• 2701 Citations
  • 17 h-Index
20032018
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Research Output 2003 2018

  • 2701 Citations
  • 17 h-Index
  • 23 Article
2018
16 Citations (Scopus)

BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer

Li, X., Baek, G. H., Ramanand, S. G., Sharp, A., Gao, Y., Yuan, W., Welti, J., Rodrigues, D. N., Dolling, D., Figueiredo, I., Sumanasuriya, S., Crespo, M., Aslam, A., Li, R., Yin, Y., Mukherjee, B., Kanchwala, M., Hughes, A. M., Halsey, W. S., Chiang, C. M. & 5 others, Xing, C., Raj, G. V., Burma, S., de Bono, J. & Mani, R. S., Jan 16 2018, In : Cell Reports. 22, 3, p. 796-808 13 p.

Research output: Contribution to journalArticle

Gene Rearrangement
DNA Repair
Prostatic Neoplasms
Repair
Double-Stranded DNA Breaks
20 Citations (Scopus)

Targeting Bromodomain and Extra-Terminal (BET) family proteins in Castration-Resistant Prostate Cancer (CRPC)

International SU2C/PCF Prostate Cancer Dream Team, Jul 1 2018, In : Clinical Cancer Research. 24, 13, p. 3149-3162 14 p.

Research output: Contribution to journalArticle

Castration
Androgen Receptors
Prostatic Neoplasms
Proteins
Organoids
2017
15 Citations (Scopus)

Androgen receptor variants mediate DNA repair after prostate cancer irradiation

Yin, Y., Li, R., Xu, K., Ding, S., Li, J., Baek, G. H., Ramanand, S. G., Ding, S., Liu, Z., Gao, Y., Kanchwala, M. S., Li, X., Hutchinson, R., Liu, X., Woldu, S. L., Xing, C., Desai, N. B., Feng, F. Y., Burma, S., De Bono, J. S. & 4 others, Dehm, S. M., Mani, R. S., Chen, B. P. C. & Raj, G. V., Sep 15 2017, In : Cancer Research. 77, 18, p. 4745-4754 10 p.

Research output: Contribution to journalArticle

Androgen Receptors
DNA Repair
Prostatic Neoplasms
Androgens
DNA Damage
2016

Erratum: TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer (Nature Communications (2014) 5 (4527) DOI: 10.1038/ncomms5527)

Banerjee, R., Russo, N., Liu, M., Basrur, V., Bellile, E., Palanisamy, N., Scanlon, C. S., Van Tubergen, E., Inglehart, R. C., Metwally, T., Mani, R. S., Yocum, A., Nyati, M. K., Castilho, R. M., Varambally, S., Chinnaiyan, A. M. & D'Silva, N. J., Feb 24 2016, In : Nature Communications. 7, 10726.

Research output: Contribution to journalArticle

Joining
Communication

Functional Analysis of a Novel Connexin30 Mutation in a Large Family with Hearing Loss, Pesplanus, Ichthyosis, Cutaneous Nodules, and Keratoderma

Pandey, N., Xavier, D. F., Chatterjee, A., Mani, R. S., Hiremagalore, R., Tharakan, A., Rajashekhar, B. & Anand, A., Jan 1 2016, In : Annals of Human Genetics. 80, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

Ichthyosis
Gap Junctions
Hearing Loss
Skin
Mutation
27 Citations (Scopus)

Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer

Mani, R. S., Amin, M. A., Li, X., Kalyana-Sundaram, S., Veeneman, B. A., Wang, L., Ghosh, A., Aslam, A., Ramanand, S. G., Rabquer, B. J., Kimura, W., Tran, M., Cao, X., Roychowdhury, S., Dhanasekaran, S. M., Palanisamy, N., Sadek, H. A., Kapur, P., Koch, A. E. & Chinnaiyan, A. M., Dec 6 2016, In : Cell Reports. 17, 10, p. 2620-2631 12 p.

Research output: Contribution to journalArticle

Oxidative stress
Gene Fusion
DNA Breaks
Prostatic Neoplasms
Oxidative Stress
2014
34 Citations (Scopus)

The emerging role of speckle-type POZ protein (SPOP) in cancer development

Mani, R. S., Sep 1 2014, In : Drug Discovery Today. 19, 9, p. 1498-1502 5 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasms
Proteins
Mutation
Tiopronin
51 Citations (Scopus)

TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer

Banerjee, R., Russo, N., Liu, M., Basrur, V., Bellile, E., Palanisamy, N., Scanlon, C. S., Van Tubergen, E., Inglehart, R. C., Metwally, T., Mani, R. S., Yocum, A., Nyati, M. K., Castilho, R. M., Varambally, S., Chinnaiyan, A. M. & D'Silva, N. J., Jul 31 2014, In : Nature Communications. 5, 4527.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Joining
cancer
DNA
deoxyribonucleic acid
2013
29 Citations (Scopus)

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease.

He, S., Xie, F., Liu, Y., Tong, Q., Mochizuki, K., Lapinski, P. E., Mani, R. S., Reddy, P., Mochizuki, I., Chinnaiyan, A. M., Mineishi, S., King, P. D. & Zhang, Y., Dec 12 2013, In : Blood. 122, 25, p. 4119-4128 10 p.

Research output: Contribution to journalArticle

T-cells
Graft vs Host Disease
Epigenomics
Grafts
T-Lymphocytes
2012
42 Citations (Scopus)

Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells

He, S., Wang, J., Kato, K., Xie, F., Varambally, S., Mineishi, S., Kuick, R., Mochizuki, K., Liu, Y., Nieves, E., Mani, R. S., Chinnaiyan, A. M., Marquez, V. E. & Zhang, Y., Feb 2 2012, In : Blood. 119, 5, p. 1274-1282 9 p.

Research output: Contribution to journalArticle

Methylation
T-cells
Graft vs Host Disease
Grafts
Histones
41 Citations (Scopus)

Role of transcriptional corepressor CtBP1 in prostate cancer progression

Wang, R., Asangani, I. A., Chakravarthi, B. V. S. K., Ateeq, B., Lonigro, R. J., Cao, Q., Mani, R. S., Camacho, D. F., McGregor, N., Schumann, T. E. W., Jing, X., Menawat, R., Tomlins, S. A., Zheng, H., Otte, A. P., Mehra, R., Siddiqui, J., Dhanasekaran, S. M., Nyati, M. K., Pienta, K. J. & 5 others, Palanisamy, N., Kunju, L. P., Rubin, M. A., Chinnaiyan, A. M. & Varambally, S., Oct 2012, In : Neoplasia (United States). 14, 10, p. 905-914 10 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Prostatic Neoplasms
Tumor Suppressor Genes
Neoplasm Metastasis
Chorioallantoic Membrane
2011
157 Citations (Scopus)

Coordinated Regulation of Polycomb Group Complexes through microRNAs in Cancer

Cao, Q., Mani, R. S., Ateeq, B., Dhanasekaran, S. M., Asangani, I. A., Prensner, J. R., Kim, J. H., Brenner, J. C., Jing, X., Cao, X., Wang, R., Li, Y., Dahiya, A., Wang, L., Pandhi, M., Lonigro, R. J., Wu, Y. M., Tomlins, S. A., Palanisamy, N., Qin, Z. & 4 others, Yu, J., Maher, C. A., Varambally, S. & Chinnaiyan, A. M., Aug 16 2011, In : Cancer Cell. 20, 2, p. 187-199 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Neoplasms
Polycomb-Group Proteins
Neoplastic Stem Cells
Epigenomics
Metagenomics
71 Citations (Scopus)

The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma

Banerjee, R., Mani, R. S., Russo, N., Scanlon, C. S., Tsodikov, A., Jing, X., Cao, Q., Palanisamy, N., Metwally, T., Inglehart, R. C., Tomlins, S., Bradford, C., Carey, T., Wolf, G., Kalyana-Sundaram, S., Chinnaiyan, A. M., Varambally, S. & D'Silva, N. J., Oct 20 2011, In : Oncogene. 30, 42, p. 4339-4349 11 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Tumor Suppressor Genes
Squamous Cell Carcinoma
Down-Regulation
Squamous Cell Neoplasms
32 Citations (Scopus)

TMPRSS2-ERG-mediated feed-forward regulation of wild-type ERG in human prostate cancers

Mani, R. S., Iyer, M. K., Cao, Q., Brenner, J. C., Wang, L., Ghosh, A., Cao, X., Lonigro, R. J., Tomlins, S. A., Varambally, S. & Chinnaiyan, A. M., Aug 15 2011, In : Cancer Research. 71, 16, p. 5387-5392 6 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Gene Fusion
Up-Regulation
Androgens
Down-Regulation
2010
512 Citations (Scopus)

An Integrated Network of Androgen Receptor, Polycomb, and TMPRSS2-ERG Gene Fusions in Prostate Cancer Progression

Yu, J., Yu, J., Mani, R. S., Cao, Q., Brenner, C. J., Cao, X., Wang, X., Wu, L., Li, J., Hu, M., Gong, Y., Cheng, H., Laxman, B., Vellaichamy, A., Shankar, S., Li, Y., Dhanasekaran, S. M., Morey, R., Barrette, T., Lonigro, R. J. & 4 others, Tomlins, S. A., Varambally, S., Qin, Z. S. & Chinnaiyan, A. M., May 18 2010, In : Cancer Cell. 17, 5, p. 443-454 12 p.

Research output: Contribution to journalArticle

Gene Fusion
Androgen Receptors
Prostatic Neoplasms
Polycomb-Group Proteins
High-Throughput Nucleotide Sequencing
88 Citations (Scopus)

Triggers for genomic rearrangements: Insights into genomic, cellular and environmental influences

Mani, R. S. & Chinnaiyan, A. M., Dec 2010, In : Nature Reviews Genetics. 11, 12, p. 819-829 11 p.

Research output: Contribution to journalArticle

Metagenomics
DNA Repair
Genetic Recombination
Chromatin
Cues
2009
45 Citations (Scopus)

Functional consequences of novel connexin 26 mutations associated with hereditary hearing loss

Mani, R. S., Ganapathy, A., Jalvi, R., Srikumari Srisailapathy, C. R., Malhotra, V., Chadha, S., Agarwal, A., Ramesh, A., Rangasayee, R. R. & Anand, A., 2009, In : European Journal of Human Genetics. 17, 4, p. 502-509 8 p.

Research output: Contribution to journalArticle

Hearing Loss
Mutation
Gap Junctions
Terminator Codon
Sensorineural Hearing Loss
272 Citations (Scopus)

Induced chromosomal proximity and gene fusions in prostate cancer

Mani, R. S., Tomlins, S. A., Callahan, K., Ghosh, A., Nyati, M. K., Varambally, S., Palanisamy, N. & Chinnalyan, A. M., Nov 27 2009, In : Science. 326, 5957, p. 1230 1 p.

Research output: Contribution to journalArticle

Fusion Oncogene Proteins
Serine Endopeptidases
Oncogene Fusion
Chromosomes, Human, Pair 21
Trans-Activators
2008
776 Citations (Scopus)

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

Varambally, S., Cao, Q., Mani, R. S., Shankar, S., Wang, X., Ateeq, B., Laxman, B., Cao, X., Jing, X., Ramnarayanan, K., Brenner, J. C., Yu, J., Kim, J. H., Han, B., Tan, P., Kumar-Sinha, C., Lonigro, R. J., Palanisamy, N., Maher, C. A. & Chinnaiyan, A. M., Dec 12 2008, In : Science. 322, 5908, p. 1695-1699 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Neoplasms
Epigenomics
Gene Silencing
histone methyltransferase
390 Citations (Scopus)

Repression of E-cadherin by the polycomb group protein EZH2 in cancer

Cao, Q., Yu, J., Dhanasekaran, S. M., Kim, J. H., Mani, R. S., Tomlins, S. A., Mehra, R., Laxman, B., Cao, X., Yu, J., Kleer, C. G., Varambally, S. & Chinnaiyan, A. M., Dec 11 2008, In : Oncogene. 27, 58, p. 7274-7284 11 p.

Research output: Contribution to journalArticle

Polycomb-Group Proteins
Cadherins
Neoplasms
Lysine
Polycomb Repressive Complex 2
2007

Implications in disclosing auditory genetic mutation to a family: A case study

Shekhawat, G. S., RamShankar, M., Jalvi, R. R., Rangasayee, R. & Anand, A., Jul 2007, In : International Journal of Audiology. 46, 7, p. 384-387 4 p.

Research output: Contribution to journalArticle

Mutation
deafness
Genetic Testing
Deafness
Biotechnology
2003
83 Citations (Scopus)

Contribution of connexin26 (GJB2) mutations and founder effect to non-syndromic hearing loss in India.

RamShankar, M., Girirajan, S., Dagan, O., Ravi Shankar, H. M., Jalvi, R., Rangasayee, R., Avraham, K. B. & Anand, A., May 2003, In : Journal of Medical Genetics. 40, 5

Research output: Contribution to journalArticle

DNA Mutational Analysis
Molecular Sequence Data
Audiology
Founder Effect
Consanguinity