Research Output

Filter
Article
2020

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome

Karsai, G., Lone, M., Kutalik, Z., Thomas Brenna, J., Li, H., Pan, D., von Eckardstein, A. & Thorsten Hornemann, X., Jan 1 2020, In : Journal of Biological Chemistry. 295, 7, p. 1889-1897 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
2019

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

Tu, B., Yao, J., Ferri-Borgogno, S., Zhao, J., Chen, S., Wang, Q., Yan, L., Zhou, X., Zhu, C., Bang, S., Chang, Q., Bristow, C. A., Kang, Y., Zheng, H., Wang, H., Fleming, J. B., Kim, M., Heffernan, T. P., Draetta, G. F., Pan, D. & 4 others, Maitra, A., Yao, W., Gupta, S. & Ying, H., Nov 1 2019, In : JCI Insight. 4, 21, e130811.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

Cai, J., Song, X., Wang, W., Watnick, T., Pei, Y., Qian, F. & Pan, D., Jun 1 2018, In : Genes and Development. 32, 11-12, p. 781-793 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Characterization of a cdc14 null allele in Drosophila melanogaster

Neitzel, L. R., Broadus, M. R., Zhang, N., Sawyer, L., Wallace, H. A., Merkle, J. A., Jodoin, J. N., Sitaram, P., Crispi, E. E., Rork, W., Lee, L. A., Pan Ph.D., D., Gould, K. L., Page-McCaw, A. & Lee, E., Jan 1 2018, In : Biology Open. 7, 7, bio035394.

Research output: Contribution to journalArticle

3 Scopus citations

Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS

Azuma, Y., Tokuda, T., Kushimura, Y., Yamamoto, I., Mizuta, I., Mizuno, T., Nakagawa, M., Ueyama, M., Nagai, Y., Iwasaki, Y., Yoshida, M., Pan, D., Yoshida, H. & Yamaguchi, M., Oct 15 2018, In : Experimental Cell Research. 371, 2, p. 311-321 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Validating upstream regulators of yorkie activity in hippo signaling through scalloped-based genetic epistasis

Yu, J. & Pan, D., Feb 15 2018, In : Development (Cambridge). 145, 4, dev157545.

Research output: Contribution to journalArticle

6 Scopus citations

YAP controls endothelial activation and vascular inflammation through TRAF6

Lv, Y., Kim, K., Sheng, Y., Cho, J., Qian, Z., Zhao, Y. Y., Hu, G., Pan, D., Malik, A. B. & Hu, G., Jan 1 2018, In : Circulation research. 123, 1, p. 43-56 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

YAP is essential for treg-mediated suppression of antitumor immunity

Ni, X., Tao, J., Barbi, J., Chen, Q., Park, B. V., Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., Zheng, Y., Zhang, X., Wu, X., Vignali, P., Yang, C. P., Li, H., Pardoll, D., Lu, L., Pan, D. & Pan, F., Aug 1 2018, In : Cancer Discovery. 8, 8, p. 1026-1043 18 p.

Research output: Contribution to journalArticle

30 Scopus citations
2017

Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex

Zheng, Y., Liu, B., Wang, L., Lei, H., Pulgar Prieto, K. D. & Pan, D., Dec 19 2017, In : Cell Reports. 21, 12, p. 3612-3623 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Inhibitors of STAT3, β-catenin, and IGF-1R sensitize mouse PIK3CA-mutant breast cancer to PI3K inhibitors

Merino, V. F., Cho, S., Liang, X., Park, S., Jin, K., Chen, Q., Pan, D., Zahnow, C. A., Rein, A. R. & Sukumar, S., May 1 2017, In : Molecular Oncology. 11, 5, p. 552-566 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity

Mindos, T., Dun, X. P., North, K., Doddrell, R. D. S., Schulz, A., Edwards, P., Russell, J., Gray, B., Roberts, S. L., Shivane, A., Mortimer, G., Pirie, M., Zhang, N., Pan, D., Morrison, H. & Parkinson, D. B., 2017, In : Journal of Cell Biology. 216, 2, p. 495-510 16 p.

Research output: Contribution to journalArticle

33 Scopus citations

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling

Serafimidis, I., Rodriguez-Aznar, E., Lesche, M., Yoshioka, K., Takuwa, Y., Dahl, A., Pan, D. & Gavalas, A., Mar 1 2017, In : PLoS biology. 15, 3, e2000949.

Research output: Contribution to journalArticle

17 Scopus citations

The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals

Wu, N., Nguyen, Q., Wan, Y., Zhou, T., Venter, J., Frampton, G. A., Demorrow, S., Pan, D., Meng, F., Glaser, S., Alpini, G. & Bai, H., Jul 1 2017, In : Laboratory Investigation. 97, 7, p. 843-853 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway

Chan, P., Han, X., Zheng, B., Deran, M., Yu, J., Jarugumilli, G. K., Deng, H., Pan, D., Luo, X. & Wu, X., Apr 1 2016, In : Nature Chemical Biology. 12, 4, p. 282-289 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Combined treatment with epigenetic, differentiating, and chemotherapeutic agents cooperatively targets tumor-initiating cells in triple-negative breast cancer

Merino, V. F., Nguyen, N., Jin, K., Sadik, H., Cho, S., Korangath, P., Han, L., Foster, Y. M. N., Zhou, X. C., Zhang, Z., Connolly, R. M., Stearns, V., Ali, S. Z., Adams, C., Chen, Q., Pan, D., Huso, D. L., Ordentlich, P., Brodie, A. & Sukumar, S., Apr 1 2016, In : Cancer research. 76, 7, p. 2013-2024 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart

Matsuda, T., Zhai, P., Sciarretta, S., Zhang, Y., Jeong, J. I., Ikeda, S., Park, J., Hsu, C. P., Tian, B., Pan, D., Sadoshima, J. & Del Re, D. P., Aug 19 2016, In : Circulation Research. 119, 5, p. 596-606 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila

Liu, B., Zheng, Y., Yin, F., Yu, J., Silverman, N. & Pan, D., Jan 28 2016, In : Cell. 164, 3, p. 406-419 14 p.

Research output: Contribution to journalArticle

100 Scopus citations
68 Scopus citations

Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization

Bai, H., Zhu, Q., Surcel, A., Luo, T., Ren, Y., Guan, B., Liu, Y., Wu, N., Joseph, N. E., Wang, T. L., Zhang, N., Pan, D., Alpini, G., Robinson, D. N. & Anders, R. A., Jan 1 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G396-G411

Research output: Contribution to journalArticle

19 Scopus citations
2015

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

Moroishi, T., Park, H. W., Qin, B., Chen, Q., Meng, Z., Plouffe, S. W., Taniguchi, K., Yu, F. X., Karin, M., Pan, D. & Guan, K. L., Jun 15 2015, In : Genes and Development. 29, 12, p. 1271-1284 14 p.

Research output: Contribution to journalArticle

135 Scopus citations

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

Chen, Q., Zhang, N., Xie, R., Wang, W., Cai, J., Choi, K. S., David, K. K., Huang, B., Yabuta, N., Nojima, H., Anders, R. A. & Pan, D., Jan 1 2015, In : Genes and Development. 29, 12, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

Zheng, Y., Wang, W., Liu, B., Deng, H., Uster, E. & Pan, D., Sep 28 2015, In : Developmental Cell. 34, 6, p. 642-655 14 p.

Research output: Contribution to journalArticle

83 Scopus citations

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

Deng, H., Wang, W., Yu, J., Zheng, Y., Qing, Y. & Pan, D., Mar 31 2015, In : eLife. 2015, 4, e06567.

Research output: Contribution to journalArticle

50 Scopus citations

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

Ni, L., Zheng, Y., Hara, M., Pan, D. & Luo, X., Jul 1 2015, In : Genes and Development. 29, 13, p. 1416-1431 16 p.

Research output: Contribution to journalArticle

65 Scopus citations

YAPing Hippo forecasts a new target for lung cancer prevention and treatment

Pan, D., Jul 10 2015, In : Journal of Clinical Oncology. 33, 20, p. 2311-2313 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

β-catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis

Cai, J., Maitra, A., Anders, R. A., Taketo, M. M. & Pan, D., Jan 1 2015, In : Genes and Development. 29, 14, p. 1493-1506 14 p.

Research output: Contribution to journalArticle

87 Scopus citations
2014

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response

Shao, D., Zhai, P., Del Re, D. P., Sciarretta, S., Yabuta, N., Nojima, H., Lim, D. S., Pan, D. & Sadoshima, J., Feb 14 2014, In : Nature communications. 5, 3315.

Research output: Contribution to journalArticle

112 Scopus citations

An evolutionary shift in the regulation of the Hippo pathway between mice and flies

Bossuyt, W., Chen, C. L., Chen, Q., Sudol, M., Mcneill, H., Pan, D., Kopp, A. & Halder, G., Mar 2014, In : Oncogene. 33, 10, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A. & Pan, D., Mar 1 2014, In : Genes and Development. 28, 5, p. 432-437 6 p.

Research output: Contribution to journalArticle

111 Scopus citations

Hippo signaling influences HNF4A and FOXA2 enhancer switching during hepatocyte differentiation

Alder, O., Cullum, R., Lee, S., Kan, A. C., Wei, W., Yi, Y., Garside, V. C., Bilenky, M., Griffith, M., Morrissy, A. S., Robertson, G. A., Thiessen, N., Zhao, Y., Chen, Q., Pan, D., Jones, S. J. M., Marra, M. A. & Hoodless, P. A., Oct 9 2014, In : Cell Reports. 9, 1, p. 261-271 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6

Qing, Y., Yin, F., Wang, W., Zheng, Y., Guo, P., Schozer, F., Deng, H. & Pan, D., Jul 15 2014, In : eLife. 3, July2014, p. 1-13 13 p., e02564.

Research output: Contribution to journalArticle

31 Scopus citations

The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease

Gurda, G. T., Zhu, Q., Bai, H., Pan, D., Schwarz, K. B. & Anders, R. A., May 2014, In : Human Pathology. 45, 5, p. 1057-1064 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Yu, F. X., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z. C. & Guan, K. L., Feb 1 2013, In : Genes and Development. 27, 11, p. 1223-1232 10 p.

Research output: Contribution to journalArticle

159 Scopus citations

Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5

Ni, L., Li, S., Yu, J., Min, J., Brautigam, C. A., Tomchick, D. R., Pan, D. & Luo, X., Oct 8 2013, In : Structure. 21, 10, p. 1757-1768 12 p.

Research output: Contribution to journalArticle

52 Scopus citations

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

Koontz, L. M., Liu-Chittenden, Y., Yin, F., Zheng, Y., Yu, J., Huang, B., Chen, Q., Wu, S. & Pan, D., May 28 2013, In : Developmental Cell. 25, 4, p. 388-401 14 p.

Research output: Contribution to journalArticle

143 Scopus citations

XSpatial organization of hippo signaling at the plasma membrane mediated by the tumor suppressor merlin/NF2

Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N. & Pan, D., Sep 12 2013, In : Cell. 154, 6, 1 p.

Research output: Contribution to journalArticle

232 Scopus citations

Yes-associated protein isoform 1 (Yapl) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury

Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D. & Sadoshima, J., Feb 8 2013, In : Journal of Biological Chemistry. 288, 6, p. 3977-3988 12 p.

Research output: Contribution to journalArticle

109 Scopus citations
2012

Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies

Bai, H., Gayyed, M. F., Lam-Himlin, D. M., Klein, A. P., Nayar, S. K., Xu, Y., Khan, M., Argani, P., Pan, D. & Anders, R. A., Sep 1 2012, In : Human Pathology. 43, 9, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S. J., Anders, R. A., Liu, J. O. & Pan, D., Jun 2012, In : Genes and Development. 26, 12, p. 1300-1305 6 p.

Research output: Contribution to journalArticle

616 Scopus citations

Neurofibromatosis 2011: A report of the Children's Tumor Foundation Annual Meeting

Kalamarides, M., Acosta, M. T., Babovic-Vuksanovic, D., Carpen, O., Cichowski, K., Gareth Evans, D., Giancotti, F., Oliver Hanemann, C., Ingram, D., Lloyd, A. C., Mayes, D. A., Messiaen, L., Morrison, H., North, K., Packer, R., Pan, D., Stemmer-Rachamimov, A., Upadhyaya, M., Viskochil, D., Wallace, M. R. & 2 others, Hunter-Schaedle, K. & Ratner, N., Mar 1 2012, In : Acta Neuropathologica. 123, 3, p. 369-380 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Premetazoan Origin of the Hippo Signaling Pathway

Sebe-Pedrs, A., Zheng, Y., Ruiz-Trillo, I. & Pan, D., Jan 26 2012, In : Cell Reports. 1, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Yes-associated protein regulates the hepatic response after bile duct ligation

Bai, H., Zhang, N., Xu, Y., Chen, Q., Khan, M., Potter, J. J., Nayar, S. K., Cornish, T., Alpini, G., Bronk, S., Pan, D. & Anders, R. A., Sep 1 2012, In : Hepatology. 56, 3, p. 1097-1107 11 p.

Research output: Contribution to journalArticle

90 Scopus citations
2010

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W. M. & Pan, D., Feb 16 2010, In : Developmental cell. 18, 2, p. 288-299 12 p.

Research output: Contribution to journalArticle

311 Scopus citations
88 Scopus citations

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to expanded

Ling, C., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S. & Pan, D., Jun 8 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 23, p. 10532-10537 6 p.

Research output: Contribution to journalArticle

228 Scopus citations

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

Cai, J., Zhang, N., Zheng, Y., De Wilde, R. F., Maitra, A. & Pan, D., Nov 1 2010, In : Genes and Development. 24, 21, p. 2383-2388 6 p.

Research output: Contribution to journalArticle

289 Scopus citations

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A. & Pan, D., Jul 1 2010, In : Developmental cell. 19, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

402 Scopus citations
2009

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

Alarcón, C., Zaromytidou, A. I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., Sapkota, G., Pan, D. & Massagué, J., Nov 13 2009, In : Cell. 139, 4, p. 757-769 13 p.

Research output: Contribution to journalArticle

463 Scopus citations
2008

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A. & Anders, R. A., Nov 1 2008, In : Human Pathology. 39, 11, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

377 Scopus citations