Research Output

Article

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response

Shao, D., Zhai, P., Del Re, D. P., Sciarretta, S., Yabuta, N., Nojima, H., Lim, D. S., Pan, D. & Sadoshima, J., Feb 14 2014, In : Nature communications. 5, 3315.

Research output: Contribution to journalArticle

114 Scopus citations

A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1

Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J. & Kopan, R., Jan 1 2000, In : Molecular cell. 5, 2, p. 197-206 10 p.

Research output: Contribution to journalArticle

Open Access
650 Scopus citations

An evolutionary shift in the regulation of the Hippo pathway between mice and flies

Bossuyt, W., Chen, C. L., Chen, Q., Sudol, M., Mcneill, H., Pan, D., Kopp, A. & Halder, G., Mar 2014, In : Oncogene. 33, 10, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

Cai, J., Song, X., Wang, W., Watnick, T., Pei, Y., Qian, F. & Pan, D., Jun 1 2018, In : Genes and Development. 32, 11-12, p. 781-793 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A. & Pan, D., Mar 1 2014, In : Genes and Development. 28, 5, p. 432-437 6 p.

Research output: Contribution to journalArticle

112 Scopus citations

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Chan, P., Han, X., Zheng, B., Deran, M., Yu, J., Jarugumilli, G. K., Deng, H., Pan, D., Luo, X. & Wu, X., Apr 1 2016, In : Nature Chemical Biology. 12, 4, p. 282-289 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F. X., Karin, M., Pan, D. & Guan, K. L., Jun 15 2015, In : Genes and Development. 29, 12, p. 1271-1284 14 p.

Research output: Contribution to journalArticle

139 Scopus citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

Pan, D. & Rubin, G. M., Feb 24 1995, In : Cell. 80, 4, p. 543-552 10 p.

Research output: Contribution to journalArticle

212 Scopus citations

Characterization of a cdc14 null allele in Drosophila melanogaster

Neitzel, L. R., Broadus, M. R., Zhang, N., Sawyer, L., Wallace, H. A., Merkle, J. A., Jodoin, J. N., Sitaram, P., Crispi, E. E., Rork, W., Lee, L. A., Pan Ph.D., D., Gould, K. L., Page-McCaw, A. & Lee, E., Jan 1 2018, In : Biology Open. 7, 7, bio035394.

Research output: Contribution to journalArticle

4 Scopus citations

Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple-negative breast cancer

Merino, V. F., Nguyen, N., Jin, K., Sadik, H., Cho, S., Korangath, P., Han, L., Foster, Y. M. N., Zhou, X. C., Zhang, Z., Connolly, R. M., Stearns, V., Ali, S. Z., Adams, C., Chen, Q., Pan, D., Huso, D. L., Ordentlich, P., Brodie, A. & Sukumar, S., Apr 1 2016, In : Cancer research. 76, 7, p. 2013-2024 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Drosophila PTEN regulates cell growth and proliferation through PI3K- dependent and -independent pathways

Gao, X., Neufeld, T. P. & Pan, D., May 15 2000, In : Developmental Biology. 221, 2, p. 404-418 15 p.

Research output: Contribution to journalArticle

203 Scopus citations

Drosophila target of rapamycin kinase functions as a multimer

Zhang, Y., Billington, C. J., Pan, D. & Neufeld, T. P., Jan 2006, In : Genetics. 172, 1, p. 355-362 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, MF., Anders, R. A., Maitra, A. & Pan Ph.D., D., Sep 21 2007, In : Cell. 130, 6, p. 1120-1133 14 p.

Research output: Contribution to journalArticle

1391 Scopus citations

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

381 Scopus citations

Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies

Bai, H., Gayyed, M. F., Lam-Himlin, D. M., Klein, A. P., Nayar, S. K., Xu, Y., Khan, M., Argani, P., Pan, D. & Anders, R. A., Sep 1 2012, In : Human Pathology. 43, 9, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome

Karsai, G., Lone, M., Kutalik, Z., Thomas Brenna, J., Li, H., Pan, D., von Eckardstein, A. & Thorsten Hornemann, X., Jan 1 2020, In : Journal of Biological Chemistry. 295, 7, p. 1889-1897 9 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Fat flies expanded the hippo pathway: a matter of size control.

Yin, F. & Pan, D., Apr 21 2007, In : Science's STKE : signal transduction knowledge environment. 2007, 380, p. pe12

Research output: Contribution to journalArticle

15 Scopus citations

Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region

Pan, D., Huang, J. D. & Courey, A. J., Oct 1991, In : Genes and Development. 5, 10, p. 1892-1901 10 p.

Research output: Contribution to journalArticle

88 Scopus citations

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S. J., Anders, R. A., Liu, J. O. & Pan, D., Jun 2012, In : Genes and Development. 26, 12, p. 1300-1305 6 p.

Research output: Contribution to journalArticle

629 Scopus citations

Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS

Azuma, Y., Tokuda, T., Kushimura, Y., Yamamoto, I., Mizuta, I., Mizuno, T., Nakagawa, M., Ueyama, M., Nagai, Y., Iwasaki, Y., Yoshida, M., Pan, D., Yoshida, H. & Yamaguchi, M., Oct 15 2018, In : Experimental Cell Research. 371, 2, p. 311-321 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

Wu, S., Huang, J., Dong, J. & Pan, D., Aug 22 2003, In : Cell. 114, 4, p. 445-456 12 p.

Research output: Contribution to journalArticle

676 Scopus citations

Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation

Alder, O., Cullum, R., Lee, S., Kan, A. C., Wei, W., Yi, Y., Garside, V. C., Bilenky, M., Griffith, M., Morrissy, A. S., Robertson, G. A., Thiessen, N., Zhao, Y., Chen, Q., Pan, D., Jones, S. J. M., Marra, M. A. & Hoodless, P. A., Oct 9 2014, In : Cell Reports. 9, 1, p. 261-271 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

Chen, Q., Zhang, N., Xie, R., Wang, W., Cai, J., Choi, K. S., David, K. K., Huang, B., Yabuta, N., Nojima, H., Anders, R. A. & Pan, D., Jun 15 2015, In : Genes and Development. 29, 12, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex

Zheng, Y., Liu, B., Wang, L., Lei, H., Pulgar Prieto, K. D. & Pan, D., Dec 19 2017, In : Cell Reports. 21, 12, p. 3612-3623 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

Zheng, Y., Wang, W., Liu, B., Deng, H., Uster, E. & Pan, D., Sep 28 2015, In : Developmental Cell. 34, 6, p. 642-655 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors

Merino, V. F., Cho, S., Liang, X., Park, S., Jin, K., Chen, Q., Pan, D., Zahnow, C. A., Rein, A. R. & Sukumar, S., May 1 2017, In : Molecular Oncology. 11, 5, p. 552-566 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W. M. & Pan, D., Feb 16 2010, In : Developmental cell. 18, 2, p. 288-299 12 p.

Research output: Contribution to journalArticle

314 Scopus citations

KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis

Rooke, J., Pan, D., Xu, T. & Rubin, G. M., 1996, In : Science. 273, 5279, p. 1227-1231 5 p.

Research output: Contribution to journalArticle

290 Scopus citations

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

Duojia, P. & Rubin, G. M., Jul 25 1997, In : Cell. 90, 2, p. 271-280 10 p.

Research output: Contribution to journalArticle

337 Scopus citations

Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity

Mindos, T., Dun, X. P., North, K., Doddrell, R. D. S., Schulz, A., Edwards, P., Russell, J., Gray, B., Roberts, S. L., Shivane, A., Mortimer, G., Pirie, M., Zhang, N., Pan, D., Morrison, H. & Parkinson, D. B., 2017, In : Journal of Cell Biology. 216, 2, p. 495-510 16 p.

Research output: Contribution to journalArticle

37 Scopus citations

Neurofibromatosis 2011: A report of the Children's Tumor Foundation Annual Meeting

Kalamarides, M., Acosta, M. T., Babovic-Vuksanovic, D., Carpen, O., Cichowski, K., Gareth Evans, D., Giancotti, F., Oliver Hanemann, C., Ingram, D., Lloyd, A. C., Mayes, D. A., Messiaen, L., Morrison, H., North, K., Packer, R., Pan, D., Stemmer-Rachamimov, A., Upadhyaya, M., Viskochil, D., Wallace, M. R. & 2 others, Hunter-Schaedle, K. & Ratner, N., Mar 1 2012, In : Acta Neuropathologica. 123, 3, p. 369-380 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart

Matsuda, T., Zhai, P., Sciarretta, S., Zhang, Y., Jeong, J. I., Ikeda, S., Park, J., Hsu, C. P., Tian, B., Pan, D., Sadoshima, J. & Del Re, D. P., Aug 19 2016, In : Circulation Research. 119, 5, p. 596-606 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

Alarcón, C., Zaromytidou, A. I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D. & Massagué, J., Nov 13 2009, In : Cell. 139, 4, p. 757-769 13 p.

Research output: Contribution to journalArticle

470 Scopus citations

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling

Serafimidis, I., Rodriguez-Aznar, E., Lesche, M., Yoshioka, K., Takuwa, Y., Dahl, A., Pan, D. & Gavalas, A., Mar 1 2017, In : PLoS biology. 15, 3, e2000949.

Research output: Contribution to journalArticle

18 Scopus citations

Premetazoan Origin of the Hippo Signaling Pathway

Sebe-Pedrs, A., Zheng, Y., Ruiz-Trillo, I. & Pan, D., Jan 26 2012, In : Cell Reports. 1, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Yu, F. X., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z. C. & Guan, K. L., Feb 1 2013, In : Genes and Development. 27, 11, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

166 Scopus citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A. & Pan, D., Jun 1 2003, In : Nature Cell Biology. 5, 6, p. 578-581 4 p.

Research output: Contribution to journalArticle

644 Scopus citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D. & Edgar, B. A., Jun 1 2003, In : Nature Cell Biology. 5, 6, p. 566-571 6 p.

Research output: Contribution to journalArticle

490 Scopus citations

Size matters. Workshop on growth control in development and disease

Pan, D., Feb 1 2004, In : EMBO Reports. 5, 2, p. 136-139 4 p.

Research output: Contribution to journalArticle

Open Access

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

Deng, H., Wang, W., Yu, J., Zheng, Y., Qing, Y. & Pan, D., Mar 31 2015, In : eLife. 2015, 4, e06567.

Research output: Contribution to journalArticle

50 Scopus citations
89 Scopus citations

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C. A., Tomchick, D. R., Pan, D. & Luo, X., Oct 8 2013, In : Structure. 21, 10, p. 1757-1768 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

Ni, L., Zheng, Y., Hara, M., Pan, D. & Luo, X., Jul 1 2015, In : Genes and Development. 29, 13, p. 1416-1431 16 p.

Research output: Contribution to journalArticle

67 Scopus citations

Targeted expression of teashirt induces ectopic eyes in Drosophila

Pan, D. & Rubin, G. M., Dec 22 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 26, p. 15508-15512 5 p.

Research output: Contribution to journalArticle

77 Scopus citations

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to expanded

Ling, C., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S. & Pan, D., Jun 8 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 23, p. 10532-10537 6 p.

Research output: Contribution to journalArticle

228 Scopus citations

The bipartite D. melanogaster twist promoter is reorganized in D. virilis

Pan, D., Valentine, S. A. & Courey, A. J., Apr 1994, In : Mechanisms of Development. 46, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

The cell surface metalloprotease/disintegrin kuzbanian is required for axonal extension in Drosophila

Fambrough, D., Pan, D., Rubin, G. M. & Goodman, C. S., Nov 12 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 23, p. 13233-13238 6 p.

Research output: Contribution to journalArticle

151 Scopus citations

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6

Qing, Y., Yin, F., Wang, W., Zheng, Y., Guo, P., Schozer, F., Deng, H. & Pan, D., Jul 15 2014, In : eLife. 3, July2014, p. 1-13 13 p., e02564.

Research output: Contribution to journalArticle

31 Scopus citations

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

Koontz, L. M., Liu-Chittenden, Y., Yin, F., Zheng, Y., Yu, J., Huang, B., Chen, Q., Wu, S. & Pan, D., May 28 2013, In : Developmental Cell. 25, 4, p. 388-401 14 p.

Research output: Contribution to journalArticle

146 Scopus citations