Research Output

Hormone-sensitive adenylate cyclase: resolution and reconstitution of some components necessary for regulation of the enzyme.

Ross, E. M., Haga, T., Howlett, A. C., Schwarzmeier, J., Schleifer, L. S. & Gilman, A. G., Jan 1 1978, In : Advances in cyclic nucleotide research. 9, p. 53-68 16 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hormone-Sensitive Adenylate Cyclase: Identity, Function, and Regulation of the Protein Components

Ross, E. M., Pedersen, S. E. & Florio, V. A., Jan 1 1983, In : Current Topics in Membranes and Transport. 18, C, p. 109-142 34 p.

Research output: Contribution to journalArticle

12 Scopus citations

Hot spots for allosteric regulation on protein surfaces

Reynolds, K. A., McLaughlin, R. N. & Ranganathan, R., Dec 23 2011, In : Cell. 147, 7, p. 1564-1575 12 p.

Research output: Contribution to journalArticle

179 Scopus citations
3117 Scopus citations

Human α1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

Loebermann, H., Tokuoka, R., Deisenhofer, J. & Huber, R., Aug 15 1984, In : Journal of Molecular Biology. 177, 3, p. 531-557 27 p.

Research output: Contribution to journalArticle

586 Scopus citations

Hydrophobic forces and the length limit of foldable protein domains

Lin, M. M. & Zewail, A. H., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 9851-9856 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Hyperactivated sperm motility driven by CatSper2 is required for fertilization

Quill, T. A., Sugden, S. A., Rossi, K. L., Doolittle, L. K., Hammer, R. E. & Garbers, D. L., Dec 9 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 25, p. 14869-14874 6 p.

Research output: Contribution to journalArticle

242 Scopus citations
Open Access
1148 Scopus citations

Identification, expression, and crystallization of the protease- resistant conserved domain of synapsin I

Wang, C. R., Esser, L., Smagula, C. S., Südhof, T. C. & Deisenhofer, J., Oct 1 1997, In : Protein Science. 6, 10, p. 2264-2267 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Identification and partial characterization of some components of hormone-stimulated adenylate cyclase

Ross, E. M., Howlett, A. C. & Gilman, A. G., 1979, Progress in Clinical and Biological Research. Vol. Vol. 31. p. 735-749 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Identification of a specific inhibitor of the Dishevelled PDZ domain

Shan, J., Shi, D. L., Wang, J. & Zheng, J., Nov 29 2005, In : Biochemistry. 44, 47, p. 15495-15503 9 p.

Research output: Contribution to journalArticle

146 Scopus citations
55 Scopus citations

Ignition of a cellular machine

Kreishman-Deltrick, M. & Rosen, M. K., Feb 23 2002, In : Nature Cell Biology. 4, 2, p. E31-E33

Research output: Contribution to journalComment/debate

7 Scopus citations

Immunoglobulin κ gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice

Xu, M., Hammer, R. E., Blasquez, V. C., Jones, S. L. & Garrard, W. T., Dec 1 1989, In : Journal of Biological Chemistry. 264, 35, p. 21190-21195 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

Immunologic mapping of the amino- and carboxy-termini of the turkey erythrocyte β-adrenergic receptor; Selective proteolysis of both domains

Luxembourg, A., Hekman, M. & Ross, E. M., May 20 1991, In : FEBS Letters. 283, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Immunophilin-ligand complexes as probes of intracellular signaling pathways

Schreiber, S. L., Liu, J., Albers, M. W., Karmacharya, R., Koh, E., Martin, P. K., Rosen, M. K., Standaert, R. F. & Wandless, T. J., Dec 1 1991, In : Transplantation Proceedings. 23, 6, p. 2839-2844 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Imprisonment of resonant phonons observed with a new technique for the detection of 1012-Hz phonons

Renk, K. F. & Deisenhofer, J., Jan 1 1971, In : Physical Review Letters. 26, 13, p. 764-766 3 p.

Research output: Contribution to journalArticle

79 Scopus citations

Improved strategy for isoleucine 1H/13C methyl labeling in Pichia pastoris

Ali, R., Clark, L. D., Zahm, J. A., Lemoff, A., Ramesh, K., Rosenbaum, D. M. & Rosen, M. K., Dec 1 2019, In : Journal of biomolecular NMR. 73, 12, p. 687-697 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance

Abdizadeh, H., Tamer, Y. T., Acar, O., Toprak, E., Atilgan, A. R. & Atilgan, C., 2017, In : Physical Chemistry Chemical Physics. 19, 18, p. 11416-11428 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Rohlmann, A., Gotthardt, M., Hammer, R. E. & Herz, J., Feb 1 1998, In : Journal of Clinical Investigation. 101, 3, p. 689-695 7 p.

Research output: Contribution to journalArticle

Open Access
362 Scopus citations

Induction of hepatocyte proliferation and death by modulation of T-antigen expression

Comerford, S. A., Clouthier, D. E., Hinnant, E. A. & Hammer, R. E., Apr 24 2003, In : Oncogene. 22, 16, p. 2515-2530 16 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inflammatory disease in HLA-B27 transgenic rats

Taurog, J. D., Maika, S. D., Satumtira, N., Dorris, M. L., McLean, I. L., Yanagisawa, H., Sayad, A., Stagg, A. J., Fox, G. M., O'Brien, A. L., Rehman, M., Zhou, M., Weiner, A. L., Splawski, J. B., Richardson, J. A. & Hammer, R. E., Jul 29 1999, In : Immunological Reviews. 169, p. 209-223 15 p.

Research output: Contribution to journalReview article

174 Scopus citations

Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits

Tu, Y., Wang, J. & Ross, E. M., Nov 7 1997, In : Science. 278, 5340, p. 1132-1135 4 p.

Research output: Contribution to journalArticle

127 Scopus citations

Inhibition of FKBP rotamase activity by immunosuppressant FK506: Twisted amide surrogate

Rosen, M. K., Standaert, R. F., Galat, A., Nakatsuka, M. & Schreiber, S. L., Jan 1 1990, In : Science. 248, 4957, p. 863-866 4 p.

Research output: Contribution to journalArticle

178 Scopus citations

Inhibitor binding changes domain mobility in the iron-sulfur protein of the mitochondrial bc1 complex from bovine heart

Kim, H., Xia, D., Yu, C. A., Xia, J. Z., Kachurin, A. M., Zhang, L., Yu, L. & Deisenhofer, J., Jul 7 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 14, p. 8026-8033 8 p.

Research output: Contribution to journalArticle

247 Scopus citations

Insertion, expression and physiology of growth-regulating genes in ruminants.

Rexroad, C. E., Hammer, R. E., Behringer, R. R., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 41, p. 119-124 6 p.

Research output: Contribution to journalReview article

25 Scopus citations

Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC

Huang, Y., Smith, B. S., Chen, L. X., Baxter, R. H. G. & Deisenhofer, J., May 5 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7403-7407 5 p.

Research output: Contribution to journalArticle

49 Scopus citations

In Silico Chemogenomics Knowledgebase and Computational System Neuropharmacology Approach for Cannabinoid Drug Research

Xie, X. Q., Wang, L., Wang, J., Xie, Z., Yang, P. & Ouyang, Q., May 13 2016, General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions. Elsevier Inc., Vol. 3. p. 183-195 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF U during pedestal formation

Vingadassalom, D., Kazlauskas, A., Skehan, B., Cheng, H. C., Magoun, L., Robbins, D., Rosen, M. K., Saksela, K. & Leong, J. M., Apr 21 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 16, p. 6754-6759 6 p.

Research output: Contribution to journalArticle

86 Scopus citations
Open Access
634 Scopus citations

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

Owen, J. L., Zhang, Y., Bae, S. H., Farooqi, M. S., Liang, G., Hammer, R. E., Goldstein, J. L. & Brown, M. S., Oct 2 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40, p. 16184-16189 6 p.

Research output: Contribution to journalArticle

140 Scopus citations

In support of the BMRB.

Markley, J. L., Akutsu, H., Asakura, T., Baldus, M., Boelens, R., Bonvin, A., Kaptein, R., Bax, A., Bezsonova, I., Gryk, M. R., Hoch, J. C., Korzhnev, D. M., Maciejewski, M. W., Case, D., Chazin, W. J., Cross, T. A., Dames, S., Kessler, H., Lange, O., Madl, T. & 71 others, Reif, B., Sattler, M., Eliezer, D., Fersht, A., Forman-Kay, J., Kay, L. E., Fraser, J., Gross, J., Kortemme, T., Sali, A., Fujiwara, T., Gardner, K. H., Luo, X., Rizo-Rey, J., Rosen, M. K., Gil, R. R., Ho, C., Rule, G., Gronenborn, A. M., Ishima, R., Klein-Seetharaman, J., Tang, P., van der Wel, P., Xu, Y., Grzesiek, S., Hiller, S., Seelig, J., Laue, E. D., Mott, H., Nietlispach, D., Barsukov, I., Lian, L. Y., Middleton, D., Blumenschein, T., Moore, G., Campbell, I., Schnell, J., Vakonakis, I. J., Watts, A., Conte, M. R., Mason, J., Pfuhl, M., Sanderson, M. R., Craven, J., Williamson, M., Dominguez, C., Roberts, G., Günther, U., Overduin, M., Werner, J., Williamson, P., Blindauer, C., Crump, M., Driscoll, P., Frenkiel, T., Golovanov, A., Matthews, S., Parkinson, J., Uhrin, D., Williams, M., Neuhaus, D., Oschkinat, H., Ramos, A., Shaw, D. E., Steinbeck, C., Vendruscolo, M., Vuister, G. W., Walters, K. J., Weinstein, H., Wüthrich, K. & Yokoyama, S., Sep 2012, In : Nature structural & molecular biology. 19, 9, p. 854-860 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Integration, expression and germ-line transmission of growth-related genes in pigs.

Pursel, V. G., Hammer, R. E., Bolt, D. J., Palmiter, R. D. & Brinster, R. L., 1990, In : Journal of reproduction and fertility. Supplement. 41, p. 77-87 11 p.

Research output: Contribution to journalReview article

48 Scopus citations

Integration of Multiple Metabolic Signals Determines Cell Fate Prior to Commitment

Argüello-Miranda, O., Liu, Y., Wood, N. E., Kositangool, P. & Doncic, A., Sep 6 2018, In : Molecular Cell. 71, 5, p. 733-744.e11

Research output: Contribution to journalArticle

6 Scopus citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J. A., Emoto, N., Hammer, R. E. & Yanagisawa, M., Dec 30 1994, In : Cell. 79, 7, p. 1277-1285 9 p.

Research output: Contribution to journalArticle

771 Scopus citations

Interfaces between mitochondrial dynamics and disease

Mishra, P., Sep 1 2016, In : Cell Calcium. 60, 3, p. 190-198 9 p.

Research output: Contribution to journalReview article

21 Scopus citations

Interhelical hydrogen bonding drives strong interactions in membrane proteins

Zhou, F. X., Cocco, M. J., Russ, W. P., Brunger, A. T. & Engelman, D. M., Feb 1 2000, In : Nature Structural Biology. 7, 2, p. 154-160 7 p.

Research output: Contribution to journalArticle

340 Scopus citations

Internal dynamics control activation and activity of the autoinhibited Vav DH domain

Li, P., Martins, I. R. S., Amarasinghe, G. K. & Rosen, M. K., Jun 1 2008, In : Nature Structural and Molecular Biology. 15, 6, p. 613-618 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice

Linden, A. G., Li, S., Choi, H. Y., Fang, F., Fukasawa, M., Uyeda, K., Hammer, R. E., Horton, J. D., Engelking, L. & Liang, G., 2018, In : Journal of lipid research. 59, 3, p. 475-487 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

Harmon, T. S., Holehouse, A. S., Rosen, M. K. & Pappu, R. V., Nov 1 2017, In : eLife. 6, e30294.

Research output: Contribution to journalArticle

107 Scopus citations

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly

Protter, D. S. W., Rao, B. S., Van Treeck, B., Lin, Y., Mizoue, L., Rosen, M. K. & Parker, R., Feb 6 2018, In : Cell Reports. 22, 6, p. 1401-1412 12 p.

Research output: Contribution to journalArticle

70 Scopus citations

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

Lin, Y., Currie, S. L. & Rosen, M. K., Nov 17 2017, In : Journal of Biological Chemistry. 292, 46, p. 19110-19120 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Intrinsic Pleckstrin Homology (PH) domain motion in phospholipase C-β exposes a Gβγ protein binding site

Kadamur, G. & Ross, E. M., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11394-11406 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
Open Access
629 Scopus citations

Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP

Labno, C. M., Lewis, C. M., You, D., Leung, D. W., Takesono, A., Kamberos, N., Seth, A., Finkelstein, L. D., Rosen, M. K., Schwartzberg, P. L. & Burkhardt, J. K., Sep 16 2003, In : Current Biology. 13, 18, p. 1619-1624 6 p.

Research output: Contribution to journalArticle

104 Scopus citations

Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats

Kasof, G. M., Mandelzys, A., Maika, S. D., Hammer, R. E., Curran, T. & Morgan, J. I., Jan 1 1995, In : Journal of Neuroscience. 15, 6, p. 4238-4249 12 p.

Research output: Contribution to journalArticle

141 Scopus citations

Karyopherins and condensates

Springhower, C. E., Rosen, M. K. & Chook, Y. M., Jun 2020, In : Current Opinion in Cell Biology. 64, p. 112-123 12 p.

Research output: Contribution to journalReview article

Open Access

Kernel mechanism of the cyanobacterial circadian clock is a relaxation oscillator

Ma, L. & Ranganathan, R., Dec 1 2011, 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011. p. 5850-5855 6 p. 6161040. (Proceedings of the IEEE Conference on Decision and Control).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Kinetic control of guanine nucleotide binding to soluble Gα(q)

Markin, V. S. & Ross, E. M., Jul 1 1999, In : Biochemical Pharmacology. 58, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Knowledge-based potential functions in protein design

Russ, W. P. & Ranganathan, R., Aug 1 2002, In : Current Opinion in Structural Biology. 12, 4, p. 447-452 6 p.

Research output: Contribution to journalReview article

61 Scopus citations