• 10528 Citations
  • 56 h-Index
19992020

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A case of endometrial cancer in the context of a BRCA2 mutation and double heterozygosity for Lynch syndrome

Gong, P., Charles, S., Rosenblum, N., Wang, Z. & Witkiewicz, A. K., Aug 2012, In : Gynecologic Oncology Reports. 2, 3, p. 69-72 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Acetate dependence of tumors

Comerford, S. A., Huang, Z., Du, X., Wang, Y., Cai, L., Witkiewicz, A., Walters, H., Tantawy, M. N., Fu, A., Manning, H. C., Horton, J. D., Hammer, R. E., McKnight, S. L. & Tu, B. P., Dec 18 2014, In : Cell. 159, 7, p. 1591-1602 12 p.

Research output: Contribution to journalArticle

257 Scopus citations

Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders

Ayli, E. E., Li, W., Brown, T. T., Witkiewicz, A., Elenitsas, R. & Seykora, J. T., Mar 1 2008, In : Journal of Cutaneous Pathology. 35, 3, p. 273-277 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

Acute aortic regurgitation due to spontaneous rupture of a fenestrated cusp: Report in a 65-year-old man and review of seven additional cases

Blaszyk, H., Witkiewicz, A. K. & Edwards, W. D., Jul 1 1999, In : Cardiovascular Pathology. 8, 4, p. 213-216 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma

Brody, J. R., Costantino, C. L., Potoczek, M., Cozzitorto, J., McCue, P., Yeo, C. J., Hruban, R. H. & Witkiewicz, A. K., May 1 2009, In : Modern Pathology. 22, 5, p. 651-659 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

Witkiewicz, A. K., Dasgupta, A., Sotgia, F., Mercier, I., Pestell, R. G., Sabel, M., Kleer, C. G., Brody, J. R. & Lisanti, M. P., Jun 2009, In : American Journal of Pathology. 174, 6, p. 2023-2034 12 p.

Research output: Contribution to journalArticle

233 Scopus citations

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs

Londina, E., Lohera, P., Telonis, A. G., Quann, K., Clark, P., Jinga, Y., Hatzimichael, E., Kirino, Y., Honda, S., Lally, M., Ramratnam, B., Comstock, C. E. S., Knudsen, K. E., Gomella, L., Spaeth, G. L., Hark, L., Katz, L. J., Witkiewicz, A., Rostami, A., Jimenez, S. A. & 18 others, Hollingsworth, M. A., Yeh, J. J., Shaw, C. A., McKenzie, S. E., Bray, P., Nelson, P. T., Zupo, S., Van Roosbroeck, K., Keating, M. J., Calin, G. A., Yeo, C., Jimbo, M., Cozzitorto, J., Brody, J. R., Delgrosso, K., Mattick, J. S., Fortina, P. & Rigoutsos, I., Mar 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 10, p. E1106-E1115

Research output: Contribution to journalArticle

242 Scopus citations

Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling

Anandanadesan, R., Gong, Q., Chipitsyna, G., Witkiewicz, A., Yeo, C. J. & Arafat, H. A., Jan 1 2008, In : Journal of Gastrointestinal Surgery. 12, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Association of RB/p16-pathway perturbations with DCIS recurrence: Dependence on tumor versus tissue microenvironment

Witkiewicz, A. K., Rivadeneira, D. B., Ertel, A., Kline, J., Hyslop, T., Schwartz, G. F., Fortina, P. & Knudsen, E. S., Sep 1 2011, In : American Journal of Pathology. 179, 3, p. 1171-1178 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

Martinez-Outschoorn, U. E., Trimmer, C., Lin, Z., Whitaker-Menezes, D., Chiavarina, B., Zhou, J., Wang, C., Pavlides, S., Martinez-Cantarin, M. P., Capozza, F., Witkiewicz, A. K., Flomenberg, N., Howell, A., Pestell, R. G., Caro, J., Lisanti, M. P. & Sotgia, F., Sep 1 2010, In : Cell Cycle. 9, 17, p. 3515-3533 19 p.

Research output: Contribution to journalArticle

247 Scopus citations

A western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer

Llaverias, G., Danilo, C., Wang, Y., Witkiewicz, A. K., Daumer, K., Lisanti, M. P. & Frank, P. G., Dec 2010, In : American Journal of Pathology. 177, 6, p. 3180-3191 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Biological specificity of CDK4/6 inhibitors: Dose response relationship, in vivo signaling, and composite response signaturez

Knudsen, E. S., Hutcheson, J., Vail, P. & Witkiewicz, A. K., 2017, In : Oncotarget. 8, 27, p. 43678-43691 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Carotid body tumor (paraganglioma)

Witkiewicz, A., Goldsmith, J. & Pantanowitz, L., Jun 1 2004, In : Ear, Nose and Throat Journal. 83, 6, p. 384-385 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

Sotgia, F., Del Galdo, F., Casimiro, M. C., Bonuccelli, G., Mercier, I., Whitaker-Menezes, D., Daumer, K. M., Zhou, J., Wang, C., Katiyar, S., Xu, H., Bosco, E., Quong, A. A., Aronow, B., Witkiewicz, A. K., Minetti, C., Frank, P. G., Jimenez, S. A., Knudsen, E. S., Pestell, R. G. & 1 others, Lisanti, M. P., Mar 2009, In : American Journal of Pathology. 174, 3, p. 746-761 16 p.

Research output: Contribution to journalArticle

96 Scopus citations

Caveolin-2-deficient mice show increased sensitivity to endotoxemia

De Almeida, C. J., Witkiewicz, A. K., Jasmin, J. F., Tanowitz, H. B., Sotgia, F., Frank, P. G. & Lisanti, M. P., Jul 1 2011, In : Cell Cycle. 10, 13, p. 2151-2161 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models

Witkiewicz, A. K., Cox, D. & Knudsen, E. S., 2014, In : Genes and Cancer. 5, 7-8, p. 261-272 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Franco, J., Witkiewicz, A. K. & Knudsen, E. S., 2014, In : Oncotarget. 5, 15, p. 6512-6525 14 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer

Knudsen, E. S., Kumarasamy, V., Ruiz, A., Sivinski, J., Chung, S., Grant, A., Vail, P., Chauhan, S. S., Jie, T., Riall, T. S. & Witkiewicz, A. K., May 2 2019, In : Oncogene. 38, 18, p. 3355-3370 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cell membrane and cytoplasmic epidermal growth factor receptor expression in pancreatic ductal adenocarcinoma

Mahipal, A., McDonald, M. J., Witkiewicz, A. & Carr, B. I., Mar 1 2012, In : Medical Oncology. 29, 1, p. 134-139 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer

Kumarasamy, V., Ruiz, A., Nambiar, R., Witkiewicz, A. K. & Knudsen, E. S., Feb 27 2020, In : Oncogene. 39, 9, p. 1831-1845 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: Implications for tumor progression and clinical outcome

Witkiewicz, A. K., Nguyen, K. H., Dasgupta, A., Kennedy, E. P., Yeo, C. J., Lisanti, M. P. & Brody, J. R., Oct 1 2008, In : Cell Cycle. 7, 19, p. 3021-3025 5 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N. L., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Composite analysis of immunological and metabolic markers defines novel subtypes of triple negative breast cancer

Adams, T. A., Vail, P. J., Ruiz, A., Mollaee, M., McCue, P. A., Knudsen, E. S. & Witkiewicz, A. K., Feb 1 2018, In : Modern Pathology. 31, 2, p. 288-298 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Contrast-enhanced sonography for detection of secondary lymph nodes in a melanoma tumor animal model

Liu, J. B., Merton, D. A., Berger, A. C., Forsberg, F., Witkiewicz, A., Zhao, H., Eisenbrey, J. R., Fox, T. B. & Goldberg, B. B., Jun 1 2014, In : Journal of Ultrasound in Medicine. 33, 6, p. 939-947 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Coordinately targeting cell-cycle checkpoint functions in integrated models of pancreatic cancer

Chung, S., Vail, P., Witkiewicz, A. K. & Knudsen, E. S., Apr 1 2019, In : Clinical Cancer Research. 25, 7, p. 2290-2304 15 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists

Wang, Y., Dean, J. L., Millar, E. K. A., Thai, H. T., McNeil, C. M., Burd, C. J., Henshall, S. M., Utama, F. E., Witkiewicz, A., Rui, H., Sutherland, R. L., Knudsen, K. E. & Knudsen, E. S., Jul 15 2008, In : Cancer research. 68, 14, p. 5628-5638 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome

Millar, E. K. A., Dean, J. L., McNeil, C. M., O'Toole, S. A., Henshall, S. M., Tran, T., Lin, J., Quong, A., Comstock, C. E. S., Witkiewicz, A., Musgrove, E. A., Rui, H., Lemarchand, L., Setiawan, V. W., Haiman, C. A., Knudsen, K. E., Sutherland, R. L. & Knudsen, E. S., Apr 16 2009, In : Oncogene. 28, 15, p. 1812-1820 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Cylindroma (dermal analog tumor) of the breast: A comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast

Albores-Saavedra, J., Heard, S. C., McLaren, B., Kamino, H. & Witkiewicz, A. K., Jun 2005, In : American journal of clinical pathology. 123, 6, p. 866-873 8 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

Hostetter, C., Licata, L. A., Witkiewicz, A., Costantino, C. L., Yeo, C. J., Brody, J. R. & Keen, J. C., Sep 2008, In : Cancer Biology and Therapy. 7, 9, p. 1498-1508 11 p.

Research output: Contribution to journalArticle

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

Hostetter, C., Licata, L. A., Witkiewicz, A., Costantino, C. L., Yeo, C. J., Brody, J. R. & Keen, J. C., Sep 2008, In : Cancer Biology and Therapy. 7, 9, p. 1496-1506 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: A dual-institutional follow-up with the RTOG 9704 trial

McAllister, F., Pineda, D. M., Jimbo, M., Lal, S., Burkhart, R. A., Moughan, J., Winter, K. A., Abdelmohsen, K., Gorospe, M., De Jesus Acosta, A., Lankapalli, R. H., Winter, J. M., Yeo, C. J., Witkiewicz, A. K., Iacobuzio-Donahue, C. A., Laheru, D. & Brody, J. R., Jun 2014, In : Cancer Biology and Therapy. 15, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Death from pulmonary thromboembolism in severe obesity: Lack of association with established genetic and clinical risk factors

Blaszyk, H., Wollan, P. C., Witkiewicz, A. K. & Björnsson, J., Jun 30 1999, In : Virchows Archiv. 434, 6, p. 529-532 4 p.

Research output: Contribution to journalArticle

62 Scopus citations

Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2-breast cancer

Knudsen, E. S. & Witkiewicz, A. K., Jan 1 2016, In : Oncotarget. 7, 43, p. 69111-69123 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Detection of merkel cell carcinoma polyomavirus in mucosal merkel cell carcinoma

Wu, K. N., McCue, P. A., Berger, A., Spiegel, J. R., Wang, Z. X. & Witkiewicz, A. K., Oct 2010, In : International Journal of Surgical Pathology. 18, 5, p. 342-346 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer

Lin, W. C., Rajbhandari, N., Liu, C., Sakamoto, K., Zhang, Q., Triplett, A. A., Batra, S. K., Opavsky, R., Felsher, D. W., DiMaio, D. J., Hollingsworth, M. A., Morris IV, J. P., Hebrok, M., Witkiewicz, A. K., Brody, J. R., Rui, H. & Wagner, K. U., Mar 15 2013, In : Cancer research. 73, 6, p. 1821-1830 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma

Valsecchi, M. E., McDonald, M., Brody, J. R., Hyslop, T., Freydin, B., Yeo, C. J., Solomides, C., Peiper, S. C. & Witkiewicz, A. K., Jul 15 2012, In : Cancer. 118, 14, p. 3484-3493 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward?

Showalter, S. L., Showalter, T. N., Witkiewicz, A., Havens, R., Kennedy, E. P., Hucl, T., Kern, S. E., Yeo, C. J. & Brody, J. R., Jul 2008, In : Cancer Biology and Therapy. 7, 7, p. 986-994 9 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

Whitaker-Menezes, D., Martinez-Outschoorn, U. E., Lin, Z., Ertel, A., Flomenberg, N., Witkiewicz, A. K., Birbe, R. C., Howell, A., Pavlides, S., Gandara, R., Pestell, R. G., Sotgia, F., Philp, N. J. & Lisanti, M. P., Jun 1 2011, In : Cell Cycle. 10, 11, p. 1772-1783 12 p.

Research output: Contribution to journalArticle

230 Scopus citations

Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma

Sullivan, J., Blair, L., Alnajar, A., Aziz, T., Ng, C. Y., Chipitsyna, G., Gong, Q., Witkiewicz, A., Weber, G. F., Denhardt, D. T., Yeo, C. J. & Arafat, H. A., Aug 1 2009, In : Surgery. 146, 2, p. 232-240 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival

Brody, J. R., Costantino, C. L., Berger, A. C., Sato, T., Lisanti, M. P., Yeo, C. J., Emmons, R. V. & Witkiewicz, A. K., Jun 15 2009, In : Cell Cycle. 8, 12, p. 1930-1934 5 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations

Expression of Indoleamine 2,3-Dioxygenase in Metastatic Pancreatic Ductal Adenocarcinoma Recruits Regulatory T Cells to Avoid Immune Detection

Witkiewicz, A., Williams, T. K., Cozzitorto, J., Durkan, B., Showalter, S. L., Yeo, C. J. & Brody, J. R., May 1 2008, In : Journal of the American College of Surgeons. 206, 5, p. 849-854 6 p.

Research output: Contribution to journalArticle

106 Scopus citations

Expression of K homology domain containing protein (KOC) in pancreatic cytology with corresponding histology

Toll, A. D., Witkiewicz, A. K. & Bibbo, M., Jan 1 2009, In : Acta Cytologica. 53, 2, p. 123-129 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Extrapancreatic neural plexus invasion by pancreatic carcinoma: Characteristics on magnetic resonance imaging

Zhang, X. M., Mitchell, D. G., Witkiewicz, A., Verma, S. & Bergin, D., Sep 1 2009, In : Abdominal Imaging. 34, 5, p. 634-641 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

EZH2 and ALDH1 expression in ductal carcinoma in situ: Complex association with recurrence and progression to invasive breast cancer

Knudsen, E. S., Dervishaj, O., Kleer, C. G., Pajak, T., Schwartz, G. F. & Witkiewicz, A. K., Jul 1 2013, In : Cell Cycle. 12, 13, p. 2042-2050 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Fibulin-5 blocks microenvironmental ROS in pancreatic cancer

Wang, M., Topalovski, M., Toombs, J. E., Wright, C. M., Moore, Z. R., Boothman, D. A., Yanagisawa, H., Wang, H., Witkiewicz, A., Castrillon, D. H. & Brekken, R. A., Dec 1 2015, In : Cancer Research. 75, 23, p. 5058-5069 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Foxp3-expressing T regulatory cells and mast cells in acute graft-versus-host disease of the skin

Wu, K. N., Emmons, R. V. B., Lisanti, M. P., Farber, J. L. & Witkiewicz, A. K., Nov 1 2009, In : Cell Cycle. 8, 21, p. 3601-3605 5 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Gallbladder abnormalities in carcinoma of pancreatic head: Findings on MR imaging

Zhang, X. M., Mitchell, D. G., Byun, J. H., Verma, S. K., Bergin, D. & Witkiewicz, A., Jul 1 2009, In : Abdominal Imaging. 34, 4, p. 507-513 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gangliocytic paraganglioma: Case report and review of the literature

Witkiewicz, A., Galler, A., Yeo, C. J. & Gross, S. D., Oct 2007, In : Journal of Gastrointestinal Surgery. 11, 10, p. 1351-1354 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions

Mercier, I., Casimiro, M. C., Zhou, J., Wang, C., Plymire, C., Bryant, K. G., Daumer, K. M., Sotgia, F., Bonuccelli, G., Witkiewicz, A. K., Lin, J., Tran, T. H., Milliman, J., Frank, P. G., Jasmin, J. F., Rui, H., Pestell, R. G. & Lisanti, M. P., Apr 2009, In : American Journal of Pathology. 174, 4, p. 1172-1190 19 p.

Research output: Contribution to journalArticle

46 Scopus citations

Genotyping and Expression Analysis of IDO2 in Human Pancreatic Cancer: A Novel, Active Target

Witkiewicz, A. K., Costantino, C. L., Metz, R., Muller, A. J., Prendergast, G. C., Yeo, C. J. & Brody, J. R., May 1 2009, In : Journal of the American College of Surgeons. 208, 5, p. 781-787 7 p.

Research output: Contribution to journalArticle

84 Scopus citations