• 3730 Citations
  • 36 h-Index
1974 …2020

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Article
2020

Late-Onset Immunotherapy Toxicity and Delayed Autoantibody Changes: Checkpoint Inhibitor–Induced Raynaud's-Like Phenomenon

Khan, S., von Itzstein, M. S., Lu, R., Bermas, B. L., Karp, D. R., Khan, S. A., Fattah, F. J., Park, J. Y., Saltarski, J. M., Gloria-McCutchen, Y., Xie, Y., Li, Q. Z., Wakeland, E. K. & Gerber, D. E., May 1 2020, In : Oncologist. 25, 5, p. e753-e757

Research output: Contribution to journalArticle

Open Access

Statin Intolerance, Anti-HMGCR Antibodies, and Immune Checkpoint Inhibitor-Associated Myositis: A “Two-Hit” Autoimmune Toxicity or Clinical Predisposition?

von Itzstein, M. S., Khan, S., Popat, V., Lu, R., Khan, S. A., Fattah, F. J., Park, J. Y., Bermas, B. L., Karp, D. R., Ahmed, M., Saltarski, J. M., Gloria-McCutchen, Y., Xie, Y., Li, Q. Z., Wakeland, E. K. & Gerber, D. E., 2020, (Accepted/In press) In : Oncologist.

Research output: Contribution to journalArticle

Open Access
2019

Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals

Jog, N. R., Young, K. A., Munroe, M. E., Harmon, M. T., Guthridge, J. M., Kelly, J. A., Kamen, D. L., Gilkeson, G. S., Weisman, M. H., Karp, D. R., Gaffney, P. M., Harley, J. B., Wallace, D. J., Norris, J. M. & James, J. A., Jan 1 2019, In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

4 Scopus citations

Mock Recruitment for the Study of Antimalarials in an Incomplete Lupus Erythematosus Trial

Karp, D. R., Chong, B. F., James, J. A., Arriens, C., Ishimori, M., Wallace, D. J., Liao, D. & Olsen, N. J., Nov 1 2019, In : Arthritis Care and Research. 71, 11, p. 1425-1429 5 p.

Research output: Contribution to journalArticle

Screening characteristics for enrichment of individuals at higher risk for transitioning to classified SLE

Young, K. A., Munroe, M. E., Guthridge, J. M., Kamen, D. L., Gilkensen, G. S., Harley, J. B., Weisman, M. H., Karp, D. R., Wallace, D. J., James, J. A. & Norris, J. M., Apr 1 2019, In : Lupus. 28, 5, p. 597-606 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018
4 Scopus citations
3 Scopus citations

Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus

Young, K. A., Munroe, M. E., Harley, J. B., Guthridge, J. M., Kamen, D. L., Gilkensen, G. S., Weisman, M. H., Karp, D. R., Wallace, D. J., James, J. A. & Norris, J. M., Jan 1 2018, (Accepted/In press) In : Lupus.

Research output: Contribution to journalArticle

1 Scopus citations

Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE): Study protocol for a randomized controlled trial

Olsen, N. J., James, J. A., Arriens, C., Ishimori, M. L., Wallace, D. J., Kamen, D. L., Chong, B., Liao, D., Chinchilli, V. M. & Karp, D. R., Dec 20 2018, In : Trials. 19, 1, 694.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Clinical and Serologic Features in Patients With Incomplete Lupus Classification Versus Systemic Lupus Erythematosus Patients and Controls

Aberle, T., Bourn, R. L., Munroe, M. E., Chen, H., Roberts, V. C., Guthridge, J. M., Bean, K., Robertson, J. M., Sivils, K. L., Rasmussen, A., Liles, M., Merrill, J. T., Harley, J. B., Olsen, N. J., Karp, D. R. & James, J. A., Dec 2017, In : Arthritis Care and Research. 69, 12, p. 1780-1788 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features

Munroe, M. E., Young, K. A., Kamen, D. L., Guthridge, J. M., Niewold, T. B., Costenbader, K. H., Weisman, M. H., Ishimori, M. L., Wallace, D. J., Gilkeson, G. S., Karp, D. R., Harley, J. B., Norris, J. M. & James, J. A., Mar 1 2017, In : Arthritis and Rheumatology. 69, 3, p. 630-642 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Transancestral mapping and genetic load in systemic lupus erythematosus

Langefeld, C. D., Ainsworth, H. C., Graham, D. S. C., Kelly, J. A., Comeau, M. E., Marion, M. C., Howard, T. D., Ramos, P. S., Croker, J. A., Morris, D. L., Sandling, J. K., Almlöf, J. C., Acevedo-Vásquez, E. M., Alarcón, G. S., Babini, A. M., Baca, V., Bengtsson, A. A., Berbotto, G. A., Bijl, M., Brown, E. E. & 88 others, Brunner, H. I., Cardiel, M. H., Catoggio, L., Cervera, R., Cucho-Venegas, J. M., Dahlqvist, S. R., D'Alfonso, S., Da Silva, B. M., De La RúaFigueroa, I., Doria, A., Edberg, J. C., Endreffy, E., Esquivel-Valerio, J. A., Fortin, P. R., Freedman, B. I., Frostegård, J., Garcýá, M. A., De La Torre, I. G., Gilkeson, G. S., Gladman, D. D., Gunnarsson, I., Guthridge, J. M., Huggins, J. L., James, J. A., Kallenberg, C. G. M., Kamen, D. L., Karp, D. R., Kaufman, K. M., Kottyan, L. C., Kovács, L., Laustrup, H., Lauwerys, B. R., Li, Q. Z., Maradiaga-Ceceną, M. A., Martín, J., McCune, J. M., McWilliams, D. R., Merrill, J. T., Miranda, P., Moctezuma, J. F., Nath, S. K., Niewold, T. B., Orozco, L., Ortego-Centeno, N., Petri, M., Pineau, C. A., Pons-Estel, B. A., Pope, J., Raj, P., Ramsey-Goldman, R., Reveille, J. D., Russell, L. P., Sabio, J. M., Aguilar-Salinas, C. A., Scherbarth, H. R., Scorza, R., Seldin, M. F., Sjöwall, C., Svenungsson, E., Thompson, S. D., Toloza, S. M. A., Truedsson, L., Tusié-Luna, T., Vasconcelos, C., Vilá, L. M., Wallace, D. J., Weisman, M. H., Wither, J. E., Bhangale, T., Oksenberg, J. R., Rioux, J. D., Gregersen, P. K., Syvänen, A. C., Rönnblom, L., Criswell, L. A., Jacob, C. O., Sivils, K. L., Tsao, B. P., Schanberg, L. E., Behrens, T. W., Silverman, E. D., Alarcón-Riquelme, M. E., Kimberly, R. P., Harley, J. B., Wakeland, E. K., Graham, R. R., Gaffney, P. M. & Vyse, T. J., Jul 17 2017, In : Nature communications. 8, 16021.

Research output: Contribution to journalArticle

95 Scopus citations

Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus

Aberle, T., Bourn, R. L., Chen, H., Roberts, V. C., Guthridge, J. M., Bean, K., Robertson, J. M., Sivils, K. L., Rasmussen, A., Liles, M., Merrill, J. T., Harley, J. B., Olsen, N. J., Karp, D. R. & James, J. A., Jan 2017, In : Lupus Science and Medicine. 4, 1, e000176.

Research output: Contribution to journalArticle

13 Scopus citations
2016

A search for blood biomarkers for autism: Peptoids

Zaman, S., Yazdani, U., Deng, Y., Li, W., Gadad, B. S., Hynan, L., Karp, D., Roatch, N., Schutte, C., Nathan Marti, C., Hewitson, L. & German, D. C., Jan 14 2016, In : Scientific Reports. 6, 19164.

Research output: Contribution to journalArticle

14 Scopus citations

Blood biomarker for Parkinson disease: peptoids

Yazdani, U., Zaman, S., Hynan, L. S., Brown, L. S., Dewey, R. B., Karp, D. & German, D. C., Dec 1 2016, In : npj Parkinson's Disease. 2, 1, 16012.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

Young, K. A., Munroe, M. E., Guthridge, J. M., Kamen, D. L., Niewold, T. B., Gilkeson, G. S., Weisman, M. H., Ishimori, M. L., Kelly, J., Gaffney, P. M., Sivils, K. H., Lu, R., Wallace, D. J., Karp, D. R., Harley, J. B., James, J. A. & Norris, J. M., Jun 9 2016, (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

20 Scopus citations

Cross-sectional imaging of adult crystal and inflammatory arthropathies

Soldatos, T., Pezeshk, P., Ezzati, F., Karp, D. R., Taurog, J. D. & Chhabra, A., May 21 2016, (Accepted/In press) In : Skeletal Radiology. p. 1-19 19 p.

Research output: Contribution to journalArticle

2 Scopus citations
5 Scopus citations

Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

Raj, P., Rai, E., Song, R., Khan, S., Wakeland, B. E., Viswanathan, K., Arana, C., Liang, C., Zhang, B., Dozmorov, I., Carr-Johnson, F., Mitrovic, M., Wiley, G. B., Kelly, J. A., Lauwerys, B. R., Olsen, N. J., Cotsapas, C., Garcia, C. K., Wise, C. A., Harley, J. B. & 9 others, Nath, S. K., James, J. A., Jacob, C. O., Tsao, B. P., Pasare, C., Karp, D. R., Li, Q. Z., Gaffney, P. M. & Wakeland, E. K., Feb 15 2016, In : eLife. 5, FEBRUARY2016, e12089.

Research output: Contribution to journalArticle

52 Scopus citations
2015

Antinuclear Antibodies Are Associated With All-Cause Mortality and Cardiovascular Outcomes in the General Population

Solow, E. B., Vongpatanasin, W., Skaug, B., Karp, D. R., Ayers, C. & de Lemos, J. A., Jun 23 2015, In : Journal of the American College of Cardiology. 65, 24, p. 2669-2670 2 p., 21269.

Research output: Contribution to journalArticle

11 Scopus citations

A subset of CD163+ macrophages displays mixed polarizations in discoid lupus skin

Chong, B. F., Tseng, L. C., Hosler, G. A., Teske, N. M., Zhang, S., Karp, D. R., Olsen, N. J. & Mohan, C., Nov 13 2015, In : Arthritis Research and Therapy. 17, 1, 324.

Research output: Contribution to journalArticle

12 Scopus citations
24 Scopus citations
2014

Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations

Kim-Howard, X., Sun, C., Molineros, J. E., Maiti, A. K., Chandru, H., Adler, A., Wiley, G. B., Kaufman, K. M., Kottyan, L., Guthridge, J. M., Rasmussen, A., Kelly, J., Sánchez, E., Raj, P., Li, Q. Z., Bang, S. Y., Lee, H. S., Kim, T. H., Kang, Y. M., Suh, C. H. & 35 others, Chung, W. T., Park, Y. B., Choe, J. Y., Shim, S. C., Lee Shin-Seok, S. S., Han, B. G., Olsen, N. J., Karp, D. R., Moser, K., Pons-Estel, B. A., Wakeland, E. K., James, J. A., Harley, J. B., Bae, S. C., Gaffney, P. M., Alarcón-Riquelme, M., Acevedo, E., La Torre, I. G. D., Maradiaga-Ceceña, M. A., Cardiel, M. H., Esquivel-Valerio, J. A., Rodriguez-Amado, J., Moctezuma, J. F., Miranda, P., Perandones, C., Castel, C., Laborde, H. A., Alba, P., Musuruana, J., Goecke, A., Foster, C., Orozco, L., Baca, V., Looger, L. L. & Nath, S. K., Mar 1 2014, In : Human molecular genetics. 23, 6, p. 1656-1668 13 p., ddt532.

Research output: Contribution to journalArticle

29 Scopus citations

Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates

Quan, J., Lakhanpal, A., Reddy, M. M., Zaman, S., Li, Q. Z., German, D. C., Olsen, N. J., Kodadek, T. & Karp, D. R., Jan 1 2014, In : Journal of Immunological Methods. 402, 1-2, p. 23-34 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Smoking is not associated with autoantibody production in systemic lupus erythematosus patients, unaffected first-degree relatives, nor healthy controls

Young, K. A., Terrell, D. R., Guthridge, J. M., Kamen, D. L., Gilkeson, G. S., Karp, D. R., Ishimori, M. L., Weisman, M. H., Holers, V. M., Harley, J. B., Norris, J. M. & James, J. A., Apr 2014, In : Lupus. 23, 4, p. 360-369 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Multifaceted effects of hydroxychloroquine in human disease

Olsen, N. J., Schleich, M. A. & Karp, D. R., Oct 1 2013, In : Seminars in Arthritis and Rheumatism. 43, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Organ damage in high-risk patients with systemic and incomplete lupus syndromes

Olsen, N. J., Yousif, M., Mutwally, A., Cory, M., Elmagboul, N. & Karp, D. R., Oct 1 2013, In : Rheumatology International. 33, 10, p. 2585-2590 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

Becker, A. M., Dao, K. H., Han, B. K., Kornu, R., Lakhanpal, S., Mobley, A. B., Li, Q. Z., Lian, Y., Wu, T., Reimold, A. M., Olsen, N. J., Karp, D. R., Chowdhury, F. Z., Farrar, J. D., Satterthwaite, A. B., Mohan, C., Lipsky, P. E., Wakeland, E. K. & Davis, L. S., Jun 24 2013, In : PloS one. 8, 6, e67003.

Research output: Contribution to journalArticle

94 Scopus citations
2012

Autoantibody profiling to follow evolution of lupus syndromes

Olsen, N. J., Li, Q. Z., Quan, J., Wang, L., Mutwally, A. & Karp, D. R., Jul 27 2012, In : Arthritis Research and Therapy. 14, 4, R174.

Research output: Contribution to journalArticle

46 Scopus citations

IgG and IgM autoantibody differences in discoid and systemic lupus patients

Chong, B. F., Tseng, L. C., Lee, T., Vasquez, R., Li, Q. Z., Zhang, S., Karp, D. R., Olsen, N. J. & Mohan, C., Dec 2012, In : Journal of Investigative Dermatology. 132, 12, p. 2770-2779 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Production of autoantibodies against citrullinated antigens/peptides by human B cells

Bellatin, M. F., Han, M., Fallena, M., Fan, L., Xia, D., Olsen, N., Branch, V., Karp, D. & Stastny, P., Apr 1 2012, In : Journal of Immunology. 188, 7, p. 3542-3550 9 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Risk factors for ANA positivity in healthy persons

Li, Q. Z., Karp, D. R., Quan, J., Branch, V. K., Zhou, J., Lian, Y., Chong, B. F., Wakeland, E. K. & Olsen, N. J., Mar 2 2011, In : Arthritis Research and Therapy. 13, 2, R38.

Research output: Contribution to journalArticle

79 Scopus citations

Toward an ontology-based framework for clinical research databases

Megan Kong, Y., Dahlke, C., Xiang, Q., Qian, Y., Karp, D. & Scheuermann, R. H., Feb 1 2011, In : Journal of Biomedical Informatics. 44, 1, p. 48-58 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2010

Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes

Li, Q. Z., Zhou, J., Lian, Y., Zhang, B., Branch, V. K., Carr-Johnson, F., Karp, D. R., Mohan, C., Wakeland, E. K. & Olsen, N. J., Mar 1 2010, In : Clinical and Experimental Immunology. 159, 3, p. 281-291 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
2009

Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis

Karp, D. R., Marthandan, N., Marsh, S. G. E., Ahn, C., Arnett, F. C., DeLuca, D. S., Diehl, A. D., Dunivin, R., Eilbeck, K., Feolo, M., Guidry, P. A., Helmberg, W., Lewis, S., Mayes, M. D., Mungall, C., Natale, D. A., Peters, B., Petersdorf, E., Reveille, J. D., Smith, B. & 3 others, Thomson, G., Waller, M. J. & Scheuermann, R. H., Nov 18 2009, In : Human molecular genetics. 19, 4, p. 707-719 13 p., ddp521.

Research output: Contribution to journalArticle

27 Scopus citations
2008

Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus

Sawalha, A. H., Kaufman, K. M., Kelly, J. A., Adler, A. J., Aberle, T., Kilpatrick, J., Wakeland, E. K., Li, Q. Z., Wandstrat, A. E., Karp, D. R., James, J. A., Merrill, J. T., Lipsky, P. & Harley, J. B., Apr 1 2008, In : Annals of the Rheumatic Diseases. 67, 4, p. 458-461 4 p.

Research output: Contribution to journalArticle

138 Scopus citations

Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans

Kelly, J. A., Kelley, J. M., Kaufman, K. M., Kilpatrick, J., Bruner, G. R., Merrill, J. T., James, J. A., Frank, S. G., Reams, E., Brown, E. E., Gibson, A. W., Marion, M. C., Langefeld, C. D., Li, Q. Z., Karp, D. R., Wakeland, E. K., Petri, M., Ramsey-Goldman, R., Reveille, J. D., Vilá, L. M. & 4 others, Alarcón, G. S., Kimberly, R. P., Harley, J. B. & Edberg, J. C., Apr 1 2008, In : Genes and Immunity. 9, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing

Qian, Y., Banerjee, S., Grossman, C. E., Amidon, W., Nagy, G., Barcza, M., Niland, B., Karp, D. R., Middleton, F. A., Banki, K. & Perl, A., Oct 1 2008, In : Biochemical Journal. 415, 1, p. 123-134 12 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes

Li, Q. Z., Zhou, J., Wandstrat, A. E., Carr-Johnson, F., Branch, V., Karp, D. R., Mohan, C., Wakeland, E. K. & Olsen, N. J., Jan 1 2007, In : Clinical and Experimental Immunology. 147, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

143 Scopus citations
2006

Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus

Wandstrat, A. E., Carr-Johnson, F., Branch, V., Gray, H., Fairhurst, A. M., Reimold, A., Karp, D., Wakeland, E. K. & Olsen, N. J., Nov 1 2006, In : Journal of Autoimmunity. 27, 3, p. 153-160 8 p.

Research output: Contribution to journalArticle

112 Scopus citations

Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype

King, M. R., Ismail, A. S., Davis, L. S. & Karp, D. R., Mar 1 2006, In : Journal of Immunology. 176, 5, p. 2765-2772 8 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations
2005

Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement

Lee, Y., Haas, K. M., Gor, D. O., Ding, X., Karp, D. R., Greenspan, N. S., Poe, J. C. & Tedder, T. F., Dec 15 2005, In : Journal of Immunology. 175, 12, p. 8011-8023 13 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase

Mineo, C., Gormley, A. K., Yuhanna, I. S., Osborne-Lawrence, S., Gibson, L. L., Hahner, L., Shohet, R. V., Black, S., Salmon, J. E., Samols, D., Karp, D. R., Thomas, G. D. & Shaul, P. W., Nov 1 2005, In : Circulation research. 97, 11, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

89 Scopus citations

Increased prevalence of activated CD70+CD4+ T cells in the periphery of patients with systemic lupus erythematosus

Han, B. K., White, A. M., Dao, K. H., Karp, D. R., Wakeland, E. K. & Davis, L. S., Sep 22 2005, In : Lupus. 14, 8, p. 598-606 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
2004

Cutting Edge: C3d Functions as a Molecular Adjuvant in the Absence of CD21/35 Expression

Haas, K. M., Toapanta, F. R., Oliver, J. A., Poe, J. C., Weis, J. H., Karp, D. R., Bower, J. F., Ross, T. M. & Tedder, T. F., May 15 2004, In : Journal of Immunology. 172, 10, p. 5833-5837 5 p.

Research output: Contribution to journalArticle

Open Access
59 Scopus citations
2003

A new type of metal recognition by human T cells: Contact residues for peptide-independent bridging of T cell receptor and major histocompatibility complex by nickel

Gamerdinger, K., Moulon, C., Karp, D. R., Van Bergen, J., Koning, F., Wild, D., Pflugfelder, U. & Weltzien, H. U., May 19 2003, In : Journal of Experimental Medicine. 197, 10, p. 1345-1353 9 p.

Research output: Contribution to journalArticle

109 Scopus citations
2002

Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses

Haas, K. M., Hasegawa, M., Steeber, D. A., Poe, J. C., Zabel, M. D., Bock, C. B., Karp, D. R., Briles, D. E., Weis, J. H. & Tedder, T. F., Dec 1 2002, In : Immunity. 17, 6, p. 713-723 11 p.

Research output: Contribution to journalArticle

118 Scopus citations
2001

Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein

Boackle, S. A., Holers, V. M., Chen, X., Szakonyi, G., Karp, D. R., Wakeland, E. K. & Morel, L., Jan 1 2001, In : Immunity. 15, 5, p. 775-785 11 p.

Research output: Contribution to journalArticle

175 Scopus citations

Expression of γ-Glutamyl Transpeptidase Protects Ramos B Cells from Oxidation-induced Cell Death

Karp, D. R., Shimooku, K. & Lipsky, P. E., Feb 9 2001, In : Journal of Biological Chemistry. 276, 6, p. 3798-3804 7 p.

Research output: Contribution to journalArticle

146 Scopus citations