• 10832 Citations
  • 56 h-Index
1986 …2020

Research output per year

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Research Output

2004

Inhibition of MAPK signaling pathways by VopA from Vibrio parahaemolyticus

Trosky, J. E., Mukherjee, S., Burdette, D. L., Roberts, M., McCarter, L., Siegel, R. M. & Orth, K., Dec 10 2004, In : Journal of Biological Chemistry. 279, 50, p. 51953-51957 5 p.

Research output: Contribution to journalArticle

82 Scopus citations
2006

AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-κB signalling pathway

Fehr, D., Casanova, C., Liverman, A., Blazkova, H., Orth, K., Dobbelaere, D., Frey, J. & Burr, S. E., Sep 1 2006, In : Microbiology. 152, 9, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation

Chosed, R., Mukherjee, S., Lois, L. M. & Orth, K., Sep 15 2006, In : Biochemical Journal. 398, 3, p. 521-529 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H. L., Goldsmith, E. J. & Orth, K., May 26 2006, In : Science. 312, 5777, p. 1211-1214 4 p.

Research output: Contribution to journalArticle

407 Scopus citations
2007

A newly discovered post-translational modification - the acetylation of serine and threonine residues

Mukherjee, S., Hao, Y. H. & Orth, K., May 1 2007, In : Trends in Biochemical Sciences. 32, 5, p. 210-216 7 p.

Research output: Contribution to journalArticle

95 Scopus citations

Arp2/3-independent assembly of actin by Vibrio type III effector VopL

Liverman, A. D. B., Cheng, H. C., Trosky, J. E., Leung, D. W., Yarbrough, M. L., Burdette, D. L., Rosen, M. K. & Orth, K., Oct 23 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 43, p. 17117-17122 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases

Chosed, R., Tomchick, D. R., Brautigam, C. A., Mukherjee, S., Negi, V. S., Machius, M. & Orth, K. A., Mar 2 2007, In : Journal of Biological Chemistry. 282, 9, p. 6773-6782 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

The elusive activity of the Yersinia protein kinase A kinase domain is revealed

Laskowski-Arce, M. A. & Orth, K., Oct 1 2007, In : Trends in Microbiology. 15, 10, p. 437-440 4 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Versatile type III effector mechanisms can disrupt target-cell functions

Orth, K., Apr 2007, In : Microbe. 2, 4, p. 183-186 4 p.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases

Trosky, J. E., Li, Y., Mukherjee, S., Keitany, G., Ball, H. & Orth, K., Nov 23 2007, In : Journal of Biological Chemistry. 282, 47, p. 34299-34305 7 p.

Research output: Contribution to journalArticle

76 Scopus citations
2008

Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus

Laskowski-Arce, M. A. & Orth, K., Dec 1 2008, In : Applied and environmental microbiology. 74, 23, p. 7183-7188 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

In vitro activation of the IκB kinase complex by human T-cell leukemia virus type-1 tax

Mukherjee, S., Negi, V. S., Keitany, G., Tanaka, Y. & Orth, K., May 30 2008, In : Journal of Biological Chemistry. 283, 22, p. 15127-15133 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

In Vitro Signaling by MAPK and NFκB Pathways Inhibited by Yersinia YopJ

Mukherjee, S. & Orth, K., 2008, In : Methods in Enzymology. 438, p. 343-353 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Microbiology: A protein pupylation paradigm

Mukherjee, S. & Orth, K., Nov 14 2008, In : Science. 322, 5904, p. 1062-1063 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Salmonella secreted factor l deubiquitinase of Salmonella typhimurium inhibits NF-κB, Suppresses IkBαUbiquitination and modulates innate immune responses

Negrate, G. L., Faustin, B., Welsh, K., Loeffler, M., Krajewska, M., Hasegawa, P., Mukherjee, S., Orth, K., Krajewski, S., Godzik, A., Guiney, D. G. & Reed, J. C., Apr 1 2008, In : Journal of Immunology. 180, 7, p. 5045-5056 12 p.

Research output: Contribution to journalArticle

101 Scopus citations

Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways

Hao, Y. H., Wang, Y., Burdette, D., Mukherjee, S., Keitany, G., Goldsmith, E. & Orth, K., Jan 2 2008, In : PloS one. 3, 1, e1375.

Research output: Contribution to journalArticle

28 Scopus citations

Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding, and then cell lysis

Burdette, D. L., Yarbrough, M. L., Orvedahl, A., Gilpin, C. J. & Orth, K., Aug 26 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 34, p. 12497-12502 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Yersinia outer proteins: Yops

Trosky, J. E., Liverman, A. D. B. & Orth, K., Mar 1 2008, In : Cellular Microbiology. 10, 3, p. 557-565 9 p.

Research output: Contribution to journalShort survey

81 Scopus citations
2009

AMPylation is a new post-translational modiFICation

Yarbrough, M. L. & Orth, K., Jun 2009, In : Nature chemical biology. 5, 6, p. 378-379 2 p.

Research output: Contribution to journalShort survey

24 Scopus citations

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling

Yarbrough, M. L., Li, Y., Kinch, L. N., Grishin, N. V., Ball, H. L. & Orth, K., Jan 9 2009, In : Science. 323, 5911, p. 269-272 4 p.

Research output: Contribution to journalArticle

234 Scopus citations

Fido, a novel ampylation domain common to fic, doc, and AvrB

Kinch, L. N., Yarbrough, M. L., Orth, K. & Grishin, N. V., Jun 5 2009, In : PloS one. 4, 6, e5818.

Research output: Contribution to journalArticle

94 Scopus citations

HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse

Nejmeddine, M., Negi, V. S., Mukherjee, S., Tanaka, Y., Orth, K., Taylor, G. P. & Bangham, C. R. M., Nov 20 2009, In : Blood. 114, 5, p. 1016-1025 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death

Burdette, D. L., Yarbrough, M. L. & Orth, K., Jan 1 2009, In : Autophagy. 5, 1, p. 100-102 3 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Viorio VopQ induces Pu-kmase-independent autophagy and antagonizes phagocytosis

Burdette, D. L., Seemann, J. & Orth, K., Aug 1 2009, In : Molecular Microbiology. 73, 4, p. 639-649 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
2010

Ampylation: Something old is new again

Woolery, A. R., Luong, P., Broberg, C. A. & Orth, K., Jan 1 2010, In : Frontiers in Microbiology. 1, OCT

Research output: Contribution to journalReview article

43 Scopus citations

A Vibrio effector protein is an inositol phosphatase and disrupts host cell membrane integrity

Broberg, C. A., Zhang, L., Gonzalez, H., Laskowski-Arce, M. A. & Orth, K., Sep 24 2010, In : Science. 329, 5999, p. 1660-1662 3 p.

Research output: Contribution to journalArticle

63 Scopus citations

Kinetic and structural insights into the mechanism of AMPylation by VopS Fic domain

Luong, P., Kinch, L. N., Brautigam, C. A., Grishin, N. V., Tomchick, D. R. & Orth, K. A., Jun 25 2010, In : Journal of Biological Chemistry. 285, 26, p. 20155-20163 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Tipping the balance by manipulating post-translational modifications

Broberg, C. A. & Orth, K., Feb 1 2010, In : Current Opinion in Microbiology. 13, 1, p. 34-40 7 p.

Research output: Contribution to journalReview article

25 Scopus citations
2011

A chemical reporter for protein AMPylation

Grammel, M., Luong, P., Orth, K. & Hang, H. C., Nov 2 2011, In : Journal of the American Chemical Society. 133, 43, p. 17103-17105 3 p.

Research output: Contribution to journalArticle

43 Scopus citations

Characterization of AMPylation on threonine, serine, and tyrosine using mass spectrometry

Li, Y., Al-Eryani, R., Yarbrough, M. L., Orth, K. & Ball, H. L., Apr 1 2011, In : Journal of the American Society for Mass Spectrometry. 22, 4, p. 752-761 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Characterization of a rabbit polyclonal antibody against threonine-AMPylation

Hao, Y. H., Chuang, T., Ball, H. L., Luong, P., Li, Y., Flores-Saaib, R. D. & Orth, K., Feb 10 2011, In : Journal of Biotechnology. 151, 3, p. 251-254 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

De-AMPylation unmasked: Modulation of host membrane trafficking

Ham, H. & Orth, K., Oct 11 2011, In : Science Signaling. 4, 194, pe42.

Research output: Contribution to journalReview article

5 Scopus citations
42 Scopus citations

Manipulation of host membranes by bacterial effectors

Ham, H., Sreelatha, A. & Orth, K., Sep 1 2011, In : Nature Reviews Microbiology. 9, 9, p. 635-646 12 p.

Research output: Contribution to journalReview article

86 Scopus citations

Manipulation of kinase signaling by bacterial pathogens

Krachler, A. M., Woolery, A. R. & Orth, K., Dec 1 2011, In : Journal of Cell Biology. 195, 7, p. 1083-1092 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
63 Scopus citations

Vibrio parahaemolyticus cell biology and pathogenicity determinants

Broberg, C. A., Calder, T. J. & Orth, K., Nov 1 2011, In : Microbes and Infection. 13, 12-13, p. 992-1001 10 p.

Research output: Contribution to journalShort survey

168 Scopus citations
2012

In vitro characterization of multivalent adhesion molecule 7-based inhibition of multidrug-resistant bacteria isolated from wounded military personnel

Krachler, A. M., Mende, K., Murray, C. & Orth, K., Jan 1 2012, In : Virulence. 3, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Subversion of cell signaling by pathogens

Alto, N. M. & Orth, K., Sep 1 2012, In : Cold Spring Harbor Perspectives in Biology. 4, 9

Research output: Contribution to journalArticle

56 Scopus citations

The role of type III secretion System 2 in Vibrio parahaemolyticus pathogenicity

Ham, H. & Orth, K., Nov 12 2012, In : Journal of Microbiology. 50, 5, p. 719-725 7 p.

Research output: Contribution to journalReview article

27 Scopus citations

Turnabout is fair play: Use of the bacterial multivalent adhesion molecule 7 as an antimicrobial agent

Krachler, A. M., Ham, H. & Orth, K., Jan 1 2012, In : Virulence. 3, 1, p. 68-71 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Type III Effector VopC Mediates Invasion for Vibrio Species

Zhang, L., Krachler, A. M., Broberg, C. A., Li, Y., Mirzael, H., Gilpin, C. J. & Orth, K., May 31 2012, In : Cell Reports. 1, 5, p. 453-460 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections

Rahman, M., Ham, H., Liu, X., Sugiura, Y., Orth, K. & Krämer, H., Jun 1 2012, In : Nature neuroscience. 15, 6, p. 871-875 5 p.

Research output: Contribution to journalArticle

41 Scopus citations
2013

A MAM7 peptide-based inhibitor of staphylococcus aureus adhesion does not interfere with in vitro host cell function

Hawley, C. A., Watson, C. A., Orth, K. & Krachler, A. M., Nov 12 2013, In : PloS one. 8, 11

Research output: Contribution to journalArticle

15 Scopus citations

An interview with Kim Orth.

Orth, K., Jul 2013, In : Trends in biochemical sciences. 38, 7, p. 331-332 2 p.

Research output: Contribution to journalComment/debate

Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides

Salomon, D., Guo, Y., Kinch, L. N., Grishin, N. V., Gardner, K. H. & Orth, K., Dec 18 2013, In : Nature communications. 4, 2973.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Lost after translation: Post-translational modifications by bacterial type III effectors

Salomon, D. & Orth, K., Apr 1 2013, In : Current Opinion in Microbiology. 16, 2, p. 213-220 8 p.

Research output: Contribution to journalReview article

6 Scopus citations

Made to stick: Anti-adhesion therapy for bacterial infections

Krachler, A. M. & Orth, K., Jul 1 2013, In : Microbe. 8, 7, p. 286-290 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting the bacteria-host interface strategies in anti-adhesion therapy

Krachler, A. M. & Orth, K., Jan 1 2013, In : Virulence. 4, 4, p. 284-294 11 p.

Research output: Contribution to journalReview article

97 Scopus citations

The first engagement of partners in the Euprymna scolopes-Vibrio fischeri symbiosis is a two-step process initiated by a few environmental symbiont cells

Altura, M. A., Heath-Heckman, E. A. C., Gillette, A., Kremer, N., Krachler, A. M., Brennan, C., Ruby, E. G., Orth, K. & Mcfall-Ngai, M. J., Nov 1 2013, In : Environmental Microbiology. 15, 11, p. 2937-2950 14 p.

Research output: Contribution to journalArticle

30 Scopus citations