Research Output

1986

Somatostatin is targeted to the regulated secretory pathway of gonadotrophs in transgenic mice expressing a metallothionein-somatostatin gene

Low, M. J., Stork, P. J., Hammer, R. E., Brinster, R. L., Warhol, M. J., Mandel, G. & Goodman, R. H., Dec 1 1986, In : Journal of Biological Chemistry. 261, 34, p. 16260-16263 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Stimulation of growth hormone synthesis by glucose in islets of langerhans isolated from transgenic mice

Welsh, M., Hammer, R. E., Brinster, R. L. & Steiner, D. F., Dec 1 1986, In : Journal of Biological Chemistry. 261, 28, p. 12915-12917 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction

Allen, J. P., Feher, G., Yeates, T. O., Rees, D. C., Deisenhofer, J., Michel, H. & Huber, R., Dec 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 22, p. 8589-8593 5 p.

Research output: Contribution to journalArticle

312 Scopus citations

The regulation of α-foetoprotein minigene expression in the germline of mice

Hammer, R. E., Krumlauf, R., Camper, S., Brinster, R. L. & Tilghman, S. M., Dec 1 1986, In : Journal of Embryology and Experimental Morphology. 97, SUPPL., p. 257-262 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Tissue‐specific Expression of Pancreatic Genes in Transgenic Mice

MacDonald, R. J., Hammer, R. E., Swift, G. H., Ornitz, D. M., Davis, B. P., Palmiter, R. D. & Brinster, R. L., Oct 1986, In : Annals of the New York Academy of Sciences. 478, 1, p. 131-146 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes

MacDonald, R. J., Hammer, R. E., Swift, G. H., Davis, B. P. & Brinster, R. L., Oct 1986, In : DNA. 5, 5, p. 393-401 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
1987

A chicken transferrin gene in transgenic mice escapes X-chromosome inactivation

Goldman, M. A., Stokes, K. R., Idzerda, R. L., McKnight, G. S., Hammer, R. E., Brinster, R. L. & Gartler, S. M., Jan 1 1987, In : Science. 236, 4801, p. 593-595 3 p.

Research output: Contribution to journalArticle

34 Scopus citations

Comparison of two highly refined structures of bovine pancreatic trypsin inhibitor

Wlodawer, A., Deisenhofer, J. & Huber, R., Jan 5 1987, In : Journal of Molecular Biology. 193, 1, p. 145-156 12 p.

Research output: Contribution to journalArticle

211 Scopus citations

Diversity of Alpha-Fetoprotein gene expression in mice is generated by a combination of separate enhancer elements

Hammer, R. E., Krumlauf, R., Camper, S. A., Brinster, R. L. & Tilghman, S. M., Jan 1 1987, In : Science. 235, 4784, p. 53-58 6 p.

Research output: Contribution to journalArticle

169 Scopus citations

Growth allometry of the organs in giant transgenic mice

Shea, B. T., Hammer, R. E. & Brinster, R. L., Dec 1 1987, In : Endocrinology. 121, 6, p. 1924-1930 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Multiple sequences regulate human beta-globin gene expression in transgenic mice.

Townes, T. M., Behringer, R. R., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., 1987, In : Progress in clinical and biological research. 251, p. 323-343 21 p.

Research output: Contribution to journalArticle

Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice

Ornitz, D. M., Hammer, R. E., Messing, A., Palmiter, R. D. & Brinster, R. L., Jan 1 1987, In : Science. 238, 4824, p. 188-193 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Progress on gene transfer in farm animals

Pursel, V. G., Rexroad, C. E., Bolt, D. J., Miller, K. F., Wall, R. J., Hammer, R. E., Pinkert, C. A., Palmiter, R. D. & Brinster, R. L., Dec 1987, In : Veterinary Immunology and Immunopathology. 17, 1-4, p. 303-312 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers.

Ornitz, D. M., Hammer, R. E., Davison, B. L., Brinster, R. L. & Palmiter, R. D., Oct 1987, In : Molecular and cellular biology. 7, 10, p. 3466-3472 7 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Role of growth hormone in regulating T‐Dependent immune events in aged, nude, and transgenic rodents

Davila, D. R., Brief, S., Simon, J., Hammer, R. E., Brinster, R. L. & Kelley, K. W., 1987, In : Journal of Neuroscience Research. 18, 1, p. 108-116 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

Targeted expression of cloned genes in transgenic mice

MacDonald, R. J., Swift, G. H., Hammer, R. E., Ornitz, D. M., Davis, B. P., Brinster, R. L. & Palmiter, R. D., Jan 1987, In : Progress in Brain Research. 71, C, p. 3-12 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins

Higashijima, T., Ferguson, K. M., Sternweis, P. C., Ross, E. M., Smigel, M. D. & Gilman, A. G., Mar 26 1987, In : Journal of Biological Chemistry. 262, 2, p. 752-756 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

The hydrophobic tryptic core of the β-adrenergic receptor retains G(s) regulatory activity in response to agonists and thiols

Rubenstein, R. C., Wong, S. K. F. & Ross, E. M., Dec 1 1987, In : Journal of Biological Chemistry. 262, 34, p. 16655-16662 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice.

Hammer, R. E., Swift, G. H., Ornitz, D. M., Quaife, C. J., Palmiter, R. D., Brinster, R. L. & MacDonald, R. J., Aug 1987, In : Molecular and cellular biology. 7, 8, p. 2956-2967 12 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Two 3' sequences direct adult erythroid-specific expression of human β-globulin genes in transgenic mice

Behringer, R. R., Hammer, R. E., Brinster, R. L., Palmiter, R. D. & Townes, T. M., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 20, p. 7056-7060 5 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations
1988

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway

Carroll, R. J., Hammer, R. E., Chan, S. J., Swift, H. H., Rubenstein, A. H. & Steiner, D. F., Jan 1 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 23, p. 8943-8947 5 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations

Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene

Mayo, K. E., Hammer, R. E., Swanson, L. W., Brinster, R. L., Rosenfeld, M. G. & Evans, R. M., Jul 1988, In : Molecular Endocrinology. 2, 7, p. 606-612 7 p.

Research output: Contribution to journalArticle

Open Access
159 Scopus citations

Expression of a metallothionein-vasopressin fusion gene in transgenic mice produces hypervasopressinemia and manifestations of nephrogenic diabetes insipidus.

Habener, J. F., Cwikel, B., Hermann, H., Hammer, R. E., Palmiter, R. D. & Brinster, R. L., Dec 1 1988, In : Transactions of the Association of American Physicians. 101, p. 155-162 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Expression of insulin-like growth factor i in transgenic mice with elevated levels of growth hormone is correlated with growth

Mathews, L. S., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., Jul 1 1988, In : Endocrinology. 123, 1, p. 433-437 5 p.

Research output: Contribution to journalArticle

138 Scopus citations

Functional domains in the β-adrenergic receptor

Ross, E. M., Wong, S. K. F., Rubenstein, R. C. & Higashijima, T., 1988, In : Cold Spring Harbor symposia on quantitative biology. 53, 1, p. 499-506 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Growth enhancement of transgenic mice expressing human insulin-like growth factor I

Mathews, L. S., Hammer, R. E., Behringer, R. R., D'Ercole, A. J., Bell, G. I., Brinster, R. L. & Palmiter, R. D., Dec 1988, In : Endocrinology. 123, 6, p. 2827-2833 7 p.

Research output: Contribution to journalArticle

353 Scopus citations
50 Scopus citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)

Higashijima, T., Uzu, S., Nakajima, T. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 14, p. 6491-6494 4 p.

Research output: Contribution to journalArticle

561 Scopus citations
79 Scopus citations
17 Scopus citations

Receptor-G protein-effector: The design of a biochemical switchboard

Ross, E. M., Dec 1 1988, In : Journal Of Chemical Education. 65, 11, p. 937-942 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Relevance of the Photosynthetic Reaction Center from Purple Bacteria to the Structure of Photosystem II

Michel, H. & Deisenhofer, J., Jan 1 1988, In : Biochemistry. 27, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

626 Scopus citations

Structure and function of the photosynthetic reaction center from Rhodopseudomonas viridis

Michel, H. & Deisenhofer, J., Jan 1 1988, In : Pure and Applied Chemistry. 60, 7, p. 953-958 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Studies of HLA-B27-associated disease

Taurog, J. D., Durand, J. P., El-Zaatari, F. A. K. & Hammer, R. E., Dec 23 1988, In : The American Journal of Medicine. 85, 6 SUPPL. 1, p. 59-60 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

The catecholamine binding site of the β-adrenergic receptor is formed by juxtaposed membrane-spanning domains

Wong, S. K. F., Slaughter, C., Ruoho, A. E. & Ross, E. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 7925-7928 4 p.

Research output: Contribution to journalArticle

85 Scopus citations

The structure of the photosynthetic reaction centre from Rhodopseudomonas viridis

Michel, H. & Deisenhofer, J., Jan 1 1988, In : Bulletin de l'Institut Pasteur. 86, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Unidirectionality of charge separation in reaction centers of photosynthetic bacteria

Michel-Beyerle, M. E., Plato, M., Deisenhofer, J., Michel, H., Bixon, M. & Jortner, J., 1988, In : BBA - Bioenergetics. 932, C, p. 52-70 19 p.

Research output: Contribution to journalArticle

182 Scopus citations

β-Adrenergic receptors display intramolecular disulfide bridges in situ: Analysis by immunoblotting and functional reconstitution

Moxham, C. P., Ross, E. M., George, S. T. & Malbon, C. C., Jan 1 1988, In : Molecular Pharmacology. 33, 5, p. 486-492 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
1989

Detergent structure in crystals of a bacterial photosynthetic reaction centre

Roth, M., Lewit-Bentley, A., Michel, H., Deisenhofer, J., Huber, R. & Oesterhelt, D., Jan 1 1989, In : Nature. 340, 6235, p. 659-662 4 p.

Research output: Contribution to journalArticle

183 Scopus citations
Open Access
44 Scopus citations

Expression of human or bovine growth hormone gene with a mouse metallothionein-1 promoter in transgenic swine alters the secretion of porcine growth hormone and insulin-like growth factor-I

Miller, K. F., Bolt, D. J., Pursel, V. G., Hammer, R. E., Pinkert, C. A., Palmiter, R. D. & Brinster, R. L., 1989, In : Journal of Endocrinology. 120, 3, p. 481-488 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Genetic engineering of livestock

Pursel, V. G., Pinkert, C. A., Miller, K. F., Bolt, D. J., Campbell, R. G., Palmiter, R. D., Brinster, R. L. & Hammer, R. E., Jan 1 1989, In : Science. 244, 4910, p. 1281-1288 8 p.

Research output: Contribution to journalArticle

308 Scopus citations

Histopathology associated with elevated levels of growth hormone and insulin-like growth factor i in transgenic mice

Quaife, C. J., Mathews, L. S., Pinkert, C. A., Hammer, R. E., Brinster, R. L. & Palmiter, R. D., Jan 1989, In : Endocrinology. 124, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

203 Scopus citations

Immunoglobulin κ gene expression after stable integration. II. Role of the intronic MAR and enhancer in transgenic mice

Xu, M., Hammer, R. E., Blasquez, V. C., Jones, S. L. & Garrard, W. T., Dec 1 1989, In : Journal of Biological Chemistry. 264, 35, p. 21190-21195 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

Metallothionein-vasopressin fusion gene expression in transgenic mice. Nephrogenic diabetes insipidus and brain transcripts localized to magnocellular neurons

Habener, J. F., Cwikel, B. J., Hermann, H., Hammer, R. E., Oalmiter, R. D. & Brinster, R. L., Jan 1 1989, In : Journal of Biological Chemistry. 264, 31, p. 18844-18852 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nobel lecture. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis.

Deisenhofer, J. & Michel, H., Aug 1989, In : The EMBO journal. 8, 8, p. 2149-2170 22 p.

Research output: Contribution to journalReview article

546 Scopus citations

Production of transgenic sheep with growth‐regulating genes

Rexroad, C. E., Hammer, R. E., Bolt, D. J., Mayo, K. E., Frohman, L. A., Palmitter, R. D. & Brinster, R. L., 1989, In : Molecular Reproduction and Development. 1, 3, p. 164-169 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Signal sorting and amplification through G protein-coupled receptors

Ross, E. M., Aug 1989, In : Neuron. 3, 2, p. 141-152 12 p.

Research output: Contribution to journalReview article

254 Scopus citations

The photosynthetic reaction center from the purple bacterium Rhodopseudomonas viridis

Deisenhofer, J. & Michel, H., 1989, In : Science. 245, 4925, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

481 Scopus citations