SY-Lab Tang Kang

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2020

AIFM2 blocks ferroptosis independent of ubiquinol metabolism

Dai, E., Zhang, W., Cong, D., Kang, R., Wang, J. & Tang, D., Mar 19 2020, In : Biochemical and Biophysical Research Communications. 523, 4, p. 966-971 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

Dai, E., Han, L., Liu, J., Xie, Y., Kroemer, G., Klionsky, D. J., Zeh, H. J., Kang, R., Wang, J. & Tang, D., Jan 1 2020, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

4 Scopus citations

ESCRT-III–dependent membrane repair blocks ferroptosis

Dai, E., Meng, L., Kang, R., Wang, X. & Tang, D., Feb 5 2020, In : Biochemical and Biophysical Research Communications. 522, 2, p. 415-421 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia

Wang, D., Zeng, T., Lin, Z., Yan, L., Wang, F., Tang, L., Wang, L., Tang, D., Chen, P. & Yang, M., Mar 2020, In : Biomedicine and Pharmacotherapy. 123, 109802.

Research output: Contribution to journalArticle

Open Access

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Li, C., Zhang, Y., Liu, J., Kang, R., Klionsky, D. J. & Tang, D., Jan 1 2020, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

The circadian clock protects against ferroptosis-induced sterile inflammation

Liu, Y., Wang, Y., Liu, J., Kang, R. & Tang, D., May 7 2020, In : Biochemical and Biophysical Research Communications. 525, 3, p. 620-625 6 p.

Research output: Contribution to journalArticle

TMEM173 Drives Lethal Coagulation in Sepsis

Zhang, H., Zeng, L., Xie, M., Liu, J., Zhou, B., Wu, R., Cao, L., Kroemer, G., Wang, H., Billiar, T. R., Zeh, H. J., Kang, R., Jiang, J., Yu, Y. & Tang, D., Apr 8 2020, In : Cell Host and Microbe. 27, 4, p. 556-570.e6

Research output: Contribution to journalArticle

1 Scopus citations
2019

AGER-mediated lipid peroxidation drives caspase-11 inflammasome activation in sepsis

Chen, R., Zhu, S., Zeng, L., Wang, Q., Sheng, Y., Zhou, B., Tang, D. & Kang, R., Jan 1 2019, In : Frontiers in immunology. 10, AUG, 1904.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

CAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis

Chen, R., Zeng, L., Zhu, S., Liu, J., Zeh, H. J., Kroemer, G., Wang, H., Billiar, T. R., Jiang, J., Tang, D. & Kang, R., Jan 1 2019, In : Science Advances. 5, 5, aav5562.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Clockophagy is a novel selective autophagy process favoring ferroptosis

Yang, M., Chen, P., Liu, J., Zhu, S., Kroemer, G., Klionsky, D. J., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., Jul 24 2019, In : Science Advances. 5, 7, eaaw2238.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth

Miller-Ocuin, J. L., Liang, X., Boone, B. A., Doerfler, W. R., Singhi, A. D., Tang, D., Kang, R., Lotze, M. T. & Zeh, H. J., Sep 2 2019, In : OncoImmunology. 8, 9, e1605822.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Lipid storage and lipophagy regulates ferroptosis

Bai, Y., Meng, L., Han, L., Jia, Y., Zhao, Y., Gao, H., Kang, R., Wang, X., Tang, D. & Dai, E., Jan 22 2019, In : Biochemical and Biophysical Research Communications. 508, 4, p. 997-1003 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma

Zhang, X., Lin, C., Song, J., Chen, H., Chen, X., Ren, L., Zhou, Z., Pan, J., Yang, Z., Bao, W., Ke, X., Yang, J., Liang, Y., Huang, H., Tang, D., Jiang, L. & Liu, J., Oct 1 2019, In : Cell Death and Disease. 10, 10, 719.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The HBx–CTTN interaction promotes cell proliferation and migration of hepatocellular carcinoma via CREB1

Li, Y., Fu, Y., Hu, X., Sun, L., Tang, D., Li, N., Peng, F. & Fan, X. G., Jun 1 2019, In : Cell Death and Disease. 10, 6, 405.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The release and activity of HMGB1 in ferroptosis

Wen, Q., Liu, J., Kang, R., Zhou, B. & Tang, D., Mar 5 2019, In : Biochemical and Biophysical Research Communications. 510, 2, p. 278-283 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia

Liao, Y., Liu, N., Xia, X., Guo, Z., Li, Y., Jiang, L., Zhou, R., Tang, D., Huang, H. & Liu, J., Dec 1 2019, In : Cell Discovery. 5, 1, 24.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2018

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc Activity

Song, X., Zhu, S., Chen, P., Hou, W., Wen, Q., Liu, J., Xie, Y., Liu, J., Klionsky, D. J., Kroemer, G., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., Aug 6 2018, In : Current Biology. 28, 15, p. 2388-2399.e5

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

AMPK regulates immunometabolism in sepsis

Huang, J., Liu, K., Zhu, S., Xie, M., Kang, R., Cao, L. & Tang, D., Aug 2018, In : Brain, Behavior, and Immunity. 72, p. 89-100 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Circular RNA 101368/miR-200a axis modulates the migration of hepatocellular carcinoma through HMGB1/RAGE signaling

Li, S., Gu, H., Huang, Y., Peng, Q., Zhou, R., Yi, P., Chen, R., Huang, Z., Hu, X., Huang, Y. & Tang, D., Oct 18 2018, In : Cell Cycle. 17, 19-20, p. 2349-2359 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Crosstalk between hepatitis B virus X and high-mobility group box 1 facilitates autophagy in hepatocytes

Fu, S., Wang, J., Hu, X., Zhou, R. R., Fu, Y., Tang, D., Kang, R., Huang, Y., Sun, L., Li, N. & Fan, X. G., Mar 2018, In : Molecular oncology. 12, 3, p. 322-338 17 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

Song, X., Zhu, S., Xie, Y., Liu, J., Sun, L., Zeng, D., Wang, P., Ma, X., Kroemer, G., Bartlett, D. L., Billiar, T. R., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., Apr 2018, In : Gastroenterology. 154, 5, p. 1480-1493 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

Kang, R., Zeng, L., Zhu, S., Xie, Y., Liu, J., Wen, Q., Cao, L., Xie, M., Ran, Q., Kroemer, G., Wang, H., Billiar, T. R., Jiang, J. & Tang, D., Jul 11 2018, In : Cell Host and Microbe. 24, 1, p. 97-108.e4

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

miR-142-3p inhibits the metastasis of hepatocellular carcinoma cells by regulating HMGB1 gene expression

Fu, Y., Sun, L. Q., Huang, Y., Quan, J., Hu, X., Tang, D., Kang, R., Li, N. & Fan, X. G., Jan 1 2018, In : Current molecular medicine. 18, 3, p. 135-141 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

Li, C., Zhang, Y., Cheng, X., Yuan, H., Zhu, S., Liu, J., Wen, Q., Xie, Y., Liu, J., Kroemer, G., Klionsky, D. J., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., Aug 20 2018, In : Developmental cell. 46, 4, p. 441-455.e8

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

TFAM is a novel mediator of immunogenic cancer cell death

Yang, M., Li, C., Zhu, S., Cao, L., Kroemer, G., Zeh, H., Tang, D. & Kang, R., Jun 3 2018, In : OncoImmunology. 7, 6, e1431086.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

The STING-STAT6 pathway drives Cas9-induced host response in human monocytes

Kang, R., Zhu, S., Zeh, H. & Tang, D., Nov 17 2018, In : Biochemical and Biophysical Research Communications. 506, 1, p. 278-283 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Elevated level of circulating histones in acute-on-chronic liver failure patients and mice with conA-induced acute liver injury

Zhong, X., Chen, R. C., Zheng, Y. X., Huang, Y., Tang, D. L., Zhou, R. R. & Fan, X. G., Feb 28 2017, In : International Journal of Clinical and Experimental Medicine. 10, 2, p. 2104-2115 12 p., IJCEM0040696.

Research output: Contribution to journalArticle

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

Xie, Y., Zhu, S., Zhong, M., Yang, M., Sun, X., Liu, J., Kroemer, G., Lotze, M., Zeh, H. J., Kang, R. & Tang, D., Nov 2017, In : Gastroenterology. 153, 5, p. 1429-1443.e5

Research output: Contribution to journalArticle

27 Scopus citations

The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation

Li, S., Huang, Y., Huang, Y., Fu, Y., Tang, D., Kang, R., Zhou, R. & Fan, X. G., Apr 12 2017, In : Journal of Experimental and Clinical Cancer Research. 36, 1, 51.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., Lotze, M. T., Zeh, H. J., Kang, R., Kroemer, G. & Tang, D., Aug 15 2017, In : Cell Reports. 20, 7, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations
2016

Antiferroptotic activity of non-oxidative dopamine

Wang, D., Peng, Y., Xie, Y., Zhou, B., Sun, X., Kang, R. & Tang, D., Nov 25 2016, In : Biochemical and Biophysical Research Communications. 480, 4, p. 602-607 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

FANCD2 protects against bone marrow injury from ferroptosis

Song, X., Xie, Y., Kang, R., Hou, W., Sun, X., Epperly, M. W., Greenberger, J. S. & Tang, D., Nov 18 2016, In : Biochemical and Biophysical Research Communications. 480, 3, p. 443-449 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

Xie, Y., Song, X., Sun, X., Huang, J., Zhong, M., Lotze, M. T., Zeh, H. J., Kang, R. & Tang, D., May 13 2016, In : Biochemical and Biophysical Research Communications. 473, 4, p. 775-780 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Novel chemokine-like activities of histones in tumor metastasis

Chen, R., Xie, Y., Zhong, X., Fu, Y., Huang, Y., Zhen, Y., Pan, P., Wang, H., Bartlett, D. L., Billiar, T. R., Lotze, M. T., Zeh, H. J., Fan, X. G., Tang, D. & Kang, R., Jan 1 2016, In : Oncotarget. 7, 38, p. 61728-61740 13 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2015

Nuclear DAMP complex-mediated RAGE-dependent macrophage cell death

Chen, R., Fu, S., Fan, X. G., Lotze, M. T., Zeh, H. J., Tang, D. & Kang, R., Mar 13 2015, In : Biochemical and Biophysical Research Communications. 458, 3, p. 650-655 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Oxidative stress-mediated HMGB1 biology

Yu, Y., Tang, D. & Kang, R., Jan 1 2015, In : Frontiers in Physiology. 6, MAR, 93.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

Boone, B. A., Orlichenko, L., Schapiro, N. E., Loughran, P., Gianfrate, G. C., Ellis, J. T., Singhi, A. D., Kang, R., Tang, D., Lotze, M. T. & Zeh, H. J., Jun 17 2015, In : Cancer Gene Therapy. 22, 6, p. 326-334 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2014

Cell death and DAMPs in acute pancreatitis

Kang, R., Lotze, M. T., Zeh, H. J., Billiar, T. R. & Tang, D., Jan 1 2014, In : Molecular Medicine. 20, JULY-DECEMBER 2014, p. 466-477 12 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

High mobility group box 1 (HMGB1) Phenotypic role revealed with stress

Tang, D., Kang, R., Van Houten, B., Zeh, H. J., Billiar, T. R. & Lotze, M. T., Jun 6 2014, In : Molecular Medicine. 20, 2, p. 359-362 4 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE

Liu, L., Yang, M., Kang, R., Dai, Y., Yu, Y., Gao, F., Wang, H., Sun, X., Li, X., Li, J., Wang, H., Cao, L. & Tang, D., Jul 18 2014, In : Biochemical and Biophysical Research Communications. 450, 1, p. 851-856 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Intracellular HMGB1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice

Kang, R., Zhang, Q., Hou, W., Yan, Z., Chen, R., Bonaroti, J., Bansal, P., Billiar, T. R., Tsung, A., Wang, Q., Bartlett, D. L., Whitcomb, D. C., Chang, E. B., Zhu, X., Wang, H., Lu, B., Tracey, K. J., Cao, L., Fan, X. G., Lotze, M. T. & 2 others, Zeh, H. J. & Tang, D., Apr 2014, In : Gastroenterology. 146, 4, p. 1097-1107.e8

Research output: Contribution to journalArticle

102 Scopus citations

MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell

Liu, K., Huang, J., Xie, M., Yu, Y., Zhu, S., Kang, R., Cao, L., Tang, D. & Duan, X., Mar 2014, In : Autophagy. 10, 3, p. 442-452 11 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

Yang, L., Xie, M., Yang, M., Yu, Y., Zhu, S., Hou, W., Kang, R., Lotze, M. T., Billiar, T. R., Wang, H., Cao, L. & Tang, D., Jul 14 2014, In : Nature communications. 5, 4436.

Research output: Contribution to journalArticle

Open Access
138 Scopus citations

RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer

Kang, R., Hou, W., Zhang, Q., Chen, R., Lee, Y. J., Bartlett, D. L., Lotze, M. T., Tang, D. & Zeh, H. J., Jan 1 2014, In : Cell Death and Disease. 5, 10, e1480.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer

Song, X., Kim, S. Y., Zhang, L., Tang, D., Bartlett, D. L., Kwon, Y. T. & Lee, Y. J., Jan 1 2014, In : Cell Death and Disease. 5, 10, e1504.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

S100A8 Contributes to drug resistance by promoting autophagy in leukemia cells

Yang, M., Zeng, P., Kang, R., Yu, Y., Yang, L., Tang, D. & Cao, L., May 12 2014, In : PloS one. 9, 5, e97242.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

Kang, R., Tang, D., Schapiro, N. E., Loux, T., Livesey, K. M., Billiar, T. R., Wang, H., Van Houten, B., Lotze, M. T. & Zeh, H. J., Jan 30 2014, In : Oncogene. 33, 5, p. 567-577 11 p.

Research output: Contribution to journalArticle

115 Scopus citations

The role of HMGB1-RAGE axis in migration and invasion of hepatocellular carcinoma cell lines

Chen, R. C., Yi, P. P., Zhou, R. R., Xiao, M. F., Huang, Z. B., Tang, D. L., Huang, Y. & Fan, X. G., May 2014, In : Molecular and Cellular Biochemistry. 390, 1-2, p. 271-280 10 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations
2013

Autophagy is required for IL-2-mediated fibroblast growth

Kang, R., Tang, D., Lotze, M. T. & Zeh, H. J., Feb 15 2013, In : Experimental Cell Research. 319, 4, p. 556-565 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

Yang, M., Cao, L., Xie, M., Yu, Y., Kang, R., Yang, L., Zhao, M. & Tang, D., Jan 1 2013, In : Biochemical Pharmacology. 86, 3, p. 410-418 9 p.

Research output: Contribution to journalArticle

57 Scopus citations