Pharmacology - Ross Lab

Research Output 1972 2019

2019

Regulating G protein-coupled receptors by topological inversion

Denard, B., Han, S., Kim, J. Y., Ross, E. M. & Ye, J., Mar 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
G-Protein-Coupled Receptors
Topology
Macrophages
Lipopolysaccharides
CCR5 Receptors
2018
2 Citations (Scopus)

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway

Gaspari, S., Purushothaman, I., Cogliani, V., Sakloth, F., Neve, R. L., Howland, D., Ring, R. H., Ross, E. M., Shen, L. & Zachariou, V., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. E2085-E2094

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Catenins
Wnt Signaling Pathway
Opioid Analgesics
Morphine
2017
1 Citation (Scopus)

The binding of activated Gq to phospholipase C- exhibits anomalous affinity

Navaratnarajah, P., Gershenson, A. & Ross, E. M., 2017, In : Journal of Biological Chemistry. 292, 40, p. 16787-16801 15 p.

Research output: Contribution to journalArticle

Type C Phospholipases
GTPase-Activating Proteins
Phosphatidylinositols
Protein Isoforms
Gq-G11 GTP-Binding Protein alpha Subunits
2016
10 Citations (Scopus)

Amino acids regulate mTORC1 by an obligate two-step mechanism

Dyachok, J., Earnest, S., Iturraran, E. N., Cobb, M. H. & Ross, E. M., Oct 21 2016, In : Journal of Biological Chemistry. 291, 43, p. 22414-22426 13 p.

Research output: Contribution to journalArticle

Amino Acids
Chemical activation
Aminoacylation
mechanistic target of rapamycin complex 1
Tuberous Sclerosis
1 Citation (Scopus)

Intrinsic Pleckstrin Homology (PH) domain motion in phospholipase C-β exposes a Gβγ protein binding site

Kadamur, G. & Ross, E. M., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11394-11406 13 p.

Research output: Contribution to journalArticle

Type C Phospholipases
GTP-Binding Proteins
Protein Binding
Binding Sites
EF Hand Motifs
2015
9 Citations (Scopus)

Differential regulation of ERK1/2 and mTORC1 through T1R1/T1R3 in MIN6 cells

Wauson, E. M., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M. & Cobb, M. H., Jul 31 2015, In : Molecular Endocrinology. 29, 8, p. 1114-1122 9 p.

Research output: Contribution to journalArticle

Aminoacylation
Amino Acids
GTP-Binding Proteins
Food
Insulin
2013
168 Citations (Scopus)

Mammalian phospholipase C

Kadamur, G. & Ross, E. M., Feb 10 2013, In : Annual Review of Physiology. 75, p. 127-154 28 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Diglycerides
Heterotrimeric GTP-Binding Proteins
Inositol 1,4,5-Trisphosphate
Monomeric GTP-Binding Proteins
2012
10 Citations (Scopus)

Activation Biosensor for G Protein-Coupled Receptors: A FRET-Based m1 Muscarinic Activation Sensor That Regulates Gq

Chang, S. & Ross, E. M., Sep 20 2012, In : PLoS One. 7, 9, e45651.

Research output: Contribution to journalArticle

biosensors
Energy Transfer
Biosensing Techniques
energy transfer
G-Protein-Coupled Receptors
2011
17 Citations (Scopus)

qand phospholipase C-β: Turn on, turn off, and do it fast

Ross, E. M., Feb 8 2011, In : Science Signaling. 4, 159, pe5.

Research output: Contribution to journalArticle

Type C Phospholipases
GTPase-Activating Proteins
GTP-Binding Proteins
Proteins
RGS Proteins
30 Citations (Scopus)

Synergistic Ca2+ responses by Gαi- and Gαq-coupled G-protein-coupled receptors require a single PLCβ isoform that is sensitive to both Gβγ and Gαq

Rebres, R. A., Roach, T. I. A., Fraser, I. D. C., Philip, F., Moon, C., Lin, K. M., Liu, J., Santat, L., Cheadle, L., Ross, E. M., Simon, M. I. & Seaman, W. E., Jan 14 2011, In : Journal of Biological Chemistry. 286, 2, p. 942-951 10 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Phospholipases
Programmable logic controllers
G-Protein-Coupled Receptors
Protein Isoforms
20 Citations (Scopus)

WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling

An, S. W., Cha, S. K., Yoon, J., Chang, S., Ross, E. M. & Huang, C. L., Dec 6 2011, In : Current Biology. 21, 23, p. 1979-1987 9 p.

Research output: Contribution to journalArticle

G-proteins
GTP-Binding Proteins
growth factors
Intercellular Signaling Peptides and Proteins
phosphotransferases (kinases)
2010
36 Citations (Scopus)

Synergistic activation of phospholipase C-β3 by Gαq and Gβγ describes a simple two-state coincidence detector

Philip, F., Kadamur, G., Silos, R. G., Woodson, J. & Ross, E. M., Aug 10 2010, In : Current Biology. 20, 15, p. 1327-1335 9 p.

Research output: Contribution to journalArticle

phospholipase C
synergism
Type C Phospholipases
detectors
Chemical activation
2008
34 Citations (Scopus)

Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP

Turcotte, M., Tang, W. & Ross, E. M., Aug 2008, In : PLoS Computational Biology. 4, 8, e1000148.

Research output: Contribution to journalArticle

GTPase-activating proteins
GTPase-Activating Proteins
G Protein
G-proteins
GTP-Binding Proteins
61 Citations (Scopus)

Coordinating Speed and Amplitude in G-Protein Signaling

Ross, E. M., Sep 9 2008, In : Current Biology. 18, 17

Research output: Contribution to journalArticle

GTPase-activating proteins
GTPase-Activating Proteins
Guanosine Triphosphate
G-proteins
GTP-Binding Proteins

Coordinating Speed and Amplitude in G-Protein Signaling (DOI: 10.1016/j.cub.2008.07.035)

Ross, E. M., Dec 9 2008, In : Current Biology. 18, 23, p. 1896 1 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
2007
156 Citations (Scopus)

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

Jiang, L. I., Collins, J., Davis, R., Lin, K. M., DeCamp, D., Roach, T., Hsueh, R., Rebres, R. A., Ross, E. M., Taussig, R., Fraser, I. & Sternweis, P. C., Apr 6 2007, In : Journal of Biological Chemistry. 282, 14, p. 10576-10584 9 p.

Research output: Contribution to journalArticle

Bioluminescence
Energy Transfer
Adenosine
Energy transfer
Sensors
2006
23 Citations (Scopus)

Gβγinhibits Gα GTPase-activating proteins by inhibition of Gα-GTP binding during stimulation by receptor

Tang, W., Tu, Y., Nayak, S. K., Woodson, J., Jehl, M. & Ross, E. M., Feb 24 2006, In : Journal of Biological Chemistry. 281, 8, p. 4746-4753 8 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Guanosine Triphosphate
Protein Subunits
Type C Phospholipases
GTP-Binding Proteins
29 Citations (Scopus)

Structural determinants for phosphatidic acid regulation of phospholipase C-β1

Ross, E. M., Mateu, D., Gomes, A. V., Arana, C., Tran, T. & Litosch, I., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33087-33094 8 p.

Research output: Contribution to journalArticle

Phosphatidic Acids
Type C Phospholipases
Programmable logic controllers
Assays
Circular dichroism spectroscopy
2005

Q & A. Elliott Ross.

Ross, E., Dec 6 2005, In : Current biology : CB. 15, 23

Research output: Contribution to journalArticle

career choice
Career Choice
Biochemistry
biochemistry
signal transduction
121 Citations (Scopus)

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors

Wang, X., Zeng, W., Syombo, A. A., Tang, W., Ross, E. M., Barnes, A. P., Milgram, S. L., Penninger, J. M., Allen, P. B., Greengard, P. & Muallem, S., Apr 2005, In : Nature Cell Biology. 7, 4, p. 405-411 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Adrenergic Receptors
RGS Proteins
GTP Phosphohydrolases
GTP-Binding Proteins
2004
23 Citations (Scopus)

Uncoupling conformational change from GTP hydrolysis in a heterotrimetric G protein α-subunit

Thomas, C. J., Du, X., Li, P., Wang, Y., Ross, E. M. & Sprang, S. R., May 18 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 20, p. 7560-7565 6 p.

Research output: Contribution to journalArticle

Protein Subunits
Guanosine Triphosphate
GTP-Binding Proteins
Hydrolysis
Mutation
2003
72 Citations (Scopus)

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Shin, D. M., Dehoff, M., Luo, X., Kang, S. H., Tu, J., Nayak, S. K., Ross, E. M., Worley, P. E. & Muallem, S., Jul 21 2003, In : Journal of Cell Biology. 162, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

RGS Proteins
G-Protein-Coupled Receptors
Inositol 1,4,5-Trisphosphate Receptors
Phosphoinositide Phospholipase C
Ryanodine Receptor Calcium Release Channel
16 Citations (Scopus)

Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I

Tu, Y., Nayak, S. K., Woodson, J. & Ross, E. M., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52273-52281 9 p.

Research output: Contribution to journalArticle

RGS Proteins
Synapsins
GTPase-Activating Proteins
Phosphorylation
Brain
2002
49 Citations (Scopus)

Mutations in the carboxyl-terminal domain of phospholipase C-β1 delineate the dimer interface and a potential Gαq interaction site

Ilkaeva, O., Kinch, L. N., Paulssen, R. H. & Ross, E. M., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4294-4300 7 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Type C Phospholipases
Dimers
Mutation
Gq-G11 GTP-Binding Protein alpha Subunits
108 Citations (Scopus)

Overview of the alliance for cellular signaling

Gilman, A. G., Dec 12 2002, In : Nature. 420, 6916, p. 703-706 4 p.

Research output: Contribution to journalArticle

Research
Cardiac Myocytes
Immune System
B-Lymphocytes
2001
51 Citations (Scopus)
RGS Proteins
GTPase-Activating Proteins
Phospholipids
Membranes
GTP-Binding Proteins
24 Citations (Scopus)

Quantitative assays for GTPase-activating proteins

Ross, E. M., 2001, In : Methods in Enzymology. 344, p. 601-617 17 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
10 Citations (Scopus)

Quench-flow kinetic measurement of individual reactions of G-protein-catalyzed GTPase cycle

Mukhopadhyay, S. & Ross, E. M., 2001, In : Methods in Enzymology. 344, p. 350-369 20 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
GTP-Binding Proteins
Kinetics
28 Citations (Scopus)

RGSZ1 and Ret RGS: Two of several splice variants from the gene RGS20

Barker, S. A., Wang, J., Sierra, D. A. & Ross, E. M., Sep 15 2001, In : Genomics. 78, 3, p. 223-229 7 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Exons
Genes
GTPase-Activating Proteins
Open Reading Frames
2000
848 Citations (Scopus)
RGS Proteins
GTP-Binding Protein Regulators
GTPase-Activating Proteins
Heterotrimeric GTP-Binding Proteins
GTP-Binding Proteins
1999
42 Citations (Scopus)

Kinetic control of guanine nucleotide binding to soluble Gα(q)

Markin, V. S. & Ross, E. M., Jul 1 1999, In : Biochemical Pharmacology. 58, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Guanine Nucleotides
GTP-Binding Proteins
Denaturation
Kinetics
Protein Subunits
66 Citations (Scopus)

Modulation of the affinity and selectivity of RGS protein interaction with Gα subunits by a conserved asparagine/serine residue

Posner, B. A., Mukhopadhyay, S., Tesmer, J. J., Gilman, A. G. & Ross, E. M., Jun 15 1999, In : Biochemistry. 38, 24, p. 7773-7779 7 p.

Research output: Contribution to journalArticle

RGS Proteins
Asparagine
Guanosine Triphosphate
GTP-Binding Proteins
Serine
85 Citations (Scopus)

Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10

Tu, Y., Popov, S., Slaughter, C. & Ross, E. M., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 38260-38267 8 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Lipoylation
GTPase-Activating Proteins
GTP Phosphohydrolases
GTP-Binding Proteins
78 Citations (Scopus)

Phospholipase C-β1 directly accelerates GTP hydrolysis by Gα(q) and acceleration is inhibited by Gβγ subunits

Chidiac, P. & Ross, E. M., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19639-19643 5 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Type C Phospholipases
Programmable logic controllers
Guanosine Triphosphate
Hydrolysis
146 Citations (Scopus)
GTPase-Activating Proteins
Guanosine Triphosphate
Hydrolysis
GTP Phosphohydrolases
Type C Phospholipases
47 Citations (Scopus)

Reciprocal signaling between heterotrimeric G proteins and the p21- stimulated protein kinase

Wang, J., Frost, J. A., Cobb, M. H. & Ross, E. M., Oct 29 1999, In : Journal of Biological Chemistry. 274, 44, p. 31641-31647 7 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Phosphorylation
Protein Kinases
GTPase-Activating Proteins
Protein Kinase C
1998
248 Citations (Scopus)

Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity

Ingi, T., Krumins, A. M., Chidiac, P., Brothers, G. M., Chung, S., Snow, B. E., Barnes, C. A., Lanahan, A. A., Siderovski, D. P., Ross, E. M., Gilman, A. G. & Worley, P. F., Sep 15 1998, In : Journal of Neuroscience. 18, 18, p. 7178-7188 11 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Neuronal Plasticity
GTP-Binding Proteins
Messenger RNA
GTP Phosphohydrolases
127 Citations (Scopus)

RGSZ1, a G(z)-selective rgs protein in brain: Structure, membrane association, regulation by Gα(z) phosphorylation, and relationship to a G(z) gtpase-activating protein subfamily

Wang, J., Ducret, A., Tu, Y., Kozasa, T., Aebersold, R. & Ross, E. M., Oct 2 1998, In : Journal of Biological Chemistry. 273, 40, p. 26014-26025 12 p.

Research output: Contribution to journalArticle

RGS Proteins
GTPase-Activating Proteins
Membrane structures
Phosphorylation
Brain
216 Citations (Scopus)

The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling

Zeng, W., Xu, X., Popov, S., Mukhopadhyay, S., Chidiac, P., Swistok, J., Danho, W., Yagaloff, K. A., Fisher, S. L., Ross, E. M., Muallem, S. & Wilkie, T. M., Dec 25 1998, In : Journal of Biological Chemistry. 273, 52, p. 34687-34690 4 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Guanosine Triphosphate
GTP-Binding Proteins
Hydrolysis
RGS Proteins
1997
32 Citations (Scopus)

A G(s)-selective analog of the receptor-mimetic peptide mastoparan binds to G(s)α in a kinked helical conformation

Sukumar, M., Ross, E. M. & Higashijima, T., Mar 25 1997, In : Biochemistry. 36, 12, p. 3632-3639 8 p.

Research output: Contribution to journalArticle

Peptide Receptors
Conformations
Peptides
GTP-Binding Proteins
Guanosine Triphosphate
64 Citations (Scopus)

A GTPase-activating protein for the G protein Gα(z). Identification, purification, and mechanism of action

Wang, J., Tu, Y., Woodson, J., Song, X. & Ross, E. M., Feb 28 1997, In : Journal of Biological Chemistry. 272, 9, p. 5732-5740 9 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
GTP-Binding Proteins
Purification
Guanosine Triphosphate
Hydrolysis

Colloquium on signaling and molecular structure in pharmacology (La Jolla, California, March 11-12, 1997)

Taylor, P., Ross, E. M., Sternweis, P. C., Neubig, R. R. & McCammon, J. A., 1997, In : Molecular Pharmacology. 52, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Protein Conformation
Rhodopsin
src Homology Domains
Structure-Activity Relationship
Molecular Structure
8 Citations (Scopus)

Expression of human muscarinic cholinergic receptors in tobacco

Mu, J. H., Chua, N. H. & Ross, E. M., May 1997, In : Plant Molecular Biology. 34, 2, p. 357-362 6 p.

Research output: Contribution to journalArticle

cholinergic receptors
Tobacco
Bony Callus
Cholinergic Receptors
Muscarinic Receptors
2 Citations (Scopus)

Guanosine Triphosphatase-Activating Proteins for Heterotrimeric G-Proteins

Ross, E. M., Wang, J., Tu, Y. & Biddlecome, G. H., 1997, In : Advances in Pharmacology. 42, C, p. 458-461 4 p.

Research output: Contribution to journalArticle

Heterotrimeric GTP-Binding Proteins
Guanosine
Proteins
127 Citations (Scopus)

Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein α subunits

Tu, Y., Wang, J. & Ross, E. M., Nov 7 1997, In : Science. 278, 5340, p. 1132-1135 4 p.

Research output: Contribution to journalArticle

RGS Proteins
Lipoylation
GTPase-Activating Proteins
Protein Subunits
GTP-Binding Proteins
127 Citations (Scopus)

PDZ domain proteins: Scaffolds for signaling complexes

Ranganathan, R. & Ross, E. M., Dec 1 1997, In : Current Biology. 7, 12

Research output: Contribution to journalArticle

scaffolding proteins
PDZ Domains
photoreceptors
Scaffolds
Drosophila
1996
57 Citations (Scopus)

Carboxyl-terminal fragments of phospholipase C-β1 with intrinsic G(q) GTPase-activating protein (GAP) activity

Paulssen, R. H., Woodson, J., Liu, Z. & Ross, E. M., 1996, In : Journal of Biological Chemistry. 271, 43, p. 26622-26629 8 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Type C Phospholipases
Programmable logic controllers
Phospholipases
GTP Phosphohydrolases
GTPase-Activating Proteins
Type C Phospholipases
Cholinergic Receptors
Muscarinic Receptors
Cholinergic Agents
95 Citations (Scopus)

Functional importance of the amino terminus of G

Hepler, J. R., Biddlecome, G. H., Kleuss, C., Camp, L. A., Hofmann, S. L., Ross, E. M. & Gilman, A. G., Jan 5 1996, In : Journal of Biological Chemistry. 271, 1, p. 496-504 9 p.

Research output: Contribution to journalArticle

Palmitates
Lipoylation
Sf9 Cells
HEK293 Cells
Type C Phospholipases
5 Citations (Scopus)

Purification and characterization of phospholipase C-β1 mutants expressed in E. coli

Meij, J. T. A. & Ross, E. M., Aug 23 1996, In : Biochemical and Biophysical Research Communications. 225, 3, p. 705-711 7 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Escherichia coli
Purification
GTPase-Activating Proteins
Muscarinic M1 Receptors