Research Output

Short survey

Prion-like properties of Tau protein: The importance of extracellular Tau as a therapeutic target

Holmes, B. B. & Diamond, M. I., Jan 1 2014, In : Journal of Biological Chemistry. 289, 29, p. 19855-19861 7 p.

Research output: Contribution to journalShort survey

110 Scopus citations
Review article

Advances in diagnostic testing for Alzheimer disease.

Schindler, S. E., McConathy, J., Ances, B. M. & Diamond, M. I., Jan 1 2013, In : Missouri medicine. 110, 5, p. 401-405 5 p.

Research output: Contribution to journalReview article

5 Scopus citations

Amyotrophic lateral sclerosis and organ donation: Is there risk of disease transmission?

Holmes, B. B. & Diamond, M. I., Dec 2012, In : Annals of Neurology. 72, 6, p. 832-836 5 p.

Research output: Contribution to journalReview article

14 Scopus citations

Cellular mechanisms of protein aggregate propagation

Holmes, B. B. & Diamond, M. I., Dec 2012, In : Current opinion in neurology. 25, 6, p. 721-726 6 p.

Research output: Contribution to journalReview article

44 Scopus citations

Design and implementation of cell-based assays to model human disease

Jones, J. O. & Diamond, M. I., Nov 1 2007, In : ACS chemical biology. 2, 11, p. 718-724 7 p.

Research output: Contribution to journalReview article

18 Scopus citations
103 Scopus citations

Mechanisms of protein seeding in neurodegenerative diseases

Walker, L. C., Diamond, M. I., Duff, K. E. & Hyman, B. T., Mar 2013, In : JAMA Neurology. 70, 3, p. 304-310 7 p.

Research output: Contribution to journalReview article

133 Scopus citations

Polyglutamine diseases: Emerging concepts in pathogenesis and therapy

Shao, J. & Diamond, M. I., Oct 15 2007, In : Human molecular genetics. 16, R2, p. R115-R123

Research output: Contribution to journalReview article

193 Scopus citations

Prion-like mechanisms in neurodegenerative diseases

Frost, B. & Diamond, M. I., Mar 1 2010, In : Nature Reviews Neuroscience. 11, 3, p. 155-159 5 p.

Research output: Contribution to journalReview article

457 Scopus citations

Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

Kaufman, S. K. & Diamond, M. I., Jul 1 2013, In : Neurotherapeutics. 10, 3, p. 371-382 12 p.

Research output: Contribution to journalReview article

22 Scopus citations

Prions and Protein Assemblies that Convey Biological Information in Health and Disease

Sanders, D. W., Kaufman, S. K., Holmes, B. B. & Diamond, M. I., Feb 3 2016, In : Neuron. 89, 3, p. 433-448 16 p.

Research output: Contribution to journalReview article

39 Scopus citations

The prion model for progression and diversity of neurodegenerative diseases

Stopschinski, B. E. & Diamond, M. I., Apr 1 2017, In : The Lancet Neurology. 16, 4, p. 323-332 10 p.

Research output: Contribution to journalReview article

63 Scopus citations
Letter

Rebuttal to Drs. Grinberg and Heinsen

Kaufman, S. K., Del Tredici, K., Braak, H. & Diamond, M. I., Nov 1 2018, In : Acta Neuropathologica. 136, 5, p. 819 1 p.

Research output: Contribution to journalLetter

Editorial

Introduction

Diamond, M. I., Jul 1 2013, In : Neurotherapeutics. 10, 3, p. 369-370 2 p.

Research output: Contribution to journalEditorial

Comment/debate

Erratum to Anti-Tau antibodies that block tau aggregate seeding invitro markedly decrease pathology and improve cognition in vivo [Neuron, 74, (2012), 227-245]

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T., Ma, S., Maloney, S., Wozniak, D., Diamond, M. & Holtzman, D., Dec 18 2013, In : Neuron. 80, 6, p. 1572 1 p.

Research output: Contribution to journalComment/debate

The expanding realm of prion phenomena in neurodegenerative disease

Frost, B. & Diamond, M. I., 2009, In : Prion. 3, 2, p. 74-77 4 p.

Research output: Contribution to journalComment/debate

Open Access
25 Scopus citations
Chapter

Active and passive immunotherapy against tau: Effects and potential mechanisms

Yanamandra, K., Diamond, M. I. & Holtzman, D. M., Jan 1 2016, Methods in Pharmacology and Toxicology. Humana Press Inc., p. 121-138 18 p. (Methods in Pharmacology and Toxicology; vol. PartF1).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

FRET and flow cytometry assays to measure proteopathic seeding activity in biological samples

Furman, J. L. & Diamond, M. I., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1523. p. 349-359 11 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
Article

A cellular conformation-based screen for androgen receptor inhibitors

Jones, J. O. & Diamond, M. I., Jul 18 2008, In : ACS chemical biology. 3, 7, p. 412-418 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

A common motif targets huntingtin and the androgen receptor to the proteasome

Chandra, S., Shao, J., Li, J. X., Li, M., Longo, F. M. & Diamond, M. I., Aug 29 2008, In : Journal of Biological Chemistry. 283, 35, p. 23950-23955 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors

Fuentealba, R. A., Marasa, J., Diamond, M. I., Piwnica-Worms, D. & Weihl, C. C., Feb 1 2012, In : Human molecular genetics. 21, 3, p. 664-680 17 p., ddr500.

Research output: Contribution to journalArticle

29 Scopus citations

An N-terminal nuclear export signal regulates trafficking and aggregation of huntingtin (Htt) protein exon 1

Zheng, Z., Li, A., Holmes, B. B., Marasa, J. C. & Diamond, M. I., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6063-6071 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Anti-tau antibodies that block tau aggregate seeding invitro markedly decrease pathology and improve cognition in vivo

Yanamandra, K., Kfoury, N., Jiang, H., Mahan, T. E., Ma, S., Maloney, S. E., Wozniak, D. F., Diamond, M. I. & Holtzman, D. M., Oct 16 2013, In : Neuron. 80, 2, p. 402-414 13 p.

Research output: Contribution to journalArticle

317 Scopus citations

A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor

Pollitt, S. K., Pallos, J., Shao, J., Desai, U. A., Ma, A. A. K., Thompson, L. M., Marsh, J. L. & Diamond, M. I., Nov 13 2003, In : Neuron. 40, 4, p. 685-694 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 199-208 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization.

Jones, J. O., An, W. F. & Diamond, M. I., Mar 20 2009, In : ACS chemical biology. 4, 3, p. 191-197 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

Stopschinski, B. E., Thomas, T. L., Nadji, S., Darvish, E., Fan, L., Holmes, B. B., Modi, A. R., Finnell, J. G., Kashmer, O. M., Estill-Terpack, S., Mirbaha, H., Luu, H. S. & Diamond, M. I., Mar 6 2020, In : Journal of Biological Chemistry. 295, 10, p. 2974-2983 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Biologically active molecules that reduce polyglutamine aggregation and toxicity

Desai, U. A., Pallos, J., Ma, A. A. K., Stockwell, B. R., Thompson, L. M., Marsh, J. L. & Diamond, M. I., Jul 2006, In : Human molecular genetics. 15, 13, p. 2114-2124 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Cellular models for the study of prions

Holmes, B. B. & Diamond, M. I., Feb 1 2017, In : Cold Spring Harbor perspectives in medicine. 7, 2, a024026.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

Kaufman, S. K., Thomas, T. L., Del Tredici, K., Braak, H. & Diamond, M. I., Jun 7 2017, In : Acta Neuropathologica Communications. 5, 1, p. 41 1 p.

Research output: Contribution to journalArticle

36 Scopus citations

Conformational diversity of wild-type tau fibrils specified by templated conformation change

Frost, B., Ollesch, J., Wille, H. & Diamond, M. I., Feb 6 2009, In : Journal of Biological Chemistry. 284, 6, p. 3546-3551 6 p.

Research output: Contribution to journalArticle

143 Scopus citations

Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening

Gerber, A. N., Masuno, K. & Diamond, M. I., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4929-4934 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

Distinct tau prion strains propagate in cells and mice and define different tauopathies

Sanders, D. W., Kaufman, S. K., DeVos, S. L., Sharma, A. M., Mirbaha, H., Li, A., Barker, S. J., Foley, A. C., Thorpe, J. R., Serpell, L. C., Miller, T. M., Grinberg, L. T., Seeley, W. W. & Diamond, M. I., Jun 18 2014, In : Neuron. 82, 6, p. 1271-1288 18 p.

Research output: Contribution to journalArticle

452 Scopus citations

Distinct therapeutic mechanisms of Tau antibodies: Promoting microglial clearance versus blocking neuronal uptake

Funk, K. E., Mirbaha, H., Jiang, H., Holtzman, D. M. & Diamond, M. I., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21652-21662 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis

Boylan, K. B., Takahashi, N., Paty, D. W., Sadovnick, A. D., Diamond, M., Hood, L. E. & Prusiner, S. B., Mar 1990, In : Annals of Neurology. 27, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

DNA length polymorphism located 5' to the human myelin basic protein gene

Boylan, K. B., Takahashi, N., Diamond, M., Hood, L. E. & Prusiner, S. B., 1987, In : American Journal of Human Genetics. 40, 5, p. 387-400 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics

Angeli, S., Shao, J. & Diamond, M. I., Feb 4 2010, In : PloS one. 5, 2, e9053.

Research output: Contribution to journalArticle

21 Scopus citations
21 Scopus citations

Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells

Reynolds, M. R., Singh, I., Azad, T. D., Holmes, B. B., Verghese, P. B., Dietrich, H. H., Diamond, M., Bu, G., Han, B. H. & Zipfel, G. J., Jan 22 2016, In : Molecular neurodegeneration. 11, 1, 9.

Research output: Contribution to journalArticle

12 Scopus citations

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Holmes, B. B., DeVos, S. L., Kfoury, N., Li, M., Jacks, R., Yanamandra, K., Ouidja, M. O., Brodsky, F. M., Marasa, J., Bagchi, D. P., Kotzbauer, P. T., Miller, T. M., Papy-Garcia, D. & Diamond, M. I., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3138-E3147

Research output: Contribution to journalArticle

359 Scopus citations

Huntington disease and the huntingtin protein

Zheng, Z. & Diamond, M. I., 2012, In : Progress in Molecular Biology and Translational Science. 107, p. 189-214 26 p.

Research output: Contribution to journalArticle

58 Scopus citations

Inert and seed-competent tau monomers suggest structural origins of aggregation

Mirbaha, H., Chen, D., Morazova, O. A., Ruff, K. M., Sharma, A. M., Liu, X., Goodarzi, M., Pappu, R. V., Colby, D. W., Mirzaei, H., Joachimiak, L. A. & Diamond, M. I., Jul 10 2018, In : eLife. 7, e36584.

Research output: Contribution to journalArticle

52 Scopus citations

Inhibition of the androgen receptor by mineralocorticoids at levels physiologically achieved in serum in patients treated with abiraterone acetate

Kim, W., Jones, J. O., Diamond, M., Haqq, C., Molina, A., Small, E. J. & Ryan, C. J., Jul 2014, In : Prostate Cancer and Prostatic Diseases. 17, 3, p. 292-299 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells

Ryan, C. J., Zavodovskaya, M., Youngren, J. F., Campbell, M., Diamond, M., Jones, J., Shiry, L., Allan, G., Maddux, B. A. & Goldfine, I. D., Aug 2008, In : Prostate. 68, 11, p. 1232-1240 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43

Fuentealba, R. A., Udan, M., Bell, S., Wegorzewska, I., Shao, J., Diamond, M. I., Weihl, C. C. & Baloh, R. H., Aug 20 2010, In : Journal of Biological Chemistry. 285, 34, p. 26304-26314 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Intravitreal Administration of HA-1077, a ROCK Inhibitor, Improves Retinal Function in a Mouse Model of Huntington Disease

Li, M., Yasumura, D., Ma, A. A. K., Matthes, M. T., Yang, H., Nielson, G., Huang, Y., Szoka, F. C., LaVail, M. M. & Diamond, M. I., Feb 11 2013, In : PloS one. 8, 2, e56026.

Research output: Contribution to journalArticle

30 Scopus citations

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

Yamada, K., Cirrito, J. R., Stewart, F. R., Jiang, H., Finn, M. B., Holmes, B. B., Binder, L. I., Mandelkow, E. M., Diamond, M. I., Lee, V. M. Y. & Holtzman, D. M., Sep 14 2011, In : Journal of Neuroscience. 31, 37, p. 13110-13117 8 p.

Research output: Contribution to journalArticle

208 Scopus citations

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

Gu, X., Cantle, J. P., Greiner, E. R., Lee, C. Y. D., Barth, A. M., Gao, F., Park, C. S., Zhang, Z., Sandoval-Miller, S., Zhang, R. L., Diamond, M., Mody, I., Coppola, G. & Yang, X. W., Feb 18 2015, In : Neuron. 85, 4, p. 726-741 16 p.

Research output: Contribution to journalArticle

36 Scopus citations

Neuronal activity enhances tau propagation and tau pathology in vivo

Wu, J. W., Hussaini, S. A., Bastille, I. M., Rodriguez, G. A., Mrejeru, A., Rilett, K., Sanders, D. W., Cook, C., Fu, H., Boonen, R. A. C. M., Herman, M., Nahmani, E., Emrani, S., Figueroa, Y. H., Diamond, M. I., Clelland, C. L., Wray, S. & Duff, K. E., Aug 1 2016, In : Nature Neuroscience. 19, 8, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

204 Scopus citations

Non-competitive androgen receptor inhibition in vitro and in vivo

Jones, J. O., Bolton, E. C., Huang, Y., Feau, C., Guy, R. K., Yamamoto, K. R., Hann, B. & Diamond, M. I., Apr 28 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 17, p. 7233-7238 6 p.

Research output: Contribution to journalArticle

67 Scopus citations