• 7979 Citations
  • 39 h-Index
19952020

Research output per year

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Research Output

Article

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

Tran, T. A., Kinch, L., Peña-Llopis, S., Kockel, L., Grishin, N., Jiang, H. & Brugarolas, J., Nov 6 2013, In : Molecular and cellular biology. 33, 19, p. 3762-3779 18 p.

Research output: Contribution to journalArticle

11 Scopus citations

Prolonged survival of a patient with papillary renal cell carcinoma and brain metastases using pazopanib

Jacobs, C., Kim, D. W. N., Straka, C., Timmerman, R. D. & Brugarolas, J., Mar 1 2013, In : Journal of Clinical Oncology. 31, 7, p. e114-e117

Research output: Contribution to journalArticle

17 Scopus citations

Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma

Gayed, B. A., Gillen, J., Christie, A., Peña-Llopis, S., Xie, X-J., Yan, J., Karam, J. A., Raj, G., Sagalowsky, A. I., Lotan, Y., Margulis, V. & Brugarolas, J. B., Apr 3 2015, In : BMC Urology. 15, p. 24 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

REDD1/DDIT4-independent mTORC1 inhibition and apoptosis by glucocorticoids in thymocytes

Wolff, N. C., McKay, R. M. & Brugarolas, J., Jun 2014, In : Molecular Cancer Research. 12, 6, p. 867-877 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W. & Kaelin, W. G., Dec 1 2004, In : Genes and Development. 18, 23, p. 2893-2904 12 p.

Research output: Contribution to journalArticle

852 Scopus citations

Regulation of TFEB and V-ATPases by mTORC1

Peña-Llopis, S., Vega-Rubin-De-Celis, S., Schwartz, J. C., Wolff, N. C., Tran, T. A. T., Zou, L., Xie, X. J., Corey, D. R. & Brugarolas, J., Aug 17 2011, In : EMBO Journal. 30, 16, p. 3242-3258 17 p.

Research output: Contribution to journalArticle

249 Scopus citations
8 Scopus citations

Renal-Cell Carcinoma Pseudoprogression With Clinical Deterioration: To Hospice and Back

Elias, R., Kapur, P., Pedrosa, I. & Brugarolas, J., Jan 1 2018, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

3 Scopus citations
1 Scopus citations

Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy

Mohamad, O., Diaz de Leon, A., Schroeder, S., Leiker, A., Christie, A., Zhang-Velten, E., Trivedi, L., Khan, S., Desai, N. B., Laine, A., Albuquerque, K., Iyengar, P., Arriaga, Y., Courtney, K., Gerber, D. E., Hammers, H., Choy, H., Timmerman, R., Brugarolas, J. & Hannan, R., Jul 3 2018, In : OncoImmunology. 7, 7, e1440168.

Research output: Contribution to journalArticle

9 Scopus citations

Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Carcinoma Extracranial Metastases

Wang, C. J., Christie, A., Lin, M-H., Jung, M., Weix, D., Huelsmann, L., Kuhn, K., Meyer, J. J., Desai, N. B., Kim, D. W. N., Pedrosa, I., Margulis, V., Cadeddu, J. A., Sagalowsky, A. I., Gahan, J., Laine, A. M., Xie, X-J., Choy, H., Brugarolas, J. B., Timmerman, R. & 1 others, Hannan, R., May 1 2017, In : International Journal of Radiation Oncology Biology Physics. 98, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Scina: Semi-supervised analysis of single cells in silico

Zhang, Z., Luo, D., Zhong, X., Choi, J. H., Ma, Y., Wang, S., Mahrt, E., Guo, W., Stawiski, E. W., Modrusan, Z., Seshagiri, S., Kapur, P., Hon, G. C., Brugarolas, J. & Wang, T., Jul 1 2019, In : Genes. 10, 7, 531.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Selective Efficacy of Temsirolimus on Bone Metastases in Chromophobe Renal Cell Carcinoma

Huelsmann, L., Kim, D. N. W., Hannan, R., Watumull, L. M. & Brugarolas, J., Nov 22 2014, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

2 Scopus citations

Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications

Peña-Llopis, S. & Brugarolas, J., Nov 8 2013, In : Nature Protocols. 8, 11, p. 2240-2255 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Sirolimus and temsirolimus for epithelioid angiomyolipoma

Wolff, N., Kabbani, W., Bradley, T., Raj, G., Watumull, L. & Brugarolas, J., Feb 10 2010, In : Journal of Clinical Oncology. 28, 5, p. e65-e68

Research output: Contribution to journalArticle

48 Scopus citations

Sirolimus in metatastic renal cell carcinoma

Brugarolas, J. B., Lotan, Y., Watumull, L. M. & Kabbani, W., Sep 15 2008, In : Journal of Clinical Oncology. 26, 20, p. 3457-3460 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes

Durinck, S., Stawiski, E. W., Pavía-Jiménez, A., Modrusan, Z., Kapur, P., Jaiswal, B. S., Zhang, N., Toffessi-Tcheuyap, V., Nguyen, T. T., Pahuja, K. B., Chen, Y. J., Saleem, S., Chaudhuri, S., Heldens, S., Jackson, M., Peña-Llopis, S., Guillory, J., Toy, K., Ha, C., Harris, C. J. & 21 others, Holloman, E., Hill, H. M., Stinson, J., Rivers, C. S., Janakiraman, V., Wang, W., Kinch, L. N., Grishin, N. V., Haverty, P. M., Chow, B., Gehring, J. S., Reeder, J., Pau, G., Wu, T. D., Margulis, V., Lotan, Y., Sagalowsky, A. I., Pedrosa, I., De Sauvage, F. J., Brugarolas, J. B. & Seshagiri, S., 2015, In : Nature Genetics. 47, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

154 Scopus citations
3 Scopus citations
3 Scopus citations

Stereotactic radiation therapy of renal cancer inferior vena cava tumor thrombus

Hannan, R., Margulis, V., Chun, S. G., Cannon, N., Kim, D. W. N., Abdulrahman, R. E., Sagalowsky, A. I., Pedrosa, I., Choy, H., Brugarolas, J. B. & Timmerman, R., Jan 1 2015, In : Cancer Biology and Therapy. 16, 5, p. 657-661 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structural analysis and functional implications of the negative mTORC1 regulator REDD1

Vega-Rubin-de-Celis, S., Abdallah, Z., Kinch, L., Grishin, N. V., Brugarolas, J. & Zhang, X., Mar 23 2010, In : Biochemistry. 49, 11, p. 2491-2501 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., Hao, G., Yousuf, Q., Joyce, A., Pedrosa, I., Geiger, H., Zhang, H., Chang, J., Gardner, K. H., Bruick, R. K., Reeves, C. & 14 others, Hwang, T. H., Courtney, K., Frenkel, E., Sun, X., Zojwalla, N., Wong, T., Rizzi, J. P., Wallace, E. M., Josey, J. A., Xie, Y., Xie, X. J., Kapur, P., McKay, R. M. & Brugarolas, J., 2016, In : Nature. 539, 7627, p. 112-117 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

The cyclin kinase inhibitor p21(CIP1/WAF1) limits glomerular epithelial cell proliferation in experimental glomerulonephritis

Yoon-Goo, K., Alpers, C. E., Brugarolas, J., Johnson, R. J., Couser, W. G. & Shankland, S. J., Jan 1 1999, In : Kidney international. 55, 6, p. 2349-2361 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

The cyclin kinase inhibitor p21(WAF1/CIP1) is required for glomerular hypertrophy in experimental diabetic nephropathy

Al-Douahji, M., Brugarolas, J., Brown, P. A. J., Stehman-Breen, C. O., Alpers, C. E. & Shankland, S. J., Jan 1 1999, In : Kidney international. 56, 5, p. 1691-1699 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

The impact of targeted molecular therapies on the level of renal cell carcinoma vena caval tumor thrombus

Cost, N. G., Delacroix, S. E., Sleeper, J. P., Smith, P. J., Youssef, R. F., Chapin, B. F., Karam, J. A., Culp, S., Abel, E. J., Brugarolas, J. B., Raj, G., Sagalowsky, A. I., Wood, C. G. & Margulis, V., Jun 1 2011, In : European urology. 59, 6, p. 912-918 7 p.

Research output: Contribution to journalArticle

110 Scopus citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

Attardi, L. D., Lowe, S. W., Brugarolas, J. & Jacks, T., Jul 15 1996, In : EMBO Journal. 15, 14, p. 3693-3701 9 p.

Research output: Contribution to journalArticle

239 Scopus citations

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

Hasan, M., Koch, J., Rakheja, D., Pattnaik, A. K., Brugarolas, J. B., Dozmorov, I., Levine, B., Wakeland, E. K., Lee-Kirsch, M. A. & Yan, N., Jan 1 2013, In : Nature immunology. 14, 1, p. 61-71 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

Brugarolas, J. B., Vazquez, F., Reddy, A., Sellers, W. R. & Kaelin, W. G., Aug 1 2003, In : Cancer Cell. 4, 2, p. 147-158 12 p.

Research output: Contribution to journalArticle

419 Scopus citations
25 Scopus citations

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

Kucejova, B., Sunny, N. E., Nguyen, A. D., Hallac, R., Fu, X., Pẽa-Llopis, S., Mason, R. P., Deberardinis, R. J., Xie, X. J., Debose-Boyd, R., Kodibagkar, V. D., Burgess, S. C. & Brugarolas, J., May 5 2011, In : Oncogene. 30, 18, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Kim, H., Rodriguez-Navas, C., Kollipara, R. K., Kapur, P., Pedrosa, I., Brugarolas, J., Kittler, R. & Ye, J., Oct 20 2015, In : Cell Reports. 13, 3, p. 495-503 9 p., 2062.

Research output: Contribution to journalArticle

21 Scopus citations

What is the role of nephrectomy following complete response to checkpoint inhibitors?

Woldu, S. L., Brugarolas, J., Kapur, P. & Margulis, V., May 1 2018, In : Urology Case Reports. 18, p. 60-63 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Whole-body MRI for metastatic cancer detection using T2-weighted imaging with fat and fluid suppression

Wang, X., Pirasteh, A., Brugarolas, J., Rofsky, N. M., Lenkinski, R. E., Pedrosa, I. & Madhuranthakam, A. J., Oct 1 2018, In : Magnetic Resonance in Medicine. 80, 4, p. 1402-1415 14 p.

Research output: Contribution to journalArticle

2 Scopus citations
Chapter

Research translation and personalized medicine

Brugarolas, J., Nov 1 2012, Renal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets. Springer US, Vol. 9781461424000. p. 161-191 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
Comment/debate
3 Scopus citations

Towards a genomic-based diagnosis

Brugarolas, J., Haynes, B. F. & Nevins, J. R., Jan 27 2001, In : Lancet. 357, 9252, p. 249-250 2 p.

Research output: Contribution to journalComment/debate

13 Scopus citations

Using "rationally designed drugs" rationally

Brugarolas, J., Clark, J. W. & Chabner, B., May 24 2003, In : Lancet. 361, 9371, p. 1758-1759 2 p.

Research output: Contribution to journalComment/debate

6 Scopus citations
Editorial

Renal-cell carcinoma - Molecular pathways and therapies

Brugarolas, J., Jan 11 2007, In : New England Journal of Medicine. 356, 2, p. 185-187 3 p.

Research output: Contribution to journalEditorial

218 Scopus citations

TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy

Peña-Llopis, S. & Brugarolas, J., Dec 1 2011, In : Cell Cycle. 10, 23, p. 3987-3988 2 p.

Research output: Contribution to journalEditorial

24 Scopus citations
Letter

In reply

Brugarolas, J., Dec 1 2008, In : Journal of Clinical Oncology. 26, 34, p. 5653-5654 2 p.

Research output: Contribution to journalLetter

Radiation-induced cell cycle arrest compromised by p21 deficiency

Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T. & Hannon, G. J., Oct 12 1995, In : Nature. 377, 6549, p. 552-557 6 p.

Research output: Contribution to journalLetter

1083 Scopus citations
Review article

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J., Cannon-Albright, L. A., Cantley, L. C., Cavenee, W. K., Chen, Z., Croce, C. M., Andrea, A. D., Gandara, D., Giorgi, C., Jia, W., Lan, Q., Mak, T. W., Manley, J. L., Mikoshiba, K., Onuchic, J. N., Pass, H. I., Pinton, P. & 8 others, Prives, C., Rothman, N., Sebti, S. M., Turkson, J., Wu, X., Yang, H., Yu, H. & Melino, G., Nov 1 2018, In : Cell Death and Differentiation. 25, 11, p. 1885-1904 20 p.

Research output: Contribution to journalReview article

7 Scopus citations

Cooperation and antagonism among cancer genes: The renal cancer paradigm

Peña-Llopis, S., Christie, A., Xie, X. J. & Brugarolas, J., Jul 15 2013, In : Cancer Research. 73, 14, p. 4173-4179 7 p.

Research output: Contribution to journalReview article

46 Scopus citations

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

Brugarolas, J. & Kaelin, W. G., Jul 2004, In : Cancer Cell. 6, 1, p. 7-10 4 p.

Research output: Contribution to journalReview article

134 Scopus citations

Familial Kidney Cancer: Implications of New Syndromes and Molecular Insights

Carlo, M. I., Hakimi, A. A., Stewart, G. D., Bratslavsky, G., Brugarolas, J. B., Chen, Y. B., Linehan, W. M., Maher, E. R., Merino, M. J., Offit, K., Reuter, V. E., Shuch, B. & Coleman, J. A., Jan 1 2019, In : European urology.

Research output: Contribution to journalReview article

7 Scopus citations

Metabolism of kidney cancer: From the lab to clinical practice

Sudarshan, S., Karam, J. A., Brugarolas, J., Thompson, R. H., Uzzo, R., Rini, B., Margulis, V., Patard, J. J., Escudier, B. & Linehan, W. M., Feb 1 2013, In : European urology. 63, 2, p. 244-251 8 p.

Research output: Contribution to journalReview article

45 Scopus citations

PBRM1 and BAP1 as novel targets for renal cell carcinoma

Brugarolas, J., Jul 1 2013, In : Cancer Journal (United States). 19, 4, p. 324-332 9 p.

Research output: Contribution to journalReview article

58 Scopus citations

Personalized Management of Advanced Kidney Cancer

Graham, J., Heng, D. Y. C., Brugarolas, J. B. & Vaishampayan, U., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 330-341 12 p.

Research output: Contribution to journalReview article

5 Scopus citations