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2020

Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation

Trötschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Bönigk, W., Körschen, H. G., Müller, A., Poetsch, A., Rennhack, A., Gui, L., Nicastro, D., Strünker, T., Seifert, R. & Kaupp, U. B., Feb 17 2020, In : EMBO Journal. 39, 4, e102723.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

Chen, S., Jiao, L., Liu, X., Yang, X. & Liu, X., Mar 19 2020, In : Molecular cell. 77, 6, p. 1265-1278.e7

Research output: Contribution to journalArticle

A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM

Peng, W., Casey, A. K., Fernandez, J., Carpinone, E. M., Servage, K. A., Chen, Z., Li, Y., Tomchick, D. R., Starai, V. J. & Orth, K., Jun 1 2020, In : Nature Structural and Molecular Biology. 27, 6, p. 589-597 9 p.

Research output: Contribution to journalArticle

A genomic perspective on the taxonomy of the subtribe Carcharodina (Lepidoptera: Hesperiidae: Carcharodini)

Zhang, J., Brockmann, E., Cong, Q., Shen, J. & Grishin, N. V., Mar 5 2020, In : Zootaxa. 4748, 1, p. 182-194 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A Legionella effector kinase is activated by host inositol hexakisphosphate

Sreelatha, A., Nolan, C., Park, B. C., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 1 2020, In : Journal of Biological Chemistry. 295, 18, p. 6214-6224 11 p.

Research output: Contribution to journalArticle

A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis

Garcia-Santamarina, S., Probst, C., Festa, R. A., Ding, C., Smith, A. D., Conklin, S. E., Brander, S., Kinch, L. N., Grishin, N. V., Franz, K. J., Riggs-Gelasco, P., Lo Leggio, L., Johansen, K. S. & Thiele, D. J., Mar 1 2020, In : Nature chemical biology. 16, 3, p. 337-344 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Analysis of asymmetry in lipid and content mixing assays with reconstituted proteoliposomes containing the neuronal SNAREs

Pan, Y. Z., Liu, X. & Rizo, J., Dec 1 2020, In : Scientific reports. 10, 1, 2907.

Research output: Contribution to journalArticle

Open Access

A Phosphorylated Intermediate in the Activation of WNK Kinases

Akella, R., Drozdz, M. A., Humphreys, J. M., Jiou, J., Durbacz, M. Z., Mohammed, Z. J., He, H., Liwocha, J., Sekulski, K. & Goldsmith, E. J., May 12 2020, In : Biochemistry. 59, 18, p. 1747-1755 9 p.

Research output: Contribution to journalArticle

A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

Xing, W., Muhlrad, D., Parker, R. & Rosen, M. K., Jun 2020, In : eLife. 9, p. 1-63 63 p., e56525.

Research output: Contribution to journalArticle

Open Access

Chlamydomonas PKD2 organizes mastigonemes, hair-like glycoprotein polymers on cilia

Liu, P., Lou, X., Wingfield, J. L., Lin, J., Nicastro, D. & Lechtreck, K., Jun 1 2020, In : Journal of Cell Biology. 219, 6, 202001122.

Research output: Contribution to journalArticle

Open Access

CLASPs at a glance

Lawrence, E. J., Zanic, M. & Rice, L. M., Apr 2020, In : Journal of cell science. 133, 8, jcs243097.

Research output: Contribution to journalArticle

Open Access

Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

Xing, C., Zhuang, Y., Xu, T. H., Feng, Z., Zhou, X. E., Chen, M., Wang, L., Meng, X., Xue, Y., Wang, J., Liu, H., McGuire, T. F., Zhao, G., Melcher, K., Zhang, C., Xu, H. E. & Xie, X. Q., Feb 20 2020, In : Cell. 180, 4, p. 645-654.e13

Research output: Contribution to journalArticle

9 Scopus citations

Cryo-EM structure of the human cohesin-NIPBL-DNA complex

Shi, Z., Gao, H., Bai, X. C. & Yu, H., Jun 26 2020, In : Science (New York, N.Y.). 368, 6498, p. 1454-1459 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

Kuo, Y. C., Chen, H., Shang, G., Uchikawa, E., Tian, H., Bai, X. C. & Zhang, X., Dec 1 2020, In : Nature communications. 11, 1, 1953.

Research output: Contribution to journalArticle

Open Access

Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA

Partin, A. C., Zhang, K., Jeong, B. C., Herrell, E., Li, S., Chiu, W. & Nam, Y., May 7 2020, In : Molecular cell. 78, 3, p. 411-422.e4

Research output: Contribution to journalArticle

1 Scopus citations

Directional allosteric regulation of protein filament length

Jermyn, A. S., Cao, W., Elam, W. A., De La Cruz, E. M. & Lin, M. M., Mar 2020, In : Physical Review E. 101, 3, 032409.

Research output: Contribution to journalArticle

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein

Zhang, R., Lee, D. M., Jimah, J. R., Gerassimov, N., Yang, C., Kim, S., Luvsanjav, D., Winkelman, J., Mettlen, M., Abrams, M. E., Kalia, R., Keene, P., Pandey, P., Ravaux, B., Kim, J. H., Ditlev, J. A., Zhang, G., Rosen, M. K., Frost, A., Alto, N. M. & 5 others, Gardel, M., Schmid, S. L., Svitkina, T. M., Hinshaw, J. E. & Chen, E. H., Jun 1 2020, In : Nature cell biology. 22, 6, p. 674-688 15 p.

Research output: Contribution to journalArticle

Fast and Robust Quantification of Detergent Micellization Thermodynamics from Isothermal Titration Calorimetry

Tso, S. C., Mahler, F., Höring, J., Keller, S. & Brautigam, C. A., Jan 7 2020, In : Analytical chemistry. 92, 1, p. 1154-1161 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

High-resolution cryo-EM reconstructions in the presence of substantial aberrations

Bromberg, R., Guo, Y., Borek, D. & Otwinowski, Z., May 1 2020, In : IUCrJ. 7, p. 445-452 8 p.

Research output: Contribution to journalArticle

Open Access

Insights into allosteric control of microtubule dynamics from a buried β-tubulin mutation that causes faster growth and slower shrinkage

Ye, X., Kim, T., Geyer, E. A. & Rice, L. M., Jun 1 2020, In : Protein Science. 29, 6, p. 1429-1439 11 p.

Research output: Contribution to journalArticle

In situ structure determination at nanometer resolution using TYGRESS

Song, K., Shang, Z., Fu, X., Lou, X., Grigorieff, N. & Nicastro, D., Feb 1 2020, In : Nature methods. 17, 2, p. 201-208 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of malaria

Kokkonda, S., Deng, X., White, K. L., El Mazouni, F., White, J., Shackleford, D. M., Katneni, K., Chiu, F. C. K., Barker, H., Mclaren, J., Crighton, E., Chen, G., Angulo-Barturen, I., Jimenez-Diaz, M. B., Ferrer, S., Huertas-Valentin, L., Martinez-Martinez, M. S., Lafuente-Monasterio, M. J., Chittimalla, R., Shahi, S. P. & 9 others, Wittlin, S., Waterson, D., Burrows, J. N., Matthews, D., Tomchick, D., Rathod, P. K., Palmer, M. J., Charman, S. A. & Phillips, M. A., May 14 2020, In : Journal of Medicinal Chemistry. 63, 9, p. 4929-4956 28 p.

Research output: Contribution to journalArticle

Modulation of the erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site

Brams, M., Govaerts, C., Kambara, K., Price, K., Spurny, R., Gharpure, A., Pardon, E., Evans, G. L., Bertrand, D., Lummis, S. C. R., Hibbs, R. E., Steyaert, J. & Ulens, C., Jan 2020, In : eLife. 9, e51511.

Research output: Contribution to journalArticle

Open Access

Mutation severity spectrum of rare alleles in the human genome is predictive of disease type

Pei, J., Kinch, L. N., Otwinowski, Z. & Grishin, N. V., May 2020, In : PLoS Computational Biology. 16, 5, e1007775.

Research output: Contribution to journalArticle

Open Access

NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution

Maszota-Zieleniak, M., Jurczak, P., Orlikowska, M., Zhukov, I., Borek, D., Otwinowski, Z., Skowron, P., Pietralik, Z., Kozak, M., Szymańska, A. & Rodziewicz-Motowidło, S., Jan 1 2020, In : FEBS Journal. 287, 2, p. 361-376 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access

Nucleating a Microtubule: Put a γ-Tubulin Ring on It

Gangadharan, B. & Rice, L. M., Jun 8 2020, In : Developmental cell. 53, 5, p. 495-497 3 p.

Research output: Contribution to journalArticle

PCRM1exportome: Database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes

Lee, Y., Baumhardt, J. M., Pei, J., Chook, Y. M. & Grishin, N. V., Feb 1 2020, In : Bioinformatics. 36, 3, p. 961-963 3 p.

Research output: Contribution to journalArticle

Re-examining how Munc13-1 facilitates opening of syntaxin-1

Magdziarek, M., Bolembach, A. A., Stepien, K. P., Quade, B., Liu, X. & Rizo, J., Jun 1 2020, In : Protein Science. 29, 6, p. 1440-1458 19 p.

Research output: Contribution to journalArticle

RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

Yenerall, P., Das, A., Wang, S., Kollipara, R. K., Li, L. S., Villalobos, P., Flaming, J., Lin, Y-F., Huffman, K., Timmons, B. C., Gilbreath, C., Sonavane, R., Kinch, L. N., Rodriguez-Canales, J., Moran, C., Behrens, C., Hirasawa, M., Takata, T., Murakami, R., Iwanaga, K. & 6 others, Chen, B. P. C., Grishin, N. V., Raj, G. V., Wistuba, I. I., Minna, J. D. & Kittler, R., Jan 16 2020, In : Cell Chemical Biology. 27, 1, p. 105-121.e14

Research output: Contribution to journalArticle

1 Scopus citations

Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation

Jun, D. J., Schumacher, M. M., Hwang, S., Kinch, L. N., Grishin, N. V. & DeBose-Boyd, R. A., May 1 2020, In : Journal of lipid research. 61, 5, p. 746-757 12 p.

Research output: Contribution to journalArticle

Open Access

Segmental labeling: Applications to protein NMR and DNP

Ghosh, R., Madrid, C. L. & Frederick, K. K., Jan 1 2020, In : eMagRes. 9, 1, p. 71-80 10 p.

Research output: Contribution to journalArticle

Speciation in North American Junonia from a genomic perspective

Cong, Q., Zhang, J., Shen, J., Cao, X., Brévignon, C. & Grishin, N. V., Jan 1 2020, (Accepted/In press) In : Systematic Entomology.

Research output: Contribution to journalArticle

Structural and mechanistic insights into secretagogin-mediated exocytosis

Qin, J., Liu, Q., Liu, Z., Pan, Y. Z., Sifuentes-Dominguez, L., Stepien, K. P., Wang, Y., Tu, Y., Tan, S., Wang, Y., Sun, Q., Mo, X., Rizo, J., Burstein, E. & Jia, D., Mar 24 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 12, p. 6559-6570 12 p.

Research output: Contribution to journalArticle

Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane

Yin, J., Chen, K. Y. M., Clark, M. J., Hijazi, M., Kumari, P., Bai, X. C., Sunahara, R. K., Barth, P. & Rosenbaum, D. M., Aug 6 2020, In : Nature. 584, 7819, p. 125-129 5 p.

Research output: Contribution to journalArticle

Synaptotagmin-1 and Doc2b Exhibit Distinct Membrane-Remodeling Mechanisms

Sorkin, R., Marchetti, M., Logtenberg, E., Piontek, M. C., Kerklingh, E., Brand, G., Voleti, R., Rizo, J., Roos, W. H., Groffen, A. J. & Wuite, G. J. L., Feb 4 2020, In : Biophysical journal. 118, 3, p. 643-656 14 p.

Research output: Contribution to journalArticle

The mitogenome of a malagasy butterfly malaza fastuosus (Mabille, 1884) recovered from the holotype collected over 140 years ago adds support for a new subfamily of hesperiidae (lepidoptera)

Zhang, J., Lees, D. C., Shen, J., Cong, Q., Huertas, B., Martin, G. & Grishin, N. V., Jan 1 2020, In : Genome. 63, 4, p. 195-202 8 p.

Research output: Contribution to journalArticle

Open Access

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Koirala, S., Klein, J., Zheng, Y., Glenn, N. O., Eisemann, T., Fon Tacer, K., Miller, D. J., Kulak, O., Lu, M., Finkelstein, D. B., Neale, G., Tillman, H., Vogel, P., Strand, D. W., Lum, L., Brautigam, C. A., Pascal, J. M., Clements, W. K. & Potts, P. R., Jul 21 2020, In : Cell Reports. 32, 3, 107922.

Research output: Contribution to journalArticle

Open Access

β-Strand-mediated interactions of protein domains

Bhat, A. S., Kinch, L. N. & Grishin, N. V., 2020, (Accepted/In press) In : Proteins: Structure, Function and Bioinformatics.

Research output: Contribution to journalArticle

2019

4D electron microscopy of T cell activation

Lu, Y., Yoo, B. K., Ng, A. H. C., Kim, J., Yeom, S., Tang, J., Lin, M. M., Zewail, A. H. & Heath, J. R., Oct 29 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 44, p. 22014-22019 6 p.

Research output: Contribution to journalArticle

Open Access

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

Lopez, V. A., Park, B. C., Nowak, D., Sreelatha, A., Zembek, P., Fernandez, J., Servage, K. A., Gradowski, M., Hennig, J., Tomchick, D. R., Pawłowski, K., Krzymowska, M. & Tagliabracci, V. S., Sep 19 2019, In : Cell. 179, 1, p. 205-218.e21

Research output: Contribution to journalArticle

6 Scopus citations

A composition-dependent molecular clutch between T cell signaling condensates and actin

Ditlev, J. A., Vega, A. R., Köster, D. V., Su, X., Tani, T., Lakoduk, A. M., Vale, R. D., Mayor, S., Jaqaman, K. & Rosen, M. K., Jul 2019, In : eLife. 8, e42695.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

Uchikawa, E., Choi, E., Shang, G., Yu, H. & Xiao-Chen, B., Aug 2019, In : eLife. 8, e48630.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

Gharpure, A., Teng, J., Zhuang, Y., Noviello, C. M., Walsh, R. M., Cabuco, R., Howard, R. J., Zaveri, N. T., Lindahl, E. & Hibbs, R. E., Nov 6 2019, In : Neuron. 104, 3, p. 501-511.e6

Research output: Contribution to journalArticle

15 Scopus citations

An improved yeast surface display platform for the screening of nanobody immune libraries

Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., Dec 1 2019, In : Scientific reports. 9, 1, 382.

Research output: Contribution to journalArticle

6 Scopus citations

Assessing predictions on fitness effects of missense variants in calmodulin

Zhang, J., Kinch, L. N., Cong, Q., Katsonis, P., Lichtarge, O., Savojardo, C., Babbi, G., Martelli, P. L., Capriotti, E., Casadio, R., Garg, A., Pal, D., Weile, J., Sun, S., Verby, M., Roth, F. P. & Grishin, N. V., Jan 1 2019, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

3 Scopus citations

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Schober, A. F., Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O. & Reynolds, K. A., Jun 11 2019, In : Cell Reports. 27, 11, p. 3359-3370.e7

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

Black, M. H., Osinski, A., Gradowski, M., Servage, K. A., Pawłowski, K., Tomchick, D. R. & Tagliabracci, V. S., May 24 2019, In : Science (New York, N.Y.). 364, 6442, p. 787-792 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations

Mann, N., Kause, F., Henze, E. K., Gharpure, A., Shril, S., Connaughton, D. M., Nakayama, M., Klämbt, V., Majmundar, A. J., Wu, C. H. W., Kolvenbach, C. M., Dai, R., Chen, J., van der Ven, A. T., Ityel, H., Tooley, M. J., Kari, J. A., Bownass, L., El Desoky, S., De Franco, E. & 13 others, Shalaby, M., Tasic, V., Bauer, S. B., Lee, R. S., Beckel, J. M., Yu, W., Mane, S. M., Lifton, R. P., Reutter, H., Ellard, S., Hibbs, R. E., Kawate, T. & Hildebrandt, F., Dec 5 2019, In : American Journal of Human Genetics. 105, 6, p. 1286-1293 8 p.

Research output: Contribution to journalArticle