Research Output

1998

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα

Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. M. A., Hammer, R. E. & Mangelsdorf, D. J., May 29 1998, In : Cell. 93, 5, p. 693-704 12 p.

Research output: Contribution to journalArticle

1134 Scopus citations

Correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease

Onderdonk, A. B., Richardson, J. A., Hammer, R. E. & Taurog, J. D., Dec 1 1998, In : Infection and immunity. 66, 12, p. 6022-6023 2 p.

Research output: Contribution to journalArticle

47 Scopus citations

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

Clouthier, D. E., Hosoda, K., Richardson, J. A., Williams, S. C., Yanagisawa, H., Kuwaki, T., Kumada, M., Hammer, R. E. & Yanagisawai, M., 1998, In : Development. 125, 5, p. 813-824 12 p.

Research output: Contribution to journalArticle

530 Scopus citations

Crystallization and preliminary X-ray analysis of ferric enterobactin receptor FepA, an integral membrane protein from Escherichia coli

Smith, B. S., Kobe, B., Kurumbail, R., Buchanan, S. K., Venkatramani, L., Van Der Helm, D. & Deisenhofer, J., Jul 1 1998, In : Acta Crystallographica Section D: Biological Crystallography. 54, 4, p. 697-699 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., De Wit, D., Emoto, N. & Hammer, R. E., Apr 11 1998, In : Development. 125, 5, p. 825-836 12 p.

Research output: Contribution to journalArticle

410 Scopus citations

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity

Ingi, T., Krumins, A. M., Chidiac, P., Brothers, G. M., Chung, S., Snow, B. E., Barnes, C. A., Lanahan, A. A., Siderovski, D. P., Ross, E. M., Gilman, A. G. & Worley, P. F., Sep 15 1998, In : Journal of Neuroscience. 18, 18, p. 7178-7188 11 p.

Research output: Contribution to journalArticle

Open Access
250 Scopus citations

Egg culture: The foundation

Hammer, R. E., Dec 2 1998, In : International Journal of Developmental Biology. 42, 7, p. 833-839 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Force titration of amino group-terminated self-assembledmonolayers using chemical force microscopy

Zhang, H., He, H. X., Wang, J., Mu, T. & Liu, Z. F., Dec 1 1998, In : Applied Physics A: Materials Science and Processing. 66, SUPPL. 1, p. S269-S271

Research output: Contribution to journalArticle

71 Scopus citations

Inducible inactivation of hepatic LRP gene by Cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

Rohlmann, A., Gotthardt, M., Hammer, R. E. & Herz, J., Feb 1 1998, In : Journal of Clinical Investigation. 101, 3, p. 689-695 7 p.

Research output: Contribution to journalArticle

Open Access
362 Scopus citations

Inhibitor binding changes domain mobility in the iron-sulfur protein of the mitochondrial bc1 complex from bovine heart

Kim, H., Xia, D., Yu, C. A., Xia, J. Z., Kachurin, A. M., Zhang, L., Yu, L. & Deisenhofer, J., Jul 7 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 14, p. 8026-8033 8 p.

Research output: Contribution to journalArticle

247 Scopus citations
Open Access
634 Scopus citations
116 Scopus citations

Mechanism of Rab geranylgeranylation: Formation of the catalytic ternary complex

Anant, J. S., Desnoyers, L., Machius, M., Demeler, B., Hansen, J. C., Westover, K. D., Deisenhofer, J. & Seabra, M. C., Sep 8 1998, In : Biochemistry. 37, 36, p. 12559-12568 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Neurexin Iα is a major α-latrotoxin receptor that cooperates in α- latrotoxin action

Geppert, M., Khvotchev, M., Krasnoperov, V., Goda, Y., Missler, M., Hammer, R. E., Ichtchenko, K., Petrenko, A. G. & Südhof, T. C., Jan 16 1998, In : Journal of Biological Chemistry. 273, 3, p. 1705-1710 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Neurexophilin binding to α-neurexins. A single LNS domain functions as an independently folding ligand-binding unit

Missler, M., Hammer, R. E. & Südhof, T. C., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34716-34723 8 p.

Research output: Contribution to journalArticle

88 Scopus citations

RGSZ1, a G(z)-selective rgs protein in brain: Structure, membrane association, regulation by Gα(z) phosphorylation, and relationship to a G(z) gtpase-activating protein subfamily

Wang, J., Ducret, A., Tu, Y., Kozasa, T., Aebersold, R. & Ross, E. M., Oct 2 1998, In : Journal of Biological Chemistry. 273, 40, p. 26014-26025 12 p.

Research output: Contribution to journalArticle

127 Scopus citations

Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice

Yanagisawa, H., Hammer, R. E., Richardson, J. A., Williams, S. C., Clouthier, D. E. & Yanagisawa, M., Jul 1 1998, In : Journal of Clinical Investigation. 102, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

Open Access
164 Scopus citations

Structural basis of functions of the mitochondrial cytochrome bc1 complex

Yu, C. A., Xia, D., Kim, H., Deisenhofer, J., Zhang, L., Kachurin, A. M. & Yu, L., Jun 10 1998, In : Biochimica et Biophysica Acta - Bioenergetics. 1365, 1-2, p. 151-158 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Structure and mutagenesis of the Dbl homology domain

Aghazadeh, B., Zhu, K., Kubiseski, T. J., Liu, G. A., Pawson, T., Zheng, Y. & Rosen, M. K., Dec 1 1998, In : Nature Structural Biology. 5, 12, p. 1098-1107 10 p.

Research output: Contribution to journalReview article

108 Scopus citations

Synapsin I is structurally similar to ATP-utilizing enzymes

Esser, L., Wang, C. R., Hosaka, M., Smagula, C. S., C.südhof, T. & Deisenhofer, J., Feb 4 1998, In : EMBO Journal. 17, 4, p. 977-984 8 p.

Research output: Contribution to journalArticle

105 Scopus citations
Open Access
471 Scopus citations

The International Journal of Developmental Biology: Preface

Hammer, R. E. & Behringer, R. R., Jan 1 1998, In : International Journal of Developmental Biology. 42, 7, p. 831-832 2 p.

Research output: Contribution to journalEditorial

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

Zeng, W., Xu, X., Popov, S., Mukhopadhyay, S., Chidiac, P., Swistok, J., Danho, W., Yagaloff, K. A., Fisher, S. L., Ross, E. M., Muallem, S. & Wilkie, T. M., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34687-34690 4 p.

Research output: Contribution to journalArticle

218 Scopus citations

Theoretical studies on force titration of amino-group-terminated self-assembled monolayers

Wang, J., Zhang, H., He, H., Hou, T., Liu, Z. & Xu, X., Oct 5 1998, In : Journal of Molecular Structure: THEOCHEM. 451, 3, p. 295-303 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

The specificity of peptides bound to human histocompatibility leukocyte antigen (HLA)-B27 influences the prevalence of arthritis in HLA-B27 transgenic rats

Zhou, B. M., Sayad, A., Simmons, W. A., Jones, R. C., Maika, S. D., Satumtira, N., Dorris, M. L., Gaskell, S. J., Bordoli, R. S., Sartor, R. B., Slaughter, C. A., Richardson, J. A., Hammer, R. E. & Taurog, J. D., Sep 7 1998, In : Journal of Experimental Medicine. 188, 5, p. 877-886 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Three-dimensional structure and functions of bovine heart mitochondrial cytochrome bc1 complex

Yu, C. A., Xia, D., Kim, H., Deisenhofer, J., Kachurin, A. M., Zhang, L., Deng, K. P. & Yu, L., Dec 1 1998, In : BioFactors. 8, 3-4, p. 187-189 3 p.

Research output: Contribution to journalShort survey

1 Scopus citations
Open Access
145 Scopus citations
1999

A Comparison of Three Heuristic Algorithms for Molecular Docking

Hou, T. J., Wang, J. M. & Xu, X. J., Jul 1 1999, In : Chinese Chemical Letters. 10, 7, p. 615-618 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor γ and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo

Devine, J. H., Eubank, D. W., Clouthier, D. E., Tontonoz, P., Spiegelman, B. M., Hammer, R. E. & Beale, E. G., May 7 1999, In : Journal of Biological Chemistry. 274, 19, p. 13604-13612 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Analysis of genomic regions involved in regulation of the rabbit surfactant protein A gene in transgenic mice

Alcorn, J. L., Hammer, R. E., Graves, K. R., Smith, M. E., Maika, S. D., Michael, L. F., Gao, E., Wang, Y. & Mendelson, C. R., Aug 1 1999, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 2 21-2, p. L349-L361

Research output: Contribution to journalArticle

26 Scopus citations

Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice

Fernández-Chacón, R., De Toledo, G. A., Hammer, R. E. & Südhof, T. C., Nov 12 1999, In : Journal of Biological Chemistry. 274, 46, p. 32551-32554 4 p.

Research output: Contribution to journalArticle

45 Scopus citations

A new MHC locus that influences class I peptide presentation.

Taurog, J. D., Lindahl, K. F., Hammer, R. E., Slaughter, C. A., Maika, S. D., Zhou, M., Roopenian, D. C., Christianson, G. J., Gaskell, S. J., Jones, R. C., Bordoli, R., Ploegh, H. L., Galocha, B. & Summerfield, S. G., Oct 1999, In : Immunity. 11, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access

A phospho-switch controls the dynamic association of synapsins with synaptic vesicles

Hosaka, M., Hammer, R. E. & Südhof, T. C., Oct 1999, In : Neuron. 24, 2, p. 377-387 11 p.

Research output: Contribution to journalArticle

200 Scopus citations
34 Scopus citations

Applications of genetic algorithms on the structure - Activity relationship analysis of some cinnamamides

Hou, T. J., Wang, J. M., Liao, N. & Xu, X. J., Jan 1 1999, In : Journal of Chemical Information and Computer Sciences. 39, 5, p. 775-781 7 p.

Research output: Contribution to journalArticle

68 Scopus citations

Automated docking of peptides and proteins by genetic algorithm

Wang, J., Hou, T., Chen, L. & Xu, X., Jan 18 1999, In : Chemometrics and Intelligent Laboratory Systems. 45, 1-2, p. 281-286 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Automated docking of peptides and proteins by using a genetic algorithm combined with a tabu search

Hou, T., Wang, J., Chen, L. & Xu, X., Jan 1 1999, In : Protein Engineering. 12, 8, p. 639-647 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Conformational analysis of peptides using Monte Carlo simulations combined with the genetic algorithm

Wang, J., Hou, T., Chen, L. & Xu, X., Jan 18 1999, In : Chemometrics and Intelligent Laboratory Systems. 45, 1-2, p. 347-351 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus

Machius, M., Henry, L., Palnitkar, M. & Deisenhofer, J., Oct 12 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 21, p. 11717-11722 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Crystal structure of the outer membrane active transporter FepA from Escherichia coli

Buchanan, S. K., Smith, B. S., Venkatramani, L., Xia, D., Esser, L., Palnitkar, M., Chakraborty, R., Van Der Helm, D. & Deisenhofer, J., May 27 1999, In : Nature Structural Biology. 6, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

458 Scopus citations

Erratum: A new MHC locus that influences class I peptide presentation (Immunity (1997) 7 (641-651))

Taurog, J. D., Lindahl, K. F., Hammer, R. E., Slaughter, C. A., Maika, S. D., Zhou, M., Roopenian, D. C., Christianson, G. J., Gaskell, S. J., Jones, R. C., Bordoli, R., Ploegh, H. L., Galocha, B. & Summerfield, S. G., Jan 1 1999, In : Immunity. 11, 4, p. x

Research output: Contribution to journalComment/debate

Erratum: Novel HY peptide antigens presented by HLA-B27 (Journal of Immunology (1997) 159 (2750-2759))

Taurog, J. D., Hammer, R. E., Moomaw, C. R., Slaughter, C. A., Roopenian, D. C., Zuberi, A. R., Gaskell, S. J., Bordoli, R. S., Hoyes, J., Colbert, R. A., Butcher, G. W. & Leong L.Y.-, W., Nov 15 1999, In : Journal of Immunology. 163, 10, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B-27-associated inflammatory disease (Journal of Immunology (1996) 156 (1661-1667))

Taurog, J. D., Hammer, R. E., Richardson, J. A., Satumtira, N., Slaughter, C. A., Butcher, G. W., Howard, J. C. & Leong, L. Y. W., Nov 15 1999, In : Journal of Immunology. 163, 10, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I

Janz, R., Südhof, T. C., Hammer, R. E., Unni, V., Siegelbaum, S. A. & Bolshakov, V. Y., Nov 1999, In : Neuron. 24, 3, p. 687-700 14 p.

Research output: Contribution to journalArticle

Open Access
227 Scopus citations

Evolutionarily conserved pathways of energetic connectivity in protein families

Lockless, S. W. & Ranganathan, R., Oct 8 1999, In : Science. 286, 5438, p. 295-299 5 p.

Research output: Contribution to journalArticle

927 Scopus citations
3 Scopus citations

Inflammatory disease in HLA-B27 transgenic rats

Taurog, J. D., Maika, S. D., Satumtira, N., Dorris, M. L., McLean, I. L., Yanagisawa, H., Sayad, A., Stagg, A. J., Fox, G. M., O'Brien, A. L., Rehman, M., Zhou, M., Weiner, A. L., Splawski, J. B., Richardson, J. A. & Hammer, R. E., Jul 29 1999, In : Immunological Reviews. 169, p. 209-223 15 p.

Research output: Contribution to journalReview article

174 Scopus citations

Kinetic control of guanine nucleotide binding to soluble Gα(q)

Markin, V. S. & Ross, E. M., Jul 1 1999, In : Biochemical Pharmacology. 58, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S. & Goldstein, J. L., Sep 2 1999, In : Nature. 401, 6748, p. 73-76 4 p.

Research output: Contribution to journalArticle

804 Scopus citations

Ligand recognition by SH3 and WW domains: The role of N-alkylation in PPII helices

Aghazadeh, B. & Rosen, M. K., Sep 1999, In : Chemistry and Biology. 6, 9, p. R241-R246

Research output: Contribution to journalReview article

16 Scopus citations