Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation

Medicine & Life Sciences

• Corneal Dystrophy, Crystalline, of Schnyder 100%
• Dimethylallyltranstransferase 89%
• Protein Domains 51%
• Autophagy 49%
• geranylgeranyl pyrophosphate 45%
• Oxidoreductases 25%
• Cholesterol 13%
• Sterols 10%
• menatetrenone 7%
• Vitamin K 2 6%
• Hydroxymethylglutaryl CoA Reductases 6%
• Terpenes 5%
• Enzyme Assays 5%
• Mutant Proteins 5%
• Hydroxymethylglutaryl-CoA Reductase Inhibitors 4%
• Cornea 4%
• Cell Membrane 3%
• Mutation 2%
• Therapeutics 0%

Chemical Compounds

• Cholesterol 46%
• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 37%
• Isoprenoid 33%
• Sterol 28%
• Refractory 26%
• Vitamin 26%
• Disorder 22%
• Mutation 21%
• Enzyme Activity 21%
• Dissociation 18%
• Protein 10%