, M. L., Granowetter, L., Gebhardt, M. & Grier, H. E., Sep 2008, In : Pediatric Blood and Cancer. 51, 3, p. 334-338 5 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Recurrence
Therapeutics
Survival
2007
22 Citations (Scopus)

Extracorporeal membrane oxygenation (ECMO) initiation without intubation in two children with mediastinal malignancy

Wickiser, J. E., Thompson, M., Leavey, P. J., Quinn, C. T., Garcia, N. M. & Aquino, V. M., Oct 15 2007, In : Pediatric Blood and Cancer. 49, 5, p. 751-754 4 p.

Research output: Contribution to journalArticle

Extracorporeal Membrane Oxygenation
Intubation
Neoplasms
Pediatrics
2006
4 Citations (Scopus)

KAI-1 expression in pediatric high-grade osteosarcoma

Leavey, P. J., Timmons, C., Frawley, W., Lombardi, D. & Ashfaq, R., May 2006, In : Pediatric and Developmental Pathology. 9, 3, p. 219-224 6 p.

Research output: Contribution to journalArticle

Osteosarcoma
Pediatrics
Neoplasm Metastasis
Neoplasms
Biopsy
19 Citations (Scopus)

The prevalence and use of antidepressant medication in pediatric cancer patients

Portteus, A., Ahmad, N., Tobey, D. & Leavey, P., Aug 2006, In : Journal of Child and Adolescent Psychopharmacology. 16, 4, p. 467-473 7 p.

Research output: Contribution to journalArticle

Antidepressive Agents
Pediatrics
Neoplasms
Opiate Alkaloids
Therapeutics
2004
16 Citations (Scopus)

Phase I Study of Oral Cyclophosphamide and Oral Topotecan for Children with Recurrent or Refractory Solid Tumors

Bowers, D. C., Aquino, V. M., Leavey, P. J., Bash, R. O., Journeycake, J. M., Tomlinson, G., Mulne, A. F., Haynes, H. J. & Winick, N. J., Jan 2004, In : Pediatric Blood and Cancer. 42, 1, p. 93-98 6 p.

Research output: Contribution to journalArticle

Topotecan
Cyclophosphamide
Pediatrics
Neoplasms
Neutropenia
2003
45 Citations (Scopus)

Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma

Dickens, D. S., Kozielski, R., Leavey, P. J., Timmons, C. & Cripe, T. P., Apr 2003, In : Journal of Pediatric Hematology/Oncology. 25, 4, p. 282-285 4 p.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Osteosarcoma
Cyclooxygenase 2
Ewing's Sarcoma
Cyclooxygenase 2 Inhibitors
10 Citations (Scopus)

Skip metastasis in osteosarcoma

Leavey, P. J., Day, M. D., Booth, T. & Maale, G., Oct 2003, In : Journal of Pediatric Hematology/Oncology. 25, 10, p. 806-808 3 p.

Research output: Contribution to journalArticle

Osteosarcoma
Neoplasm Metastasis
Adjuvant Chemotherapy
Histology
15 Citations (Scopus)

The epidermal growth factor receptor HER2 is not a major therapeutic target in Ewing sarcoma

Ye, D., Maitra, A., Timmons, C. F., Leavey, P. J., Ashfaq, R. & Ilaria, R. L., Jun 2003, In : Journal of Pediatric Hematology/Oncology. 25, 6, p. 459-466 8 p.

Research output: Contribution to journalArticle

Ewing's Sarcoma
Epidermal Growth Factor Receptor
Primitive Neuroectodermal Tumors
Therapeutics
Cell Line
2002
41 Citations (Scopus)

A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activity

Leavey, P. J., Gonzalez-Aller, C., Thurman, G., Kleinberg, M., Rinckel, L., Ambruso, D. W., Freeman, S., Kuypers, F. A. & Ambruso, D. R., Nov 22 2002, In : Journal of Biological Chemistry. 277, 47, p. 45181-45187 7 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Cell-Free System
NADPH Oxidase
Phospholipases A2
Superoxides
51 Citations (Scopus)

Effective removal of methotrexate by high-flux hemodialysis

Saland, J. M., Leavey, P. J., Bash, R. O., Hansch, E., Arbus, G. S. & Quigley, R., 2002, In : Pediatric Nephrology. 17, 10, p. 825-829 5 p.

Research output: Contribution to journalArticle

Methotrexate
Renal Dialysis
gamma-Glutamyl Hydrolase
Compassionate Use Trials
Poisons

In vivo treatment with granulocyte colony-stimulating factor does not delay apoptosis in human neutrophils by increasing the expression of the vacuolar proton ATPase

Zimbelman, J., Thurman, G., Leavey, P. J., Ellison, M. C. & Ambruso, D. R., 2002, In : Journal of Investigative Medicine. 50, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Granulocyte Colony-Stimulating Factor
Adenosine Triphosphatases
Protons
Neutrophils

Variability in dose intensity of high-dose methotrexate for nonmetastatic osteosarcoma

Leavey, P. J., Mantadakis, E. & Maale, G., Oct 2002, In : Pediatric Hematology and Oncology. 19, 7, p. 483-489 7 p.

Research output: Contribution to journalArticle

Chemotherapy
Osteosarcoma
Methotrexate
Hydration
Toxicity
2001
30 Citations (Scopus)

Lack of prognostic significance of intratumoral angiogenesis in nonmetastatic osteosarcoma

Mantadakis, E., Kim, G., Reisch, J., McHard, K., Maale, G., Leavey, P. J. & Timmons, C., 2001, In : Journal of Pediatric Hematology/Oncology. 23, 5, p. 286-289 4 p.

Research output: Contribution to journalArticle

Osteosarcoma
Microvessels
Survivors
Neoplasms
Endothelial Cells
2000
9 Citations (Scopus)

Fractionated cyclophosphamide and etoposide for children with advanced or refractory solid tumors: A phase II window study

Mantadakis, E., Herrera, L., Leavey, P. J., Bash, R. O., Winick, N. J. & Kamen, B. A., Jul 2000, In : Journal of Clinical Oncology. 18, 13, p. 2576-2581 6 p.

Research output: Contribution to journalArticle

Etoposide
Cyclophosphamide
Neutropenia
4-hydroxycyclophosphamide
Granulocyte Colony-Stimulating Factor
31 Citations (Scopus)

Functional characteristics of neutrophils collected and stored after administration of G-CSF

Leavey, P. J., Thurman, G. & Ambruso, D. R., 2000, In : Transfusion. 40, 4, p. 414-419 6 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
NADPH Oxidase
Neutrophils
Blood Component Removal
Chemotaxis
1998
67 Citations (Scopus)

In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro

Leavey, P. J., Sellins, K. S., Thurman, G., Elzi, D., Hiester, A., Silliman, C. C., Zerbe, G., Cohen, J. J. & Ambruso, D. R., Dec 1 1998, In : Blood. 92, 11, p. 4366-4374 9 p.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
Neutrophils
Therapeutics
Lactoferrin
Cell membranes
3 Citations (Scopus)

The Effects of Stem Cell Factor and Granulocyte Colony Stimulating Factor Therapy on the Activity of the Neutrophil NADPH Oxidase Enzyme System

Leavey, P. J., Thurman, G., Gonzalez-Aller, C., Zerbe, G. & Ambruso, D. R., Apr 1998, In : Journal of Investigative Medicine. 46, 4, p. 121-126 6 p.

Research output: Contribution to journalArticle

Stem Cell Factor
NADPH Oxidase
Granulocyte Colony-Stimulating Factor
Neutrophils
Cytokines
1997
23 Citations (Scopus)

Intra-operative radiation therapy in pediatric neuroblastoma

Leavey, P. J., Odom, L. F., Poole, M., McNeely, L., Tyson, R. W. & Haase, G. M., 1997, In : Medical and Pediatric Oncology. 28, 6, p. 424-428 5 p.

Research output: Contribution to journalArticle

Neuroblastoma
Radiotherapy
Pediatrics
Disease-Free Survival
Survivors
1996
1 Citation (Scopus)
Granulocyte Colony-Stimulating Factor
Healthy Volunteers
Neutrophils
Coloring Agents
Half-Life
1992
23 Citations (Scopus)

Osteogenic sarcoma and Rothmund Thomson syndrome

Varughese, M., Leavey, P., Smith, P., Sneath, R., Breatnach, F. & O'Meara, A., May 1992, In : Journal of Cancer Research and Clinical Oncology. 118, 5, p. 389-390 2 p.

Research output: Contribution to journalArticle

Rothmund-Thomson Syndrome
Osteosarcoma
Hypogonadism
Radiation Tolerance
Nails
1991
12 Citations (Scopus)

Langerhans cell histiocytosis - a 31 year review

Leavey, P., Varughese, M., Breatnach, F. & O'Meara, A., Jan 1991, In : Irish Journal of Medical Science. 160, 9, p. 271-274 4 p.

Research output: Contribution to journalArticle

Langerhans Cell Histiocytosis
Morbidity
Exanthema
Ear
Radiotherapy
1989

Inappropriate long-term medication in patients admitted to a coronary care unit

O'Sullivan, J. J., Leavey, P. & Mulcahy, R., 1989, In : Journal of the Royal College of Physicians of London. 23, 4, p. 232-235 4 p.

Research output: Contribution to journalArticle